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1 Maurer, K.; Ihl, R.; Dierks, T.; Fröhlich, L.
Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
Phytomed, 1998, 5(6), 417-424
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial, Tebonin
2 Kanowski, S.; Hermann, W.M.; Stephan, K.; Wierich, W.; Hoerr, R.
Proof of efficacy of the Gingko biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
Pharmacopsychiatry, 1997, 4(1), 3-14
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
3 Allain, H.; Schuck, S.; Lebreton, S.; Strenge-Hesse, A.; Braun, W.; Gandon, J.M.; Brissot, P.
Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer´s disease
Dement Geriatr Cogn Disord, 1999, 10, 181-185
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
4 Akhondzadeh, S.; Noroozian, M.; Mohammadi, M.; Ohadinia, S.; Jamshidi, A.H.; Khani, M.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
A double blind, randomized and placebo-controlled trial
J Clin Pharm Ther, 2003, 28, 53-59
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, sage
5 Yancheva, S.; Ihl, R.; Schlaefke, S.; Hoerr, R.
Ginkgo-biloba-Extract EGb 761, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features
A randomised, double-blind trial
Z Phytother, 2006, 27(Kongressband), S17
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
6 Lee, S.-T.; Chu, K.; Shim, J.-Y.; Heo, J.-H.; Kim, M.
Panax ginseng enhances cognitive performance in Alzheimer diesease
Alzheimer Dis Assoc Disord, 2008, 22(3), 222-226
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
7 Heo, J.-H.; Lee, S.-T.; Chu, K.; Oh, M.J.; Park, H.-J.; Shim, J.-Y.; Kim, M.
An open-label study of Korean red ginseng as an adjuvant treatment for coginitve impairment in patients with Alzheimer's disease
Eur J Neurol, 2008, 15(8), 865-868
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
8 Snitz, B.E.; O'Meara, E.S.; Calrson, M.C.; Arnold, A.M.; Ives, D.G.; Rapp, S.R.; Saxton, J.; Lopez, O.L.; Dunn, L.O.; Sink, K.M.; DeKosky, S.T.
Ginkgo biloba for preventing cognitive decline in older adults
A randomized trial
JAMA, 2009, 302(24), 2663-2670
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
9 Jimbo, D.; Kimura, Y.; Taniguchi, M.; Inoue, M.; Urakami, K.
Effect of aromatherapy on patients with Alzheimer's disease
Psychogeriatrics, 2009, 9(4), 173-179
Alzheimer's disease, Aromatherapy, Citrus, lime leaves [kaffir-], Citrus sinensis, Dementia, Geriatrics, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Non-randomized trial, Phytomedicine, rosemary
10 Akhondzadeh, S.; Sabet, M.S.; Haririchian; M.H.; Togha, M.; Cheraghmakani, H.; Razeghi, S.; Hejazi, S.S.; Yousefi, M.H.; Alimardani, R.; Jamshidi, A.; Rezazadeh, S.-A.; Yousefi, A.; Zare, F.; Moradi, A.; Vossoughi, A.
A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease
Psychopharmacol, 2010, 207(4), 637-643
Alzheimer's disease, Crocus, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
11 Oken, B.S.; Fonareva, I.
Pilot controlled trial of mindfulness meditation and education for dementia caregivers
J Altern Complement Med, 2010, 16(10), 1031-1038
Mindfulness meditation, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Mind-body medicine, Nervous system, Mental diseases, Randomized trial, Stress
12 Akhondzadeh, S.; Sabet, M.S.; Harirchian, M.H.; Togha, M.; Cheraghmakani, H.; Razeghi, S.; Hejazi, S.S.; Yousefi, M.H.; Alimardani, R.; Jamshidi, A.; Zare, F.; Moradi, A.
Saffron in the treatment of patients with mild to moderate Alzheimer's disease
A 16-week, randomized and placebo-controlled trial
J Clin Pharm Ther, 2010, 35(5), 581-588
Alzheimer's disease, Crocus, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
13 Quinn, J.F.; Raman, R.; Thomas, R.G.; Yurko-Mauro, K.; Nelson, E.B.; Van Dyck, C.; Galvin, J.E.; Emond, J.; Jack, C.R. jr.; Weiner, M.; Shinto, L.; Aisen, P.S.
