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101 Rautava, S.; Salminen, S.; Isolauri, E.
Specific probiotics in reducing the risk of acute infections in infancy
A randomised, double-blind, placebo-controlled study
Br J Nutr, 2009, 101(11), 1722-1726
Bifidobacterium lactis, Bifidobacterium spec., Nutrition/diet, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Lactobacillus rhamnosus, Lactobacillus spec., Pediatrics, Placebo-controlled, Prevention, Probiotics, Randomized trial
102 Raus, K.; Pleschka, S.; Klein, P.; Schoop, R.; Fisher, P.
Effect of an echinacea-based hot drink versus olseltamivir in influenza treatment
A randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial
Curr Ther Res, 2015, 77, 66-72
Echinacea, Echinacea purpurea, Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
103 Zakay-Rones, Z.; Thom, E.; Wollan, T.; Wadstein, J.
Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza a and b virus infections
J Int Med Res, 2004, 32, 132-140
Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Sambucus, Viruses
104 Ha, M.S.; Kim, D.Y.; Baek, Y.H.
Effects of Hatha yoga exercise on plasma malondialdehyde concentration and superoxide dismutase activity in female patients with shoulder pain
J Phys Ther Sci, 2015, 27(7), 2019-2112
Muscoskeletal -/Connective tissue system, Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Non-randomized trial, Schulterschmerz (unspezifisch), Yoga
105 Tian, H.; Qin, W.; Wu, W.; Guo, P.; Lu, Y.; Liu, P.; Liu, Q.; Su, F.
Effects of traditional Chinese medicine on chemotherapy-induced myelosuppression and febrile neutropenia in breast cancer patients
eCAM, 2015, 2015, 736197; (1-11)
Breast cancer, Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial, Traditional Chinese medicine
106 Lim, S.A.; Cheong, K.J.
Regular yoga practice improves antioxidant status, immune function, and stress hormone releases in young healthy people
A randomized, double-blind, controlledpPilot study
J Altern Complement Med, 2015, 21(9), 530-538
Endocrinology, Healthy probands, Immunomodulation, Immune system, Internal medicine, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Mental diseases, Randomized trial, Stress, Yoga
107 Lewis, J.E.; Melillo, A.B.; Tiozzo, E.; Chen, L.; Leonard, S.; Howell, M. Diaz, J.; Gonzalez, K.; Woolger, J.M.; Konefal, J.; Paterson, E.; Barnes, D.
A double-blind, randomized clinical trial of dietary supplementation on cognitive and immune functioning in healthy older adults
BMC Complement Altern Med, 2014, 14, 332; (1-9)
Dementia, Nutrition/diet, Geriatrics, Healthy probands, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial
108 Mahmoud, F.; Haines, D.; Al-Ozairi, E.; Dashti, A.
Effet of black tea consumption on intracellular cytokines, regulatory T cells and metabolic biomarkers in type 2 diabetes patients
Phytother Res, 2016, 30(3), 454-462
Camellia, Camellia sinensis, Diabetes mellitus, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Metabolic diseases, Tea
109 Pilat, C.; Frech, T.; Wagner, A.; Krüger, K.; Hillebrecht, A.; Pons-Kühnemann, J.; Scheibelhut, C.; Bödeker, R.-H.; Mooren, F.-C.
Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response
A double-blind RCT
Scand J Med Sci Sports, 2015, 25(4), 534-542
Inflammation, Healthy probands, Homeopathy, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Placebo-controlled, Randomized trial, Traumeel
110 Ryu, K.H.; Shin, H.S.; Yang, E.Y.
Effects of laughter therapy on immune responses in postpartum women
J Altern Complement Med, 2015, 21(12), 781-788
Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Mind-body medicine, Non-randomized trial, Obstetrics, laughter therapy
