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101 Shikov, A.N.; Djachuk, G.I.; Sergeev, D.V.; Pozharitskaya, O.N.; Esaulenko, E.V.; Kosman, V.M.; Makarov, V.G.
Birch bark extract as therapy for chronic hepatitis C - A pilot study
Phytomed, 2011, 18(10), 807-810

Observational trial, Betula, Betula alba, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21377854

102 Ohene-Yeboah, M.; Togbe, B.
Perforated gastric and duodenal ulcers in an urban African population
West Afr J Med, 2006, 25(3), 205-211

Observational trial, Dyspepsia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Gastric ulcer, Phytomedicine, Duodenal ulcer

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/17191420

103 Setiawan, V.W.; Zhang, Z.-F.; Yu, G.-P.; Lu, Q.-Y.; Li, Y.-L.; Lu, M.-L.; Wang, M.-R.; Guo, C.H.; Yu, S.-Z.; Kurtz, R.C.; Hsieh, C.-C.
Protective effect of green tea on the risks of chronic gastritis and stomach cancer
Int J Cancer, 2001, 92, 600-604

Observational trial, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Stomach cancer, Gastric mucosal inflammation, Phytomedicine, Prevention, Tea

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/11304697

104 Naftali, T.; Lev, L.B.; Yablecovitch, D.; Half, E.; Konikoff, F.M.
Treatment of Crohn's disease with cannabis
An observational study
Isr Med Assoc J, 2011, 13(8), 455-458

Observational trial, Cannabis, Cannabis sativa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Retrospective design

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21910367

105 Joos, S.
Stellenwert von Komplementärmedizin in der Primärversorgung
Evaluation von Nutzen, Patientensichtweisen und ärztlicher Expertise
2009, 1-75 + Anh. (Dissertation (Habilitationsschrift))

Acupuncture, Asthma, Respiratory diseases, Ulcerative colitis, Attitude, Assesment, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Patient satisfaction, Phytomedicine, Traditional Chinese medicine, Review (CR)

106 Rahimi, R.; Abdollahi, M.
Herbal medicines for the managment of irritable bowel syndrome
A comprehensive review
World J Gastroenterol, 2012, 18(7), 589-600

Basic Research, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22363129

107 Meyer, U.
Anwendungsbeobachtung WALA Carum carvi Kinderzäpfchen
Merkurstab, 2003, 56(6), 376-377

Anthroposophic medicine, Applikationsform, Observational trial, Carum carvi Kinderzäpfchen (WALA), Homeopathy, Clinical research, Colic, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Pediatrics, Phytomedicine, Zäpfchen

108 Karaman, A.; Baskol, M.; Gursoy, S.; Torun, E.; Yurci, A.; Celikbilek, M.; Guven, K.; Ozbakir, O.; Yucesoy, M.
Endoscopic topical application of Ankaferd Blood Stopper(R) in gastrointestinal bleeding
J Altern Complement Med, 2012, 18(1), 65-68

Alpinia, Alpinia officinarum, Observational trial, Glycyrrhiza, liquorice root, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Thymus, Thymus vulgaris, Urtica, Urtica dioica, Vitis vinifera, Vitis

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22268970

109 Lahat, A.; Lang, A.; Ben-Horin, S.
Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients
A pilot prospective study
Digestion, 2012, 85(1), 1-8

Observational trial, Cannabis, Cannabis sativa, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Irritable bowel syndrome

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22095142

110 Hines, S.; Steels, E.; Chang, A.; Gibbons, K.
Aromatherapy for treatment of postoperative nausea and vomiting
Cochrane Database Syst Rev, 2012, 4(CD007598), 1-52

Aromatherapy, Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Postoperative complaints, Systematic review, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22513952

111 Ding, M.; Leach, M.; Bradley, H.
The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting
A systematic review
Women Birth, 2013, 26(1), e26-e30

Vomiting, Gynaecology, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Obstetrics, Systematic review, Sickness (pregnancy), ginger

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22951628

112 Suskind, D.L.; Wahbeh, G.; Burpee, T.; Cohen, M.; Christie, D.; Weber, W.
Tolerability of curcumin in pediatric inflammatory bowel disease
A forced dose titration study
J Pediatr Gastroeneterol Nutrition, 2013, 56(3), 277-279

Observational trial, Ulcerative colitis, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Pediatrics, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23059643

113 Perry, R.; Hunt, K.; Ernst, E.
Nutritional supplements and other complementary medicines for infantile colic
A systematic review
Pediatrics, 2011, 127, 720-733

