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1 Bensoussan, A.; Talley, N.J.; Hing, M.; Menzies, R.; Guo, A.; Ngu, M.
Treatment of irritable bowel syndrome with Chinese herbal medicine
A randomized controlled trial
JAMA, 1998, 280(18), 1585-1589
Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Irritable bowel syndrome, Traditional Chinese medicine
2 Pittler, M.H.; Ernst, E.
Peppermint Oil for irritable bowel syndrome
A critical review and metaanalysis
Am J Gastroenterol, 1998, 93(7), 1131-1135
Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Meta-analysis, Oil, Phytomedicine, Randomized trial, Irritable bowel syndrome
3 Batey, R.G.; Bensoussan, A.; Yang, Y.F.; Bollip, S.; Hossain, M.A.
Preliminary report of a randomized, double-blind placebo controlled trial of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C
J Gastroenterol Hepatol, 1998, 13, 244-247
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Traditional Chinese medicine
4 Melchart, D.; Linde, K.; Hager, S.; Kaesmayr, J.; Shaw, D.; Bauer, R.; Weidenhammer, W.
Monitoring of liver enzymes in patients treated with traditional Chinese drugs
Complement Ther Med, 1999, 7(4), 208-216
Observational trial, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Traditional Chinese medicine
5 Rasyid, A.; Lelo, A.
The effect of curcumin and placebo on human gall-bladder function
An ultrasound study
Aliment Pharmacol Ther, 1999, 13, 245-249
Curcuma, Curcuma longa, Gallbladder, Healthy probands, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
6 Greenfield, S.M.; Green, A.T.; Teare, J.P.; Jenkins, A.P.; Punchard, N.A.; Ainley, C.C.; Thompson, R.P.H.
A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis
Aliment Pharmacol Ther, 1993, 7, 159-166
Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Oil, Oenothera, Oenothera biennis, Phytomedicine, Randomized trial, fish oil
7 Schopen, R.-D.; Lange, O.-K.; Panne, C.; Kirnberger, E.J.
Auf der Suche nach einem neuen therapeutischen Prinzip
Erfahrungen mit dem Lebertherapeutikum Legalon
Med Welt, 1969, 20(15), 888-893
Observational trial, Basic Research, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Liver, Legalon, Gastrointestinal tract, Phytomedicine, milk thistle, Review (BR)
8 Tan, P.V.; Nyasse, B.
Anti-ulcer compound from Voacanga africana with possible histamine H2 receptor blocking activity
Phytomed, 2000, 7(6), 509-515
Experiment, Basic Research, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Gastric ulcer, Pharmacology, Phytomedicine, Randomized trial, Animal, Voacanga africana
9 Gupta, I.; Parihar, A.; Malhotra, P.; Gupta, S.; Lüdtke, R.; Safayhi, H.; Ammon, H.P.T.
Effects of gum resin of boswellia serrata in patients with chronic colitis
Planta Med, 2001, 67, 391-395
Boswellia, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine
10 Tsubono, Y.; Nishino, Y.; Komatsu, S.; Hsieh, C.-C.; Kanemura, S.; Tsuji, I.; Nakatsuka, H.; Fukao, A.; Satoh, H.; Hisamichi, S.
Green tea and the risk of gastric cancer in Japan
New Engl J Med, 2001, 344(9), 632-636
Observational trial, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Stomach cancer, Phytomedicine
11 Nir, Y.; Potasman, I.; Stermer, E. et al.
Controlled trial of the effect of cinnamon extract on Helicobacter pylori
Helicobacter, 2000, 5, 94-97
Observational trial, Cinnamomum, Helicobacter pylori, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
12 Huber, R.; Lüdtke, R.; Klassen, M.; Müller-Buscher, G.; Wolff-Vorbeck, G.; Scheer, R.
Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C
An individually controlled cohort study
Eur J Med Res, 2001, 6, 399-405
Observational trial, Hepatitis, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Viscum, Viscum album
13 Madisch, A.
Ein Phytotherapeutikum und seine modifizierte Rezeptur bei funktioneller Dyspepsie
Ergebnisse einer doppelblinden plazebokontrollierten Vergleichsstudie
Z Gastroenterol, 2001, 39, 511-517
Dyspepsia, bitter candytuft, Iberogast, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
14 Liu, J.; Lin, H.; McIntosh, H.
Genus phyllanthus for chronic hepatitis B virus infection
A systematic review
J Viral Hepatitis, 2001, 8, 358-366
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phyllanthus, Phytomedicine
15 Agrawal, A.K.; Tripathi, D.M.; Sahai, R.; Gupta, N.; Saxena, R.P.; Puri, A.; Singh, M; Misra, R.N.; Dubey, C.B.; Saxena, K.C.