111 George, A.; Suzuki, N.; Abas, A.B.; Mohri, K.; Utsuyama, M.; Hirokawa, K.; Takara, T.
Immunomodulation in midde-aged humans via the ingestion of Physta® standardized root water extract of Eurycoma longifolia Jack
A randomized, double-blind, placebo-controlled, parallel study
Phytother Res, 2016, 30(4), 627-635
Eurycoma longifolia, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
112 Dehghan, P.; Farhangi, M.A.; Tavakoli, F.; Aliasgarzadeh, A.; Akbari, A.M.
Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus
A randomized placebo-controlled trial
Complement Ther Med, 2016, 24, 96-102
Diabetes mellitus, Nutrition/diet, Fructooligosaccharide, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Dietary supplementation, Placebo-controlled, Prebiotics, Randomized trial, Metabolic diseases
113 Creswell, J.D.; Taren, A.A.; Lindsay, E.K.; Greco, C.M.; Gianoros, P.J.; Fairgrieve, A.; Marsland, A.L.; Brown, K.W.; Way, B.M.; Rosen, R.K.; Ferris, J.L.
Alterations in resting-state functional connectivity in mindfulness meditation with reduced interleukin-6
A randomized controlled trial
Biol Psych, 2016, 80(1), 53-61
Mindfulness meditation, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Mental diseases, Psychoneuroimmunology, Randomized trial, Stress
114 Li, H.; Xu, S.; Cheng, T.; Tang, L.; Bai, J.; Lin, M.
Effects of traditional Chinese medicine Fu Zheng decoction on the immunological function and clinical prognosis of the elderly patients with pneumonia
Cell Biochem Biophys, 2016, 71(1), 473-480
Respiratory diseases, Geriatrics, Chinese medicinal herbs, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lung inflammation, Randomized trial, Traditional Chinese medicine, Fu Zheng
115 Talvas, J.; Garrait, G.; Goncalves-Mendes, N.; Rouanet, J.; Vergnaud-Gauduchon, J.; Kwiatkowski, F.; Bachmann, P.; Bouteloup, C.; Bienvenu, J.; Vasson, M.-P.
Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients
A double-blind randomized clinical trial
Clin Nutr, 2015, 34, 810-817
Arginin, Nutrition/diet, Essential fatty acids, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Dietary supplementation, Esophageal cancer, Randomized trial
116 Hasselaar, G.; Nijnatten, W. van; Golden, I.
A pilot study into the comparative effectiveness and safety in the elderly of a homeopathic flu prophylaxis and the regular flu vaccination in the Netherlands
Hom Links, 2016, 29(2), 120-126
Geriatrics, Flu, Homeopathy, Immunomodulation, Immune system, Vaccination, Infections, Clinical research, Complementary and alternative medicine, Conventional medicine, Non-randomized trial, Homeoprophylaxis
117 Lopez-Moreno, J.; Quintana-Navarro, G.M.; Delgado-Lista, J.; Garcia-Rios, A.; Delgado-Cassado, N.; Camargo, A.; Perez-Martinez, P.; Striker, G.E.; Tinahones, F.J.; Perez-Jimenez, F.; Lopez-Miranda, J.; Yubero-Serrano, E.M.
Mediterranean diet reduces serum advanced glycation end products and increases antioxidant defenses in elderly adults
A randomized controlled trial
J Am Geriatr Soc, 2016, 64(4), 901-904
Diet, Nutrition/diet, Geriatrics, Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Mediterranian diet, Randomized trial, Metabolic diseases
118 Muroya, D.; Yutani, S.; Shichijo, S.; Yamada, A.; Sakamoto, S.; Naito, M.; Okuda, K.; Morita, M.; Yamaguchi, R.; Itoh, K.