Nutrition/diet, Clinical research, Colic, Complementary and alternative medicine, Gastrointestinal tract, Dietary supplementation, Pediatrics, Phytomedicine, Systematic review

114 Ferrugiari, L.; Ragione, B.; Rich, E.R.; Lock, K.
The effect of aromatherapy on postoperative nausea in women undergoing surgical procedures
J Perianaesth Nurs, 2012, 27(4), 246-251

Aromatherapy, Observational trial, Surgery, Vomiting, Gynaecology, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Postoperative complaints, Prevention, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22828020

115 Holt, P.R.; Katz, S.; Kirshoff, R.
Curcumin therapy in inflammatory bowel disease
A pilot study
Digest Dis Sci, 2005, 50(11), 2191-2193

Observational trial, Ulcerative colitis, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16240238

116 Jeong, T.Y.; Park, B.K.; Cho, J.H.; Kim, Y.I.; Ahn, Y.C.; Son, C.G.
A prospective study on the safety of herbal medicines, used alone or with conventional medicine
J Ethnopharmacol, 2012, 143(3), 884-888

Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Adverse effect

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22940254

117 Vitalone, A.; Menniti-Ippolito, F.; Raschetti, R.; Renda, F.; Tartaglia, L.; Mazzanti, G.
Surveillance of suspected adverse reactions to herbal products used as laxatives
Eur J Clin Pharmacol, 2012, 68(3), 231-238

Observational trial, Cascara, Cascara sagrada, Cassia, Cassia acutifolia, Cassia angustifolia, Glycyrrhiza, liquorice root, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Plantago, Plantago afra, Rheum, Adverse effect, Constipation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21964980

118 Muss, C.; Mosgoeller, W.; Endler, T.
Papaya preparation (Caricol®) in digestive disorders
Neuro Endocrinol Lett, 2013, 34(1), 38-46

Carica, pawpaw, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meteorism, Non-randomized trial, Phytomedicine, Heartburn, Constipation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23524622

119 Uehleke, B.; Zahradnicek, S.; Vennos, C.
Die Tibetische Rezeptur Padma Lax in der ärztlichen Praxis
Eine retrospektive Fallstudie bei Obstipation mit 174 Patienten
Forsch Komplementärmed, 2013, 20(S2), 8-15

Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Padma, Phytomedicine, Traditional Tibetan medicine, Constipation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23860106

120 Meier, R.; Hengstler, P.; Weber, F.; Maurer, H.; Bommeli, C.; Brignoli, R.
The Tibetan Herbal Formula Padma Digestin in Functional Dyspepsia
An Open-Label Study
Forsch Komplementärmed, 2013, 20(S2), 2-7

Observational trial, Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Padma, Phytomedicine, Traditional Tibetan medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23860105

121 Ng, S.C.; Lam, Y.T.; Tsoi, K.K.F.; Chan, F.K.L.; Sung, J.J.Y.; Wu, J.C.Y.
Systematic review: the efficacy of herbal therapy in inflammatory bowel disease
Aliment Pharmacol Ther, 2013, 38(8), 854-863

Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23981095

122 Farina, V.H.; Lima, A.P.; Balducci, I.; Brandão, A.A.
Effects of the medicinal plants Curcuma zedoaria and Camellia sinensis on halitosis control
Braz Oral Res, 2012, 26(6), 523-529

Observational trial, Camellia, Camellia sinensis, Curcuma, Curcuma zedoaria, Halitosis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23019084

123 Biedermann, L.; Mwinyi, J.; Scharl, M.; Frei, P.; Zeitz, J.; Kullak-Ublick, G.A.; Vavricka, S.R.; Fried, M.; Weber, A.; Humpf, H.-U.; Peschke, S.; Jetter, A.; Krammer, G.; Rogler, G.
Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis
An open pilot study
J Crohn's Colitis, 2013, 7, 271-279

Observational trial, Ulcerative colitis, Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Vaccinium, blueberry

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22883440

124 Barakat, E.M.F.; El Wakeel, L.M.; Hagag, R.S.
Effects of Nigella sativa on outcome of hepatitis C in Egypt
World J Gastroenterol, 2013, 19(16), 2529-2536

Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nigella sativa, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23674855

125 Stuglin, C.; Prasad, K.
Effect of flaxseed consumption on blood pressure, serum lipids, hemopoietic system and liver and kidney enzymes in healthy humans
J Cardiovasc Pharmacol Ther, 2005, 10(1), 23-27

