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101 Boehm, K.; Büssing, A.; Ostermann, T.
Aromatherapy as an adjuvant treatment in cancer care
A descriptive systematic review
Afr J Tradit Compl Altern Med, 2012, 9(4), 503-518
Aromatherapy, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Systematic review
102 Russo, G.I.; Cimino, S.; Salamone, C.; Madonia, M.; Favilla, V.; Castelli, T.; Morgia, G.
Potential efficacy of some African plants in benign prostatic hyperplasia and prostate cancer
Mini Rev Med Chem, 2013, 13(11), 1564-1571
Andrology, Basic Research, Urinary tract, Hypericum, St John's wort, Hypoxis, African potato, Clinical research, Complementary and alternative medicine, Cancer, Oleander, Phytomedicine, Prostate cancer, Prostatic enlargement (benign), Pygeum africanum, Systematic review, Traditional African Medicine
103 Lin, Y.W.; Hu, Z.H.; Wang, X.; Mao, Q.Q.; Qin, J.; Zheng, X.Y.; Xie, L.P.
Tea consumption and prostate cancer
An updated meta-analysis
World J Surg Oncol, 2014, 12, 38; (1-7)
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prostate cancer, Tea
104 Wang, W.; Yang, Y.; Zhang, W.; Wu, W.
Association of tea consumption and the risk of oral cancer
A meta-analysis
Oral Oncol, 2014, 50(4), 276-281
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Meta-analysis, Oral cavity cancer, Phytomedicine, Prevention, Tea
105 Green, C.J.; Dauwe, P. de; Boyle, T.; Tabatabaei, S.M.; Fritschi, L.; Heyworth, J.S.
Tea, coffee, and milk consumption on colorectal cancer risk
J Epidemiol, 2014, 24(2), 146-153
Camellia, Camellia sinensis, Coffea, Coffea tosta, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, milk, Non-randomized trial, Phytomedicine, Prevention, Tea
106 Alsanad, S.M.; Williamson, E.M.; Howard, R.L.
Cancer patients at risk of herb/food supplement-drug interactions
A systematic review
Phytother Res, 2014, 28(12), 1729-1755
Arzneimittelwechselwirkung, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Dietary supplementation, Phytomedicine, Systematic review
107 Fritz, H.; Seely, D.; McGowan, J.; Skidmore, B.; Fernandes, R.; Kennedy, D.A.; Cooley, K.; Wong, R.; Sagar, S.; Balneaves, L.G.; Fergusson, D.
Black cohosh and breast cancer
A systematic review
Integr Cancer Ther, 2014, 13(1), 12-29
Breast cancer, Black cohosh, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Menopause, Phytomedicine, Systematic review, Adverse effect
108 Wang, L.; Zhang, X.; Liu, J.; Shen, L.; Li, Z.
Tea consumption and lung cancer risk
A meta-analysis of case-control and cohort studies
Nutrition, 2014, 30(10), 1122-1127
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Meta-analysis, Phytomedicine, Prevention, Tea
109 Cho, S.-H.; Kim, W.-J.
Traditional herbal medicine as adjunctive therapy for nasopharyngeal cancer
A systematic review and meta-analysis
Forsch Komplementärmed, 2013, 20(suppl. 1), 60 (Abstract; Symposiumsbeitrag)
Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Meta-analysis, Nasal tumor, Phytomedicine, Systematic review, Traditional Chinese medicine
110 Mastron, J.K.; Siveen, K.S.; Sethi, G.; Bishayee, A.
Silymarin and hepatocellular carcinoma
A systematic, comprehensive, and critical review
Anticancer Drugs, 2015, 26(5), 475-486
Basic Research, Clinical research, Complementary and alternative medicine, Cancer, Liver cancer, Phytomedicine, milk thistle
111 Kraft, K.; Nieber, K.; Kelber, O.
Valerian
No clinically relevan interactions
Forsch Komplementärmed, 2013, 20(Suppl 3), 37 (Symposiumsbeitrag; Abstract)
Arzneimittelwechselwirkung, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Systematic review, Valeriana
112 Sanatani, M.; Younus, J.; Stitt, L.; Malik, N.
Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia
J Complement Integr Med, 2015, 12(1), 57-60
Curcuma, Curcuma longa, Gentiana, Gentiana lutea, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Non-randomized trial, Phytomedicine, ginger, Appetitlosigkeit
113 Kodali, R.T.; Eslick, G.D.
Meta-analysis
Does garlic intake reduce risk of gastric cancer?
