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1 Irnich, D.; Behrens, N.; Molzen, H.; König, A.; Gleditsch, J.; Krauss, M.; Natalis, M.; Senn, E.; Beyer, A.; Schöps, P.
Randomised trial of acupuncture compared with conventional massage and "sham" laser acupuncture for treatment of chronic neck pain
BMJ, 2001, 322, 1-6
Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Placebo-controlled, Randomized trial, Traditional Chinese medicine
2 Ernst, E.
Prospective investigations into the safety of spinal manipulation
J Pain Symptom Manage, 2001, 21(3), 238-242
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Back pain (non-specific), Systematic review, Adverse effect
3 Korthals-de Bos, I.B.C.; Hoving, J.L.; Tulder, M.W. van; Rutten-van Mölken, P.M.H.; Adèr, H.J.; Vet, C.W. de; Koes, B.W.; Vondeling, H.; Bouter, L.M.
Cost effectiveness of physiotherapy, manual therapy, and general practitioner care for neck pain
Economic evaluation alongside a randomised controlled trial
BMJ, 2003, 326, (1-6)
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Economy, Physical therapy, Randomized trial, Cost-effectiveness
4 Bischoff, A.; Nürnberger, A.; Voigt, P.; Schwerla, F.; Resch, K.-L.
Osteopathy alleviates pain in chronic non-specific neck pain: randomised controlled trial
FACT, 2003, 8(4), 537 (Abstract; Symposiumsbeitrag)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Placebo-controlled, Randomized trial
5 Ernst, E.
Chiropractic spinal manipulation for neck pain
A systematic review
J Pain , 2003, 4(8), 417.421
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review
6 Bronfort, G.; Haas, M.; Evans, R.L.; Bouter, L.M.
Efficacy of spinal manipulation and mobilization for low back pain and neck pain
A systematic review and best evidence synthesis
Spine J, 2004, 4, 335-356
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Back pain (non-specific), Systematic review, Spine
7 Dziedzic, K.; Hill, J.; Lewis, M.; Sim, J.; Daniels, J.; Hay, E.H.
Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders
A pragmatic randomized controlled trial in physical therapy clinics
Arthritis Rheum, 2005, 53, 214-222
Muscoskeletal -/Connective tissue system, Exercise therapy, Electrotherapy, Clinical research, Complementary and alternative medicine, Short-wave therapy, Lifestyle modification, Manual therapy, Mind-body medicine, Neck pain, Physical therapy, Randomized trial
8 Sherman, K.J.; Cherkin, D.C.; Hawkes, R.J.; Miglioretti, D.L.; Deyo, R.A.
Randomized trial of therapeutic massage vs self-care book for chronic neck pain
Altern Ther Health Med, 2006, 12(3), 63 (Abstract)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Mind-body medicine, Neck pain, Lifestyle therapy, Randomized trial
9 Haraldsson, B.G.; Gross, A.R.; Myers, C.D.; Ezzo, J.M.; Morien, A.; Goldsmith, C.; Peloso, P.M.; Bronfort, G.
Massage for mechanical neck disorders
Cochrane Database Syst Rev, 2006, 3(CD004871), 1-58
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Systematic review
10 Vernon, H.; Humphreys, B.K.
Manual therapy for neck pain
An overview of randomized clinical trials and systematic reviews
Eura Medicophys, 2007, 43(1), 91-118
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Systematic review, Review (CR)
11 Wiedemann, A.M.
Auswirkungen von Qigong und Nackenübungen auf Beschwerden der Halswirbelsäule bei älteren Menschen
2008, 1-68 (Dissertation)
Muscoskeletal -/Connective tissue system, Geriatrics, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physiotherapy, Qi Gong, Randomized trial, Traditional Chinese medicine
12 Schwerla, F.; Bischoff, A.; Nürnberger, A.; Genter, P.; Guillaume, J.-P.; Resch, K.-L.
Osteopathic treatment of patients with chronic non-specific neck pain
A randomised controlled trial of efficacy
Forsch Komplementärmed, 2008, 15(3), 138-145
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Randomized trial
13 Franca, D.L.M.; Senna-Fernandes, V.; Cortez, C.M.; Jackson, M.N.; Bernardo-Filho, M.; Guimaraes, M.A.M.
Tension neck syndrome treated by acupuncture combined with physiotherapy
A comparative clinical trial (pilot study)
Complement Ther Med, 2008, 16(5), 268-277
Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physiotherapy, Randomized trial, Traditional Chinese medicine
14 Blikstad, A.; Gemmell, H.
Immediate effect of activator trigger point therapy and myofascial band therapy on nonspecific neck pain in patients with upper trapezius trigger points compared to sham ultrasound
A randomised controlled trial
Clin Chiropract, 2008, 11(1), 23-29
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Placebo-controlled, Randomized trial