Observational trial, High blood pressure, Nutrition/diet, Healthy probands, Urinary tract, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Liver, Linum usitatissimum, Gastrointestinal tract, Kidney, Phytomedicine, Metabolic diseases

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15821835

126 Marx, W.M.; Teleni, L.; McCarthy, A.L.; Vitetta, L.; McKavanagh, D.; Thomson, D.; Isenring, E.
Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting
A systematic literature review
Nutrition Rev, 2013, 71(4), 245-254

Vomiting, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Systematic review, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23550785

127 Cruz-Correa, M.; Shoskes, D.A.; Sanchez, P.; Zhao, R.; Hyling, L.M.; Wexner, S.D.; Giardiello, F.M.
Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis
Clin Gastroenterol Hepatol, 2006, 4, 1035-1038

Observational trial, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Quercetin

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16757216

128 Zevallos, V.F.; Herencia, L.I.; Chang, F.; Donnelly, S.; Ellis, H.J.; Ciclitira P.J.
Gastrointestinal effects of eating quinoa (Chenopodium quinoa Willd.) in celiac patients
Am J Gastroenterol, 2014, 109(2), 270-278

Observational trial, Chenopodium, Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Metabolic diseases, Coeliac disease, Chenopodium quinoa

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/24445568

129 Belcaro, G.; Gizzi, G.; Hu, S.; Dugall, m.; Pellegrini, L.; Cornelli, U.; Cesarone, M.R.; Trignani, M.; Maione, C.
Robuvit® (French oak wood extract) in the management of functional, temporary hepatic damage
A registry, pilot study
Minerva Med, 2014, 105(1), 41-50

Observational trial, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Quercus robur

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/24572451

130 Reimelt, H.J.
Intestinale Candida-Mykosen
Anwendungsbeobachtung zur Wirksamkeit von Bärlauch Frischblattgranulat auf die Darmflora
Vitaminspur, 1998, 2, 98-99

Allium, Allium ursinum, Observational trial, Candidiasis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mycosis, Phytomedicine

131 Yang, Z.; Zhuang, L.; Lu, Y.; Xu, Q.; Chen, X.
Effects and tolerance of Silymarin (milk thistle) in chronic hepatitis C virus infection patients
A meta-analysis of randomized controlled trials
Biomed Res Int, 2014, 2014, 941085; (1-9)

Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, milk thistle

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25247194

132 Lee, J.; Son, C.; Lee, J.A.; Choi, J.; Lee, M.S.
Do herbal medicines negatively affect liver tests?
A systematic review of Korean clinical studies on safety
Eur J Integr Med, 2014, 6(4), 441-450

Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Systematic review, Adverse effect

133 Chedid, V.; Dhalla, S.; Clarke, J.O.; Roland, B.C.; Dunbar, K.B.; Koh, J.; Justino, E.; Tomakin, E.; Mullin, G.E.
Herbal therapy is equivalent to Rifaximin for the treatment of small intesinal bacterial overgrowth
Global Adv Health Med, 2014, 3(3), 16-24

Darm, Small bowel, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/24891990

134 Xiao, Q.; Sinha, R.; Graubard, B.I.; Freedman, N.D.
Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010
Hepatology, 2014, 60(6), 2091-2098

Observational trial, Coffea, Coffea tosta, Nutrition/diet, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25124935

135 Langhorst, J.; Wulfert, H.; Lauche, R.; Klose, P.; Cramer, H.; Dobos, G.J.; Korzenik, J.
Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases
J Crohn's Colitis, 2015, 9(1), 86-106

Acupuncture, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mind-body medicine, Crohn's disease, Phytomedicine, Systematic review, Traditional Chinese medicine

Abstract: https://ecco-jcc.oxfordjournals.org/content/early/2014/11/27/ecco-jcc.jju007

136 Sanatani, M.; Younus, J.; Stitt, L.; Malik, N.
Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia
J Complement Integr Med, 2015, 12(1), 57-60

Curcuma, Curcuma longa, Gentiana, Gentiana lutea, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Non-randomized trial, Phytomedicine, ginger, Appetitlosigkeit

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25324460

137 Lacet Silva Ferreira, G.; Pérez, A.L.A. de; Rocha, I.M.; Pinheiro, M.A.; Castro, R.D. de; Carlo, H.L.; Oliveira Lima, E. de; Castellano, L.R.
Does scientific evidence for the use of natural products in the treatment of oral candisiasis exist?
A systematic review
eCAM, 2015, Article ID 147804, (1-8)

