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1 Batey, R.G.; Bensoussan, A.; Yang, Y.F.; Bollip, S.; Hossain, M.A.
Preliminary report of a randomized, double-blind placebo controlled trial of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C
J Gastroenterol Hepatol, 1998, 13, 244-247
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Traditional Chinese medicine
2 Liu, J.; Lin, H.; McIntosh, H.
Genus phyllanthus for chronic hepatitis B virus infection
A systematic review
J Viral Hepatitis, 2001, 8, 358-366
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phyllanthus, Phytomedicine
3 Das, D.G.
A double-blind clinical trial of kamalahar, an indigenous compound preparation, in acute viral hepatitis
Ind J Gastroenterol, 1993, 12(4), 126-8
Embelia, Embelia ribes, Hepatitis, Kamalahar, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Nyctanthes arbor-tristis, Phyllanthus, Phytomedicine, Placebo-controlled, Randomized trial, Taraxacum, Tecoma undulata, Terminalia, Terminalia arjuna
4 Trinchet, J.C.; Coste, T.; Levy, V.G.
Traitement de l´hepatite alcoolique par la silymarine
Une etude comparative en double insu chez 116 malades (Treatment of alcoholic hepatitis with silymarin. A double-blind comparative study in 116 patients)
Gastroenterol Clin Biol, 1989, 13, 120-124
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
5 Tanasescu, C.; Petrea, S.; Baldescu, R.; Macarie, E.; Chiriloiu, C.; Purice, S.
Use of the Romanian product Silimarina in the treatment of chronic liver disease
Rev Roum Méd Int, 1988, 26, 311-322
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
6 Magliulo, E.; Gagliardi, B.; Fiori, G.P.
Zur Wirkung von Silymarin bei der Behandlung der akuten Virushepatitis
Med Klin, 1978, 79, 1060-1065
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
7 Buzzelli, G.; Moscarella, S.; Giusti, A.; Duchini, A.; Marena, C.; Lampertico, M.
A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB 1016) in chronic acitve hepatitis
Int J Clin Pharmacol Ther Toxicol, 1993, 31, 456-460
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
8 Kiesewetter, E.; Leodolter, I.; Thaler, H.
Ergebnisse zweier Doppelblindstudien zur Wirksamkeit von Silymarin bei chronischer Hepatitis
Leber Magen Darm, 1977, 7, 318-323
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
9 Ernst, E.; Sherman, K.J.
Is acupuncture a risk factor for hepatitis?
Systematic review of epidemiological studies
J Gastroenterol Hepatol, 2003, 18, 1231-1236
Acupuncture, Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Systematic review, Traditional Chinese medicine, Prevalence
10 Jakkula, M.; Boucher, T.A.; Beyendorff, U.; Ac, L.; Conn, S.M.; Johnson,J.E.; Nolan, C.J.; Peine, C.J.; Albrecht, J.H.
A randomized trial of chinese herbal medicines for the treatment jof symptomatic hepatitis C
Arch Intern Med, 2004, 164(12), 1341-1346
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine
11 Orlent, H.; Hansen, B.E.; Willems, M.; Brouwer, J.T.; Huber, R.; Kullak, Ublick, G.A.; Gerken, G.; Zeuzem, S.; Nevens, F.; Tielemans, C.M.; Zondervan, P.E.; Lagging, M.; Westin, J.; Schalm, S.W.
Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C
A randomized phase II trial
J Hepatol, 2006, 45(4), 539-546
Biochemistry, Glycyrrhiza, liquorice root, Glycyrrhizinsäure, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial
12 Rambaldi, A.; Jacobs, B.P.; Gluud, C.
Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Cochrane Database Syst Rev, 2007, 4(CD003620), 1-76
Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle, Systematic review
13 El-Kamary, S.S.; Shardell, M.D.; Abdel-Hamid, M.; Ismail, S.; El-Ateek, M.; Metwally, M.; Mikhail, N.; Hashem, M.; Mousa, A.; Aboul-Fotouh, A.; El-Kassas, M.; Esmat, G.; Strickland, G.T.
A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis
Phytomed, 2009, 16(5), 391-400
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
14 Berle, C.A.; Cobbin, D.; Smith, N.; Zaslawski, C.
A novel approach to evaluate traditional Chinese medicine treatment outcomes using pattern identification
J Altern Complement Med, 2010, 16(4), 357-367
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Methodology, Randomized trial, Theory, Traditional Chinese medicine
15 Sumida, Y.; Kanemasa, K.; Fukumoto, K.; Yoshida, N.; Sakai, K.
Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C
Results from a randomized, controlled trial on 40 Japanese patients
Intern Med, 2007, 46(10), 637-642
Purgative therapy, Bloodletting, Diet, Nutrition/diet, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Randomized trial
16 Zheng, S.; Du, J.; Lu, X.; Zhang, Y.; Hu, L.; Wang, W.
Quality of randomized controlled trials in acupuncture treatment of hepatitis B virus infection
A systematic review
Acupunct Electrother Res, 2010, 35(3-4), 119-131
Acupuncture, Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Systematic review, Traditional Chinese medicine
17 Xia, Y.; Luo, H.; Liu, J.P.; Gluud, C.
Phyllanthus species for chronic hepatitis B virus infection (Review)
Cochrane Database Syst Rev, 2011, 7(CD008960), 1-61
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phyllanthus, Phytomedicine, Systematic review
18 Zeng, X.X.; Bian, Z.X.; Wu, T.X.; Fu, S.F.; Ziea, E.; Woon, W.T.
Traditional Chinese medicine syndrome distribution in chronic hepatitis B populations
A systematic review
Am J Chin Med, 2011, 39(6), 1061-1074
Diagnostics, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Systematic review, Traditional Chinese medicine
19 Hu, Y.; Chen, L.; Shu, J.; Yao, Y.; Yan, H.M.
Clinical study on treatment of infantile cytomegalovirus hepatitis with integrated Chinese and Western medicine
Chin J Integr Med, 2012, 18(2), 100-105
Hepatitis, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Pediatrics, Qinggan Lidan, Randomized trial, Traditional Chinese medicine, Yigan Jiangmei
20 Raymond, R.S.; Fallon, M.B.; Abrams, G.A.
Oral thymic extract for chronic hepatitis C in patients previously treated with interferon
A randomized, double-blind, placebo-controlled trial
Ann Intern Med, 1998, 129(10), 797-800
Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Organotherapy, Placebo-controlled, Randomized trial, Thymus therapy
21 Deng, X.; Liang, J.; Wu, F.S.; Li, Y.B.; Tang, Y.F.
Effects of the Ganning formula on liver fibrosis in patients with chronic hepatitis B
J Trad Chin Med, 2011, 31(4), 282-287
Angelica, Astragalus, Astragalus membranaceus, Atractylodes, Atractylodes macrocephala, Catharanthus roseus, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Hepatic fibrosis, Lycopus, Gastrointestinal tract, Paeonia, Paeonia alba, Randomized trial, Tadehagi, Traditional Chinese medicine
22 Fried, M.W.; Navarro, V.J.; Afdhal, N.; Belle, S.H.; Wahed, A.S.; Hawke, R.L.; Doo, E.; Meyers, C.M.; Reddy, K.R.
Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy
A randomized controlled trial
JAMA, 2012, 308(3), 274-282
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
23 Reddy, K.R.; Belle, S.H.; Fried, M.W.; Afdhal, N.; Navarro, V.J.; Hawke, R.L.; Wahed, A.S.; Doo, E.; Meyers, C.M.
Rationale, challenges, and participants in a phase II trial of a botanical product for chronic hepatitis C
Clin Trials, 2012, 9(1), 102-112
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
24 Song, Y.N.; Sun, J.J.; Lu, Y.Y.; Xu, L.M.; Gao, Y.Q.; Zhang, W.; Wang, X.S.; Xue, D.Y.; Zheng, Q.S.; Su, S.B.
Therapeutic efficacy of fuzheng-huayu tablet based traditional Chinese medicine syndrome differentiation on hepatitis-B-caused cirrhosis
A mutlticenter double-blind randomized controlled trial
eCAM, 2013, 2013, 709305; (1-8)
Fuzheng Huayu, Chinese medicinal herbs, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Randomized trial, Traditional Chinese medicine
25 Wong, V.W.-S.; Wong, G.L.-H.; Chan, A.W.-H.; Chu, W.C.-W.; Choi, P.C.-L.; Chim, A.M.-L.; Yiu, K.K.-L.; Yu, J.; Chan, F.K.-L.; Chan, H.L.-Y.
Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria
A randomized trial
J Gastroenterol Hepatol, 2013, 28, 57-62
Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phyllanthus, Phyllanthus urinaria, Phytomedicine, Randomized trial
26 He, J.; Zhou, D.; Tong, G.; Xing, Y.; Chen, Y.; Zhang, X.; Zhan, B.; Gao, H.; Zhou, X.; Xiong, Y.; Liu, X.; Peng, L.; Qiu, M.; Zheng, Y.
Efficacy and safety of a Chinese herbal formula (invigorating kidney and strengthening spleen) in chronic hepatitis B virus carrier
Results from a multicenter, randomized, double-blind, and placebo-controlled trial
eCAM, 2013, Article ID 961926, (1-12)
Chinese medicinal herbs, Hepatitis, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Traditional Chinese medicine
27 Zhu, X.-J.; Sun, X.-H.; Zhou, Z.-H.; Liu, S.-Q.; Lv, H.; Li, M.; Gao, Y.-Q.
Lingmao formula combined with Entecavir for HBeAg-positive chronic hepatitis B patients with mildly elevated alanine aminotransferase
A multicenter, randomized, double-blind, placebo-controlled trial
eCAM, 2013, Article ID 620230, (1-7)
Chinese medicinal herbs, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lingmao Formula, Gastrointestinal tract, Placebo-controlled, Randomized trial, Traditional Chinese medicine
28 Rusu, E.; Jinga, M.; Enache, G.; Rusu, F.; Dragomir, A.D.; Ancuta, I.; Dragut, R.; Parpala, C.; Nan, R.; Sima, I.; Ateia, S.; Stoica, V.; Cheta, D.M.; Radulian, G.
Effects of lifestyle changes including specific dietary intervention and physical activitiy in the management of patients with chronic hepatitis C - a randomized trial
Nutr J, 2013, 12, 119; (1-12)
Exercise therapy, Diet, Nutrition/diet, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Physical therapy, Randomized trial
29 Lee, C.J.; Cheng, C.H.; Li, Y.H.; Liu, C.Y.; Hsu, C.H.
A chinese medicine, kuan-sin-yin decoction, improves liver function in hepatitis B virus carriers
A randomized, controlled study
J Altern Complement Med, 2013, 19(12), 964-969
Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Kuan-Sin-Yin, Gastrointestinal tract, Randomized trial, Traditional Chinese medicine
30 Loft, P.; Petrie, K.J.; Booth, R.J.; Thomas, M.; Robinson, E.; Vedhara, K.
Effects of massage on antibody responses after hepatits B vaccination
Psychosomatic Med, 2012, 74(9), 982-987
Hepatitis, Immune system, Vaccination, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Manual therapy, Massage, Randomized trial
31 Ma, X.; Wang, J.; He, X.; Zhao, Y.; Wang, J.; Zhang, P.; Zhu, Y.; Zhong, L.; Zheng, Q.; Xiao, X.
Large dosage of Chishao in formulae for cholestatic hepatitis
A systematic review and meta-analysis
eCAM, 2014, Article ID 328152, (1-10)
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Paeonia, Paeonia rubra, Systematic review, Traditional Chinese medicine
32 Yang, Z.; Zhuang, L.; Lu, Y.; Xu, Q.; Chen, X.
Effects and tolerance of Silymarin (milk thistle) in chronic hepatitis C virus infection patients
A meta-analysis of randomized controlled trials
Biomed Res Int, 2014, 2014, 941085; (1-9)
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, milk thistle
33 Wei, F.; Lang, Y.; Gong, D.; Fan, Y.
Effect of Dahuang zhechong formula on liver fibrosis in patients with chronic hepatitis B
A meta-analysis
Complement Ther Med, 2015, 23(1), 129-138
Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Hepatic fibrosis, Gastrointestinal tract, Meta-analysis, Traditional Chinese medicine, Dahuang zhechong
34 Xia, Y.; Luo, H.; Liu, J.P.; Gluud, C.
Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection
Cochrane Database Syst Rev, 2013, 4(CD009004), 1-30
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phyllanthus, Phytomedicine, Systematic review, Traditional Chinese medicine, Viruses
35 Shawkat, H.; Yakoot, M.; Shawkat, T.; Helmy, S.
Efficacy and safety of a herbal mixture (Viron® tablets) in the treatment of patients with chronic hepatitis C virus infection
A prospective, randomized, open-label, proof-of-concept study
Drug Design Devel Ther, 2015, 9, 799-804
Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Viron
36 Chen, Z.; Ma, X.; Zhao, Y.; Wang, J.; Zhang, Y.; Zhu, Y.; Wang, L.; Chen, C.; Wei, S.; Yang, Z.; Gong, M.; Shen, H.; Bai, Z.; Guo, Y.; Niu, M.; Xiao, X.