15 Sundberg, T.; Petzold, M.; Wandell, P.; Ryden, A.; Falkenberg, T.
Exploring integrative medicine for back and neck pain
A pragmatic randomised clinical pilot trial
BMC Complement Altern Med, 2009, 9, 33; (1-12)
Acupressure, Acupuncture, Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Qi Gong, Randomized trial, Back pain (non-specific), Traditional Chinese medicine
16 Groeneweg, R.; Kropman, H.; Leopold, H.; Assen, L.V.; Mulder, J.; Tulder, M.W.; Oostendorp, R.A.
The effectiveness and cost-evaluation of manual therapy and physical therapy in patients with sub-acute and chronic non specific neck pain
Rationale and design of a randomized controlled trial (RCT)
BMC Musculoskel Disord, 2010, 11(1), 14; (1-8)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Economy, Physical therapy, Randomized trial, Cost-effectiveness
17 Gonzalez-Iglesias, J.; Fernandez-de-las-Penas, C.; Cleland, J.A.; Alburquerque-Sendín, F.; Palomeque-del-Cerro, L.; Méndez-Sánchez, R.
Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the managment of patients with acute mechanical neck pain
A randomized clinical trial
Man Ther, 2009, 14(3), 306-313
Muscoskeletal -/Connective tissue system, Chiropractic, Electrotherapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Thermotherapy
18 Skillgate, E.; Bohman, T.; Holm, L.W.; Vingard, E.; Alfredsson, L.
The long-term effects of naprapathic manual therapy on back and neck pain
Results from a pragmatic randomized controlled trial
BMC Musculoskel Disord, 2010, 11, 26; (1-11)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Back pain (non-specific)
19 Murphy, B.; Haavik Taylor, H.; Marshall, P.
The effect of spinal manipulation on the efficacy of a rehabilitation protocol for patients with chronic neck pain
A pilot study
J Manipulative Physiol Ther, 2010, 33(3), 168-177
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Rehabilitation
20 D'Sylva, J.; Miller, J.; Gross, A.; Burnie, S.J.; Goldsmith, C.H.; Graham, N.; Haines, T.; Bronfort, G.; Hoving, J.L.
Manual therapy with or without physical medicine modalities for neck pain
A systematic review
Man Ther, 2010, 15(5), 415-433
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Systematic review
21 Gross, A.; Miller, J.; D'Sylva, J.; Burnie, S.J.; Goldsmith, C.H.; Graham, N.; Haines, T.; Bronfort, G.; Hoving, J.L.
Manipulation or mobilisation for neck pain
A Cochrane review
Man Ther, 2010, 15(4), 315-333
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review
22 Martel, J.; Descarreaux, M.; Dugas, C.
A randomized controlled trial of preventive spinal manipulation with and without a home exercise program for patients with chronic neck pain
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 32 (Symposiumsbeitrag; Abstract)
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Prevention, Randomized trial
23 Gonzáles-Iglesias, J.; Fernández-de-las-Penas, C.; Cleland, J.A.; Rosario Gutiérrez-Vega, M. del
Thoracic spine manipulation for the management of patients with neck pain
A randomized clinical trial
J Orthop Sports Phys Ther, 2009, 39(1), 20-27
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
24 Miller, J.; Gross, A.; D'Sylva, J.; Burnie, S.J.; Goldsmith, C.H.; Graham, N.; Haines, T.; Bronfornt, G.; Hoving, J.L.
Manual therapy and exercise for neck pain
A systematic review
Man Ther, 2010, 15(4), 334-354
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review
25 Gemmell, H.; Miller, P.
Relative effectiveness and adverse effects of cervical manipulation, mobilisation and the activator instrument in patients with sub-acute non-specific neck pain
Results from a stopped randomised trial
Chiroprac Osteop, 2010, 18(1), 20; (1-14)
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Randomized trial
26 Cleland, J.A.; Childs, J.D.; McRae, M.; Palmer, J.A.; Stowell, T.
Immediate effects of thoracic manipulation in patients with neck pain
A randomized clinical trial
Man Ther, 2005, 10(2), 127-135
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
27 Gross, A.R.; Miller, J.; D’Sylva, J.; Burnie, S.J.; Goldsmith, C.H.; Graham, N.; Haines, T.; Brønfort, G.; Hoving, J.L.