Candidiasis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mycosis, Phytomedicine, Systematic review

Abstract: https://www.hindawi.com/journals/ecam/2015/147804

138 Xia, Y.; Luo, H.; Liu, J.P.; Gluud, C.
Phyllanthus species versus antiviral drugs for chronic hepatitis B virus infection
Cochrane Database Syst Rev, 2013, 4(CD009004), 1-30

Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phyllanthus, Phytomedicine, Systematic review, Traditional Chinese medicine, Viruses

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/23633363

139 Rahmani, N.; Khademloo, M.; Vosoughi, K.; Assadpour, S.
Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection
A prospective double blind clinical trial
Eur Rev Med Pharmacol Sci, 2014, 18(7), 1078-1084

Aloe, Aloe vera, Applikationsform, Blood/Lymphatic system, Haemorrhage, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Salbe, Pain, Wound healing

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/24763890

140 Patel, M.V.; Patel, K.B.; Gupta, S.; Michalsen, A.; Stapelfeldt, E.; Kessler, C.S.
A complex multiherbal regimen based on Ayurveda medicine for the management of hepatic cirrhosis complicated by ascites
Nonrandomized, uncontrolled, single group, open-label observational clinical study
eCAM, 2015, Article ID 613182, (1-12)

Ascites, Ayurveda, Observational trial, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Punarnavadi-kvatha

Abstract: https://www.hindawi.com/journals/ecam/aa/613182/

141 Lever, E.; Cole, J.; Scott, S.M.; Emery, P.W.; Whelan, K.
Systematic review
The effect of prunes on gastrointestinal function
Aliment Pharmacol Ther, 2014, 40(7), 750-758

Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Prunus, Prunus domestica, Systematic review, Constipation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25109788

142 Uehara, S.; Ogawa, K.; Arimitsu, J.; Okuyama, H.
"Ninjinto" (ginseng decoction), a traditional Japanese herbal medicine, improves gastrointestinal symptoms and immune competence in patients with chronic intestinal failure
eCAM, 2015, Article ID 462586, (1-6)

Atractylodes, Atractylodes japonica, Observational trial, Glycyrrhiza, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Short bowel syndrome, Gastrointestinal tract, Ninjin Yoei To, Phytomedicine, Traditional Japanese medicine, ginger, Panax, Panax ginseng

Abstract: https://www.hindawi.com/journals/ecam/2015/462586/

143 Wegener, T.
Anwendung von Manna-Feigen-Sirup bei Darmträgheit und Obstipation
Z Phytother, 2015, 36(5), 197-201

Applikationsform, Observational trial, Ficus, Fraxinus, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Sirup, Constipation, Ficus carica, Fraxinus ornus

144 Woo, H.J.; Kim, H.Y.; Choi, E.S.; Cho, Y.H.; Kim, Y.; Lee, J.H.; Jang, E.
Drug-induced liver injury
A 2-year retrospective study of 1169 hospitalized patients in a single medical center
Phytomed, 2015, 22(13), 1201-1205

Observational trial, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Retrospective design, Toxicology, Adverse effect

Abstract: https://dx.doi.org/10.1016/j.phymed.2015.10.002

145 Wegener, T.; Heimüller, E.
Anwendung von Gastritol® Liquid bei leichten gastrointestinalen Beschwerden - Ergebnisse einer prospektiven nicht-interventionellen Studie
Z Phytother, 2015, 36(Suppl. 1), S15 (Abstract; Symposiumsbeitrag)

Observational trial, Dyspepsia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Magenschmerzen (allg.), Meteorism, Phytomedicine, Gastritol

146 Madisch, A.; Vinson, B.; Abdel-Aziz, H.; Kelber, O.; Nieber, K.; Kraft, K.; Storr, M.
Regulatorische Einschränkungen bei den Gastroprokinetika
Die Phytotherapie als Therapie der Wahl bei funktionellen gastrointestinalen Erkrankungen
Z Phytother, 2015, 36(Suppl. 1), S16 (Abstract; Symposiumsbeitrag)

Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Systematic review

147 Noé, S.; Malek, F.A.; Stracke, B.; Madisch, A.
Menthacarin bei funktionellen gastrointestinalen Beschwerden - eine offene, multizentrische, apothekenbasierte, prospektive Kohortenstudie
Z Phytother, 2015, 36(Suppl. 1), S38 (Abstract; Symposiumsbeitrag)

Bauchschmerz (unspezifisch), Observational trial, Carum, Carum carvi Kinderzäpfchen (WALA), Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Meteorism, Phytomedicine

148 Wegener, T.; Heimueller, E.
Treatment of mild gastrointestinal disorders with a herbal combination
Results of a non-interventional study with Gastritol® liquid
Phytother Res, 2016, 30(1), 72-77

Bauchschmerz (unspezifisch), Diabetes mellitus, Vomiting, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Meteorism, Non-randomized trial, Phytomedicine, Heartburn, Metabolic diseases, Sickness, Gastritol

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26522087

149 Marx, W.; Kiss, N.; Isenring, L.
Is ginger beneficial for nausea and vomiting?
An update of the literature
Curr Opin Support Palliat Care, 2015, 9(2), 189-195

Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Systematic review, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25872115

150 Song, W.-J.; Luo, J.; Wu, T.; Yao, S.-k.
Oral oxymatrine preparation for chronic hepatitis B
A systematic review of randomized controlled trials
Chin J Integr Med, 2016, 22(2), 141-149

Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26016455

151 Maekita, T.; Kato, J.; Enomoto, S.; Yoshida, T.; Utsunomiya, H.; Hayashi, H.; Hanamitsu, T.; Inoue, I.; Maeda, Y.; Moribata, K.; Muraki, Y.; Shingaki, N.; Deguchi, H.; Ueda, K.; Iguchi, M.; Tamai, H.; Ichinose, M.
Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease
World J Gastroenterol, 2015, 21(26), 8170-8177

Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Prunus, Prunus mume, Heartburn, Traditional Japanese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26185391

152 Johnson, J.R.; Rivard, R.L.; Griffin, K.H.; Kolste, A.K.; Joswiak, D.; Kinney, M.E.; Dusek, J.A.
The effectiveness of nurse-delivered aromatherapy in an acute care setting
Complement Ther Med, 2016, 25, 164-169

Anxiety, Aromatherapy, Observational trial, Citrus, Citrus reticulata, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Gastrointestinal tract, Origanum, Origanum majorana, Phytomedicine, Mental diseases, Retrospective design, Pain, Sickness, ginger, Pflege

Abstract: https://dx.doi.org/10.1016/j.ctim.2016.03.006

153 Vinaya, T.M.; Aravind, B.S.; Sibbritt, D.; Tapasbrata, T.; Shivakumar, S.
The use of Benincasa hispida for the treatment of uninvestigated dyspepsia
Preliminary results of a non-randomised open label pilot clinical trial
Adv Integr Med, 2015, 2, 130-134

Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Benincasa hispida

Abstract: https://www.aimedjournal.com/article/S2212-9588%2815%2900108-1/abstract

154 Lee, W.J.; Kim, H.W.; Lee, H.Y.; Son, C.G.
Systematic review on herb-induced liver injury in Korea
Food Chem Toxicol, 2015, 84, 47-54

Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Systematic review, Traditional Korean Medicine, Adverse effect

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26165727

155 Latorre Palma, C.G.; Lera, A.T.; Lerner, T.; Oliveira, M.M. de; Borta, T.M. de; Barbosa, R.P.; Brito, G.M.; Guazelli, C.A.; Cruz, F.J.; Giglio, A. del
Guarana (Paullinia cupana) improves anorexia in patients with advanced cancer
J Diet Suppl, 2016, 13(2), 221-231

Observational trial, Guarana, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Appetitlosigkeit

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/25695932

156 Bahrami, H.R.; Hamedi, S.; Salari, R.; Noras, M.
Herbal medicines for the management of irritable bowel syndrome
A systematic review
Electronic Physician, 2016, 8(8), 2719-2725

Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Systematic review

157 Bespalov, V.; Sherbakov, A.; Novik, V.; Kalinovsky, V.; Shamsi, K.; Soultanov, V.
Conifer green needle complex in patients with precancerous gastric lesions
An observational pilot study
eCAM, 2016, Article ID 3848409, (1-12)

Observational trial, Helicobacter pylori, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Pinus, Pinus abies, Pinus sylvestris

Abstract: https://www.hindawi.com/journals/ecam/2016/3848409/

158 Oki, T.; Kano, M.; Watanabe, O.; Goto, K.; Boelsma, E.; Ishikawa, F.; Suda, I.
Effect of consuming a purple-fleshed sweet potato beverage on health-related biomarkers and safety parameters in Caucasian subjects with elevated levels of blood pressure and liver function biomarkers
A 4-week, open-label, non-comparative trial
Biosci Microbiot, 2016, 35(3), 129-136