Management of giardiasis by a herbal drug "Pippali Rasayana"
A clinical study
J Ethnopharmacol, 1997, 56(3), 233-236
Ayurveda, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Pippali Rasayana, Placebo-controlled, Randomized trial, Constipation
16 Das, D.G.
A double-blind clinical trial of kamalahar, an indigenous compound preparation, in acute viral hepatitis
Ind J Gastroenterol, 1993, 12(4), 126-8
Embelia, Embelia ribes, Hepatitis, Kamalahar, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Nyctanthes arbor-tristis, Phyllanthus, Phytomedicine, Placebo-controlled, Randomized trial, Taraxacum, Tecoma undulata, Terminalia, Terminalia arjuna
17 Chawla, Y.K.; Dubey, P.; Singh, R.; Nundy, S.; Tandon, B.N.
Treatment of dyspepsia with Amalaki (Emblica officinalis Linn.)
An ayurvedic drug
Ind J Med Res, 1982, 76, 95-8
Ayurveda, Dyspepsia, Indian gooseberry, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine
18 Rege, N.; Bapat, R.D.; Koti, R.; Desai, N.K.; Dahanukar, S.
Immunotherapy with Tinospora cordifolia
A new lead in the management of obstructive jaundice
Ind J Gastroenterol, 1993, 12(1), 5-8
Ayurveda, Icterus, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Tinospora, Tinospora cordifolia
19 Kainuma, M.; Ogata, N.; Kogure, T.; Kohta, K.; Hattori, N.; Mitsuma, T.; Teresawa, K.
The efficacy of a herbal medicine (Mao-to) in combination with intravenous natural interferon-ß for patients with chronic hepatitis C, genotype 1b and high viral load: a pilot study
Phytomed, 2002, 9(5), 365-372
Observational trial, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine, Traditional Japanese medicine
20 Mantani, N.; Kogure, T.; Sakai, S.; Kainuma, M.; Kasahara, Y.; Niizawa, A.; Shimada, Y.; Teresawa, K.
A comparative study between excess-dose users and regular-dose users of rhubarb contained in Kampo medicines
Phytomed, 2002, 9(5), 373-376
Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, posology, Rheum, Traditional Japanese medicine, Constipation
21 Mantani, N.; Kogure, T.; Sakai, S.; Goto, H.; Shibahara, N.; Kita, T.; Shimada, Y.; Teresawa, K.
Incidence and clinical features of liver injury related to Kampo (Japanese herbal) medicine in 2496 cases between 1979 and 1999: Problems of the lymphocyte transformation test as a diagnostic method
Phytomed, 2002, 9(4), 280-287
Observational trial, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Retrospective design, Traditional Japanese medicine, Adverse effect
22 Bortolotti, M.; Coccia, G.; Grossi, G.
Red pepper and functional dyspepsia
New Engl J Med, 2002, 346, 947-948
Capsicum, Dyspepsia, Spices, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
23 Iten, F.; Meier, B.; Saller, R.
Wirksamkeit von Teemischungen bei dyspeptischen Beschwerden - eine Anwendungsbeaobachtung
Forsch Komplementärmed, 2002, 9(5), 277-282
Observational trial, Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Tea
24 Ferenci, P.; Dragosics, B.; Dittrich, H.; Frank, H.; Benda, L.; Lochs, H.; Meryn, S.; Base, W.
Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver
J Hepatol, 1989, 9(1), 105-113
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
25 Pares, A.; Planas, R.; Torres, M.; Caballería, J.; Viver, J.M.; Acero, D.; Panés, J.; Rigau, J.; Santos, J.; Rodés, J.