Nutr Cancer, 2015, 67(1), 1-11
Allium, Allium sativum, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Meta-analysis, Phytomedicine, Prevention, Systematic review
114 Zhu, B.; Zhou, L.; Qi, L.; Zhong, R.; Miao, X.
Allium vegetables and garlic supplements do not reduce risk of colorectal cancer, based on meta-analysis of prospective studies
Clin Gastroenterol Hepatol, 2014, 12(12), 1991-2001
Allium, Allium sativum, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prevention
115 Riza, E.; Linos, A.; Petralias, A.; Martinis, L. de; Duntas, L.; Linos, D.
The effect of Greek herbal tea consumption on thyroid cancer
A case-control study
Eur J Public Health, 2015, 25(6), 1001-1005
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial, Phytomedicine, Thyroid cancer, Tea
116 Tuong, W.; Kuo, S.; Sivamani, R.K.
Photoprotective effect of botanicals and vitamins
A systematic review of clinical trials
J Dermatolog Treat, 2015, 26(6), 558-570
Nutrition/diet, Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Malignant melanoma, Phytomedicine, Prevention, Sunburn, Systematic review, Vitamins, Skin aging
117 Zhu, G.; Hua, J.; Wang, Z.; She, F.; Chen, Y.
Tea consumption and risk of gallbladder cancer
A meta-analysis of epidemiolotical studies
Mol Clin Oncol, 2015, 3(3), 613-618
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prevention, Tea, Gallbladder cancer
118 Shanmugam, M.K.; Rane, G.; Kanchi, M.M.; Arfuso, F.; Chinnathambi, A.; Zayed, M.E.; Alharbi, S.A.; Tan B.K.H.; Kumar, A.P.; Sethi, G.
The multifaceted role of curcumin in cancer prevention and treatment
Molecules, 2015, 20, 2728-2769
Curcuma, Curcuma longa, Basic Research, Clinical research, Complementary and alternative medicine, Cancer, Pharmacology, Phytomedicine, posology, Review (BR), Review (CR), Mechanism of action
119 Chen, M.; May, B.H.; Zhou, I.W.; Xue, C.C.L.; Zhang, A.L.
Meta-analysis of oxaliplatin-based chemotherapy combined with traditional medicines for colorectal cancer
Contributions of specific plants to tumor responses
Integr Cancer Ther, 2016, 15(1), 40-59
Bowel cancer, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Traditional Chinese medicine, Traditional Japanese medicine
120 Kim, W.; Lee, W.B.; Lee, J.W.; Min, B.I.; Baek, S.K.; Lee, H.S.; Cho, S.H.
Traditional herbal medicine as adjunctive therapy for breast cancer
A systematic review
Complement Ther Med, 2015, 23(4), 626-632
Breast cancer, Gynaecology, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Systematic review, Traditional Chinese medicine
121 Tang, J.; Zheng, J.S.; Fang, L.; Jin, Y.; Cai, W.; Li, D.
Tea consumption and mortality of all cancers, CVD and all causes
A meta-analysis of eighteen prospective cohort studies
Br J Nutr, 2015, 114(5), 673-683
Camellia, Camellia sinensis, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Tea
122 Tanaka, T.; Morimoto, K.; Nishikwawa, N.; Kuratsukuri, K.; Ishii, K.; Yoshimura, R.; Nakatani, T.
Suppressive effects of Eviprostat, a phytotherapeutic agent, on lower urinary tract symptoms in prostate cancer patients treated with brachytherapy
Low Urin Tract Symptoms, 2012, 4(1), 25-28
Eviprostat, Urinary tract, Urinary tract infection, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Cancer, Non-randomized trial, Phytomedicine, Prevention, Prostate cancer