Observational trial, High blood pressure, Homespun remedies, Cardiovascular diseases, Ipomoea, Ipomoea batatas, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Juice/distillate, Traditional medicine, Potato Juice

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27508114

159 Langhorst, J.; Lauche, R.; Koch, A.K.
Myrrhe, Kamille und Kaffeekohle in der Therapie von Patienten mit Colitis ulcerosa
Eine retrospektive Kohortenstudie mit 5-Jahres-Follow-up
Z Phytother, 2016, 37(6), 249-253

Observational trial, Chamomilla, Coffea, Coffea carbo, Ulcerative colitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Myrrhis odorata, Phytomedicine, Myrrhinil-Intest

Abstract: https://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000101

160 Mcilvoy, L.; Richmer, L.; Kramer, D.; Jackson, R.; Shaffer, L.; Lawrence, J.; Inman, K.
The efficacy of aromatherapy in the treatment of postdischarge nausea in patients undergoing outpatient abdominal surgery
J Perianesth Nurs, 2015, 30(5), 383-388

Aromatherapy, Observational trial, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Gastrointestinal tract, Mentha, spearmint, Phytomedicine, Postoperative complaints, Sickness, ginger

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26408512

161 Hashem-Dabaghian, F.; Agah, S.; Taghavi-Shirazi, M.; Ghobadi, A.
Combination of Nigella sativa and honey in eradication of gastric helicobacter pylori infection
Iran Red Crescent Med J, 2016, 18(11), e23771; (1-6)

Observational trial, Homespun remedies, Helicobacter pylori, Honey, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nigella sativa, Phytomedicine, Traditional medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28191328

162 Çetinkaya, B.; Başbakkal, Z.
The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic
Int J Nurs Pract, 2012, 18, 164-169

Aromatherapy, Observational trial, Clinical research, Colic, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Gastrointestinal tract, Manual therapy, Massage, Pediatrics, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22435980

163 Briggs, P.; Hawrylack, H.; Mooney, R.
Inhaled peppermint oil for postop nausea in patients undergoing cardiac surgery
Nursing, 2016, 46(7), 61-67

Aromatherapy, Observational trial, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Postoperative complaints, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27333231

164 Wu, W.-C.; Fang, K.C.; Yang, B.-L.; Lin, S.-K.; Hu, H.-Y.
Short-term use of Ginkgo-flavone glycosides increase risk of gastrointestinal bleeding
A nationwide population-based case-crossover study
Clin Gastroenterol Hepatol, 2017, 15, e45-e46 (Abstract)

Observational trial, Ginkgo, Clinical research, Complementary and alternative medicine, Stomach, Gastrointestinal tract, Phytomedicine, Adverse effect

Abstract: https://www.cghjournal.org/article/S1542-3565(16)30768-6/pdf

165 Abdel-Moneim, A.; Morsy, B.M.; Mahmoud, A.M.; Abo-Seif, M.A.
Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt
EXCLI J, 2013, 12, 943-955

Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Nigella sativa, Phytomedicine, ginger

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27298610

166 Wang, X.; Lin, H.; Zhang, R.
The clinical efficacy and adverse effects of interferon combined with matrine in chronic hepatitis B
A systematic review and meta-analysis
Phytother Res, 2017, 31(6), 849-857

Hepatitis, Interferon, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Sophora, Sophora flavescens, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28382770

167 Lee, Y.R.; Shin, H.S.
Effectiveness of ginger essential oil on postoperative nausea and vomiting in abdominal surgery patients
J Altern Complement Med, 2017, 23(3), 196-200

Aromatherapy, Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Placebo-controlled, Postoperative complaints, Sickness, ginger

Abstract: https://dx.doi.org/10.1089/acm.2015.0328

168 Madisch, A.; Vinson, B.R.; Abdel-Aziz, H.; Kelber, O.; Nieber, K.; Kraft, K.; Storr, M.
Modulation of gastrointestinal motility beyond metoclopramide and domperidone
Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders
Wien Med Wochenschr, 2017, 167(7-8), 160-68

Dyspepsia, Basic Research, Iberogast, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Stomach, Gastrointestinal tract, Pharmacology, Phytomedicine, Irritable bowel syndrome, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28424994

169 Zhou, Y.; Wang, L.; Huang, X.; Li, H.; Xiong, Y.
Add-on effect of crude rhubarb to somatostatin for acute pancreatitis
A meta-analysis of randomized controlled trials
J Ethnopharmacol, 2016, 194, 495-505

Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Pancreatitis, Phytomedicine, Rheum, Rheum palmatum