Personalized Kampo medicine facilitated both cytotoxic T lymphocyte response and clinical benefits induced by personalized peptide vaccination for advanced esophageal cancer
eCAM, 2016, 2016, 5929525; (1-12)
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial, Esophageal cancer, Traditional Japanese medicine
119 Kamei, M.; Nishimura, H.; Takahashi, T.; Takahashi, N.; Inokuchi, K.; Mato, T.; Takahashi, K.
Anti-influenza virus effects of cocoa
J Sci Food Agric, 2016, 96(4), 1150-1158
Nutrition/diet, Experiment, Flu, Basic Research, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Prevention, Theobroma cacao, Animal, Viruses
120 Vera, F.M.; Manzaneque, J.M.; Rodriguez, F.M.; Bendayan, R.; Fernández, N.; Alonso, A.
Acute effects on the counts of innate and adaptive immune response cells after 1 month of Taoist qigong practice
Int J Behav Med, 2016, 23(2), 198-203
Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Qi Gong, Randomized trial, Traditional Chinese medicine
121 Buijze, G.A.; Sierevelt, I.N.; Heijden, B.C.J.M. van der; Dijkgraaf, M.G.; Frings-dresen, M.H.W.
The effect of cold showering on health and work
A randomized controlled trial
PLoS ONE, 2016, 11(9), e0161749; (1-15)
Balneology, Common cold, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Physical therapy, Prevention, Randomized trial
122 Williams, N.C.; Johnson, M.A.; Shaw, D.E.; Spendlove, I.
A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation
Br J Nutr, 2016, 116(5), 798-804
Asthma, Respiratory diseases, Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Placebo-controlled, Probiotics, Randomized trial
123 Pilch, W.; Pokora, I.; Szygula, Z.; Palka, T.; Pilch, P.; Cisoń, T.; Malik, L.; Wiecha, S.
Effect of a single Finnish sauna session on white blood cell profile and cortisol levels in athletes and non-athletes
J Human Kinet, 2013, 39, 127-135
Blood/Lymphatic system, Endocrinology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Non-randomized trial, Physical therapy, Sauna, Cortisone
124 Arefnasabm T,; Babmahmoodi, A.; Babamahmoodi, F.; Noorbala, A.A.; Alipour, A.; Panahi, Y.; Shams, J.; Rad, F.R.; Khaze, V.; Ghanei, M.
Mindfulness-based stress reduction (MBSR) and its effects on psychoimmunological factors of chemically pulmonary injured veterans
Iran J Allergy Asthma Immunol, 2016, 15(6), 476-486
Mindfulness meditation, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Mental diseases, Psychoneuroimmunology, Randomized trial, Stress
125 Kimata, H.
Kissing reduces allergic skin wheal responses and plasma neurotrophin levels
Physiol Behav, 2003, 80, 395-398
Allergies, House-dust allergy, Skin diseases, Hay fever, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Neurodermitis, Randomized trial
126 Kimata, H.
Kissing selectively decreases allergen-specific IgE production in atopic patients
J Psychosom Res, 2006, 60, 545-547
Allergies, Skin diseases, Hay fever, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Neurodermitis, Randomized trial
127 Kheirouri, S.; Hadi, V.; Alizadeh, M.
Immunomodulatory effect of Nigella sativa oil on T lymphocytes in patients with rheumatoid arthritis
Immunol Invest, 2016, 45(4), 271-283
Arthritis, Muscoskeletal -/Connective tissue system, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Nigella sativa, Phytomedicine, Placebo-controlled, Randomized trial, Rheumatic diseases
128 Zhong, J.; Karlsson, O.; Wang, G.; Li, J.; Guo, Y.; Lin, X.; Zemplenyi, M.; Sanchez-Guerra, M.; Trevisi, L.; Urch, B.; Speck, M.; Liang, L.; Coull, B.A.; Koutrakis, P.; Silverman, S.; Gold, D.R.; Wu, T.; Baccarelli, A.A.