Manipulation and mobilisation for neck pain
Cochrane Database Syst Rev, 2010, 1(CD004249), 1-107
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review, Mobilisation
28 Häkkinen, A.; Salo, P.; Tarvainen, U.; Wiren, K.; Ylinen, J.
Effect of manual therapy and stretching on neck muscle strength and mobility in chronic neck pain
J Rehabil Med, 2007, 39(7), 575-579
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Stretching
29 Walker, J.M.; Boyles, R.E.; Young, B.A.; Strunce, J.B.; Garber, M.B.; Whitman, J.M.; Deyle, G.; Wainner, R.S.
The effectiveness of manual physical therapy and exercise for mechanical neck pain
A randomized clinical trial
Spine, 2008, 33(22), 2371-2378
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial
30 Cleland, J.A.; Glynn, P.; Whitman, J.M.; Eberhart, S.L.; MacDonald, C.; Childs, J.D.
Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the thoracic spine in patients with neck pain
A randomized clinical trial
Phys Ther, 2007, 87(4), 431-440
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Mobilisation
31 Sherman, K.J.; Cherkin, D.C.; Hawkes, R.J.; Miglioretti, D.L.; Deyo, R.A.
Randomized trial of therapeutic massage for chronic neck pain
Clin J Pain, 2009, 25(3), 233-238
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Randomized trial
32 Gam, A.N.; Warming, S.; Larsen, L.H.; Jensen, B.; Hoydalsmo, O.; Allon, I.; Andersen, B.; Gotzsche, N.E.; Petersen, M.; Mathiesen, B.
Treatment of myofascial trigger-points with ultrasound combined with massage and exercise
A randomised controlled trial
Pain, 1998, 77(1), 73-79
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Physical therapy, Randomized trial, Schulterschmerz (unspezifisch), Therapeutic ultrasound
33 Escortell-Mayor, E.; Riesgo-Fuertes, R.; Garrido-Elustondo, S.; Asúnsolo-Del Barco, A.; Díaz-Pulido, B.; Blanco-Díaz, M.; Bejerano-Álvarez, E.
Primary care randomized clinical trial
Manual therapy effectiveness in comparison with TENS in patients with neck pain
Man Ther, 2011, 16(1), 66-73
Muscoskeletal -/Connective tissue system, Electrotherapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Transcutaneous electrical nerve stimulation (TENS)
34 Lau, H.M.; Wing Chiu, T.T.; Lam, T.H.
The effectiveness of thoracic manipulation on patients with chronic mechanical neck pain
A randomized controlled trial
Man Ther, 2011, 16(2), 141-147
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
35 Leaver, A.M.; Maher, C.G.; Herbert, R.D.; Latimer, J.; McAuley, J.H.; Jull, G.; Refshauge, K.M.
A randomized controlled trial comparing manipulation with mobilization for recent onset neck pain
Arch Phys Med Rehabil, 2010, 91(9), 1313-1318
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Randomized trial, Mobilisation
36 Braun, M.; Schwickert, M.; Nielsen, A.; Brunnhuber, S.; Dobos, G.; Musial, F.; Lüdtke, R.; Michalsen, A.
Effectiveness of Traditional Chinese "Gua Sha" Therapy in patients with chronic neck pain
A randomized controlled trial
Pain Med, 2011, 12(3), 362-369
Muscoskeletal -/Connective tissue system, Gua Sha, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Traditional Chinese medicine
37 Martel, J.; Dugas, C.; Dubois, J.D.; Descarreaux, M.
A randomised controlled trial of preventive spinal manipulation with and without a home exercise program for patients with chronic neck pain
BMC Musculoskel Disord, 2011, 12(1), 41; (1-13)
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Prevention, Randomized trial
38 Puentedura, E.J.; Landers, M.R.; Cleland, J.A.; Mintken, P.E.; Huijbregts, P.; Fernández-de-Las-Penas, C.
Thoracic spine thrust manipulation versus cervical spine thrust manipulation in patients with acute neck pain
A randomized clinical trial
J Orthop Sports Phys Ther, 2011, 41(4), 208-220
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
39 Madson, T.J.; Cieslak, K.R.; Gay, R.E.
Joint mobilization vs massage for chronic mechanical neck pain
A pilot study to assess recruitment strategies and estimate outcome measure variability
J Manipulative Physiol Ther, 2010, 33(9), 644-651
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Physiotherapy, Randomized trial, Mobilisation
40 Lundblad, I.; Elert, J.; Gerdle, B.
Randomized controlled trial of physiotherapy and feldenkrais interventions in female workers with neck-shoulder complaints
J Occup Rehab, 1999, 9(3), 179-194
Occupational health, Muscoskeletal -/Connective tissue system, Feldenkrais, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physiotherapy, Randomized trial, Schulterschmerz (unspezifisch)