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/27693773

170 Märtens, D.; Range, N.; Günnewich, N.; Gruber, N.; Schmidt, S.
Homöopathisch-phytotherapeutische Behandlung des Reizdarmsyndroms mit Magen-Darm-Entoxin N®
Eine Anwendungsbeobachtung
Complement Med Res, 2017, 24(3), 147-152

Observational trial, Homeopathy, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Magen-Darm-Entoxin N

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28535512

171 Seo, E.-Y.
Effects of aroma mouthwash on stress level, xerostomia, and halitosis in healthy nurses
A non-randomized controlled clinical trial
Eur J Integr Med, 2017, 10, 82-89

Applikationsform, Aromatherapy, Citrus, lime leaves [kaffir-], Halitosis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Melaleuca, Melaleuca alternifolia, Mentha, peppermint, Dry mouth, Mundwasser, Non-randomized trial, Phytomedicine, Mental diseases, Stress, Ylang ylang

Abstract: https://www.sciencedirect.com/science/article/pii/S187638201730032X

172 Schneider, A.; Hossain, I.; VanderMolen, J.; Nicol, K.
Comparison of Remicade to curcumin for the treatment of Crohn's disease
A systematic review
Complement Ther Med, 2017, 33, 32-38

Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Systematic review

Abstract: https://dx.doi.org/10.1016/j.ctim.2017.06.002

173 Carrieri, M.P.; Protopopescu, C.; Marcellin, F.; Salmon-Ceron, D.; Dabis, F.; Spire, B.
Protective effect of coffee consumption on all-cause mortality of French HIV-HCV co-infected patients
J Hepatol, 2017, 67(6), 1157-1167

Observational trial, Coffea, Hepatitis, HIV, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/28942916

174 Kim, S.; Lee, B.-H.; Zhang, X.; Park, J.-W.; Lee, S.; Lee, H.
Adjunctive herbal medicine therapy for inflammatory bowel disease
A systematic review and meta-analysis
Eur J Integr Med, 2017, 12, 12-22

Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Crohn's disease, Phytomedicine, Systematic review

Abstract: https://www.sciencedirect.com/science/article/pii/S187638201730077X

175 Cao Van, H.; Guinand, N.; Damis, E.; Mansbach, A.L.; Poncet, A.; Hummel, T.; Landis, B.N.
Olfactory stimulation may promote oral feeding in immature newborn
A randomized controlled trial
Eur Arch Otorhinolaryngol, 2018, 275(1), 125-129

Aromatherapy, Cinnamomum, Illicium, Illicium verum, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Neonatologie, Pediatrics, Phytomedicine, Frühgeborene

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29119319

176 Akram, M.; Tahir, I.M.; Shah, S.M.A.; Mahmood, Z.; Altaf, A.; Ahmad, K.; Munir, N.; Daniyal, M.; Nasir, S.; Mehboob, H.
Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus
A systematic review
Phytother Res, 2018, 32(5), 811-822

Skin diseases, Hepatitis, Herpes simplex, HIV, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Systematic review, Viruses

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29356205

177 Hu, J.; Li, P.; Zhang, T.
Rhubarb combined with trypsin inhibitor for severe acute pancreatitis
A systematic review and meta-analysis
Phytother Res, 2018, 32(8), 1450-1458

Appendicitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Rheum, Systematic review, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29672966

178 Hines, S.; Steels, E.; Chang, A.; Gibbons, K.
Aromatherapy for treatment of postoperative nausea and vomiting
Cochrane Database Syst Rev, 2018, 3(CD007598), 1-66

Aromatherapy, Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Postoperative complaints, Systematic review, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29523018

179 Belcaro, G.; Gizzi, G.; Pellegrini, L.; Feragalli, B.; Cotellese, R.; Cacchio, M.; Corsi, M.
Pycnogenol® supplementation improves the control of irritable bowel syndrome symptoms
Panminerva Med, 2018, 60(2), 65-69

Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Pycnogenol, Irritable bowel syndrome

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29737150

180 Chen, A.G.Y.; Offereins, M.S.L.; Mulder, C.J.; Frampton, C.M.; Gearry, R.B.
A pilot study of the effect of green kiwifruit on human intestinal fermentation measured by hydrogen and methane breath testing
J Med Food, 2018, 21(12), 1295-1298

Actinidia, Actinidia deliciosa, Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Irritable bowel syndrome, Microbiology, Microbiome