B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial
Proc Natl Acad Sci USA, 2017, 114(13), 3503-3508
Inflammation, Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Dietary supplementation, Non-randomized trial, Placebo-controlled, Vitamins
129 Chen, P.J.; Yang, L.; Chou, C.C.; Li, C.C.; Chang, Y.C.; Liaw, J.J.
Effects of prenatal yoga on women's stress and immune function across pregnancy
A randomized controlled trial
Complement Ther Med, 2017, 31, 109-117
Healthy probands, Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Mental diseases, Randomized trial, Obstetrics, Stress, Yoga
130 Madineh, H.; Yadollahi, F.; Yadollahi, F.; Mofrad, E.P.; Kabiri, M.
Impact of garlic tablets on nosocomial infections in hospitalized patients in intensive care units
Electronic Physician, 2017, 9(4), 4064-4071
Allium, Allium sativum, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Intensivmedizin
131 Brustin, R.; Toledano, M.; Geffen, T.; Goona, R.; Hochberg, M.; Kreisberg, B.; Murad, S.; Pitcovski, J.
Immune modulation and treatment of human papilloma virus-related warts with energetics of living systems acupuncture
Med Acupunct, 2017, 29(3), 145-154
Acupuncture, Skin diseases, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Warts
132 Arrighi, A.
Citomix vs Immucytal® nella prevenzione e terapia delle infezioni respiratorie acute in età pediatrica - studio prospettico controllato
[Citomix vs Immucytal® in the prevention and therapy of acute respiratory infections in paediatrics - a controlled clinical trial]
Med Biol, 2009, 2009(3), 3-11
Respiratory diseases, Common cold, Homeopathy, Homotoxicology, Cough, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Non-randomized trial, Pediatrics, Prevention, Cold, Citomix
133 Gupta, A.; Kumar, S.; Dole, S.; Deshpande, S.; Deshpande, V.; Singh, S.; Sasibhushan, V.
Evaluation of Cyavanaprāśa on health and immunity related parameters in healthy children
A two arm, randomized, open labeled, prospective, multicenter, clinical study
Anc Sci Life, 2017, 36(3), 141-150
Ayurveda, Healthy probands, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Pediatrics, Randomized trial, Cyavanaprāśa
134 Heilmann, A.
A combination injection preparation as a prophylactic for flu and common colds
Biol Ther, 1994, 7(4), 249-253
Applikationsform, Respiratory diseases, Engystol, Common cold, Flu, Homeopathy, Immunomodulation, Immune system, Infections, Injektion, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Placebo-controlled, Prevention, Randomized trial
135 Lages, P.C.; Generoso, S.V.; Correia, M.I.T.D.
Postoperative symbiotic in patients with head and neck cancer
A double-blind randomised trial
Br J Nutr, 2018, 119(2), 190-195
Bifidobacterium lactis, Bifidobacterium spec., Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus spec., Gastrointestinal tract, Placebo-controlled, Probiotics, Randomized trial, Lactobacillus paracasei
136 Maleki, B.H.; Tartibian, B.; Mooren, F.C.; Krüger, K.; FitzGerald, L.Z.; Chehrazi, M.
A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists
Cytokine, 2016, 88, 222-231
Apitherapy, Exercise therapy, Healthy probands, Homespun remedies, Honey, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Physical therapy, Randomized trial, Traditional medicine
137 Ra Cho, A.; Lee, S.Y.; Cho, Y.H.; Kim, C.M.; Kim, S.G.
Effects of 4-week intervention with Ulmus macrocarpa hance extract on immune function biomarkers in healthy adults
A randomized controlled trial
eCAM, 2018, Article ID 5690816, (1-6)
Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Ulmus, Ulmus macrocarpa
138 Batbold, U.; Butov, D.O.; Kutsyna, G.A.; Damdinpurev, N.; Grinishina, E.A.; Mijiddorj, O.; Kovolev, M.E.; Baasanjav, K; Butova, T.S.; et al.