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease
A randomized trial
JAMA, 2010, 304(17), 1903-1911
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial
14 Ihl, R.; Bachinskaya, N.; Korczyn, A.D.; Vakhapova, V.; Tribanek, M.; Hoerr, R.; Napryeyenko, O.
Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features
A randomized controlled trail
Geriatr Psychiatry, 2011, 26(11), 1186-1194
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
15 Yurko-Mauro, K.; McCarthy, D.; Rom, D.; Nelson, E.B.; Ryan, A.S.; Blackwell, A.; Salem, N. jr.; Stedman, M.; MIDAS Investigators
Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
Alzheimers Dement, 2010, 6(6), 456-464
Alzheimer's disease, Dementia, Essential fatty acids, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Docosahexaensäure
16 Galasko, D.R.; Peskind, E.; Clark, C.M.; Quinn, J.F.; Ringman, J.M.; Jicha, G.A.; Cotman, C.; Cottrell, B.; Montine, T.J.; Thomas, R.G.; Aisen, P.;
Antioxidants for Alzheimer disease
A randomized clinical trial with cerebrospinal fluid biomarker measures
Arch Neurol, 2012, 69(7), 836-841
Acidum, Acidum ascorbicum, Alpha-Liponsäure, Alzheimer's disease, Antioxidants, Coenzyme, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial, Tokopherol, Vitamins
17 Wang, Z.; Nie, B.; Li, D.; Zhao, Z.; Han, Y.; Song, H.; Xu, J.; Shan, B.; Lu, J.; Li, K.
Effect of acupuncture in mild cognitive impairment and Alzheimer disease
A functional MRI study
PLoS ONE, 2012, 7(8), e42730; (1-13)
Acupuncture, Alzheimer's disease, Chemistry, Dementia, FMRI, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Physical Chemistry, Traditional Chinese medicine
18 Vellas, B.; Coley, N.; Ousset, P.-J.; Berrut, G.; Dartigues, J.-F.; Dubois, V.; Grandjean, H.; Pasquier, F.; Piette, F.; Robert, P.; Touchon, J.; Garnier, P.; Mathiex-Fortunet, H.; Andrieu, S.
Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge)
A randomised placebo-controlled trial
Lancet (Neurology), 2012, 11(10), 851-859
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
19 Akhondzadeh, S.; Noroozian, M.; Mohammadi, M.; Ohadinia, S.; Jamshidi, A.H.; Khani, M.
Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
A double blind, randomised, placebo controlled trial
J Neurol Neurosurg Psychiatry, 2003, 74, 863-866
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, lemon balm, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
20 Wells, R.E.; Kerr, C.E.; Wolkin, J.; Dossett, M.; Davis, R.B.; Walsh, J.; Wall, R.B.; Kong, J.; Kaptchuk, T.; Press, D.; Phillips, R.S.; Yeh, G.
Meditation for adults with mild cognitve impairment
A pilot randomized trial
J Am Geriatr Soc, 2013, 61(4), 642-645
Mindfulness meditation, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Randomized trial
21 Danucalov, M.A.D.; Kozasa, E.H.; Ribas, K.T.; Galduróz, J.C.F.; Garcia, M.C.; Verreschi, I.T.N.; Oliveira, K.C.; Oliveira, L.R. de; Leite, J.R.
A yoga and compassion meditation program reduces stress in familial caregivers of Alzheimer's disease patients
eCAM, 2013, Article ID 513149, (1-8)
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Nervous system, Randomized trial, Yoga, Pflege
22 Miao, Y.C.; Tian, J.Z.; Shi, J.; Mao, M.
Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment
A randomized, double-blind and parallel-controlled trial
J Chinese Integr Med, 2012, 10(4), 390-397
Alzheimer's disease, Dementia, Epimedium, Epimedium brevicornum, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Polygala, Randomized trial, Traditional Chinese medicine, Panax, Panax ginseng
23 Nasab, N.M.; Bahrammi, M.A.; Nikpour, M.R.A.; Rahim, F.; Naghibi, S.N.
Efficacy of rivastigmine in comparison to ginkgo for treating Alzheimer's dementia
J Pak Med Assoc, 2012, 62, 677-680
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
24 Sakamoto, M.; Ando, H.; Tsutou, A.
Comparing the effects of different individualized music interventions for elderly individuals with severe dementia
Int Psychogeriatr, 2013, 25(5), 775-784
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Randomized trial
25 Dysken, M.W.; Sano, M.; Asthana, S.; Vertrees, J.E.; Pallaki, M.; Llorente, M.; Love, S.; Schellenberg, G.D.; McCarten, J.R.; Malphurs, J.; Prieto, S.; Chen, P.; Loreck, D.J.; Trapp, G.; Bakshi, R.S.; Mintzer, J.E.; Heidebrink, J.L.; Vidal-Cardona, A.; Arroyo, L.M.; Cruz, A.R.; Zachariah, S.; Kowall, N.W.; Chopra, M.P.; Craft, S.; Thielke, S.; Turvey, C.L.; Woodman, C.; Monnell, K.A.; Gordon, K.; Tomaska, J.; Segal, Y.; Peduzzi, P.N.; Guarino, P.D.