Effect of silymarinin alcoholic patients with cirrhosisof the liver
Results of a controlled, double-blind, randomized and multicenter trial
J Hepatol, 1998, 28, 615-621
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
26 Trinchet, J.C.; Coste, T.; Levy, V.G.
Traitement de l´hepatite alcoolique par la silymarine
Une etude comparative en double insu chez 116 malades (Treatment of alcoholic hepatitis with silymarin. A double-blind comparative study in 116 patients)
Gastroenterol Clin Biol, 1989, 13, 120-124
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
27 Benda, L.; Dittrich, H.; Ferenci, P.; Frank, H.; Wewalka, F.
Zur Wirksamkeit von Silymarin auf die Überlebensrate von Patienten mit Leberzirrhose
Wien Klin Wochenschr, 1980, 92, 678-683
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
28 Tanasescu, C.; Petrea, S.; Baldescu, R.; Macarie, E.; Chiriloiu, C.; Purice, S.
Use of the Romanian product Silimarina in the treatment of chronic liver disease
Rev Roum Méd Int, 1988, 26, 311-322
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
29 Magliulo, E.; Gagliardi, B.; Fiori, G.P.
Zur Wirkung von Silymarin bei der Behandlung der akuten Virushepatitis
Med Klin, 1978, 79, 1060-1065
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
30 Buzzelli, G.; Moscarella, S.; Giusti, A.; Duchini, A.; Marena, C.; Lampertico, M.
A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB 1016) in chronic acitve hepatitis
Int J Clin Pharmacol Ther Toxicol, 1993, 31, 456-460
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
31 Kiesewetter, E.; Leodolter, I.; Thaler, H.
Ergebnisse zweier Doppelblindstudien zur Wirksamkeit von Silymarin bei chronischer Hepatitis
Leber Magen Darm, 1977, 7, 318-323
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
32 Szilard, S.; Szentgyrogyi, D.; Demeter, I.
Protective effect of Legalon in workers exposed to organic solvents
Acta Med Hung, 1988, 45(2), 249-256
Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle, Environmental medicine
33 Schmidt, U.; Dürr, H.K.; Bode, J.C.
Zur Therapie der akuten Virushepatitis mit Silymarin
Bericht über eine kontrollierte Studie
Verh Dt Ges Inn Med, 1977, 83, 563-565
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
34 Realini, S.; Gonvers, J.J.; Hofstetter, J.R.
Essai clinique de la silymarine dans les affections chroniques du foie
Schweiz Rundsch Med Prax, 1975, 64(19), 595-598
Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
35 Reutter, F.W.; Haase, W.
Klinische Erfahrungen mit Silymarin bei chronischen Lebererkrankungen
Schweiz Rundsch Med Prax, 1975, 64(36), 1145-1151
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle
36 Müzes, G.; Deak, G.; Lang, I.; Nekam, K.; Niederland, V.; Feher, J.
Silymarin (Legalon) kezelés hatása idült alkoholos májbetegek antioxidáns védörendszerére és a lipid peroxidációra (kettös vak protokoll)
(Effects of silymarin (Legalon) treatment on the antioxidant defense system and lipid peroxidation in patients with chronic alcohol liver disease. A double blind study)
Orv Hetil, 1990, 131(16), 863-866
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
37 Deak, G.; Muzes, G.; Lang, I.; Niederland, V.; Nekam, K.; Gonzalez-Cabello, R.; Gergely, P.; Feher, J.
Silymarin kezelés immunmodláns hatása krónikus alkoholos májbetegségben
(Immunomodulatory effects of silymarin treatment in chronic alcohol liver disease)
Orv Hetil, 1990, 131(24), 1295-1296
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
38 Lang, I.; Nekam, K.; Deak, G.; Muzes, G.; Gonzales-Cobello, R.; Gergely, P.; Cosmos, G.; Feher, J.
Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers
Ital J Gastroenterol, 1990, 22(5), 283-287
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
39 Allain, H.; Schuck, S.; Lebreton, S.; Strenge-Hesse, A.; Braun, W.; Gandon, J.M.; Brissot, P.
Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer´s disease
Dement Geriatr Cogn Disord, 1999, 10, 181-185
Alzheimer's disease, Dementia, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
40 Bode, J.C.; Schmidt, U.; Dürr, H.K.
Zur Behandlung der akuten Virushepatitis mit Silymarin
Ergebnisse einer kontrollierten Studie
Med Klin, 1977, 72, 513-518
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
41 Lirussi, F.; Okolicsanyi, L
Cytoprotection in the Nineties: Experiences with urodeoxycholic acid and silymarin in chronic liver disease
Acta Physiol Hung, 1992, 80, 363-367
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Randomized trial, milk thistle
