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201 Gaffey, A.; Slater, H.; Porritt, K.; Campbell, J.M.
The effects of curcuminoids on musculoskeletal pain
A systematic review
JBI Database Sys Rev Implement Rep, 2017, 15(2), 486-516 (Abstract)

Arthrosis, Muscoskeletal -/Connective tissue system, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Osteoporosis, Phytomedicine, Rheumatic diseases, Back pain (non-specific), Pain, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28178024

202 Chou, R.; Deyo, R.; Friedly, J.; Skelly, A.; Hashimoto, R.; Weimer, M.; Fu, R.; Dana, T.; Kraegel, P.; Griffin, J.; Grusin, S.; Brodt, E.D.
Nonpharmacologic therapies for low back pain
A systematic review for an Americal College of Physicians Clinical Practice guideline
Ann Intern Med, 2017, 166(7), (1-14)

Acupuncture, Muscoskeletal -/Connective tissue system, Exercise therapy, Relaxation, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Massage, Meditation, Mind-body medicine, Physical therapy, Back pain (non-specific), Systematic review, Taiji, Traditional Chinese medicine, Yoga

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28192793

203 Kizhakkeveettil, A.; Rose, K.A.; Kadar, G.E.; Hurwitz, E.L.
Integrative acupuncture and spinal manipulative therapy versus either alone for low back pain
A randomized controlled trial feasibility study
J Manipulative Physiol Ther, 2017, 40(3), 201-213

Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Massage, Randomized trial, Back pain (non-specific), Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28259496

204 Brämberg, E.B.; Bergström, G.; Jensen, I.; Hagberg, J.; Kwak, L.
Effects of yoga, strength training and advice on back pain
A randomized controlled trial
BMC Musculoskel Disord, 2017, 18, 132

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Physical therapy, Randomized trial, Back pain (non-specific), Yoga, Strength training

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28356091

205 Arguiselas, M.D.; Lisón, J.F.; Sánchez-Zuriaga, D.; Martínez-Hurtado, I.; Doménech-Fernández, J.
Effects of myofascial release in nonspecific chronic low back pain
A randomized clinical trial
Spine, 2017, 42(9), 627-634

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Placebo-controlled, Randomized trial, Back pain (non-specific)

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28441294

206 Ushinohama, A.; Cunha, B.P.; Costa, L.O.P.; Barela, A.M.F.; Freitas, P.B. de
Effect of a single session of ear acupuncture on pain intensity and postural control in individuals with chronic low back pain
A randomized controlled trial
Braz J Phys Ther, 2016, 20(4), 328-335

Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Ear acupuncture, Placebo-controlled, Randomized trial, Back pain (non-specific), Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27556389

207 Preece, H.; White, P.
Does kinesiology tape increase trunk forward flexion?
J Bodyw Mov Ther, 2017, 21(3), 618-625

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Physical therapy, Placebo-controlled, Randomized trial, Back pain (non-specific), Taping, Kinesio-taping

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28750974

208 Groessl, E.J.; Liu, L.; Chang, D.G.; Wetherell, J.L.; Bormann, J.E.; Atkinson, J.H.; Baxi, S.; Schmalzl, L.
Yoga for military veterans with chronic low back pain
A randomized clinical trial
Am J Prev Med, 2017, 53(5), 599-608

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Randomized trial, Back pain (non-specific), Pain, Yoga, Chronic pain

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28735778

209 Romanowski, M.W.; Spiritovic, M.; Rutkowski, R.; Dudek, A.; Samborski, W.; Straburzynska-Lupa, A.
Comparison of deep tissue massage and therapeutic massage for lower back pain, disease activity, and functional capacity of ankylosing spondylitis patients
A randomized clinical pilot study
eCAM, 2017, Article ID 9894128, (1-7)

Muscoskeletal -/Connective tissue system, Connective tissue massage, Clinical research, Complementary and alternative medicine, Manual therapy, Bechterew's disease, Randomized trial, Rheumatic diseases, Back pain (non-specific)