Effect of vitamin E and memantine on functional decline in Alzheimer disease
The TEAM-AD VA cooperative randomized trial
JAMA, 2014, 311(1), 33-44
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Nervous system, Randomized trial, Tokopherol, Vitamins
26 Mangialasche, F.
Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
Exp Gerontol, 2013, 48(12), 1428-1435
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Tokopherol, Vitamins
27 Xing, S.-H.; Zhu C.-X.; Zhang, R.; An, L.
Huperzine A in the treatment of Alzheimer's disease and vascular dementia
A meta-analysis
eCAM, 2014, Article ID 363985, (1-10)
Alzheimer's disease, Dementia, Huperzia, Huperzia dentata, Huperzia serrata, Clinical research, Complementary and alternative medicine, Meta-analysis, Nervous system, Phytomedicine, Vaskuläre Demenz
28 Pan, W.; Wang, Q.; Kwak, S.; Song, Y.; Qin, B.; Wang, M.; Yamamoto, Y.
Shen-Zhi-Ling oral liquid improves behavioral and psychological symptoms of dementia in Alzheimer's disease
eCAM, 2014, Article ID 913687, (1-6)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Shen-Zhi-Ling
29 Canevelli, M.; Adali, N.; Kelaiditi, E.; Cantet, C.; Ousset, P.J.; Cesari, M.
Effects of Gingko biloba supplementation in Alzheimer's disease patients receiving cholinesterase inhibitors
Data from the ICTUS study
Phytomed, 2014, 21(6), 888-892
Alzheimer's disease, Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Phytomedicine
30 Chan, A.S.; Sze, S.L.; Woo, J.; Yu, R.H.
A Chinese chan-based lifestyle intervention improves memory of older adults
Front Aging Neurosci, 2014, 6, 50; (1-9)
Alzheimer's disease, Dementia, Geriatrics, Complementary and alternative medicine, Lifestyle modification, Mind-body medicine, Nervous system, Non-randomized trial
31 Zhang, J.; Wang, Z.; Xu, S.; Chen, Y.; Chen, K.; et al.
The effects of CCRC on cognition and brain activity in aMCI patients
A pilot placebo controlled BOLD fMRI study
Curr Alzheimer Res, 2014, 11(5), 484-493
Alzheimer's disease, Chemistry, Dementia, FMRI, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Physical Chemistry, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Congrongyizhi
32 Farokhnia, M.; Shafiee Sabet, M.; Iranpour, N.; Gougol, A.; Yekehtaz, H.; Alimardani, R.; Farsad, F.; Kamalipour, M.; Akhondzadeh, S.
Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease
A double-blind randomized clinical trial
Hum Psychopharmacol, 2014, 29(4), 351-359
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
33 Jia, B.; Liu, Z.; Min, B.; Wang, Z.; Zhou, A.; Li, Y.; Qiao, H.; Jia, J.
The effects of acupuncture at real or sham acupoints on the intrinsic brain activity in mild cognitive impairment patients
eCAM, 2015, Article ID 529675, (1-9)
Acupuncture, Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Placebo-controlled, Traditional Chinese medicine
34 Kudoh, C.; Arita, R.; Honda, M.; Kishi, T.; Komatsu, Y.; Asou, H.; Mimura, M.
Effect of ninjin'yoeito, a Kampo (traditional Japanese) medicine, on cognitive impairment and depression in patients with Alzheimer's disease
2 years of observation
Psychogeriatrics, 2016, 16(2), 85-92
Alzheimer's disease, Dementia, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Non-randomized trial, Ninjin Yoei To, Mental diseases, Traditional Japanese medicine