123 Chen, T.-H.; Tung, T.-H.; Chen, P.-S.; Wang, S.-H.; Chao, C.-M.; Hsiung, N.-H.; Chi, C.-C.
The clinical effects of aromatherapy massage on reductin pain for the cancer patients
Meta-analysis of randomized controlled trials
eCAM, 2016, Article ID 9147974, (1-6)
Aromatherapy, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Meta-analysis, Phytomedicine, Chronic pain
124 Hutton, B.; Yazdi, F.; Bordeleau, L.; Morgan, S.; Cameron, C.; Kanji, S.; Fergusson, D.; Tricco, A.; Straus, S.; Skidmore, B.; Hersi, M.; Pratt, M.; Mazzarello, S.; Brouwers, M.; Moher, D.; Clemons, M.
Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer
Protocol for a systematic review incorporating network meta-analysis
Syst Rev, 2015, 4, 114 (Studienprotokoll)
Breast cancer, Gynaecology, Clinical research, Cognitive behavioral therapy, Complementary and alternative medicine, Cancer, Meditation, Menopause, Meta-analysis, Mind-body medicine, Physical therapy, Phytomedicine, Psychology/psychotherapy, Systematic review, Yoga
125 Die, M.D. van; Bone, K.M.; Emery, J.; Williams, S.G.; Pirotta, M.V.; Paller, C.J.
Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer
A systematic review of randomised trials
BJU Int, 2016,
Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Prostate cancer, Systematic review
126 Ara, S.A.; Mudda, J.A.; Lingappa, A.; Rao, P.
Research on curcumin
A meta-analysis of potentially malignant disorders
J Cancer Res Ther, 2016, 12(1), 175-181
Muscoskeletal -/Connective tissue system, Curcuma, Curcuma longa, Fibrosis, Ear-nose-throat disorders, Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Lichen, Meta-analysis, Mouth, Phytomedicine, Systematic review, burning mouth syndrome
127 Li, Y.; Zhu, X.; Bensussan, A.; Li, P.; Moylan, E.; Delaney, G.; McPherson, L.
Herbal medicine for hot flushes induced by endocrine therapy in women with breast cancer
A systematic review and meta-analysis
eCAM, 2016, Article ID 1327251, (1-11)
Breast cancer, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review
128 Shin, E.S.; Seo, K.H.; Lee, S.H.; Jang, J.E.; Jung, Y.M.; Kim, M.J.; Yeon, J.Y.
Massage with or without aromatherapy for symptom relief in people with cancer
Cochrane Database Syst Rev, 2016, 6(CD009873), 1-68
Aromatherapy, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Phytomedicine, Systematic review
129 Feng, Y.; Zhou, J.; Jiang, Y.
Resveratrol in lung cancer
A systematic review
J BUON, 2016, 21(4), 950-963
Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Phytomedicine, Resveratrol, Systematic review
130 Aune, D.; Keum, N.; Giovannucci, E.; Fadnes, L.T.; Boffetta, P.; Greenwood, D.C.; Tonstad, S.; Vatten, L.J.; Riboli, E.; Norat, T.
Nut consumption, and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality
A systematic review and dose-response meta-analysis of prospective studies
BMC Med, 2016, 14, 207; (1-14)
Anacardium, Anacardium occidentale, Arachis hypogaea, Carya illoinesis, Corylus avellana, Diabetes mellitus, Nutrition/diet, Cardiovascular diseases, Immune system, Juglans, walnut, Clinical research, Complementary and alternative medicine, Coronary heart disease, Cancer, Meta-analysis, Phytomedicine, Prevention, Prunus, Prunus dulcis, Metabolic diseases, Systematic review
131 Tariq, A.; Sadia, S.; Pan, K.; Ullah, I.; Mussarat, S.; Sun, F.; Abiodun, O.O.; Batbaatar, A.; Li, Z.; Song, D.; Xiong, Q.; Ullah, R.; Khan, S.; Basnet, B.B.; Kumar, B.; Adnan, M.