42 Velussi, M.; Cernigoi, A.M.; Monte, A. de; Dapas, F.; Caffau, C.; Zilli, M.
Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients
J Hepatol, 1997, 26(4), 871-879
Diabetes mellitus, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle, Metabolic diseases
43 Lucena, M.I.; Andrade, R.J.; Cruz, J.P. de la; Rodriguez-Mendizabal, M.; Blanco, E.; Sánchez de la Cuesta, F.
Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis
Results of a randomized, double-blind, placebo-controlled clinical study
Int J Clin Pharmacol Ther, 2002, 40(1), 2-8
Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
44 Angulo, P.; Patel, T.; Jorgensen, R.A.; Therneau, T.M.; Lindor, K.D.
Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxcholic acid
Hepatology, 2000, 32(5), 897-900
Observational trial, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle
45 Moser, E.H.; Hübner, W.-D.
Behandlung von Patienten mit Reizdarmsyndrom mittels Eucarbon-Tabletten
Z Phytother, 2003, 24(1), 15-21
Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Irritable bowel syndrome
46 Marakis, G.; Walker, A.F.; Middleton, R.W.; Booth, J.C.L.; Wright, J.; Pike, D.J.
Artichoke leaf extract reduces mild dyspepsia in an open study
Phytomed, 2002, 9(8), 694-699
Observational trial, Cynara cardunculus subsp. flavescens, Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
47 Sallon, S.; Ben-Arye, E.; Davidson, R.; Shapiro, H.; Ginsberg, G.; Ligumsky, M.
A novel treatment for constipation-predominant irritable bowel syndrome using Padma Lax, a Tibetean herbal formula
Digestion, 2002, 65, 161-171
Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Padma, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome, Traditional Tibetan medicine
48 Alexandrovich, I.; Rakovitskaya, O.; Kolmo, E.; Sidorova, T.; Shusshunov,S.
The Effect of Fennel (Foeniculum Vulgare) Seed Oil Emulsion in Infantile Colic
A Randomized, Placebo-Controlled Study
Altern Ther Health Med, 2003, 9(4), 5861
Foeniculum vulgare, Clinical research, Colic, Complementary and alternative medicine, Gastrointestinal tract, Pediatrics, Phytomedicine, Placebo-controlled, Randomized trial
49 Kainuma, M.; Sakai, S.; Sekiya, N.; Mantani, N.; Ogata, N.; Shimada, Y.; Terasawa, K.
The effects of a herbal medicine (Mao-to) in patients with chronic hepatitis C after injection of IFN-ß
Phytomed, 2004, 11(1), 5-10
Observational trial, Hepatitis, Interferon, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine
50 Gupta, I.; Parihar, A.; Malhotra, P.; Singh, G.B.; Lüdtke, R.; Safayhi, H.; Ammon, H.P.T.
Effects of Boswellia serrata gum resin in patients with ulcerative colitis
Eur J Med Res, 1997, 2 (20.1), 37-43
Ayurveda, Boswellia, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine
51 Jakkula, M.; Boucher, T.A.; Beyendorff, U.; Ac, L.; Conn, S.M.; Johnson,J.E.; Nolan, C.J.; Peine, C.J.; Albrecht, J.H.
A randomized trial of chinese herbal medicines for the treatment jof symptomatic hepatitis C
Arch Intern Med, 2004, 164(12), 1341-1346
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine
52 Bundy, R.; Walker, A.F.; Middleton, R.W.; Marakis, G.; Booth, C.L.
Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia
A subset analysis
J Altern Complement Med, 2004, 10(4), 667-669
Observational trial, Cynara cardunculus subsp. flavescens, Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Irritable bowel syndrome, Retrolective design
53 Madisch, A.; Holtmann, G.; Plein, K.; Hotz, J.
Treatment of irritable bowel syndrome with herbal preparations
Results of a double-blind, randomized, placebo-controlled, multi-centre trial
Aliment Pharmacol Ther, 2004, 19, 271-279
Angelica, Angelica archangelica, Carum, caraway, Chamomilla, calendine, Glycyrrhiza, liquorice root, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Melissa, lemon balm, Mentha, peppermint, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome, milk thistle