Double-blind, placebo-controlled, 1:1 randomized phase III clinical trial of immunoxel honey lozenges as an adjunct immunotherapy in 269 patients with pulmonary tuberculosis
Immunother, 2017, 9(1), 13-24
Apitherapy, Respiratory diseases, Homespun remedies, Honey, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Placebo-controlled, Randomized trial, Tuberculosis, Traditional medicine
139 Schad, F.; Thronicke, A.; Merkle, A.; Matthes, H.; Steele, M.L.
Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients
Phytomed, 2017, 36, 54-58
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Non-randomized trial, Phytomedicine, posology, Retrospective design, Adverse effect, Viscum, Viscum album
140 Angurana, S.K.; Bansal, A.; Singhi, S.; Aggarwal, R.; Jayashree, M.; Salaria, M.; Mangat, N.K.
Evaluation of effect of probiotics on cytokine levels in critically ill children with severe sepsis
A double-blind, placebo-controlled trial
Crit Care Med, 2018, 46(10), 1656-1664
Bifidobacterium longum, Bifidobacterium spec., Sepsis, Nutrition/diet, Immunomodulation, Immune system, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lactobacillus acidophilus, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus spec., Maltose, Pediatrics, Placebo-controlled, Probiotics, Randomized trial, Lactobacillus paracasei, Bifidobacterium breve, Bifidobacterium infantis, Streptococcus salivarius
141 Swanson, B.; Keithley, J.; Baum, L.; Leurgans, S.; Adeyemi, O.; Barnes, L.L.; Mata, M.; Rosdil, A.
Effects of fish oil on HIV-related inflammation and markers of immunosenescence
A randomized clinical trial
J Altern Complement Med, 2018, 24(7), 709-716
Inflammation, Nutrition/diet, Essential fatty acids, HIV, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Randomized trial, fish oil
142 Magar, S.; Nayak, D.; Mahajan, U.B.; Patil, K.R.; Shinde, S.D.; Goyal, S.N.; Swaminarayan, S.; Patil, C.R.; Ojha, S.; Kundu, C.N.
Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats
Sci Rep, 2018, 8(1), 13562; (1-11)
Experiment, Basic Research, Homeopathy, Immunomodulation, Immune system, Complementary and alternative medicine, Nervous system, Neuropathy, Phytomedicine, Rhus, Rhus toxicodendron, Animal
143 Pelzer, F.; Tröger, W.; Nat, D.R.
Complementary treatment with mistletoe extracts during chemotherapy
Safety, neutropenia, fever, and quality of life assessed in a randomized study
J Altern Complement Med, 2018, 24(9-10), 954-961
Blood/Lymphatic system, Breast cancer, Fever, Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Neutropenia, Phytomedicine, Randomized trial
144 Loeb, M.; Russell, M.L.; Neupane, B.; Thanabalan, V.; Singh, P.; Newton, J.; Pullenayegum, E.
A randomized, blinded, placebo-controlled trial comparing antibody responses to homeopathic and conventional vaccines in university students
Vaccine, 2018, 36(48), 7423-7429
Diphterinum, Homeopathy, Immunomodulation, Immune system, Vaccination, Clinical research, Complementary and alternative medicine, Morbillinum, Nosoden, Ourlianum, Pertussinum, Placebo-controlled, Randomized trial, Tetanotoxinum
145 Niu, A.
Effect of "Tai Chi" exercise on antioxidant enzymes activities and immunity function in middle-aged participants
Afr J Tradit Compl Altern Med, 2016, 13(5), 87-90
Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Randomized trial, Taiji, Traditional Chinese medicine
146 Hamrin, E.; Ernerudh, J.; Rosén, A.
Immunological and quality-of-life profiles in women with breast cancer
Complementary versus conventional care
Complement Med Res, 2018, 25(6), 391-397
Anthroposophic medicine, Breast cancer, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial
147 Ji, L.S.; Gao, Q.T.; Guo, R.W.; Zhang, X.; Zhou, Z.H.; Yu, Z.; Zhu, X.J.; Gao, Y.T.; Sun, X.H.; Gao, Y.Q.; Li, M.
Immunomodulatory effects of combination therapy with Bushen formula plus Entecavir for chronic hepatitis B patients
J Immunol Res, 2019, 2019, 8983903; (1-10)
Chinese medicinal herbs, Hepatitis, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Traditional Chinese medicine, Bushen, osteopenia