A systematic review on ethnomedicines of anti-cancer plants
Phytother Res, 2017, 31(2), 202-264
Ethnomedicine, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Systematic review
132 Jiang, R.; Botma, A.; Rudolph, A.; Hüsing, A.; Chang-Claude, J.
Phyto-oestrogens and colorectal cancer risk
A systematic review and dose-response meta-analysis of observational studies
Br J Nutr, 2016, 116(12), 2115-2128
Bowel cancer, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review
133 Bae, K.; Park, J.-h.; Kim, J.; Cho, C.-k.; Oh, B.; Costa, D.; Lim, S.; Deng, G.; Yoo, H.-S.
Traditional oriental herbal medicine and natural killer cells for cancer patients
A systematic review and meta-analysis
Phytother Res, 2017, 3(4), 519-532
Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review
134 Huang, Y.-Q.; Lu, X.; Min, H.; Wu, Q.-Q.; Shi, X.-T.; Bian, K.-Q.; Zou, X.-P.
Green tea and liver cancer risk
A meta-analysis of prospective cohort studies in Asian populations
Nutrition, 2016, 32, 3-8
Clinical research, Complementary and alternative medicine, Cancer, Liver cancer, Meta-analysis, Phytomedicine, Prevention, Tea, Green Tea, Cohort study
135 Jacob, S.A.; Khan, T.M.; Lee, L.H.
The effect of green tea consumption on prostatic cancer risk and progression
A systematic review
Nutr Cancer, 2017, 69(3), 353-364
Andrology, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Prevention, Prostate cancer, Systematic review, Tea, Green Tea
136 Guo, Y.; Zhi, F.; Chen, P.; Zhao, K.; Xiang, H.; Mao, Q.; Wang, X.; Zhang, X.
Green tea and the risk of prostate cancer
A systematic review and meta-analysis
Medicine, 2017, 96(13), e6426; (1-9)
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prostate cancer, Systematic review, Tea, Green Tea
137 Lu, D.; Pan, C.; Ye, C.; Duan, H.; Xu, F.; Yin, L.; Tian, W.; Zhang, S.
Meta-analysis of soy consumption and gastrointestinal cancer risk
Sci Reports, 2017, 7, 4048; (1-14)
Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Meta-analysis, Phaseolus, Phaseolus max, Phytomedicine
138 Thronicke, A.; Steele, M.L.; Grah, C.; Matthes, B.; Schad, F.
Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer
BMC Complement Altern Med, 2017, 17(1), 534; (1-10)
Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Non-randomized trial, Phytomedicine, Viscum, Viscum album
139 Yeung, K.S.; Hernandez, M.; Mao, J.J.; Haviland, I.; Gubili, J.
Herbal medicine for depression and anxiety
A systematic review with assessment of potential psycho-oncologic relevance
Phytother Res, 2018, 32(5), 865-891
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Mental diseases, Systematic review
140 Noh, H.; Yoon, S.W.; Park, B.
A systematic review of herbal medicine for chemotherapy induced peripheral neuropathy
eCAM, 2018, Article ID 6194184, (1-15)
Clinical research, Complementary and alternative medicine, Cancer, Nervous system, Neuropathy, Phytomedicine, Systematic review
141 Dai, F.; Gao, X.; Li, H.; Wang, J.; Gao, X.; Chai, W.
Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoraric perfusion
BMC Cancer, 2018, 18, 411; (1-13)
Brucea, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Meta-analysis, Oil, Phytomedicine, Traditional Chinese medicine, Brucea javanica
142 Deng, B.; Sun, W.
Herbal medicine for hand-foot syndrome induced by fluoropyrimidines
A systematic review and meta-analysis
Phytother Res, 2018, 32(7), 1211-1228
Hand-foot syndrome, Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review
143 Ho, S.S.M.; Kwong, A.N.L.; Wang, K.W.S.; Ho, R.M.L.; Chow, K.M.
Experiences of aromatherapy massage among adult female cancer patients
A qualitative study
J Clin Nurs, 2017, 26(23-24), 4519-4526
Aromatherapy, Assesment, Gynaecology, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Patient satisfaction, Phytomedicine