54 Holtmann, G.; Adam, B.; Haag, S.; Collet, W.; Grünewald, E.; Windeck, T.
Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia
A six-week placebo-controlled, double-blind, multicentre trial
Aliment Pharmacol Ther, 2003, 18, 1099-1105
Cynara cardunculus subsp. flavescens, Dyspepsia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
55 Subbotina, M.D.; Timchenko, V.N.; Vorobyov, M.M.; Konunova, Y.S.; Aleksandrovih, Y.S.; Shushunov, S.
Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children
A randomized, double blind, controlled trial
Pediatr Infect Dis J, 2003, 22, 706-710
Diarrhoeal disorder, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Pediatrics, Phytomedicine, Placebo-controlled, Potentilla, Potentilla tormentilla, Randomized trial, Viruses
56 ; Wittemer, S.M.
Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans
Phytomed, 2005, 12(1-2), 28-38
Cynara cardunculus subsp. flavescens, Dyspepsia, Healthy probands, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Pharmacology, Phytomedicine, Randomized trial, Pharmacocinetics
57 Madisch, A.; Holtmann, G.; Mayr, G.; Vinson, B.; Hotz, J.
Treatment of functional dyspepsia with a herbal preparation
A double-blind, randomized, placebo-controlled, multicenter trial
Digestion, 2004, 69, 45-52
Carum, caraway, Dyspepsia, Glycyrrhiza, liquorice root, bitter candytuft, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Matricaria, Matricaria recutita, Melissa, lemon balm, Mentha, peppermint, Phytomedicine, Placebo-controlled, Randomized trial
58 Langmead, L.; Feakins, R.M.; Goldthorpe, S.; Holt, H.; Tsironi, E.; Silva, A de; Jewell, D.P.; Rampton, D.S.
Randomised, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis
Aliment Pharmacol Ther, 2004, 19, 739-747
Aloe, Aloe vera, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
59 Kainuma, M.; Hikiami, H.; Nozaki, K.; Hayashi, K.; Shimada, Y.; Terasawa, K.
The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C
A pilot study
Hum Psychopharmacol, 2004, 19, 235-241
Observational trial, Depression, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine, Mental diseases, Traditional Japanese medicine
60 Bundy, R.; Walker, A.F.; Middleton, R.W.; Booth, J.
Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults
A pilot study
J Altern Complement Med, 2004, 10(6), 1015-1018
Curcuma, Curcuma longa, Healthy probands, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Irritable bowel syndrome
61 Brown, A.C.; Shovic, A.; Ibrahim, S.A.; Holck, P.; Huang, A.
A non-dairy probiotic's (poi) influence on changing the gastrointestinal tract's microflora environment
Altern Ther Health Med, 2005, 11(1), 58-64
dasheen, Nutrition/diet, Healthy probands, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Probiotics, Randomized trial
62 Huseini, H.F.; Alavian, S.M.; Heshmat, R.; Heydari, M.R.; Abolmaali, K.
The efficacy of Liv-52 on liver cirrhotic patients
A randomized, double-blind, placebo-controlled first approach
Phytomed, 2005, 12(9), 619-624
Ayurveda, Capparis, Capparis spinosa, Cichorium intybus, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Liver cirrhosis, Liv-52, Gastrointestinal tract, Mandur basma, Millefolium, Phytomedicine, Placebo-controlled, Randomized trial, Solanum, Tamarix gallica, Terminalia, Terminalia arjuna
63 Oikawa, T.; Ito, G.; Koyama, H.; Hanawa, T.
Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia
Phytomed, 2005, 12(10), 730-734
Dyspepsia, Hange-koboku-to, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Magnolia, Magnolia officinalis, Non-randomized trial, Perilla, Phytomedicine, Pinellia Tuber, Poria, Poria cocos, Traditional Japanese medicine, ginger
64 Chrubasik, S.; Chrubasik, C.; Torda, T.; Madisch, A.
Efficacy and tolerability of potato juice in dyspeptic patients
A pilot study.