Abstract: https://www.hindawi.com/journals/ecam/2017/9894128/

210 Lin, M.-L.; Wu, J.-H.; Lin, C.-W.; Su, C.-W.; Su, C.-T.; Wu, H.-C.; Shih, Y.-S.; Chiu, I.-T.; Chen, C.-Y.; Chang, W.-D.
Clinical effects of laser acupuncture plus Chinese cupping on the pain and plasma cortisol levels in patients with chronic nonspecific lower back pain
A randomized controlled trial
eCAM, 2017, Article ID 3140403, (1-7)

Purgative therapy, Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Laserneedle acupuncture, Randomized trial, Back pain (non-specific), Cupping, Traditional Chinese medicine

Abstract: https://www.hindawi.com/journals/ecam/2017/3140403/

211 Lopes, S.; Correia, C.; Félix, G.; Lopes, M.; Cruz, A.; Ribeiro, F.
Immediate effects of Pilates based therapeutic exercise on postural control of young individuals with non-specific low back pain
A randomized controlled trial
Complement Ther Med, 2017, 34, 104-110

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Physical therapy, Randomized trial, Back pain (non-specific), Pilates

Abstract: https://dx.doi.org/10.1016/j.ctim.2017.08.006

212 Haines, T.; Bowles, K.-A.
Cost-effectiveness of using a motion-sensor biofeedback treatment approach for the management of sub-acute or chronic low back pain
Economic evaluation alongside a randomised controlled trial
BMC Musculoskel Disord, 2017, 18, 18; (1-10)

Muscoskeletal -/Connective tissue system, Biofeedback, Clinical research, Complementary and alternative medicine, Low back pain, Mind-body medicine, Economy, Randomized trial, Back pain (non-specific), Pain, Cost-effectiveness, Chronic pain

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28095832

213 Movahedi, M.; Ghafari, S.; Nazari, F.; Valiani, M.
The effects of acupressure on pain severity in female nurses with chronic low back pain
Iran J Nurs Midwifery Res, 2017, 22, 339-342

Acupressure, Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Placebo-controlled, Randomized trial, Back pain (non-specific), Traditional Chinese medicine, Pflege

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28720230

214 Pecos-Martin, D.; Melo Aroeira, A.E. de; Verás Silva, R.L.; Martínez de Tejada Pozo, G.; Rodriguez Solano, L.M.; Plaza-Manzano, G.; Gallego-Izquierdo, T.; Falla, D.
Immediate effects of thoracic spinal mobilisation on erector spinae muscle activity and pain in patients with thoracic spine pain
A preliminary randomised controlled trial
Physiotherapy, 2017, 103(1), 90-97

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Randomized trial, Back pain (non-specific), Spine, Mobilisation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27012824

215 Ibrahim, M.A.M.; Hasbollah, H.R.; Ibrahim, M.A.H.; Marican, N.D.; Halim, M.h.A.; RAshid, A.F.A.; Yasin, N.H.M.
Physical activity associate low back pain and intervention program
Review
AIP Conference Proceedings, 2017, 1891, 020062; (1-7)

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Low back pain, Physical therapy, Back pain (non-specific), Systematic review

Abstract: https://aip.scitation.org/doi/abs/10.1063/1.5005395

216 Akhtar, M.W.; Karimi, H.; Gilani, S.A.
Effectiveness of core stabilization exercises and routine exercise therapy in management of pain in chronic non-specific low back pain
A randomized controlled clinical trial
Pak J Med Sci, 2017, 33(4), 1002-1006

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Physical therapy, Randomized trial, Back pain (non-specific), Rückenschule

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29067082

217 Hoffmann de Oliveira, B.; Abreu da Silva, A.Q. de; Ludtke, D.D.; Madeira, F.; Silva Medeiros, G.M. da; Parreira, R.B.; Salgado, A.S.I.; Belmonte, L.A.O.; Cidral-Filho, F.J.; Martins, D.F.
Foot reflexotherapy induces analgesia in elderly individuals with low back pain
A randomized, double-blind, controlled pilot study
eCAM, 2017, Article ID 2378973, (1-9)

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Randomized trial, Reflexology, Back pain (non-specific), Pain

Abstract: https://www.hindawi.com/journals/ecam/2017/2378973/

218 Bishop, A.; Ogollah, R.; Bartlam, B.; Barlas, P.; Holden, M.A.; Ismail, K.M; Jowett, S.; Lewis, M.; Lloyd, A.; kettle, C.; kigozi, J.; Foster, N.E.
Evaluating acupuncture and standard care for pregnant women with back pain
The EASE back pilot randomised controlled trial (ISCRTN49955124)
Pilot Feasibility Stud, 2016, 2, 72; (1-19)

Acupuncture, Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Randomized trial, Back pain (non-specific), Obstetrics, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27965887

219 Sayilir, S.; Yildizgoren, M.T.
The medium-term effects of diadynamic currents in chronic low back pain
TENS versus diadynamic currents: a randomised, follow-up study
Complement Ther Clin Pract, 2017, 29, 16-19

Muscoskeletal -/Connective tissue system, Diadynamic currents, Electrotherapy, Clinical research, Complementary and alternative medicine, Low back pain, Physical therapy, Randomized trial, Back pain (non-specific), Transcutaneous electrical nerve stimulation (TENS)

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29122255

220
NeyChondrin-Behandlung des Zervikalen- und Lumbalen-Syndroms (Klinische Studie)
1992, gesamt (Manuskript)

Muscoskeletal -/Connective tissue system, Cervical syndrome, Clinical research, Complementary and alternative medicine, Low back pain, Neck pain, Neural therapy, Organotherapy, Placebo-controlled, Randomized trial, Back pain (non-specific)

221 Bellido-Fernández, L.; Jiménez-Rejano, J.J.; Chillón-Martínez, R.; Gómez-Benítez, M.A.; De-La-Casa-Almeida, M.; Rebollo-Salas, M.
Effectiveness of massage therapy and abdominal hypopressive gymnastics in nonspecific chronic low back pain
A randomized controlled pilot study
eCAM, 2018, Article ID 3684194, (1-9)

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Physical therapy, Randomized trial, Back pain (non-specific)

Abstract: https://www.hindawi.com/journals/ecam/2018/3684194/

222 Teut, M.; Ullmann, A.; Ortiz, M.; Rotter, G.; Binting, S.; Cree, M.; Lotz, F.; Roll, S.; Brinkhaus, B.
Pulsatile dry cupping in chronic low back pain - a randomized three-armed controlled clinical trial
BMC Complement Altern Med, 2018, 18, 115; (1-9)

Purgative therapy, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Randomized trial, Back pain (non-specific), Cupping

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29609566

223 Asama, T.; Matsuzaki, H.; Fukushima, S.; Tatefuji, T.; Hashimoto, K.; Takeda, T.
Royal jelly supplementation improves menopausal symptoms such as backache, low back pain, and anxiety in postmenopausal Japanese women
eCAM, 2018, Article ID 4868412, (1-7)

Anxiety, Apitherapy, Muscoskeletal -/Connective tissue system, Gelee royale, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Placebo-controlled, Mental diseases, Randomized trial, Back pain (non-specific)

Abstract: https://www.hindawi.com/journals/ecam/2018/4868412/

224 Kuvacic, G.; Fratini, P.; Padulo, J.; Iacono, A. dello; Giorgio, A. de
Effectiveness of yoga and educational intervention on disability, anxiety, depression, and pain in people with CLBP
A randomized controlled trial
Complement Ther Clin Pract, 2018, 31, 262-267

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Meditation, Mind-body medicine, Randomized trial, Back pain (non-specific), Yoga

Abstract: https://www.sciencedirect.com/science/article/pii/S1744388117305054

225 Movahedi, M.; Ghafari, S.; Nazari, F.; Valiani, M.
The effect of acupressure on fatigue among female nurses with chronic back pain
Appl Nurs Res, 2017, 36, 111-114

Acupressure, Acupuncture, Muscoskeletal -/Connective tissue system, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Placebo-controlled, Mental diseases, Randomized trial, Back pain (non-specific), Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28720230

226 Goertz, C.M.; Long, C.R.; Vining, R.D.; Pohlman, K.A.; Walter, J.; Coulter, I.
Effect of usual medical care plus chiropractic care vs usual medical care alone on pain and disability among US service members with low back pain
A comparative effectiveness clinical trial
JAMA Network Open, 2018, 1(1), e180105; (1-15)

Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Randomized trial, Back pain (non-specific)

Abstract: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2680417

227 Martí-Salvador, M.; Hidalgo-Moreno, L.; Doménech-Fernández, J.; Lisón, J.F.; Arguisuelas, M.D.
Osteopathic manipulative treatment including specific diaphragm techniques improves pain and disability in chronic non-specific low back pain
A randomized trial
Arch Phys Med Rehabil, 2018, 99(9), 1720-1729

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Osteopathy, Placebo-controlled, Randomized trial, Back pain (non-specific)

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29787734

228 Carvalho, R.C. de; Parisi, J.R.; Prado, W.A.; Araújo, J.E.; Silva, A.M.; Silva, J.R.T.; Silva, M.L.
Single or multiple electroacupuncture sessions in nonspecific low back pain
Are we low-responders to electroacupuncture?
J Acupunct Meridian Stud, 2018, 11(2), 54-61

Acupuncture, Muscoskeletal -/Connective tissue system, Electroacupuncture, Clinical research, Complementary and alternative medicine, Non-randomized trial, Back pain (non-specific), Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29703337

229 Seo, B.-K.; Han, K.; Kwon, O.; Jo, D.-J.; Lee, J.-H.
Efficacy of bee venom acupuncture for chronic low back pain
A randomized, double-blinded, sham-controlled trial
Toxins, 2017, 9, 361; (1-14)

Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Placebo-controlled, Randomized trial, Back pain (non-specific), Traditional Chinese medicine, Bee venom acupuncture

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29112155

230 Shetty, P.; Hedge, K.; Sujatha, K.J.
Comparative study on effect of hot mud and hot mustard application as an adjuvant to a comprehensive naturopathy treatment in management of low back pain
A randomized control trial
Int J Sci Res, 2018, 7(7), 48-50

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Physical therapy, Randomized trial, Back pain (non-specific), Compress, Peloidtherapie, Peat therapy

Abstract: https://www.iosrjournals.org/iosr-jdms/papers/Vol15-Issue%209/Version-13/C1509131319.pdf

231 Foster, N.E.; Bishop, A.; Bartlam, B.; Ogollah, R.; Barlas, P.; Holden, M.; Ismail, K.; Jowett, S.; Kettle, C.; Kigozi, J.; Lewis, M.; Lloyd, A.; Waterfield, J.; Young, J.
Evaluating acupuncture and standard carE for pregnant women with back pain (EASE Back)
A feasibility study and pilot randomised trial
Health Technol Assess, 2016, 20(33), 1-236

Acupuncture, Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Randomized trial, Back pain (non-specific), Obstetrics, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27133814

232 Leite, P.M.S.; Mendonça, A.R.C.; Maciel, L.Y.S.; Poderoso-Neto, M.L.; Araujo, C.C.A.; Góis, H.C.J.; Souza, J.H.S.; DeSantana, J.M.
Does electroacupuncture treatment reduce pain and change quantitative sensory testing responses in patients with chronic nonspecific low back pain?
A randomized controlled clinical trial
eCAM, 2018, Article 8586746, (1-8)

Acupuncture, Muscoskeletal -/Connective tissue system, Electroacupuncture, Clinical research, Complementary and alternative medicine, Randomized trial, Back pain (non-specific), Traditional Chinese medicine

Abstract: https://www.hindawi.com/journals/ecam/2018/8586746

233 Bidoki, F.Z.; Zolaktaf, V.; Ghasemi,G.A.
The effects of home therapeutic exercise on pain and disability of women with back pain
Paripex Ind J Res, 2017, 6(6), 582-585

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Non-randomized trial, Physical therapy, Back pain (non-specific)