144 Najafi, M.N.; Salehi, M.; Ghazanfarpour, M.; Hoseini, Z.S.; Khadem-Rezaiyan, M.
The association between green tea consumption and breast cancer risk
A systematic review and meta-analysis
Phytother Res, 2018, 32(10), 1855-1864
Breast cancer, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review, Tea, Green Tea
145 Schad, F.; Thronicke, A.; Merkle, A.; Matthes, H.; Steele, M.L.
Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients
Phytomed, 2017, 36, 54-58
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Non-randomized trial, Phytomedicine, posology, Retrospective design, Adverse effect, Viscum, Viscum album
146 Reale, G.; Russo, G.I.; Di Mauro, M.; Regis, F.; Campisi, D.; Giudice, A.L.; Marranzano, M.; Ragusa, R.; Castelli, T.; Cimino, S.; Morgia, G.
Association between dietary flavonoids intake and prostate cancer risk
A case-control study in Sicily
Complement Ther Med, 2018, 39, 14-18
Andrology, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial, Phytomedicine, Prostate cancer
147 Tôrres de Lima, R.M.; Reis, A.C. dos; Melo de Menezes, A.-A.P.; Oliveira Santos, J.V. de; Oliveira Filho, J.W.G. de;
Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer
A comprehensive review
Phytother Res, 2018, 32(10), 1885-1907
Basic Research, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Systematic review, ginger
148 Kim, K.-I.; Jun, J.H.; Baek, H.; Kim, J.-H.; Lee, B.-J.; Jung, H.-J.
Oral administration of herbal medicines for radiation pneumonitis in lung cancer patients
A systematic review and meta-analysis
PLoS ONE, 2018, 13(5), e0198015; (1-19)
Respiratory diseases, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Meta-analysis, Phytomedicine, Systematic review, Pneumonitis
149 Zhang, H.; Xie, M.; Archibald, S.D.; Jackson, B.S.; Gupta, M.K.
Association of marijuana use with psychosocial and quality of life outcomes among patients with head and neck cancer
JAMA Otolaryngol Head Neck Surg, 2018, 144(11), 1017-1022
Cannabis, Cannabis sativa, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Non-randomized trial, Phytomedicine
150 Bahall, M.
Prevalence, patterns, and perceived value of complementary and alternative medicine among cancer patients
A cross-sectional, descriptive study
BMC Complement Altern Med, 2017, 17 (345), (epub)
Breast cancer, Bowel cancer, Assesment, Cervical cancer, Complementary and alternative medicine, Cancer, Mind-body medicine, Patient satisfaction, Phytomedicine, Prevalence
151 Theuser, A.-K.; Knoll, S.; Weber, N.; Sievers, H.; Schwitulla, J.; Fasching, P.A.; Beckmann, M.W.; Hack, C.C.
Anwendung von pflanzlichen Produkten durch Patientinnen mit Mammakarzinom
Z Phytother, 2017, 38 (Suppl.1), 42-43 (Abstract (Poster))
Arnica, Breast cancer, Assesment, Healthy probands, Clinical research, Complementary and alternative medicine, Cancer, Mentha, peppermint, Phytomedicine, Tea, Prevalence, ginger, Green Tea
152 Rabinovich, L.; Kazlouskaya, V.
Herbal sun protection agents
Human studies
Clin Dermatol, 2018, epub ahead of print,
Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Malignant melanoma, Phytomedicine, Sunburn, Review (CR), Skin aging
153 Bodagh, M.N.; Maleki, I.; Hekmatdoost, A.
Ginger in gastrointestinal disorders
A systematic review of clinical trials
Food Sci Nutr, 2019, 7, 96-108
Dyspepsia, Vomiting, Fatty liver, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Stomach cancer, Gastric mucosal inflammation, Phytomedicine, Irritable bowel syndrome, Systematic review, Sickness, ginger
154 Nishino, T.; Yoshida, T.; Goto, M.; Inoue, S.; Minato, T.; Fujiwara, S.; Yamamoto, Y.; Furukita, Y.; Yamai, H.; Takechi, H.; Toba, H.; Takizawa, H.; Yoshida, M.; Seike, J.; Myoshi, T.; Tangoku, A.
The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection
Open-label, randomized controlled trial
Esophagus, 2018, 15, 75-82
Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Non-randomized trial, Phytomedicine, Traditional Japanese medicine