Phytomed, 2006, 13(1-2), 11-15
Observational trial, Dyspepsia, Nutrition/diet, Homespun remedies, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Solanum, potatoe, Traditional medicine, Potato Juice
65 Agarwal, A.; Dhiraaj, S.; Tandon, M.; Singh, P.K.; Singh, U.; Pawar, S.
Evaluation of capsaicin ointment at the Korean hand acupressure point K-D2 for prevention of postoperative nausea and vomiting
Anaesthesia, 2005, 60, 1185-1188
Acupressure, Acupuncture, Capsicum, Surgery, Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Pain, Traditional Chinese medicine, Sickness
66 Weisser, L.
Das Verhalten der Serum-Eiweiß-Konstellation bei Leberschädigung während der Behandlung mit Mariendistel- und Löwenzahnextrakten
Aus unserer Arbeit, 1955, 1(10), 19-20
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle, Taraxacum
67 Zhang, X.H.; Andreotti, G.; Gao, Y.T.; Deng, J.; Liu, E.; Rashid, A.; Wu, K., Sun, L.; Sakoda, L.C.; Cheng, J.-R.; Shen, M.-C., Wang, B.-S.; Han, T.-Q.; Zhang, B.-H.; Gridley, G.; Fraumeni, J.F. jr.; Hsing, A.W.
Tea drinking and the risk of biliary tract cancers and biliary stones
A population-based case-control study in Shanghai, China
Int J Cancer, 2006, 118, 3089-3094
Observational trial, Camellia, Camellia sinensis, Cholangiocarcinoma, Gall stones, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Retrospective design, Tea
68 Orlent, H.; Hansen, B.E.; Willems, M.; Brouwer, J.T.; Huber, R.; Kullak, Ublick, G.A.; Gerken, G.; Zeuzem, S.; Nevens, F.; Tielemans, C.M.; Zondervan, P.E.; Lagging, M.; Westin, J.; Schalm, S.W.
Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C
A randomized phase II trial
J Hepatol, 2006, 45(4), 539-546
Biochemistry, Glycyrrhiza, liquorice root, Glycyrrhizinsäure, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial
69 Davis, K.; Philpott, S.; Kumar, D.; Mendall, M.
Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome
Int J Clin Pract, 2006, 60, 1080-1086
Aloe, Aloe vera, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome
70 Gundermann, K.-J.; Godehardt, E.; Ulbrich, M.
Wirksamkeit eines pflanzlichen Kombinationspräparats bei funktioneller Dyspepsie
Metaanalyse randomisierter Doppelblindstudien auf Basis eines validen gastrointestinalen Symptomprofils
MMW Fortschr Med, 2004, 146, 71-76
Dyspepsia, Iberogast, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Randomized trial
71 Hanai, H.; Iida, T.; Takeuchi, K.; Watanabe, F.; Maruyama, Y.; Andoh, A. et al.
Curcumin maintenance therapy for ulcerative colitis
Randomized, multicenter, double-blind, placebo-controlled trial
Clin Gastroenterol Hepatol, 2006, 4(12), 1502-1506
Ulcerative colitis, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
72 Becker, B.; Kuhn, U.; Hardewig-Budny, B.
Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea
Arzneim Forsch, 2006, 56(6), 387-393
Chamomilla, Diarrhoeal disorder, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Malus, Pediatrics, Phytomedicine, Randomized trial
73 Omer, B.; Krebs, S.; Omer, H.; Noor, T.O.
Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease
A double-blind placebo-controlled study
Phytomed, 2007, 14(2-3), 87-95
Artemisia, Artemisia absinthium, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
74 Hill, L.L.; Foote, J.C.; Erickson, B.D.; Cerniglia, C.E.; Denny, G.S.
Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota
J Clin Pharm Ther, 2006, 31(6), 599-604
Observational trial, Echinacea, Healthy probands, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
75 Uehleke, B.; Ortiz, M.; Stange, R.
Cholesterol reduction using psyllium husks
Do gastrointestinal adverse effects limit compliance? Results of a specific observational study
Phytomed, 2008, 15(3), 153-159
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Plantago, Plantago ovata, Metabolic diseases, Adverse effect
76 Gail, M.H.; Pfeiffer, R.M.; Brown, L.M.; Zhang, L.; Ma, J.-l.; Pan, K.-f.; Liu, W.-d.; You, W.-c.
Garlic, vitamin, and antibiotic treatment for Helicobacter pylori
A randomized factorial controlled trial
Helicobacter, 2007, 12(5), 575-578
Acidum ascorbicum, Allium, Allium sativum, Nutrition/diet, Helicobacter pylori, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Dietary supplementation, Phytomedicine, Randomized trial, Selenium, Tokopherol, Vitamins
77 Uehleke, B.; Ortiz, M.; Stange, R.
Cholesterol reduction using psyllium husks - Do gastrointestinal adverse effects limit compliance?
Results of a specific observational study
Z Phytother, 2008, 29(Suppl 1, Kongressband), S17 (Abstract; Symposiumsbeitrag)
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Plantago, Plantago ovata, Metabolic diseases, Adverse effect
78 Amagase, H.; Nance, D. M.
A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi
J Altern Complement Med, 2008, 14(4), 403-412
Muscoskeletal -/Connective tissue system, Chinese medicinal herbs, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lycium, Lycium barbarum, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Psychology/psychotherapy, Randomized trial, Traditional Chinese medicine, Adverse effect
79 Levine, M.E.; Gillis, M.G.; Koch, S.Y.; Voss, A.C.; Stern, R.M.; Koch, K.L.
Protein and ginger for the treatment of chemotherapy-induced delayed nausea
J Altern Complement Med, 2008, 14(5), 545-551
Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Randomized trial, Sickness, ginger
80 Kupcinskas, L.; Lafolie, P.; Lignell, A.; Kiudelis, G.; Jonaitis, L.; Adamonis, K.; Andersen, L. P.; Wadstrom, T.
Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection
A prospective, randomized, double blind, and placebo-controlled study
Phytomed, 2008, 15(6-7), 391-399
Dyspepsia, Helicobacter pylori, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Astaxanthin
81 Yun, Y.J.; Nah, S.S.; Park, J.H.; Jung, S.K.; Paeck, E.K.; Park, J.H.; Lee, E.J.; Kim, S.H.; Park, H.M.; Lee, S.D.; Kim, J.Y.; Hong, S.J.; Choe, B.K.; Chung, J.H.
Assessment of prescribed herbal medicine on liver function in Korea
A prospective observational study
J Altern Complement Med, 2008, 14(9), 1131-1136
Observational trial, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine
82 Wu, K.L.; Rayner, C.K.; Chuah, S.H.; Changchien, C.S.; Lu, S.N.; Chiu, Y.C.; Chiu, K.W.; Lee, C.M.
Effects of ginger on gastric emptying and motility in healthy humans
Eur J Gastroenterol Hepatol, 2008, 20(5), 436-440
Healthy probands, Clinical research, Complementary and alternative medicine, Stomach, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, ginger
83 Teschke, R.; Schwarzenboeck, A.
Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root)
Critical analysis and structured causality assessment
Phytomed, 2009, 16(1), 72-84
Observational trial, Black cohosh, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Toxicology, Adverse effect
84 Arikan, D.; Alp, H.; Gözüm, S.; Orbak, Z.; Cifci, E.K.
Effectiveness of massage, sucrose solution, herbal tea or hydrolysed formula in the treatment of infantile colic
J Clin Nurs, 2008, 17(13), 1757-1761
Nutrition/diet, Clinical research, Colic, Complementary and alternative medicine, Gastrointestinal tract, Manual therapy, Massage, Pediatrics, Phytomedicine, Randomized trial, Tea
85 El-Kamary, S.S.; Shardell, M.D.; Abdel-Hamid, M.; Ismail, S.; El-Ateek, M.; Metwally, M.; Mikhail, N.; Hashem, M.; Mousa, A.; Aboul-Fotouh, A.; El-Kassas, M.; Esmat, G.; Strickland, G.T.
A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis
Phytomed, 2009, 16(5), 391-400
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
86 Enck, P.; Vinson, B.; Malfertheiner, P.; Zipfel, S.; Klosterhalfen, S.
The placebo response in functional dyspepsia
Reanalysis of trial data
Neurogastroenterol Motil, 2009, 21(4), 370-377
Dyspepsia, Iberogast, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
87 Ferenci, P.; Scherzer, T.M.; Kerschner, H.; Rutter, K.; Beinhardt, S.; Hofer, H.; Schöniger-Hekele, M.; Holzmann, H.; Steindl-Munda, P.
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
Gastroenterol, 2008, 135(5), 1561-1567
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, milk thistle
88 Zick, S.M.; Ruffin, M.T.; Lee, J.; Normolle, D.P.; Siden, R.; Alrawi, S.; Brenner, D.E.
Phase II trial of encapsulated ginger as a treatment of chemotherapy-induced nausea and vomiting
Support Care Cancer, 2009, 17(5), 563-572
Vomiting, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Sickness, ginger
89 Frank, J.; George, T.W.; Lodge, J.K.; Rodriguez-Mateos, A.M.; Spencer, J.P.E.; Minihane, A.M.; Rimbach, G.
Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men
J Nutr, 2009, 139(1), 58-62
Camellia, Camellia sinensis, Healthy probands, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Liver, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Tea, Adverse effect
90 Ozgoli, G.; Goli, M.; Simbar, M.
Effects of ginger capsules on pregnancy, nausea, and vomiting
J Altern Complement Med, 2009, 15(3), 243-246
Vomiting, Gynaecology, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Obstetrics, Sickness, ginger
91 Puttler, K.; Jaklic, B.; Rieg, T.S.; Lucha, P.A. Jr.
Reduction of conscious sedation requirements by olfactory stimulation
A prospective randomized single-blinded trial
J Altern Complement Med, 2009, 15(4), 381-385
Aromatherapy, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Prunus, Prunus avium, Randomized trial, Pain
92 Huber, R.; Müller, M.; Naumann, J.; Schenk, T.; Lüdtke, R.
Artichoke leave extract for chronic hepatitis C
A pilot study
Phytomed, 2009, 16(9), 801-804
Observational trial, Cynara cardunculus subsp. flavescens, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
93 Madisch, A.; Miehlke, S.; Eichele, O.; Bethke, B.; Mrwa, J.; Kuhlisch, E.; Bästlein, B.; Wilhelms, G.; Debus, M.; Wigginghaus, B.; Stolte, M.
Boswellia-serrata-Extrakt bei kollagener Kolitis
Eine randomisierte, placebokontrollierte, doppelblinde Multicenterstudie
Z Phytother, 2009, 30(Suppl.1 Kongressband), S11-S12 (Abstract; Symposiumsbeitrag)
Boswellia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
94 Belcaro, G.; Cesarone, M.R.; Errichi, B.; Di Renzo, A.; Grossi, M.G.; Ricci, A.; Dugall, M.; Cornelli, U.; Cacchio, M.; Rohdewald, P.
Pycnogenol treatment of acute hemorrhoidal episodes
Phytother Res, 2010, 24(3), 438-444
Hemorrhoids, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Pycnogenol, Randomized trial
95 Qu, Y.; Gan, H.Q.; Mei, Q.B.
Study on the effect of Jia-Wei-Xiao-Yao-San decoction on patients with functional dyspepsia
Phytother Res, 2010, 24(2), 245-248
Observational trial, Dyspepsia, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Traditional Chinese medicine
96 Dabos, K.J.; Sfika, E.; Vlatta, L. J.; Giannikopoulos, G.
The effect of mastic gum on Helicobacter pylori
A randomized pilot study
Phytomed, 2010, 17(3-4), 296-299
Helicobacter pylori, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, pistachio, Pistacia lentiscus, Randomized trial
97 Saito, Y.A.; Rey, E.; Almazar-Elder, A.E.; Harmsen, W.S.; Zinsmeister, A.R.; Locke, G.R.; Talley, N.J.
A randomized, double-blind, placebo-controlled trial of St John's wort for treating irritable bowel syndrome
Am J Gastroenterol, 2010, 105(1), 170-177
Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome
98 Krebs, S.; Omer, T. N.; Omer, B.
Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn's disease
A controlled clinical trial
Phytomed, 2010, 17(5), 305-309
Artemisia, Artemisia absinthium, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Randomized trial
99 Ladas, E.J.; Kroll, D.J.; Oberlies, N.H.; Cheng, B.; Ndao, D.H.; Rheingold, S.R.; Kelly, K.M.
A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL)
Cancer, 2010, 116(2), 506-513
Clinical research, Complementary and alternative medicine, Cancer, Liver, Leukaemia, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle, Adverse effect
100 Bandyopadhyay, U.; Biswas, K.; Sengupta, A.; Moitra, P.; Dutta, P.; Sarkar, D.; Debnath, P.; Ganguly, C.K.; Banerjee, R.K.
Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
Life Sci, 2004, 75(24), 2867-2878
Azadirachta indica, Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Gastric ulcer, Phytomedicine, Duodenal ulcer