Abstract: https://wwjournals.com/index.php/gjra/article/view/12261

234 Lorenc, A.; Feder, G.; MacPherson, H.; Little, P.; Mercer, S.W.; Sharp, D.
Scoping review of systematic reviews of complementary medicine for musculoskeletal and mental health conditions
BMJ Open, 2018, 8, e020222; (1-15)

Arthritis, Arthrosis, Muscoskeletal -/Connective tissue system, Depression, Clinical research, Complementary and alternative medicine, Mental diseases, Rheumatic diseases, Back pain (non-specific), Sleep disorders, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30327397

235 Ford, J.J.; Slater, S.L.; Richards, M.C.; Surkitt, L.D.; Chan, A.Y.P.; Taylor, N.F.; Hahne, A.J.
Individualised manual therapy plus guideline-based advice vs advice alone for people with clinical features of lumbar zygapophyseal joint pain
A randomised controlled trial
Physiotherapy, 2018, epub ahead of print,

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Physiotherapy, Randomized trial, Back pain (non-specific)

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30316547

236 Hickstein, L.; Kiel, S.; Raus, C.; Heß, S.; Walker, J.; Chenot, J.-F.
Akupunktur als Leistung der gesetzlichen Krankenversicherung in Deutschland
Eine retrospektive Beobachtungstudie basierend auf Abrechnungsdaten
Schmerz, 2018, 32(1), 30-38

Acupuncture, Muscoskeletal -/Connective tissue system, Attitude, Assesment, Joints, Complementary and alternative medicine, Health insurance, Economy, Patient structure, Back pain (non-specific), Pain, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29230550

237 Hohmann, C.-D.; Stange, R.; Steckhan, N.; Robens, S.; Ostermann, T.; Paetow, A.; Michalsen, A.
Wirksamkeit der Blutegeltherapie bei chronischen unteren Rückenschmerzen
Eine randomisierte kontrollierte Studie
Dt Ärztebl Int, 2018, 115(47), 785-792 (+ Anh.: Zusatzmaterial, I-VII)

Purgative therapy, Muscoskeletal -/Connective tissue system, Leech therapy, Clinical research, Complementary and alternative medicine, Low back pain, Randomized trial, Back pain (non-specific)

Abstract: https://www.aerzteblatt.de/archiv/203025/Wirksamkeit-der-Blutegeltherapie-bei-chronischen-unteren-Rueckenschmerzen

238 González-Gálvez, N.; Marcos-Pardo, P.J.; Carrasco-Poyatos, M.
Functional improvements after a pilates program in adolescents with a history of back pain
A randomised controlled trial
Complement Ther Clin Pract, 2019, 35, 1-7

Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Physical therapy, Randomized trial, Back pain (non-specific), Pilates

Abstract: https://www.sciencedirect.com/science/article/pii/S1744388118305206

239 Aoyagi, K.; Heller, D.; Hazlewood, D.; Sharma, N.; Santos, M. dos
Is spinal mobilization effective for low back pain?
A systematic review
Complement Ther Clin Pract, 2019, 34, 51-63

Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Massage, Physiotherapy, Back pain (non-specific), Systematic review

Abstract: https://www.sciencedirect.com/science/article/pii/S1744388118304201

240 Castro Moura, C. de; Hollanda Iunes, D.; Ruginsk, S.G.; Souza, V.H.S.; Assis, B.B. de; Chaves, E. de C.L.
Action of ear acupuncture in people with chronic pain in the spinal column
A randomized clinical trial
Rev Lat Am Enfermagem, 2018, 26, e3050; (1-9)

Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Ear acupuncture, Randomized trial, Back pain (non-specific), Pain, Traditional Chinese medicine, Spine, Chronic pain

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30183875

241 Liu, J.; Yeung, A.; Xiao, T. ,Tian, X.; Kong, Z.; Zou, L.; Wang, X.
Chen-style Tai Chi for individuals (aged 50 years old or above) with chronic non-specific low back pain
A randomized controlled trial
Int J Environ Res Public Health, 2010, 16(3), 1-9

Muscoskeletal -/Connective tissue system, Geriatrics, Clinical research, Complementary and alternative medicine, Randomized trial, Back pain (non-specific), Taiji, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30759778

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