Kushenin combined with nucleos(t)ide analogues for chronic hepatitis B
A systematic review and meta-analysis
eCAM, 2015, Article ID 529636, (1-12)
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Sophora, Sophora flavescens, Systematic review, Traditional Chinese medicine
37 He, M.; Wu, Y.; Wang, M.; Chen, W.; Yuan, W; Jiang, J.
The clinical value of oxymatrine in preventing lamivudine induced YMDD mutation
A meta-analysis
eCAM, 2015, Article ID 971616, 40
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Sophora, Traditional Chinese medicine, Sophora alopecuroides
38 Song, W.-J.; Luo, J.; Wu, T.; Yao, S.-k.
Oral oxymatrine preparation for chronic hepatitis B
A systematic review of randomized controlled trials
Chin J Integr Med, 2016, 22(2), 141-149
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Systematic review
39 Guo, Y.-M.; Gong, M.; Zhang, L.; Wang, J.-B.; Xiao, X.-H.; Li, J.; Zhao, Y.-L.; Wang, L.-F.; Zhang, X.-F.
Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs
A randomized controlled trial
Chin J Integr Med, 2016, 22(8), 573-580
Chinese medicinal herbs, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Randomized trial, Traditional Chinese medicine, Yinchenzhufu
40 Liu, C.Y.; Ko, P.H.; Yen, H.R.; Cheng, C.H.; Li, Y.H.; Liao, Z.H.; Hsu, C.H.
The Chinese medicine Kuan-Sin-Yin improves liver function in patients with chronic hepatitis C
A randomised and placebo-controlled trial
Complement Ther Med, 2016, 27, 114-122
Chinese medicinal herbs, Hepatitis, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Kuan-Sin-Yin, Gastrointestinal tract, Placebo-controlled, Randomized trial, Traditional Chinese medicine
41 Chen, F.P.; Chang, C.M.; Wu, T.P.; Yang, J.L.; Kung, Y.Y.; Huang, Y.H.; Su, C.W.; Lan, K.H.; Chiang, S.C.; Hwang, S.J.
Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C
A double-blinded randomized placebo-controlled crossover study
J Ethnopharmacol, 2017, 196, 1-8
Chinese medicinal herbs, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Rong-Yang-Jyh-Gan-Tang
42 Choi, S.H.; Yang, K.J.; Lee, D.S.
Effects of complementary combination therapy of Korean red ginseng and antiviral agents in chronic hepatitis B
J Altern Complement Med, 2016, 22(12), 964-969
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Viruses, Panax, Panax ginseng
43 Lin, T.H.; Yen, H.R.; Chiang, J.H.; Sun, M.F.; Chang, H.H.; Huang, S.T.
The use of Chinese herbal medicine as an adjuvant therapy to reduce incidence of chronic hepatitis in colon cancer patients
A Taiwanese population-based cohort study
J Ethnopharmacol, 2017, 202, 225-233
Bowel cancer, Dickdarmkrebs, Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Randomized trial, Traditional Chinese medicine
44 Wang, X.; Lin, H.; Zhang, R.
The clinical efficacy and adverse effects of interferon combined with matrine in chronic hepatitis B
A systematic review and meta-analysis
Phytother Res, 2017, 31(6), 849-857
Hepatitis, Interferon, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Sophora, Sophora flavescens, Systematic review
45 Iqbal, O.; Nazar, H.; Afzal, S.; Usmanghani, K.
Alternative treatment in Hepatitis B by using polyherbal formulation
Pak J Pharm Sci, 2017, 30(1), 49-54
Artemisia, Artemisia absinthium, Hepatitis, Kaempferol, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Millefolium, Phytomedicine, Quercetin, Randomized trial, Rosa, Rosa damascena
46 Wang, T.; Zhou, X.; Liu, H.; Wang, J.; Zhang, P.; Zhu, Y.; Li, K.; Wei, S.; Li, H.; Wang, L.; Wang, R.; Zhao, Y.
Fuzheng Huayu capsule as an adjuvant treatment for HBV-related cirrhosis
A systematic review and meta‐analysis
Phytother Res, 2018, 32(5), 757-768
Fuzheng Huayu, Chinese medicinal herbs, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Meta-analysis, Systematic review, Traditional Chinese medicine
47 Akram, M.; Tahir, I.M.; Shah, S.M.A.; Mahmood, Z.; Altaf, A.; Ahmad, K.; Munir, N.; Daniyal, M.; Nasir, S.; Mehboob, H.
Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus
A systematic review
Phytother Res, 2018, 32(5), 811-822
Skin diseases, Hepatitis, Herpes simplex, HIV, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Systematic review, Viruses
48 Terziroli Beretta-Piccoli, B.; Mieli-Vergani, G.; Vergani, D.
Autoimmune hepatitis
Standard treatment and systematic review of alternative treatments
World J Gastroenterol, 2017, 23(33), 6030-6048
Hepatitis, Clinical research, Complementary and alternative medicine, Conventional medicine, Gastrointestinal tract, Systematic review
49 Baiguera, C.; Boschetti, A.; Raffetti, E.; Zanini, B.; Puoti, M.; Donato, F.
Phyllanthus niruri versus placebo for chronic hepatitis B virus infection
A randomized controlled trial
Complement Med Res, 2018, 25(6), 376-382
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phyllanthus, Phyllanthus niruri, Phytomedicine, Placebo-controlled, Randomized trial