181 Philips, C.A.; Paramaguru, R.; Joy, A.K.; Antony, K.L.; Augustine, P.
Clinical outcomes, histopathological patterns, and chemical analysis of Ayurveda and herbal medicine associated with severe liver injury
A single-center experience from southern India
Indian J Gastroenterol, 2018, 37(1), 9-17

Ayurveda, Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29476406

182 Venancio, V.P.; Kim, H.; Sirven, M.A.; Tekwe, C.D.; Honvoh, G.; Talcott, S.T.; Mertens-Talcott, S.U.
Polyphenol-rich mango (Mangifera indica L.) ameliorate functional constipation symptoms in humans beyond equivalent amount of fiber
Mol Nutr Food Res, 2018, 62(12), 1071034; (1-8)

Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, mango, Non-randomized trial, Phytomedicine, Constipation

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/29733520

183 Aziz, Z.; Huin, W.K.; Badrul Hisham, M.D.; Tang, W.L.; Yaacob, S.
Efficacy and tolerability of micronized purified flavonoid fractions (MPFF) for haemorrhoids
A systematic review and meta-analysis
Complement Ther Med, 2018, 39, 49-55

Hemorrhoids, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Systematic review

Abstract: https://dx.doi.org/10.1016/j.ctim.2018.05.011

184 Tóth, B.; Lantos, T.; Hegyi, P.; Viola, R.; Vasas, A.; Benkò, R.; Gyöngyi, Z.; Vincze, A.; Csécsei, P.; Mikó, A.; Hegyi, D.; Szentesi, A.; Matuz, M.; Csupor, D.
Ginger (Zingiber officinale): an alternative for the prevention of postoperative nausea and vomiting
A meta-analysis
Phytomed, 2018, 50, 8-18

Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Postoperative complaints, Sickness, ginger

Abstract: https://www.sciencedirect.com/science/article/pii/S0944711318302885

185 Fang, H.; Zhang, C.; Wang, J.; Xu, Z.; Qian, C.; Zhang, L.
Therapeutic effects of Ginkgo biloba extract against acute ischemic colitis
Medicine, 2018, 97(35), e12166; (1-7)

Blood/Lymphatic system, Darm, Ginkgo, Ischaemia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30170462

186 Kuo, Y.J.; Chang, H.P.; Chang, Y.J.; Wu, H.H.; Chen, C.H.
Evaluation of nephroprotection of silymarin on contrast-induced nephropathy in liver cirrhosis patients
A population-based cohort study
Medicine, 2018, 97(37), e12243; (1-6)

Urinary tract, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Nephropathy, Non-randomized trial, Phytomedicine, Retrospective design, milk thistle

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30212956

187 Jiang, X.; Jiang, C.; Huang, C.; Chen, G.; Jiang, K.; Huang, B.; Liu, F.
Berberine combined with triple therapy versus triple therapy for Helicobacter pylori eradication
A meta-analysis of randomized controlled trials
eCAM, 2018, Article I8716910, (1-15)

Coptis, Coptis chinensis, Helicobacter pylori, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine

Abstract: https://www.hindawi.com/journals/ecam/2018/8716910/

188 Bodagh, M.N.; Maleki, I.; Hekmatdoost, A.
Ginger in gastrointestinal disorders
A systematic review of clinical trials
Food Sci Nutr, 2018, 1-13 (epub)

Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Systematic review, Sickness, ginger

189 Ejtahed, H.S.; Soroush, A.R.; Siadat, S.D.; Hoseini-Tavassol, Z.; Larijani, B.; Hasani-Ranjbar, S.
Targeting obesity management through gut microbiota modulation by herbal products
A systematic review
Complement Ther Med, 2019, 42, 184-204

Biology/Biological Sciences, Darm, Obesitiy, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Metabolic diseases, Systematic review, Microbiology, Microbiome

Abstract: http://dx.doi.org/10.1016/j.ctim.2018.11.019

190 Nikkah-Bodaghi, M.; Darabi, Z.; Agah, S.; Hekmatdoost, A.
The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis
Phytother Res, 2019, epub ahead of print,

Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nigella sativa, Phytomedicine, Systematic review

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30666747

191 Bodagh, M.N.; Maleki, I.; Hekmatdoost, A.
Ginger in gastrointestinal disorders
A systematic review of clinical trials
Food Sci Nutr, 2019, 7, 96-108

Dyspepsia, Vomiting, Fatty liver, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Stomach cancer, Gastric mucosal inflammation, Phytomedicine, Irritable bowel syndrome, Systematic review, Sickness, ginger

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30680163

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