41 Bronfort, G.; Evans, R.; Anderson, A.V.; Svendsen, K.H.; Bracha, Y.; Grimm, R.H.
Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain
Ann Intern Med, 2012, 156(1 Pt1), 1-10
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial
42 Lin, J.H.; Chiu, T.T.; Hu, J.
Chinese manipulation for mechanical neck pain
A systematic review
Clin Rehabil, 2012, 26(11), 963-973
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review, Traditional Chinese medicine
43 Peterson, C.K.; Bolton, J.; Humphreys, B.K.
Predictors of outcome in neck pain patients undergoing chiropractic care
Comparison of acute and chronic patients
Chiropr Man Therap, 2012, 20(1), 27; (1-11)
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Non-randomized trial
44 Reid, S.A.; Rivett, D.A.; Katekar, M.; Callister, R.
Efficacy of manual therapy treatments for people with cervicogenic dizziness and pain
Protocoll of a randomised controlled trial
BMC Musculoskel Disord, 2012, 13, 201; (1-8) (Studienprotokoll)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Neck pain, Nervous system, Randomized trial, Vertigo, Mobilisation
45 Topolska, M.; Chrzan, S.; Sapula, R.; Kowerski, M.; Sobon, M.; Marczewski, K.
Evaluation of the effectiveness of therapeutic massage in patients with neck pain
Ortop Traumatol Rehabil, 2012, 14(2), 115-124
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Non-randomized trial, Physiotherapy
46 McLean, S.M.; Klaber Moffett, J.A.; Sharp, D.M.; Gardiner, E.
A randomised controlled trial comparing graded exercise treatment and usual physiotherapy for patients with non-specific neck pain (the GET UP nack pain trial)
Man Ther, 2013, 18(3), 199-205
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Physiotherapy, Randomized trial
47 Patel, K.C.; Gross, A.; Graham, N.; Goldsmith, C.H.; Ezzo, J.; Morien, A.; Peloso, P.M.
Massage for mechanical neck disorders
Cochrane Database Syst Rev, 2012, 9(CD004871), 1-91
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Massage, Neck, Neck pain, Systematic review
48 Vincent, K.; Maigne, J.Y.; Fischhoff, C.; Lanlo, O.; Dagenais, S.
Systematic review of manual therapies for nonspecific neck pain
Joint Bone Spine, 2013, 80(5), 508-515
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review
49 Lauche, R.; Wübbeling, K.; Lüdtke, R.; Cramer, H.; Choi, K.E.; Rampp, T.; Michalsen, A.; Langhorst, J.; Dobos, G.
Randomized controlled pilot study
Pain intensity and pressure pain threshold in patients with neck and low back pain before and after traditional East Asian "gua sha" therapy
Am J Chin Med, 2012, 40(5), 905-917
Muscoskeletal -/Connective tissue system, Gua Sha, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Neck pain, Randomized trial
50 Humphreys, B.K.; Peterson, C.
Comparison of outcomes in neck pain patients with and without dizziness undergoing chiropractic treatment
Chiropr Man Therap, 2013, 21(1), 3; (1-9)
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Nervous system, Non-randomized trial, Vertigo
51 Schuth, M.
Randomisierte, kontrollierte Studie zur Wirkung der F.M. Alexandertechnik bei chronischen Nachkenschmerzen
Eine Pilotstudie
2011, 1-118 (Dissertation)
Alexander technique, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Pain, Thermotherapy, Chronic pain
52 Klein, R.; Bareis, A.; Schneider, A.; Linde, K.
Strain-counterstrain to treat restrictions of the mobility of the cervical spine in patients with neck pain
A sham-controlled randomized trial
Complement Ther Med, 2013, 21(1), 1-7
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Placebo-controlled, Randomized trial, Spine
53 Smith, J.; Bolton, P.S.
What are the clinical criteria justifying spinal manipulation therapy for neck pain?
A systematic review of randomized controlled trial
Pain Med, 2013, 14(4), 460-468
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Systematic review
54 Klein, R.; Bareis, A.; Schneider, A.; Linde, K.
Strain-counterstrain to treat restrictions of the mobility of the cervical spine in patients with neck pain
A sham-controlled randomized trial
Albrecht, H., Frühwald, M. (Hrsg.): Jahrbuch der Karl und Veronica Carstens-Stiftung, Band 19 (2012), 2013, 69-70 (Abstract)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Placebo-controlled, Randomized trial, Pain, Chronic pain
55 Saavedra-Herandez, M.; Arroyo-Morales, M.; Cantarero-Villanueva, I.; Fernández-Lao, C.; Castro-Sánchez, A.M.; Puentedura, E.J.; Fernández-de-las-Peñas, C.
Short-term effects of spinal thrust joint manipulation in patients with chronic neck pain
A randomized clinical trial
Clin Rehabil, 2013, 27(6), 504-512
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Pain, Chronic pain
56 Izquierdo Pérez, H.; Alonso Perez, J.L.; Gil Martinez, A.; La Touche, R.; Lara, S.L.; Commeaux Gonzalez, N.; Arribas Perez, H.; Bishop, M.D.; Fernández-Carnero, J.
Is one better than another?
A randomized clinical trial of manual therapy for patients with chronic neck pain
Man Ther, 2014, 19(3), 215-221
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Pain, Chronic pain
57 Bareis, A.R.
Behandlung von Bewegungseinschränkungen im Bereich der Halswirbelsäule mit der Strain-Counterstrain-Methode
Eine randomisierte Studie
2014, 1-63 (Dissertation)
Muscoskeletal -/Connective tissue system, Exercise therapy, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Randomized trial
58 Abdul-Rasheed, A.
The effectiveness of spinal manipulation and dry needling versus spinal manipulation and Traumeel®S injectable solution in the treatment of mechanical neck pain associated with trapezius myofascial trigger points
2013, 1-97 (Dissertation)
Acupuncture, Applikationsform, Muscoskeletal -/Connective tissue system, Homeopathy, Injektion, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Traditional Chinese medicine, Traumeel
59 Lin, J.H.; Shen, T.; Chung, R.C.K.; Chiu, T.T.W.
The effectiveness of Long's manipulation on patients with chronic mechanical neck pain
A randomized controlled trial
Man Ther, 2013, 18, 308-315
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Randomized trial
60 Lundqvist, L.O.; Zetterlund, C.; Richter, H.O.
Effects of Feldenkrais method on chronic neck/scapular pain in people with visual impairment
A randomized controlled trial with one-year follow-up
Arch Phys Med Rehabil, 2014, 95(9), 1656-1661
Eye diseases, Muscoskeletal -/Connective tissue system, Feldenkrais, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Pain, Chronic pain
61 Sherman, K.J.; Cook, A.J.; Wellman, R.D.; Hawkes, R.J.; Kahn, J.R.; Deyo, R.A.; Cherkin, D.C.
Five-week outcomes from a dosing trial of therapeutic massage for chronic neck pain
Ann Fam Med, 2014, 12(2), 112-120
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Randomized trial
62 Akhter, S.; Khan, M.; Ali, S.S.; Soomro, R.R.
Role of manual therapy with exercise regime versus exercise regime alone in the management of non-specific chronic neck-pain
Pak J Pharm Sci, 2014, 27(6 Suppl), 2125-2128
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial
63 Vihstadt, C.; Maiers, M.; Westrom, K.; Bronfort, G.; Evans, R.; Hartvigsen, J. Schulz, C.
Short term treatment versus long term management of neck and back disability in older adults utilizing spinal manipulative therapy and supervised exercise
A parallel-group randomized clinical trial evalutating relative effectiveness and harms
Chiropr Man Therap, 2014, 22, 26; (1-15)
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Geriatrics, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Back pain (non-specific)
64 Klein, S.D.; Bayard, C.; Wolf, C.
The Alexander technique and musicians
A systematic review of controlled trials
BMC Complement Altern Med, 2014, 14, 414; (1-11)
Alexander technique, Anxiety, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Mental diseases, Back pain (non-specific), Stress, Systematic review
65 Haller, H.; Ostermann, T.; Lauche, R.; Cramer, H.; Dobos, G.
Credibility of a comparative sham control intervention for Craniosacral Therapy in patients with chronic neck pain
Complement Ther Med, 2014, 22(6), 1053-1059
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Cranio-sacral therapy, Manual therapy, Neck pain, Placebo-controlled, Randomized trial, Pain, Chronic pain
66 Haller, H.; Cramer, H.; Lauche, R.; Gass, F.; Rampp, T.; Saha, F.J.; Dobos, G.J.
Craniosacral therapy in chronic neck pain
A randomized sham-controlled trial
Forsch Komplementärmed, 2013, 20(suppl.1), 73 (Abstract; Symposiumsbeitrag)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Cranio-sacral therapy, Manual therapy, Neck pain, Placebo-controlled, Randomized trial
67 Saenlee, K.; Eungpinichpong, W.; Chatchawan, U.
Therapeutic effects of scrapping therapy on neck and shoulder pain associated with myofascial trigger points
A pilot study
Forsch Komplementärmed, 2013, 20(suppl. 1), 102 (Abstract; Symposiumsbeitrag)
Muscoskeletal -/Connective tissue system, Gua Sha, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Placebo-controlled, Randomized trial, Schulterschmerz (unspezifisch), Traditional Chinese medicine
68 Beltran-Alacreu, M.; López-de-Uralde-Villanueva, I.; Fernández-Carnero, J.; La Touche, R.
Manual therapy, therapeutic patient education, and therapeutic exercise, an effective multimodal treatment of nonspecific chronic neck pain
A randomized controlled trial
Am J Phys Med Rehabil, 2015, 94(10), 887-897
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Pain, Chronic pain
69 Langenfeld, A.; Humphreys, B.K.; Bie, R.A. de; Swanenburg, J.
Effect of manual versus mechanically assisted manipulations of the thoracic spine in neck pain patients
Study protocol of a randomized controlled trial
Trials, 2015, 16(1), 233; (1-10) (Studienprotokoll)
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
70 Cook, A.J.; Wellman, R.D.; Cherkin, D.C.; Kahn, J.R.; Sherman, K.J.
Randomized clinical trial assessing if additional massage treatments for chronic neck pain improve 12 and 26 week outcomes
Spine J, 2015, epub ahead of print,
Muscoskeletal -/Connective tissue system, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Randomized trial
71 Griswold, D.; Learman, K.; O'Halloran, B.; Cleland, J.
A preliminary study comparing the use of cervical /upper thoracic mobilization and manipulation for individuals with mechanical neck pain
J Man Manip Ther, 2015, 23(2), 75-83
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Mobilisation
72 Llamas-Ramos, R.; Pecos-Martín, D.; Gallego-Izquierdo, T.; Llamas-Ramos, I.; Plaza-Manzano, G.; Ortega-Santiago, R.; Cleland, J.; Fernandez-de-las-Penas, C.
Comparison of the short-term outcomes between trigger point dry needling and trigger point manual therapy for the management of chronic mechanical neck pain
A randomized clinical trial
J Orthop Sports Phys Ther, 2014, 44(11), 852-861
Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Traditional Chinese medicine
73 Wei, X.; Wang, S.; Li, J.; Gao, J.; Yu, J.; Feng, M.; Zhu, L.
Complementary and alternative medicine for the management of cervical radiculopathy
An overview of systematic reviews
eCAM, 2015, Article ID 793649, (1-10)
Acupuncture, Muscoskeletal -/Connective tissue system, Chinese medicinal herbs, Cervical syndrome, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Nervous system, Systematic review, Traditional Chinese medicine, Jingfukang, radiculopathy
74 Skillgate, E.; Bill, A.S.; Côté, P.; Viklund, P.; Peterson, A.; Holm, L.W.
The effect of massage therapy and/or exercise therapy on subacute or long-lasting neck pain - The Stockholm neck trial (STONE)
Study protocol for a randomized controlled trial
Trials, 2015, 16(1), 414; (1-11) (Studienprotokoll)
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Physical therapy, Randomized trial
75 MacPherson, H.; Tilbrook, H.; Richmond, S.; Woodman, J.; Ballard, K.; Atkin, K.; Bland, M.; Eldred, J.; Essex, H.; Hewitt, C.; Hopton, A.; Keding, A.; Lansdown, H.; Parrott, S.; Torgerson, D.; Wenham, A.; Watt, I.
Alexander technique lessons or acupuncture sessions for persons with chronic neck pain
A randomized trial
Ann Intern Med, 2015, 163(9), 653-662
Acupuncture, Alexander technique, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial, Traditional Chinese medicine
76 Dongen, J.M. van; Groeneweg, R.; Rubinstein, S.M.; Bosmans, J.E.; Oostendorp, R.A.; Ostelo, R.W.; Tulder, M.W. van
Cost-effectiveness of manual therapy versus physical therapy in patients with sub-acute and chronic neck pain
A randomized controlled trial
Value Health, 2015, 18(7), A669-A670 (Abstract)
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Economy, Physical therapy, Randomized trial, Cost-effectiveness, Mobilisation
77 Lauche, R.; Schuth, M.; Schwickert, M.; Lüdtke, R.; Musial, F.; Michalsen, A.; Dobos, G.; Choi, K.E.
Efficacy of the Alexander technique in treating chronic non-specific neck pain
A randomized controlled trial
Clin Rehabil, 2016, 30(3), 247-258
Alexander technique, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
78 Bevilaqua-Grossi, D.; Goncalves, M.C.; Carvalho, G.F.; Florencio, L.L.; Dach, F.; Speciali, J.G.; Bigal, M.E.; Chaves, T.C.
Additional effects of a physical therapy protocol on headache frequency, pressure pain threshold, and improvement perception in patients with migraine and associated neck pain
A randomized clinical trial
Arch Phys Med Rehabil, 2016, 97(6), 866-874
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Migraine, Neck pain, Nervous system, Physiotherapy, Randomized trial
79 Wong, J.J.; Shearer, H.M.; Mior, S.; Jacobs, C.; Côté, P.; Randhawa, K.; Yu, H.; Southerst, D.; Varatharajan, S.; Sutton, D.; Velde, G. van der; Carroll, L.J.; Ameis, A.; Ammendolia, C.; Brison, R.; Nordin, M.; Stupar, M.; Taylor-Vaisey, A.
Are manual therapies, passive physical modalities, or acupuncture effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders
An update of the bone and joint decade task force on neck pain and its associated disorders by the optima collaboration
Spine J, 2016, 16(12), 1598-1630
Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Whiplash-associated disorders, Systematic review, Traditional Chinese medicine
80 Celenay, S.T.; Akbayrak, T.; Kaya, D.O.
A comparison of the effects of stabilization exercises plus manual therapy to stabilization exercises alone in patients with nonspecific mechanic neck pain
A randomized clinical trial
J Orthop Sports Phys Ther, 2016, 46(2), 44-55
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial
81 Bareis, A.R.
Behandlung von Bewegungseinschränkungen im Bereich der Halswirbelsäule mit der Strain-Counterstrain-Methode
Eine randomisierte Studie
2014, 1-63 (Dissertation)
Muscoskeletal -/Connective tissue system, Exercise therapy, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Osteopathy, Randomized trial
82 Dissing, K.B.; Hartvigsen, J.; Wedderkopp, N.; Hestbaek, L.
Conservative care with or without manipulative therapy in the management of back and neck pain in Danish children aged 9-15
Study protocol for a randomized controlled trial
Chiropr Man Therap, 2016, 24, 5; (1-10) (Studienprotokoll)
Muscoskeletal -/Connective tissue system, Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Pediatrics, Randomized trial, Back pain (non-specific)
83 Lopez-Lopez, A.; Perez, J.L.A.; Gutierez, G.; Touche, R. la; Lara, S.L.; Izquierdo, H.; Fernández-Carnero, J.
Mobilization versus manipulations versus sustain apohyseal natural glide techniques and interaction with psychological factors for patients with chronic neck pain
Randomized controlled trial
Eur J Phys Rehabil Med, 2015, 51(2), 121-132
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Neck pain, Randomized trial
84 Dunning, J.R.; Butts, R.; Mourad, F.; Young, I.; Fernandez-de-las-Penas, C.; Hagins, M.; Stanislawski, T.; Donley, J.; Buck, D.; Hooks, T.R.; Cleland, J.A.
Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cevicogenic headache
A multi-center randomized clinical trial
BMC Musculoskel Disord, 2016, 17(1), 64; (1-12)
Muscoskeletal -/Connective tissue system, Exercise therapy, Chiropractic, Clinical research, Complementary and alternative medicine, Headache, Manual therapy, Neck pain, Nervous system, Physical therapy, Randomized trial, Mobilisation
85 Dunning, J.R.; Butts, R.; Mourad, F.; Young, I.; Fernandez-de-las Peñas, C.; Hagins, M.; Stanislawski, T.; Donley, J.; Buck, D.; Hooks, T.R.; Cleland, J.A.
Upper cervical and upper thoraric manipulation versus mobilization and exercise in patients with cervicogenic headache
A multi-center randomized clinical trial
BMC Musculoskel Disord, 2016, 17, 64; (1-12)
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Headache, Manual therapy, Massage, Neck pain, Nervous system, Physical therapy, Randomized trial
86 Dongen, J.M. van; Groeneweg, R.; Rubinstein, S.M.; Bosmans, J.E.; Oostendorp, R.A.; Ostelo, R.W.; Tulder, M.W. van
Cost-effectiveness of manual therapy versus physiotherapy in patients with sub-acute and chronic neck pain
A randomised controlled trial
Eur Spine J, 2016, 25(7), 2087-2096
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Economy, Physiotherapy, Randomized trial, Cost-effectiveness, Mobilisation
87 Paanalahti, K.; Holm, L.W.; Nordin, M.; Höijer, J.; Lyander, J.; Asker, M.; Skillgate, E.
Three combinations of manual therapy techniques within naprapathy in the treatment of neck and/or back pain
A randomized controlled trial
BMC Musculoskel Disord, 2016, 17, 176; (1-10)
Muscoskeletal -/Connective tissue system, Cervical syndrome, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Massage, Neck pain, Randomized trial, Back pain (non-specific)
88 Haller, H.; Lauche, R.; Cramer, H.; Rampp, T.; Saha, F.J.; Ostermann, T.; Dobos, G.
Craniosacral therapy for the treatment of chronic neck pain
A randomized sham-controlled trial
Clin J Pain, 2016, 32(5), 441-449
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Cranio-sacral therapy, Manual therapy, Neck pain, Placebo-controlled, Randomized trial
89 Ris, I.; Sogaard, K.; Gram, B.; Agerbo, K.; Boyle, E.; Juul-Kristensen, B.
Does a combination of physical training, specific exercises and pain education improve health-related quality of life in patients with chronic neck pain?
A randomised control trial with a 4-month follow up
Man Ther, 2016, 26, 132-140
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Physiotherapy, Randomized trial
90 Trott, C.A.; Ruiz Aguila, M.E.; Leaver, A.M.
The clinical significance of immediate symptom responses to manual therapy treatment for neck pain
Observational secondary data analysis of a randomized trial
Man Ther, 2014, 19(6), 549-554
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Randomized trial
91 Kojidi, M.M.; Okhovatian, F.; Rahimi, A.; Baghban, A.A.; Azimi, H.
Comparison between the effects of passive and active soft tissue therapies on latent trigger points of upper trapezius muscle in women
Single-blind, randomized clinical trial
J Chiropract Med, 2016, 15(4), 235-242
Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Muscles, Neck pain, Placebo-controlled, Randomized trial
92 Castaldo, M.; Catena, A.; Chiarotto, A.; Fernandez-de-las-Penas, C.; Arendt-Nielsen, L.
Do subjects with whiplash-associated disorders respond differently in the short-term to manual therapy and exercise than those with mechanical neck pain?
Pain Med, 2017, 18(4), 791-803
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Non-randomized trial, Physiotherapy, Whiplash-associated disorders
93 Celenay, S.T.; Kaya, D.O.; Akbayrak, T.
Cervical and scapulothoracic stabilization exercises with and without connective tissue massage for chronic mechanical neck pain
A prospective, randomised controlled trial
Man Ther, 2016, 21, 144-150
Muscoskeletal -/Connective tissue system, Connective tissue massage, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physiotherapy, Randomized trial
94 Dibai-Filho, A.V.; Oliveira, A.K. de; Girasol, C.E.; Dias, F.R.; Guirro, R.R.
Additional effect of static ultrasound and diadynamic currents on myofascial trigger points in a manual therapy program for patients with chronic neck pain
A randomized clinical trial
Am J Phys Med Rehabil, 2017, 96(4), 243-252
Muscoskeletal -/Connective tissue system, Diadynamic currents, Electrotherapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial, Therapeutic ultrasound
95 Groeneweg, R.; Assen, L. van; Kropman, H.; Leopold, H.; Mulder, J.; Smits-Engelsman, B.C.M.; Ostelo, R.W.J.G.; Oostendorp, R.A.B.; Tulder, M.W. van
Manual therapy compared with physical therapy in patients with non-specific neck pain
A randomized controlled trial
Chiropr Man Therap, 2017, 25, 12; (1-12)
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Randomized trial
96 Castro-Martín, E.; Ortiz-Comino, L.; Gallart-Aragón, T.; Esteban-Moreno, B.; Arroyo-Morales, M.; Galiano-Castillo, N.
Myofascial induction effects on neck-shoulder pain in breast cancer survivors
Randomized, single-blind, placebo-controlled crossover design
Arch Phys Med Rehabil, 2017, 98, 832-840
Muscoskeletal -/Connective tissue system, Connective tissue massage, Breast cancer, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Neck pain, Physiotherapy, Placebo-controlled, Randomized trial
97 Hidalgo, B.; Hall, T.; Bossert, J.; Dugeny, A.; Cagnie, B.; Pitance, L.
The efficacy of manual therapy and exercise for treating non-specific neck pain
A systematic review
J Back Musculoskelet Rehabil, 2017, 30(6), 1149-1169
Muscoskeletal -/Connective tissue system, Exercise therapy, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physical therapy, Systematic review
98 Essex, H.; Parrott, S.; Atkin, K.; Ballard, K.; Bland, M.; Eldred, J.; Hewitt, C.; Hopton, A.; Keding, A.; Lansdown, H.; Richmond, S.; Tilbrook, H.; Torgerson, D.; Watt, I.; Wenham, A.; Woodman, J.; MacPherson, H.
An economic evaluation of Alexander technique lessons or acupuncture sessions for patients with chronic neck pain
A randomized trial (ATLAS)
PLoS ONE, 2017, 12(12), e0178918; (1-16)
Acupuncture, Alexander technique, Muscoskeletal -/Connective tissue system, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Economy, Randomized trial, Traditional Chinese medicine, Cost-effectiveness
99 Domingo, A.R.; Diek, M.; Goble, K.M.; Maluf, K.S.; Goble, D.J.; Baweja, H.S.
Short-duration therapeutic massage reduces postural upper trapezius muscle activity
Neuroreport, 2017, 28(2), 108-110
Muscoskeletal -/Connective tissue system, Healthy probands, Clinical research, Complementary and alternative medicine, Manual therapy, Muscles, Neck pain, Randomized trial, Schulterschmerz (unspezifisch)
100 Cho, J.; Lee, E.; Lee, S.
Upper thoracic spine mobilization and moblity exercise versus upper cervical spine mobilization and stabilization exercise in individuals with forward head posture
A randomized clinical trial
BMC Musculoskel Disord, 2017, 18, 525; (1-10)
Muscoskeletal -/Connective tissue system, Cervical syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Neck pain, Physiotherapy, Randomized trial