35 Chua, K.K.; Wong, A.; Kwan, P.W.; Song, J.X.; Chen, L.L.; Chan, A.L.; Lu, J.H.; Mok, V.; Li, M.
The efficacy and safety of the Chinese herbal medicine Di-Tan decoction for treating Alzheimer's disease
Protocol for a randomized controlled trial
Trials, 2015, 16(1), 199; (1-7) (Studienprotokoll)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Di-Tan
36 Zhang, Y.; Lin, C.; Zhang, L.; Cui, Y.; Gu, Y.; Guo, J.; Wu, D.; Li, Q.; Wong, W.
Cognitive improvement during treatment for mild Alzheimer's disease with a Chinese herbal formula
A randomized controlled trial
PLoS ONE, 2015, 10(6), e0130353; (1-14)
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Yishen Huazhuo
37 Liang, P.; Wang, Z.; Qian, T.; Li, K.
Acupuncture stimulation of Taichong (Liv3) and Hegu (LI4) modulates the default mode network activity in Alzheimer's disease
Am J Alzheimers Dis Other Demen, 2014, 29(8), 739-748
Acupuncture, Alzheimer's disease, Chemistry, Dementia, FMRI, Brain, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Physical Chemistry, Traditional Chinese medicine
38 Chen, S.; Yao, X.; Liang, Y.; Mei, W.; Liu, X.; Zhang, C.
Alzheimer's disease treated with combined therapy based on nourishing marrow and reinforcing Qi
J Trad Chin Med, 2015, 35(3), 255-259
Alzheimer's disease, Applikationsform, Dementia, Geriatrics, Injektion, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Shenfu, Traditional Chinese medicine, Shenmai
39 Ancoli-Israel, S.; Gehrmann, P.; Martin, J.L.; Shochat, T.; Marler, M.; Corey-Bloom, J.; Levi, J.
Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients
Behav Sleep Med, 2003, 1(1), 22-36
Alzheimer's disease, Chronobiology, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Light therapy, Nervous system, Physical therapy, Mental diseases, Randomized trial, Sleep disorders
40 Li, N.; Wang, J.; Ma, J.; Gu, Z.; Jiang, C.; Yu, L.; Fu, X.
Neuroprotective effects of Cistanches herba therapy on patients with moderate Alzheimer's disease
eCAM, 2015, Article ID 103985, (1-12)
Alzheimer's disease, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Traditional Chinese medicine, Cistanche, Cistanche deserticola
41 Meador, K.; Loring, D.; Nichols, M.; Zamrini, E.; Rivner, M.; Posas, H.; Thompson, E.; Moore, E.
Preliminary findings of high-dose thiamine in dementia of Alzheimer's type
J Geriatr Psych Neurol, 1993, 6(4), 222-229
Alzheimer's disease, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Randomized trial, Thiamin, Vitamins
42 Molina, J.A.; Jiménez-Jiménez, F.J.; Hernánz, A.; Fernández-Vivancos, E.; Bustos, S.M.F. de; Gómez-Escalonilla, C.; Sayed, Y.
Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease
J Neural Transm, 2002, 109(7-8), 1035-1044
Alzheimer's disease, Dementia, Diagnostics, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Thiamin, Vitamins
43 Turner, R.S.; Thomas, R.G.; Craft, S.; Dyck, C.H.; Mintzer, J.; Reynolds, B.A.; Brewer, J.B.; Rissman, R.A.; Raman, R.; Aisen, P.S.
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
Neurology, 2015, 85, 1-9
Alzheimer's disease, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Resveratrol
44 Tajadini, H.; Saifadini, R.; Choopani, R.; Mehrabani, M.; Kamalinejad, M.; Haghdoost, A.A.
Herbal medicine Davaie Loban in mild to moderate Alzheimer's disease
A 12-week randomized double-blind placebo-controlled clinical trial
Complement Ther Med, 2015, 23(6), 767-772
Alzheimer's disease, Dementia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Davaie Loban, Traditionelle Persische Medizin
45 Furukawa, K.; Tomita, N.; Uematsu, D.; Okahara, K.; Shimada, H.; Ikeda, M.; Matsui, T.; Kozaki, K.; Fujii, M.; Ogawa, T.; Umegaki, H.; Urakami, K.; Nomura, H.; Kobayashi, N.; Nakanishi, A.; Washimi, Y.; Yonezawa, H.; Takahashi, S.; Kubota, M.; Wakutani, Y.; Ito, D.; Sasaki, T.; Matsubara, E.; Une, K.; Ishiki, A.; Yahagi, Y.; Shoji, M.; Sato, H.; Tereyama, Y.; Kuzuya, M.; Araki, N.; Kodama, M.; Yamaguchi, T.; Arai, H.
Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease
Geriatr Gerontol Int, 2017, 17(2), 211-218
Alzheimer's disease, Dementia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Mental diseases, Randomized trial, Traditional Japanese medicine, Yokukansan
46 Miyazawa, T.; Nakagawa, K.; Takekoshi, H.; Higuchi, O.; Kato, S.; Kondo, M.; Kimura, f.; Miyazawa, T.
Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects
J Oleo Sci, 2013, 62(11), 873-881
Alzheimer's disease, Chlorella, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Sea remedies, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
47 Kim, H.J.; Yang, Y.; Oh, J.G.; Oh, S.; Choi, H.; Kim, K.H.; Kim, S.H.
Effectiveness of a community-based multidomain cognitive intervention progam in patients with Alzheimer's disease
Geriatr Gerontol Int, 2016, 16(2), 191-199
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Cognitive behavioral therapy, Complementary and alternative medicine, Art therapy, Music therapy, Nervous system, Psychology/psychotherapy, Randomized trial
48 Külzow, N.; Witte, A.V.; Kerti, L.; Grittner, U.; Schuchardt, J.P.; Hahn, A.; Flöel, A.
Impact of omega-3 fatty acid supplementation on memory functions in healthy older adults
J Alzheimers Dis, 2016, 51(3), 713-725
Alzheimer's disease, Dementia, Nutrition/diet, Essential fatty acids, Geriatrics, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Placebo-controlled, Prevention, Randomized trial
49 Palisson, J.; Roussel-Baclet, C.; Maillet, D.; Belin, C.; Ankri, J.; Narme, P.
Music enhances verbal episodic memory in Alzheimer's disease
J Clin Exp Neuropsychol, 2015, 37(5), 503-517
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Non-randomized trial
50 Li, C.-H.; Liu, C.-K.; Yang, Y.-H.; Chou, M.-C.; Chen, C.-H.; Lai, C.-L.
Adjunct effect of music therapy on cognition in Alzheimer's disease in Taiwan
A pilot study
Neuropsychiatr Dis Treat, 2015, 11, 291-296
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Non-randomized trial
51 Satoh, M.; Yuba, T.; Tabei, K.-I.; Okubo, Y.; Kida, H.; Sakuma, H.; Tomimoto, H.
Music therapy using singing training improves psychomotor speed in patients with Alzheimer's disease
A neuropsychological and fMRI study
Dement Geriatr Cogn Disord, 2015, 5, 296-308
Alzheimer's disease, Chemistry, Dementia, FMRI, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Non-randomized trial, Physical Chemistry, Singen
52 Innes, K.E.; Selfe, T.K.; Khalsa, D.S.; Kandati, S.
Effects of meditation versus music listening on perceived stress, mood, sleep, and quality of life in adults with early memory loss
A pilot randomized controlled trial
J Alzheimers Dis, 2016, 52(4), 1277-1298
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Mental diseases, Randomized trial, Sleep disorders, Stress
53 Hu Yang, I.; De la Rubia Orti, J.E.; Selvi Sabater, P.; Sancho Castillo, S.; Rochina, M.J.; Manresa Ramón, N.; Montoya-Castilla, I.
Aceite de coco: tratamiento alternativo no farmacológico frente a la enfermedad de Alzheimer
Coconut oil: non-alternative drug treatment against Alzheimer's disease
Nutr Hosp, 2015, 32(6), 2822-2827
Alzheimer's disease, Cocos nucifera, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Oil, Phytomedicine
54 Ringman, J.M.; Frautschy, S.A.; Teng, E.; Begum, A.N.; Bardens, J.; Beigi, M.; Gylys, K.H.; Badmaev, V.; Heath, D.D.; Apostolova, L.G.; Porter, V.; Vanek, Z.; Marshall, G.A.; Hellemann, G.; Sugar, C.; Masterman, D.L.; Montine, T.J.; Cummings, J.L.; Cole, G.M.
Oral curcumin for Alzheimer's disease
Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
Alzheimers Res Ther, 2012, 4, 43; (1-8)
Alzheimer's disease, Curcuma, Curcuma longa, Spices, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
55 Innes, K.E.; Selfe, T.K.; Khalsa, D.S.; Kandati, S.
A randomized controlled trial of two simple mind-body programs, Kirtan Kriya meditation and music listening, for adults with subjective cognitive decline
Feasibility and acceptability
Complement Ther Med, 2016, 26, 98-107
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Randomized trial
56 Brueggen, K.; Kasper, E.; Ochmann, S.; Pfaff, H.; Webel, S.; Schneider, W.; Teipel, S.
Cognitive rehabilitation in Alzheimer's disease
A controlled intervention trial
J Alzheimers Dis, 2017, 57(4), 1315-1324
Alzheimer's disease, Dementia, Geriatrics, Complementary and alternative medicine, Nervous system, Randomized trial, Rehabilitation
57 Kryscio, R.J.; Abner, E.L. Caban-Holt, A.; Lovell, M.; Goodman, P.; Darke, A.K.; Yee, M.; Crowley, J.; Schmitt, F.A.
Association of antioxidant supplement use and dementia in the prevention of Alzheimer's disease by Vitamin E and Selenium Trial (PREADViSE)
JAMA Neurol, 2017, 74(5), 567-573
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Placebo-controlled, Prevention, Randomized trial, Selenium, Trace elements, Tokopherol, Vitamins
58 Guo, Z.; Liu, X.; Cao, Y.; Hou, H.; Chen, X.; Chen, Y.; Huang, F.; Chen, W.
Common 1H-MRS characteristics in patients with Alzheimer's disease and vascular dementia diagnosed with kidney essence deficiency syndrome
A preliminary study
Altern Ther Health Med, 2017, 23(3), 12-18
Alzheimer's disease, Dementia, Diagnostics, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Neurophysiology, Non-randomized trial, Physiology, Traditional Chinese medicine, Vaskuläre Demenz
59 Tohda, C.; Yang, X.; Matsui, M.; Inada, Y.; Kadomoto, E.; Nakada, S.; Watari, H.; Shibahara, N.
Diosgenin-rich yam extract enhances cognitive function
A placebo-controlled, randomized, double-blind, crossover study of healthy adults
Nutrients, 2017, 9(10), 1160; (1-13)
Alzheimer's disease, Dementia, Dioscorea, Dioscorea batatas, Nutrition/diet, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
60 Lin, C.; Zhou, Z.; Xu, J.; Li, Q.; Guo, J.; Long, M.; Wu, D.; Zhang, Y.
Changes of brain activity during a functional magnetic resonance imaging stroop task study
Effect of Chinese herbal formula in Alzheimer’s disease
Eur J Integr Med, 2017, 16, 46-53
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Yishen Huazhuo
61 Shi, J.; Ni, J.; Lu, T.; Zhang, X.; Wei, M.; Li, T.; Liu, W.; Wang, Y.; Shi, Y.; Tian, J.
Adding Chinese herbal medicine to conventional therapy brings cognitive benefits to patients with Alzheimer's disease
A retrospective analysis
BMC Complement Altern Med, 2017, 17(1), 533; (1-7)
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Retrospective design, Traditional Chinese medicine
62 Jia, Y.; Zhang, X.; Yu, J.; Han, J.; Yu, T.; Shi, J.; Zhao, L.; Nie, K.
Acupuncture for patients with mild to moderate Alzheimer's disease
A randomized controlled trial
BMC Complement Altern Med, 2017, 17, 556; (1-8)
Acupuncture, Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine
63 Petersen, S.; Houston, S.; Qin, H.; Tague, C.; Studley, J.
The utilization of robotic pets in dementia care
J Alzheimers Dis, 2017, epub ahead of print,
Alzheimer's disease, Biofeedback, Dementia, Clinical research, Complementary and alternative medicine, Mind-body medicine, Nervous system, Psychology/psychotherapy, Randomized trial, Pflege, animal-assisted therapy
64 Öhman, H.; Savikko, N.; Strandberg, T.E.; Kautiainen, H.; Raivio, M.M.; Laakkonen, M.L.; Tilvis, R.; Pitkälä, K.H.
Effects of exercise on cognition: The Finnish Alzheimer Disease Exercise Trial
A randomized, controlled trial
J Am Geriatr Soc, 2016, 64(4), 731-738
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
65 Lautenschlager, N.T.; Cox, K.L.; Flicker, L.; Foster, J.K.; Bockxmeer, F.M. van; Xiao, J.; Greenop, K.R.; Almeida, O.P.
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease
A randomized trial
JAMA, 2008, 300(9), 1027-1037
Alzheimer's disease, Exercise therapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
66 Öhman, H.; Savikko, N.; Strandberg, T.; Kautiainen, H.; Raivio, M.; Laakkonen, M.-L.; Tilvis, R.; Pitkälä, K.H.
Effects of exercise on functional performance and fall rate in subjects with mild or advanced Alzheimer's disease
Secondary analyses of a randomized controlled study
Dement Geriatr Cogn Disord, 2016, 41(3-4), 233-241
Alzheimer's disease, Muscoskeletal -/Connective tissue system, Exercise therapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
67 Arcoverde, C.; Deslandes, A.; Moraes, H.; Almeida, C.; Araujo, N.B.; Vasques, P.E.; Silveira, H.; Laks, J.
Treadmill training as an augmentation treatment for Alzheimer's disease
A pilot randomized controlled study
Arq Neuropsiquiatr, 2014, 72(3), 190-196
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
68 Öhman, H.; Savikko, N.R.N.; Strandberg, T.E.; Kautiainen, H.; Raivio, M.M.; Laakkonen, M.L.; Tilvis, R.; Pitkälä, K.H.
Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease
Secondary analyses of a randomized, controlled trial (FINALEX)
Eur Geriatr Med, 2017, 8, 153-157
Alzheimer's disease, Anxiety, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial, Sleep disorders
69 Holthoff, V.A.; Marschner, K.; Scharf, M.; Steding, J.; Meyer, S.; Koch, R.; Donix, M.
Effects of physical activity training in patients with Alzheimer's dementia
Results of a pilot RCT study
PLoS ONE, 2015, 10(4), e0121478; (1-11)
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
70 Steinberg, M.; Leoutsakos, J.-M.S.; Podewils, L.J.; Lyketsos, C.G.
Evaluation of a home-based exercise program in the treatment of Alzheimer's disease
The Maximizing Independence in Dementia (MIND) study
Int J Geriatr Psychiatr, 2009, 24(7), 680-685
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
71 Morris, J.K.; Vidoni, E.D.; Johnson, D.K.; Sciver, A. van; Mahnken, J.D.; Honea, R.A.; Wilkins, H.M.; Brooks, W.M.; Billinger, S.A.; Swerdlow, R.H.; Burns, J.M.
Aerobic exercise for Alzheimer's disease
A randomized controlled pilot trial
PLoS ONE, 2017, 12(2), e0170547; (1-14)
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial, Aerobic training
72 Williams, C.L.; Tappen, R.M.
Exercise training for depressed older adults with Alzheimer's disease
Aging Ment Health, 2008, 12(1), 72-80
Alzheimer's disease, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial
73 Liang, J.H.; Xu, Y.; Lin, L.; Jia, R.X.; Zhang, H.B.; Hang, L.
Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment
A PRISMA-compliant network meta-analysis
Medicine, 2018, 97(20), e10744; (1-12)
Alzheimer's disease, Exercise therapy, Dementia, Nutrition/diet, Geriatrics, Clinical research, Complementary and alternative medicine, Meta-analysis, Music therapy, Nervous system, Physical therapy
74 Lanza, G.; Centonze, S.S.; Destro, G.; Vella, V.; Bellomo, M.; Pennisi, M.; Bella, R.; Ciavardelli, D.
Shiatsu as an adjuvant therapy for depression in patients with Alzheimer's disease
A pilot study
Complement Ther Med, 2018, 38, 74-78
Alzheimer's disease, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Mental diseases, Randomized trial, Traditional Japanese medicine, Shiatsu
75 Chevreau, P.; Nizard, I.; Allain, P.
Récupérer ses souvenirs grâce à la musique dans la maladie d’Alzheimer
Retrieval of memories with the help of music in Alzheimer's disease
Geriatr Psychol Neuropsychiatr Vieil, 2017, 15(3), 309-318
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Non-randomized trial
76 Lazarou, I.; Parastatidis, T.; Tsolaki, A.; Gkioka, M.; Karakostas, A.; Douka, S.; Tsolaki, M.
International ballroom dancing against neurodegeneration
A randomized controlled trial in Greek community-dwelling elders with mild cognitive impairment
Am J Alzheimers Dis Other Demen, 2017, 32(8), 489-499
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Prevention, Randomized trial, Tanztherapie
77 Williams, C.L.; Tappen, R.M.
Effect of exercise on mood in nursing home residents with Alzheimer's disease
Am J Alzheimers Dis Other Demen, 2007, 22(5), 389-397
Alzheimer's disease, Exercise therapy, Dementia, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Mental diseases, Randomized trial, Walking, Strength training
78 Law, L.L.F.; Barnett, F.; Yau, M.K.; Gray, M.A.
Effects of functional tasks exercise on older adults with cognitive impairment at risk of Alzheimer's disease
A randomised controlled trial
Age Ageing, 2014, 43, 813-820
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
79 Burns, A.; Perry, E.; Holmes, C.; Francis, P.; Morris, J.; Howes, M.-J.R.; Chazot, P.; Lees, G.; Ballard, C.
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease
Dement Geriatr Cogn Disord, 2011, 31, 158-164
Alzheimer's disease, Aromatherapy, Dementia, Clinical research, Complementary and alternative medicine, lemon balm, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
80 Suttanon, P.; Hill, K.D.; Said, C.M.; Williams, S.B.; Byrne, K.N.; LoGiudice, D.; Lautenschlager, N.T.; Dodd, K.J.
Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease
A pilot randomized controlled trial
Clin Rehabil, 2013, 27(5), 427-438
Alzheimer's disease, Exercise therapy, Dementia, Clinical research, Complementary and alternative medicine, Nervous system, Physical therapy, Randomized trial
81 Yang, Y.; Liu, J.P.; Fang, J.Y.; Wang, H.C.; Wei, Y.; Cao, Y.; Liu, J.G.; Liu L.T.; Li, H.
Effect and safety of Huannao Yicong formula () on patients with mild-to-moderate Alzheimer's disease
A randomized, double-blinded, Donepezil-controlled trial
Chin J Integr Med, 2018, epub ahead of print,
Alzheimer's disease, Dementia, Geriatrics, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Randomized trial, Traditional Chinese medicine, Huannao Yicong
82 Soininen, H.; Solomon, A.; Visser, P.J.; Hendrix, S.B.; Blennow, K.; Kivipelto, M.; Hartmann, T.
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipDiDiet)
A randomised, double-blind, controlled trial
Lancet Neurol, 2017, 16(12), 965-975
Alzheimer's disease, Dementia, Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Dietary supplementation, Nervous system, Orthomolecular medicine, Randomized trial, Fortasyn Connect
83 Meguro, K.; Yamaguchi, S.
Decreased behavioral asbnormalities after treatment with combined Donepezil and Yokukansankachimpihange in Alzheimer Disease
An observational study. The Osaki-Tajiri Project
Neurol Ther, 2018, 7(2), 333-340
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Non-randomized trial, Traditional Japanese medicine, Yokukansankachimpihange
84 Giovagnoli, A.R.; Manfredi, V.; Schifano, L.; Paterlini, C.; Parente, A.; Tagliavini, F.
Combining drug and music therapy in patients with moderate Alzheimer's disease
A randomized study
Neurol Sci, 2018, 39(6), 1021-1028
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Music therapy, Nervous system, Randomized trial
85 Innes, K.E.; Selfe, T.K.; Brundage, K.; Montgomery, C.; Wen, S.; Kandati, S.; Bowles, H.; Khalsa, D.S.; Huysmans, Z.
Effects of meditation and music-listening on blood biomarkers of cellular aging and Alzheimer's disease in adults with subjective cognitive decline
An exploratory randomized clinical trial
J Alzheimers Dis, 2018, 66(5), 947-970
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Music therapy, Nervous system, Randomized trial
86 Zao, J.; Li, H.; Lin, R.; Wei, Y.; Yang, A.
Effects of creative expression therapy for older adults with mild cognitive impairment at risk of Alzheimer's disease
A randomized controlled clinical trial
Clin Interv Aging, 2018, 13, 1313-1320
Alzheimer's disease, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Art therapy, Nervous system, Randomized trial
87 Chen, C.L.H.; Sharma, P.R.; Tan, B.Y.; Low, C.; Venketasubramanian, N.
The Alzheimer's disease THErapy with NEuroaid (ATHENE) study protocol
Assessing the safety and efficacy of Neuroaid II (MLC901) in patients with mild-to-moderate Alzheimer's disease stable on cholinesterase inhibitors or memantine - a randomized, double-blind, placebo-controlled trial
Alzheimers Dement, 2019, 5, 38-45
Alzheimer's disease, Dementia, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine