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1 Maurer, K.; Ihl, R.; Dierks, T.; Fröhlich, L.
Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
Phytomed, 1998, 5(6), 417-424
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial, Tebonin
2 Kanowski, S.; Hermann, W.M.; Stephan, K.; Wierich, W.; Hoerr, R.
Proof of efficacy of the Gingko biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
Pharmacopsychiatry, 1997, 4(1), 3-14
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
3 Allain, H.; Schuck, S.; Lebreton, S.; Strenge-Hesse, A.; Braun, W.; Gandon, J.M.; Brissot, P.
Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer´s disease
Dement Geriatr Cogn Disord, 1999, 10, 181-185
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
4 Akhondzadeh, S.; Noroozian, M.; Mohammadi, M.; Ohadinia, S.; Jamshidi, A.H.; Khani, M.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
A double blind, randomized and placebo-controlled trial
J Clin Pharm Ther, 2003, 28, 53-59
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, sage
5 Yancheva, S.; Ihl, R.; Schlaefke, S.; Hoerr, R.
Ginkgo-biloba-Extract EGb 761, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features
A randomised, double-blind trial
Z Phytother, 2006, 27(Kongressband), S17
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
6 Santos-Neto, L.L. dos; Vilhena Toledo, M.A. de; Medeiros-Souza, P.; Souza, G.A. de
The use of herbal medicine in Alzheimer's disease - a systematic review
eCAM, 2006, 3(4), 441-445
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Systematic review
7 Man, S.C.; Durairajan, S.S.; Kum, W.F.; Lu, J.H.; Huang, J.D.; Cheng, C.F.; Chung, V.; Xu, M; Li, M.
Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease
J Alzheimers Dis, 2008, 14(2), 209-223
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Systematic review
8 Lee, S.-T.; Chu, K.; Shim, J.-Y.; Heo, J.-H.; Kim, M.
Panax ginseng enhances cognitive performance in Alzheimer diesease
Alzheimer Dis Assoc Disord, 2008, 22(3), 222-226
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
9 Heo, J.-H.; Lee, S.-T.; Chu, K.; Oh, M.J.; Park, H.-J.; Shim, J.-Y.; Kim, M.
An open-label study of Korean red ginseng as an adjuvant treatment for coginitve impairment in patients with Alzheimer's disease
Eur J Neurol, 2008, 15(8), 865-868
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
10 Lee, M.S.; Yang, E.J.; Kim, J.I.; Ernst, E.
Ginseng for cognitive function in Alzheimer's disease
A systematic review
J Alzheimers Dis, 2009, 18(2), 339-344
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Systematic review, Panax, Panax ginseng
11 Snitz, B.E.; O'Meara, E.S.; Calrson, M.C.; Arnold, A.M.; Ives, D.G.; Rapp, S.R.; Saxton, J.; Lopez, O.L.; Dunn, L.O.; Sink, K.M.; DeKosky, S.T.
Ginkgo biloba for preventing cognitive decline in older adults
A randomized trial
JAMA, 2009, 302(24), 2663-2670
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
12 Lee, M.S.; Shin, B.C.; Ernst, E.
Acupuncture for Alzheimer's disease
A systematic review
Int J Clin Pract, 2009, 63(6), 874-879
Acupuncture, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
13 Fu, L.M.; Li, J.T.
A systematic review of single Chinese herbs for Alzheimer's disease treatment
eCAM, 2011, 2011, 640284; (1-8)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
14 Akhondzadeh, S.; Sabet, M.S.; Haririchian; M.H.; Togha, M.; Cheraghmakani, H.; Razeghi, S.; Hejazi, S.S.; Yousefi, M.H.; Alimardani, R.; Jamshidi, A.; Rezazadeh, S.-A.; Yousefi, A.; Zare, F.; Moradi, A.; Vossoughi, A.
A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease
Psychopharmacol, 2010, 207(4), 637-643
Alzheimer's disease, Crocus, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
15 Oken, B.S.; Fonareva, I.
Pilot controlled trial of mindfulness meditation and education for dementia caregivers
J Altern Complement Med, 2010, 16(10), 1031-1038
Mindfulness meditation, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Mind-body medicine, Nervous system, Mental diseases, Randomized trial, Stress
16 Akhondzadeh, S.; Sabet, M.S.; Harirchian, M.H.; Togha, M.; Cheraghmakani, H.; Razeghi, S.; Hejazi, S.S.; Yousefi, M.H.; Alimardani, R.; Jamshidi, A.; Zare, F.; Moradi, A.
Saffron in the treatment of patients with mild to moderate Alzheimer's disease
A 16-week, randomized and placebo-controlled trial
J Clin Pharm Ther, 2010, 35(5), 581-588
Alzheimer's disease, Crocus, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
17 Quinn, J.F.; Raman, R.; Thomas, R.G.; Yurko-Mauro, K.; Nelson, E.B.; Van Dyck, C.; Galvin, J.E.; Emond, J.; Jack, C.R. jr.; Weiner, M.; Shinto, L.; Aisen, P.S.
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease
A randomized trial
JAMA, 2010, 304(17), 1903-1911
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial
18 Janßen, I.M.; Sturtz, S.; Skipka, G.; Zentner, A.; Garrido, M.V.; Busse, R.
Ginkgo biloba in Alzheimer's disease
A systematic review
Wien Med Wochenschr, 2010, 160(21-22), 539-546
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Systematic review
19 Ihl, R.; Bachinskaya, N.; Korczyn, A.D.; Vakhapova, V.; Tribanek, M.; Hoerr, R.; Napryeyenko, O.
Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features
A randomized controlled trail
Geriatr Psychiatry, 2011, 26(11), 1186-1194
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
20 Dangour, A.D.; Whitehouse, P.J.; Rafferty, K.; Mitchell, S.A.; Smith, L.; Hawkesworth, S.; Vellas, B.
B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia
A systematic review
J Alzheimers Dis, 2010, 22(1), 205-224
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Prevention, Systematic review, Vitamins
21 Yurko-Mauro, K.; McCarthy, D.; Rom, D.; Nelson, E.B.; Ryan, A.S.; Blackwell, A.; Salem, N. jr.; Stedman, M.; MIDAS Investigators
Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
Alzheimers Dement, 2010, 6(6), 456-464
Alzheimer's disease, Dementia, Essential fatty acids, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Docosahexaensäure
22 Galasko, D.R.; Peskind, E.; Clark, C.M.; Quinn, J.F.; Ringman, J.M.; Jicha, G.A.; Cotman, C.; Cottrell, B.; Montine, T.J.; Thomas, R.G.; Aisen, P.;
Antioxidants for Alzheimer disease
A randomized clinical trial with cerebrospinal fluid biomarker measures
Arch Neurol, 2012, 69(7), 836-841
Acidum, Acidum ascorbicum, Alpha-Liponsäure, Alzheimer's disease, Antioxidants, Coenzyme, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial, Tokopherol, Vitamins
23 Vellas, B.; Coley, N.; Ousset, P.-J.; Berrut, G.; Dartigues, J.-F.; Dubois, V.; Grandjean, H.; Pasquier, F.; Piette, F.; Robert, P.; Touchon, J.; Garnier, P.; Mathiex-Fortunet, H.; Andrieu, S.
Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge)
A randomised placebo-controlled trial
Lancet (Neurology), 2012, 11(10), 851-859
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
24 Farina, N.; Issac, M.G.; Clark, A.R.; Rusted, J.; Tabet, N.
Vitamin E for Alzheimer's dementia and mild cognitive impairment
Cochrane Database Syst Rev, 2012, 11(CD002854), 1-31
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Tokopherol, Vitamins
25 Akhondzadeh, S.; Noroozian, M.; Mohammadi, M.; Ohadinia, S.; Jamshidi, A.H.; Khani, M.
Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
A double blind, randomised, placebo controlled trial
J Neurol Neurosurg Psychiatry, 2003, 74, 863-866
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, lemon balm, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
26 Forbes, D.; Forbes, S.; Morgan, D.G.; Markle-Reid, M.; Wood, J.; Culum, I.
Physical activity programs for persons with dementia
Cochrane Database Syst Rev, 2008, 3 (Art. No. CD006489), (1-26)
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Systematic review
27 Wells, R.E.; Kerr, C.E.; Wolkin, J.; Dossett, M.; Davis, R.B.; Walsh, J.; Wall, R.B.; Kong, J.; Kaptchuk, T.; Press, D.; Phillips, R.S.; Yeh, G.
Meditation for adults with mild cognitve impairment
A pilot randomized trial
J Am Geriatr Soc, 2013, 61(4), 642-645
Mindfulness meditation, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Randomized trial
28 Danucalov, M.A.D.; Kozasa, E.H.; Ribas, K.T.; Galduróz, J.C.F.; Garcia, M.C.; Verreschi, I.T.N.; Oliveira, K.C.; Oliveira, L.R. de; Leite, J.R.
A yoga and compassion meditation program reduces stress in familial caregivers of Alzheimer's disease patients
eCAM, 2013, Article ID 513149, (1-8)
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Randomized trial, Yoga, Pflege
29 Miao, Y.C.; Tian, J.Z.; Shi, J.; Mao, M.
Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment
A randomized, double-blind and parallel-controlled trial
J Chinese Integr Med, 2012, 10(4), 390-397
Alzheimer's disease, Dementia, Epimedium, Epimedium brevicornum, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Polygala, Randomized trial, Traditional Chinese medicine, Panax, Panax ginseng
30 Nasab, N.M.; Bahrammi, M.A.; Nikpour, M.R.A.; Rahim, F.; Naghibi, S.N.
Efficacy of rivastigmine in comparison to ginkgo for treating Alzheimer's dementia
J Pak Med Assoc, 2012, 62, 677-680
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
31 Sakamoto, M.; Ando, H.; Tsutou, A.
Comparing the effects of different individualized music interventions for elderly individuals with severe dementia
Int Psychogeriatr, 2013, 25(5), 775-784
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Randomized trial
32 Forbes, D.; Culum, I.; Lischka, A.R.; Morgan, D.G.; Peacock, S.; Forbes, J.; Forbes, S.
Light therapy for managing cognitive, sleep, functional, behavioural, or psychiatric disturbances in dementia
Cochrane Database Syst Rev, 2009, 4(CD003946), 1-53
Alzheimer's disease, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Light therapy, Nervous system, Physical therapy, Mental diseases, Sleep disorders, Systematic review, Conduct disorder
33 Dysken, M.W.; Sano, M.; Asthana, S.; Vertrees, J.E.; Pallaki, M.; Llorente, M.; Love, S.; Schellenberg, G.D.; McCarten, J.R.; Malphurs, J.; Prieto, S.; Chen, P.; Loreck, D.J.; Trapp, G.; Bakshi, R.S.; Mintzer, J.E.; Heidebrink, J.L.; Vidal-Cardona, A.; Arroyo, L.M.; Cruz, A.R.; Zachariah, S.; Kowall, N.W.; Chopra, M.P.; Craft, S.; Thielke, S.; Turvey, C.L.; Woodman, C.; Monnell, K.A.; Gordon, K.; Tomaska, J.; Segal, Y.; Peduzzi, P.N.; Guarino, P.D.
Effect of vitamin E and memantine on functional decline in Alzheimer disease
The TEAM-AD VA cooperative randomized trial
JAMA, 2014, 311(1), 33-44
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Nervous system, Randomized trial, Tokopherol, Vitamins
34 Mangialasche, F.
Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
Exp Gerontol, 2013, 48(12), 1428-1435
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Tokopherol, Vitamins
35 Pan, W.; Wang, Q.; Kwak, S.; Song, Y.; Qin, B.; Wang, M.; Yamamoto, Y.
Shen-Zhi-Ling oral liquid improves behavioral and psychological symptoms of dementia in Alzheimer's disease
eCAM, 2014, Article ID 913687, (1-6)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Shen-Zhi-Ling
36 Miroddi, M.; Navarra, M.; Quattropani, M.C.; Calalpai, F.; Gangemi, S.; Calapai, G.
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment, and Alzheimer's disease
CNS Neurosci Ther, 2014, 20(6), 485-495
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Pharmacology, Phytomedicine, sage, Systematic review
37 Zhang, J.; Wang, Z.; Xu, S.; Chen, Y.; Chen, K.; et al.
The effects of CCRC on cognition and brain activity in aMCI patients
A pilot placebo controlled BOLD fMRI study
Curr Alzheimer Res, 2014, 11(5), 484-493
Alzheimer's disease, Chemistry, Dementia, FMRI, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Physical Chemistry, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Congrongyizhi
38 Zeng, L.F.; Wang, N.S.; Wang, Q.; Zou, Y.P.; Liang, Z.H.; Kong, L.S.; Wu, H.T.; Liao, N.Y.; Liang, X.W.; Mo, Y.S.
Oral Chinese herbal medicine for kidney nourishment in Alzheimer's disease
A systematic review of the effect on MMSE index measures and safety
Complement Ther Med, 2015, 23(2), 283-297
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
39 Farokhnia, M.; Shafiee Sabet, M.; Iranpour, N.; Gougol, A.; Yekehtaz, H.; Alimardani, R.; Farsad, F.; Kamalipour, M.; Akhondzadeh, S.
Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease
A double-blind randomized clinical trial
Hum Psychopharmacol, 2014, 29(4), 351-359
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
40 Chua, K.K.; Wong, A.; Kwan, P.W.; Song, J.X.; Chen, L.L.; Chan, A.L.; Lu, J.H.; Mok, V.; Li, M.
The efficacy and safety of the Chinese herbal medicine Di-Tan decoction for treating Alzheimer's disease
Protocol for a randomized controlled trial
Trials, 2015, 16(1), 199; (1-7) (Studienprotokoll)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Di-Tan
41 Zhang, Y.; Lin, C.; Zhang, L.; Cui, Y.; Gu, Y.; Guo, J.; Wu, D.; Li, Q.; Wong, W.
Cognitive improvement during treatment for mild Alzheimer's disease with a Chinese herbal formula
A randomized controlled trial
PLoS ONE, 2015, 10(6), e0130353; (1-14)
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Yishen Huazhuo
42 Chen, S.; Yao, X.; Liang, Y.; Mei, W.; Liu, X.; Zhang, C.
Alzheimer's disease treated with combined therapy based on nourishing marrow and reinforcing Qi
J Trad Chin Med, 2015, 35(3), 255-259
Alzheimer's disease, Applikationsform, Dementia, Geriatrics, Injektion, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Shenfu, Traditional Chinese medicine, Shenmai
43 Ancoli-Israel, S.; Gehrmann, P.; Martin, J.L.; Shochat, T.; Marler, M.; Corey-Bloom, J.; Levi, J.
Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients
Behav Sleep Med, 2003, 1(1), 22-36
Alzheimer's disease, Chronobiology, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Light therapy, Nervous system, Physical therapy, Mental diseases, Randomized trial, Sleep disorders
44 Zhou, J.; Peng, W.; Li, W.; Liu, Z.
Acupuncture for patients with Alzheimer's disease
A systematic review protocol
BMJ Open, 2014, 4, e005896; (1-5) (Studienprotokoll)
Acupuncture, Alzheimer's disease, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
45 Meador, K.; Loring, D.; Nichols, M.; Zamrini, E.; Rivner, M.; Posas, H.; Thompson, E.; Moore, E.
Preliminary findings of high-dose thiamine in dementia of Alzheimer's type
J Geriatr Psych Neurol, 1993, 6(4), 222-229
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial, Thiamin, Vitamins
46 Turner, R.S.; Thomas, R.G.; Craft, S.; Dyck, C.H.; Mintzer, J.; Reynolds, B.A.; Brewer, J.B.; Rissman, R.A.; Raman, R.; Aisen, P.S.
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
Neurology, 2015, 85, 1-9
Alzheimer's disease, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Resveratrol
47 Tajadini, H.; Saifadini, R.; Choopani, R.; Mehrabani, M.; Kamalinejad, M.; Haghdoost, A.A.
Herbal medicine Davaie Loban in mild to moderate Alzheimer's disease
A 12-week randomized double-blind placebo-controlled clinical trial
Complement Ther Med, 2015, 23(6), 767-772
Alzheimer's disease, Dementia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Davaie Loban, Traditionelle Persische Medizin
48 Furukawa, K.; Tomita, N.; Uematsu, D.; Okahara, K.; Shimada, H.; Ikeda, M.; Matsui, T.; Kozaki, K.; Fujii, M.; Ogawa, T.; Umegaki, H.; Urakami, K.; Nomura, H.; Kobayashi, N.; Nakanishi, A.; Washimi, Y.; Yonezawa, H.; Takahashi, S.; Kubota, M.; Wakutani, Y.; Ito, D.; Sasaki, T.; Matsubara, E.; Une, K.; Ishiki, A.; Yahagi, Y.; Shoji, M.; Sato, H.; Tereyama, Y.; Kuzuya, M.; Araki, N.; Kodama, M.; Yamaguchi, T.; Arai, H.
Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease
Geriatr Gerontol Int, 2017, 17(2), 211-218
Alzheimer's disease, Dementia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Mental diseases, Randomized trial, Traditional Japanese medicine, Yokukansan
49 Loef, M.; Walach, H.
The omega-6/omega-3 ratio and dementia or cognitive decline
A systematic review on human studies and biological evidence
J Nutr Gerontol Geriatr, 2013, 32(1), 1-23
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Geriatrics, Basic Research, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review
50 Loef, M.; Schrauzer, G.N.; Walach, H.
Selenium and Alzheimer's disease
A systematic review
J Alzheimers Dis, 2011, 26(1), 81-104
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Basic Research, Clinical research, Complementary and alternative medicine, Nervous system, Selenium, Trace elements, Systematic review
51 Loef, M.; Walach, H.
Copper and iron in Alzheimer's disease
A systematic review and its dietary implications
Br J Nutr, 2012, 107, 7-19
Alzheimer's disease, Cuprum, Nutrition/diet, Ferrum, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review
52 Loef, M.; Stillfried, N. von; Walach, H.
Zinc diet and Alzheimer's disease
A systematic review
Nutritional Neurosci, 2012, 15(5), 2-12
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Prevention, Trace elements, Systematic review, Zincum
53 Miyazawa, T.; Nakagawa, K.; Takekoshi, H.; Higuchi, O.; Kato, S.; Kondo, M.; Kimura, f.; Miyazawa, T.
Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects
J Oleo Sci, 2013, 62(11), 873-881
Alzheimer's disease, Chlorella, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Sea remedies, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
54 Kim, H.J.; Yang, Y.; Oh, J.G.; Oh, S.; Choi, H.; Kim, K.H.; Kim, S.H.
Effectiveness of a community-based multidomain cognitive intervention progam in patients with Alzheimer's disease
Geriatr Gerontol Int, 2016, 16(2), 191-199
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Cognitive behavioral therapy, Complementary and alternative medicine, Art therapy, Music therapy, Nervous system, Psychology/psychotherapy, Randomized trial
55 Külzow, N.; Witte, A.V.; Kerti, L.; Grittner, U.; Schuchardt, J.P.; Hahn, A.; Flöel, A.
Impact of omega-3 fatty acid supplementation on memory functions in healthy older adults
J Alzheimers Dis, 2016, 51(3), 713-725
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Geriatrics, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Placebo-controlled, Prevention, Randomized trial
56 Innes, K.E.; Selfe, T.K.; Khalsa, D.S.; Kandati, S.
Effects of meditation versus music listening on perceived stress, mood, sleep, and quality of life in adults with early memory loss
A pilot randomized controlled trial
J Alzheimers Dis, 2016, 52(4), 1277-1298
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Mental diseases, Randomized trial, Sleep disorders, Stress
57 Ringman, J.M.; Frautschy, S.A.; Teng, E.; Begum, A.N.; Bardens, J.; Beigi, M.; Gylys, K.H.; Badmaev, V.; Heath, D.D.; Apostolova, L.G.; Porter, V.; Vanek, Z.; Marshall, G.A.; Hellemann, G.; Sugar, C.; Masterman, D.L.; Montine, T.J.; Cummings, J.L.; Cole, G.M.
Oral curcumin for Alzheimer's disease
Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
Alzheimers Res Ther, 2012, 4, 43; (1-8)
Alzheimer's disease, Curcuma, Curcuma longa, Spices, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
58 Innes, K.E.; Selfe, T.K.; Khalsa, D.S.; Kandati, S.
A randomized controlled trial of two simple mind-body programs, Kirtan Kriya meditation and music listening, for adults with subjective cognitive decline
Feasibility and acceptability
Complement Ther Med, 2016, 26, 98-107
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Randomized trial
59 Brueggen, K.; Kasper, E.; Ochmann, S.; Pfaff, H.; Webel, S.; Schneider, W.; Teipel, S.
Cognitive rehabilitation in Alzheimer's disease
A controlled intervention trial
J Alzheimers Dis, 2017, 57(4), 1315-1324
Alzheimer's disease, Dementia, Geriatrics, Complementary and alternative medicine, Nervous system, Randomized trial, Rehabilitation
60 Kryscio, R.J.; Abner, E.L. Caban-Holt, A.; Lovell, M.; Goodman, P.; Darke, A.K.; Yee, M.; Crowley, J.; Schmitt, F.A.
Association of antioxidant supplement use and dementia in the prevention of Alzheimer's disease by Vitamin E and Selenium Trial (PREADViSE)
JAMA Neurol, 2017, 74(5), 567-573
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Prevention, Randomized trial, Selenium, Trace elements, Tokopherol, Vitamins
61 Theleritis, C.; Siarkos, K.; Katirtzoglou, E.; Politis, A.
Pharmacological and nonpharmacological treatment for apathy in Alzheimer disease
A systematic review across modalities
J Geriatr Psychiatry Neurol, 2017, 30(1), 26-49
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Conventional medicine, Nervous system, Systematic review
62 Yang, W.T.; Zheng, X.W.; Chen, S.; Shan, C.S.; Xu, Q.Q.; Zhu, J.Z.; Bao, X.Y.; Lin, Y.; Zheng, G.Q.; Wang, Y.
Chinese herbal medicine for Alzheimer's disease
Clinical evidence and possible mechanism of neurogenesis
Biochem Pharmacol, 2017, 141, 143-155
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
63 Piersol, C.V.; Canton, K.; Connor, S.E.; Giller, I.; Lipman, S.; Sager, S.
Effectiveness of interventions for caregivers of people with Alzheimer's disease and related major neurocognitive disorders
A systematic review
Am J Occup Ther, 2017, 71, 7105180020p1
Mindfulness meditation, Alzheimer's disease, Dementia, Clinical research, Cognitive behavioral therapy, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Psychology/psychotherapy, Systematic review
64 Tohda, C.; Yang, X.; Matsui, M.; Inada, Y.; Kadomoto, E.; Nakada, S.; Watari, H.; Shibahara, N.
Diosgenin-rich yam extract enhances cognitive function
A placebo-controlled, randomized, double-blind, crossover study of healthy adults
Nutrients, 2017, 9(10), 1160; (1-13)
Alzheimer's disease, Dementia, Dioscorea, Dioscorea batatas, Nutrition/diet, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
65 Jensen, L.; Padilla, R.
Effectiveness of environment-based interventions that address behavior, perception, and falls in people with Alzheimer's disease and related major neurocognitive disorders
A systematic review
Am J Occup Ther, 2017, 71(5), 7105180030p1-7105180030p10
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Light therapy, Music therapy, Nervous system, Physical therapy, Systematic review
66 Lin, C.; Zhou, Z.; Xu, J.; Li, Q.; Guo, J.; Long, M.; Wu, D.; Zhang, Y.
Changes of brain activity during a functional magnetic resonance imaging stroop task study
Effect of Chinese herbal formula in Alzheimer’s disease
Eur J Integr Med, 2017, 16, 46-53
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Yishen Huazhuo
67 Jia, Y.; Zhang, X.; Yu, J.; Han, J.; Yu, T.; Shi, J.; Zhao, L.; Nie, K.
Acupuncture for patients with mild to moderate Alzheimer's disease
A randomized controlled trial
BMC Complement Altern Med, 2017, 17, 556; (1-8)
Acupuncture, Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine
68 Petersen, S.; Houston, S.; Qin, H.; Tague, C.; Studley, J.
The utilization of robotic pets in dementia care
J Alzheimers Dis, 2017, epub ahead of print,
Alzheimer's disease, Biofeedback, Dementia, Clinical research, Complementary and alternative medicine, Mind-body medicine, Nervous system, Psychology/psychotherapy, Randomized trial, Pflege, animal-assisted therapy
69 Yakimicki, M.L.; Edwards, N.E.; Richards, E.; Beck, A.M.
Animal-assisted intervention and dementia
A systematic review
Clin Nurs Res, 2018, 28(1), 9-29
Alzheimer's disease, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Mental diseases, Psychology/psychotherapy, Systematic review, Pflege, animal-assisted therapy
70 Öhman, H.; Savikko, N.; Strandberg, T.E.; Kautiainen, H.; Raivio, M.M.; Laakkonen, M.L.; Tilvis, R.; Pitkälä, K.H.
Effects of exercise on cognition: The Finnish Alzheimer Disease Exercise Trial
A randomized, controlled trial
J Am Geriatr Soc, 2016, 64(4), 731-738
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
71 Lautenschlager, N.T.; Cox, K.L.; Flicker, L.; Foster, J.K.; Bockxmeer, F.M. van; Xiao, J.; Greenop, K.R.; Almeida, O.P.
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease
A randomized trial
JAMA, 2008, 300(9), 1027-1037
Alzheimer's disease, Exercise therapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
72 Öhman, H.; Savikko, N.; Strandberg, T.; Kautiainen, H.; Raivio, M.; Laakkonen, M.-L.; Tilvis, R.; Pitkälä, K.H.
Effects of exercise on functional performance and fall rate in subjects with mild or advanced Alzheimer's disease
Secondary analyses of a randomized controlled study
Dement Geriatr Cogn Disord, 2016, 41(3-4), 233-241
Alzheimer's disease, Muscoskeletal -/Connective tissue system, Exercise therapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
73 Arcoverde, C.; Deslandes, A.; Moraes, H.; Almeida, C.; Araujo, N.B.; Vasques, P.E.; Silveira, H.; Laks, J.
Treadmill training as an augmentation treatment for Alzheimer's disease
A pilot randomized controlled study
Arq Neuropsiquiatr, 2014, 72(3), 190-196
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
74 Öhman, H.; Savikko, N.R.N.; Strandberg, T.E.; Kautiainen, H.; Raivio, M.M.; Laakkonen, M.L.; Tilvis, R.; Pitkälä, K.H.
Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease
Secondary analyses of a randomized, controlled trial (FINALEX)
Eur Geriatr Med, 2017, 8, 153-157
Alzheimer's disease, Anxiety, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial, Sleep disorders
75 Holthoff, V.A.; Marschner, K.; Scharf, M.; Steding, J.; Meyer, S.; Koch, R.; Donix, M.
Effects of physical activity training in patients with Alzheimer's dementia
Results of a pilot RCT study
PLoS ONE, 2015, 10(4), e0121478; (1-11)
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
76 Steinberg, M.; Leoutsakos, J.-M.S.; Podewils, L.J.; Lyketsos, C.G.
Evaluation of a home-based exercise program in the treatment of Alzheimer's disease
The Maximizing Independence in Dementia (MIND) study
Int J Geriatr Psychiatr, 2009, 24(7), 680-685
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
77 Morris, J.K.; Vidoni, E.D.; Johnson, D.K.; Sciver, A. van; Mahnken, J.D.; Honea, R.A.; Wilkins, H.M.; Brooks, W.M.; Billinger, S.A.; Swerdlow, R.H.; Burns, J.M.
Aerobic exercise for Alzheimer's disease
A randomized controlled pilot trial
PLoS ONE, 2017, 12(2), e0170547; (1-14)
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial, Aerobic training
78 Williams, C.L.; Tappen, R.M.
Exercise training for depressed older adults with Alzheimer's disease
Aging Ment Health, 2008, 12(1), 72-80
Alzheimer's disease, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial
79 Lanza, G.; Centonze, S.S.; Destro, G.; Vella, V.; Bellomo, M.; Pennisi, M.; Bella, R.; Ciavardelli, D.
Shiatsu as an adjuvant therapy for depression in patients with Alzheimer's disease
A pilot study
Complement Ther Med, 2018, 38, 74-78
Alzheimer's disease, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Mental diseases, Randomized trial, Traditional Japanese medicine, Shiatsu
80 Lazarou, I.; Parastatidis, T.; Tsolaki, A.; Gkioka, M.; Karakostas, A.; Douka, S.; Tsolaki, M.
International ballroom dancing against neurodegeneration
A randomized controlled trial in Greek community-dwelling elders with mild cognitive impairment
Am J Alzheimers Dis Other Demen, 2017, 32(8), 489-499
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Prevention, Randomized trial, Tanztherapie
81 Williams, C.L.; Tappen, R.M.
Effect of exercise on mood in nursing home residents with Alzheimer's disease
Am J Alzheimers Dis Other Demen, 2007, 22(5), 389-397
Alzheimer's disease, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial, Walking, Strength training
82 Law, L.L.F.; Barnett, F.; Yau, M.K.; Gray, M.A.
Effects of functional tasks exercise on older adults with cognitive impairment at risk of Alzheimer's disease
A randomised controlled trial
Age Ageing, 2014, 43, 813-820
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
83 Burns, A.; Perry, E.; Holmes, C.; Francis, P.; Morris, J.; Howes, M.-J.R.; Chazot, P.; Lees, G.; Ballard, C.
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease
Dement Geriatr Cogn Disord, 2011, 31, 158-164
Alzheimer's disease, Aromatherapy, Dementia, Clinical research, Complementary and alternative medicine, lemon balm, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
84 Suttanon, P.; Hill, K.D.; Said, C.M.; Williams, S.B.; Byrne, K.N.; LoGiudice, D.; Lautenschlager, N.T.; Dodd, K.J.
Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease
A pilot randomized controlled trial
Clin Rehabil, 2013, 27(5), 427-438
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
85 Rao, A.K.; Chou, A.; Bursley, B.; Smulofsky, J.; Jezequel, J.
Systematic review of the effects of exercise on activities of daily living in people with Alzheimer's disease
Am J Occup Ther, 2014, 68, 50-56
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Systematic review
86 Yang, Y.; Liu, J.P.; Fang, J.Y.; Wang, H.C.; Wei, Y.; Cao, Y.; Liu, J.G.; Liu L.T.; Li, H.
Effect and safety of Huannao Yicong formula () on patients with mild-to-moderate Alzheimer's disease
A randomized, double-blinded, Donepezil-controlled trial
Chin J Integr Med, 2018, epub ahead of print,
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Huannao Yicong
87 Soininen, H.; Solomon, A.; Visser, P.J.; Hendrix, S.B.; Blennow, K.; Kivipelto, M.; Hartmann, T.
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipDiDiet)
A randomised, double-blind, controlled trial
Lancet Neurol, 2017, 16(12), 965-975
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Dietary supplementation, Nervous system, Orthomolecular medicine, Randomized trial, Fortasyn Connect
88 Giovagnoli, A.R.; Manfredi, V.; Schifano, L.; Paterlini, C.; Parente, A.; Tagliavini, F.
Combining drug and music therapy in patients with moderate Alzheimer's disease
A randomized study
Neurol Sci, 2018, 39(6), 1021-1028
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Randomized trial
89 Innes, K.E.; Selfe, T.K.; Brundage, K.; Montgomery, C.; Wen, S.; Kandati, S.; Bowles, H.; Khalsa, D.S.; Huysmans, Z.
Effects of meditation and music-listening on blood biomarkers of cellular aging and Alzheimer's disease in adults with subjective cognitive decline
An exploratory randomized clinical trial
J Alzheimers Dis, 2018, 66(5), 947-970
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Randomized trial
90 Zao, J.; Li, H.; Lin, R.; Wei, Y.; Yang, A.
Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease
A randomized controlled clinical trial
Clin Interv Aging, 2018, 13, 1313-1320
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Art therapy, Nervous system, Randomized trial
91 Ma, H.-k.; Liu, Y.; Li, B.; Zhang, Y.; Sun, L.-j.; Xu, F.-q.
Chinese medicine for Alzheimer's disease
A meta-analysis of randomized controlled trials
Chin J Integr Med, 2018, 24(12), 938-943
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Systematic review, Traditional Chinese medicine
92 Chen, C.L.H.; Sharma, P.R.; Tan, B.Y.; Low, C.; Venketasubramanian, N.
The Alzheimer's disease THErapy with NEuroaid (ATHENE) study protocol
Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild-to-moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine - a randomized, double-blind, placebo-controlled trial
Alzheimers Dement, 2019, 5, 38-45
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine