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301 Abadian, K.; Keshavarz, Z.; Mojab, F.; Majd, H.A.; Abbasi, N.M.
Comparison the effect of mefenamic acid and Teucrium polium on the severity and systemic symptoms of dysmenorrhea
Complement Ther Clin Pract, 2016, 22, 12-15
Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Teucrium, Teucrium polium
302 Mirghafourvand, M.; Mohammad-Alizadeh-Charandabi, S.; Ahmadpour, P.; Javadzadeh, Y.
Effects of Vitex agnus and Flaxseed on cyclic mastalgia
A randomized controlled trial
Complement Ther Med, 2016, 24, 90-95
Agnus castus, Gynaecology, Clinical research, Complementary and alternative medicine, Linum usitatissimum, Mastodynia, Phytomedicine, Placebo-controlled, Randomized trial
303 Kazemipoor, M.; Hamzah, S.; Hajifaraji, M.; Radzi, C.W.J.B.W.M.; Cordell, G.A.
Slimmming and appetite-suppressing effects of caraway aqueous extract as a natural therapy in physically active women
Phytother Res, 2016, 30(6), 981-987
Carum, caraway, Obesitiy, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Overweight
304 Mahdavi, R.; Namazi, N.; Alizadeh, M.; Farajnia, S.
Effects of Nigella sativa oil with a low-caloric diet on cardiometabolic risk factors in obese women
A randomized controlled cliical trial
Foot Funct, 2015, 6(6), 2041-2048
Diet, Nutrition/diet, Obesitiy, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Nigella sativa, Oil, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
305 Gerstgrasser, A.; Röchter, S.; Dressler, D.; Schön, C.; Reule, C.; Buchwald-Werner, S.
In vitro activation of eNOS by Mangifera indica (Careless™) and determination of an effective dosage in a randomized, double-blind, human pilot study on microcirculation
Planta Med, 2016, 82(04), 298-304
Circulatory disorder, Healthy probands, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, mango, Phytomedicine, posology, Randomized trial
306 Pattanittum, P.; Kunyanone, N.; Brown, J.; Sangkomkamhang, U.S.; Barnes, J.; Seyfoddin, V.; Marjoribanks, J.
Dietary supplements for dysmenorrhoea
Cochrane Database Syst Rev, 2016, 3(CD002124), 1-122
Dysmenorrhea, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Systematic review
307 Larmo, P.S.; Yang, B.; Hyssälä, J.; Kallio, H.P.; Erkkola, R.
Effects of sea buckthorn oil intake on vaginal atrophy in postmenopausal women
A randomized, double-blind, placebo-controlled study
Maturitas, 2014, 79, 316-321
Gynaecology, Hippophae rhamnoides, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Hippophae, Vaginal atrophy
308 Jenabi, E.; Fereidoony, B.
Effect of Achillea millefolium on relief of primary dysmenorrhea
A double-blind randomized clinical trial
J Pediatr Adolesc Gynecol, 2015, 28, 402-404
Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Millefolium, Phytomedicine, Placebo-controlled, Randomized trial
309 Jiang, K.; Jin, Y.; Huang, L.; Feng, S.; Hou, X.; Du, B.; Zheng, J.; Li, L.
Black cohosh improves objective sleep in postmenopausal women with sleep disturbance
Climacteric, 2015, 18(4), 559-567
Black cohosh, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
310 Shakeri, F.; Taavoni, S.; Goushegir, A.; Haghani, H.
Effectiveness of red clover in alleviating menopausal symptoms
A 12-week randomized, controlled trial
Climacteric, 2015, 18(4), 568-573
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Randomized trial, Trifolium, Trifolium pratense
311 Lu, P.H.; Hsu, C.H.
Does supplementation with green tea extract improve acne in post-adolescent women?
A randomized, double-blind, and placebo-controlled clinical trial
Complement Ther Med, 2016, 25, 159-163
Acne, Camellia, Camellia sinensis, Gynaecology, Skin diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
312 Matsumoto, T.; Kimura, T.; Hayashi, T.
Aromatic effects of a Japanese citrus fruit -yuzu (Citrus junos Sieb. ex Tanaka)- on psychoemotional states and autonomic nervous system activity during the menstrual cycle
A single-blind randomized controlled crossover study
Biopsychosoc Med, 2016, 10, 11; (1-11)
Aromatherapy, Citrus, Citrus junos, Gynaecology, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Vegetative nervous system
313 Beiranvand, S.P.; Beiranvand, N.S.; Moghadem, Z.B.; Birjandi, M.; Azhari, S.; Rezaei, E.; Salehnia, A.N.; Beiranvand, S.
The effect of Crocus sativus (saffron) on the severity of premenstrual syndrome
Eur J Integr Med, 2016, 8(1), 55-61
Crocus, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Premenstrual syndrome, Randomized trial
314 Mirghafourvand, M.; Charandabi, S.M.-A.; Hakimi, S.; Khodaie, L.; Galeshi, M.
Effect of orange peel essential oil on postpartum sleep quality
A randomized controlled clinical trial
Eur J Integr Med, 2016, 8(1), 62-66
Aromatherapy, Citrus, Citrus sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Obstetrics
315 Rahi, P.; Mirghafourvand, M.; Mohammad-Alizadeh-Charandabi, S.; Javadzadeh, Y.; Seidi, S.
Comparison of the effect of mefenamic acid and quince on the level of menstrual bleeding and hemoglobin
A randomized controlled clinical trial
Eur J Integr Med, 2016, 8(1), 67-72
Cydonia, Cydonia vulgaris, Gynaecology, Clinical research, Complementary and alternative medicine, Menorrhagie, Phytomedicine, Randomized trial
316 Uysal, M.; dogru, h.Y.; Sapmaz, E.; Tas, U.; Cakmak, B.; Ozsoy, A.Z.; Sahin, F.; Ayan, S.; Esen, M.
Investigating the effect of rose essential oil in patients with primary dysmenorrhea
Complement Ther Clin Pract, 2016, 24, 45-49
Aromatherapy, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Rosa, Rosa damascena
317 Chen, C.X.; Barrett, B.; Kwekkeboom, K.L.
Efficacy of oral ginger (Zingiber officinale) for dysmenorrhea
A systematic review and meta-analysis
eCAM, 2016, Article ID 6295737, (1-10)
Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Systematic review, ginger
318 Seo, S.K.; Hong, Y.; Yun, B.H.; Chon, S.J.; Jung, Y.S.; Park, J.H.; Cho, S.; Choi, Y.S.; Lee, B.S.
Antioxidative effects of Korean red ginseng in postmenopausal women
A double-blind randomized controlled trial
J Ethnopharmacol, 2014, 154, 753-757
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
319 Aghamiri, V.; Mirghafourvand, M.; Mohammad-Alizadeh-Charandabi, S.; Nazemiyeh, H.
The effect of hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes
A randomized placebo-controlled trial
Complement Ther Clin Pract, 2016, 23, 130-135
Gynaecology, hop, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
320 Gholami, F.; Samani, L.N.; Kashanian, M.; Naseri, M.; Hosseini, A.F.; Nejad, S.A.H.
Onset of labor in post-term pregnancy by chamomile
Iran Red Crescent Med J, 2016, 18(11), e19871; (1-5)
Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Obstetrics, Tedious labour
321 Tanmahasamut, P.; Vichinsartvichai, P.; Rattanachaiyanont, M.; Techatraisak, K.; Dagrat, C.; Sardod, P.
Cimicifuga racemosa extract for relieving menopausal symptoms
A randomized controlled trial
Climacteric, 2015, 18(1), 79-85
Black cohosh, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
322 Samani, N.B.; Jokar, A.; Soveid, M.; Heydari, M.; Mosavat, S.H.
Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus
A double-blind randomized placebo-controlled clinical trial
J Evid Based Compl Altern Med, 2016, 21(4), NP91-NP97
Diabetes mellitus, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Tribulus terrestris
323 Boltman-Binkowski, H.
A systematic review
Are herbal and homeopathic remedies used during pregnancy safe?
Curationis, 2016, 39(1), 1514; (e1-e8)
Gynaecology, Homeopathy, Clinical research, Complementary and alternative medicine, Phytomedicine, Obstetrics, Systematic review, Adverse effect
324 Salihah, N.; Mazlan, N.; Lua, P.L.
The effectiveness of inhaled ginger essential oil in improving dietary intake in breast-cancer patients experiencing chemotherapy-induced nausea and vomiting
FACT, 2016, 21(1), 8-16
Aromatherapy, Breast cancer, Vomiting, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Sickness, ginger
325 Franco, O.H.; Chowdhury, R.; Troup, J.; Voortman, T.; Kunutsor, S.; Kavousi, M.; Oliver-Williams, C.; Muka, T.
Use of plant-based therapies and menopausal symptoms
A systematic review and meta-analysis
JAMA, 2016, 315(23), 2554-2563
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Phytomedicine, Systematic review
326 Shirazi, M.; Mohebitabar, S.; Bioos, S.; Yekaninejad, M.S.; Rahimi, R.; Shahpiri, Z.; Malekshahi, F.; Nejatbakhsh, F.
The effect of topical Rosa damascena (rose) oil on pregnancy-related low back pain
A randomized controlled clinical trial
J Evid Based Compl Altern Med, 2017, 22(1), 120-126
Aromatherapy, Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Rosa, Rosa damascena, Back pain (non-specific), Obstetrics
327 Asgharikhatooni, A.; Bani, S.; Hasanpoor, S.; Alizade, S.M.; Javadzadeh, Y.
The effect of Equisetum arvense (horse tail) ointment on wound healing and pain intensity after episiotomy
A randomized placebo-controlled trial
Iran Red Crescent Med J, 2016, 17(3), e25637; (1-7)
Applikationsform, Surgery, Equisetum, Equisetum arvense, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Postoperative complaints, Randomized trial, Salbe, Pain, Obstetrics, Wound healing, episiotomy
328 Li, Y.; Zhu, X.; Bensussan, A.; Li, P.; Moylan, E.; Delaney, G.; McPherson, L.
Herbal medicine for hot flushes induced by endocrine therapy in women with breast cancer
A systematic review and meta-analysis
eCAM, 2016, Article ID 1327251, (1-11)
Breast cancer, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Systematic review
329 Javan, R.; Yousefi, M.; Nazari, S.-M.; Amiri, P.; Mosavi-Jarrahi, A.; Amiri, P.; Mosavi-Jarrahi, A.; Modiramani, P.; Naghedi-Baghdar, H.
Herbal medicines in idiopathic heavy menstrual bleeding
A systematic review
Phytother Res, 2016, 30(10), 1584-1591
Gynaecology, Hypermenorrhea, Clinical research, Complementary and alternative medicine, Phytomedicine, Systematic review
330 Shamshad Begum, S.; Jayalakshmi, H.K.; Vidyavathi, H.G.; Gopakumar, G.; Abin, I.; Balu, M.; Geetha, K.; Suresha, S.V.; Vasundhara, M.; Krishnakumar, I.M.
A novel extract of fenugreek husk (FenuSMART™) alleviates postmenopausal symptoms and helps to establish the hormonal balance
A randomized, double-blind, placebo-controlled study
Phytother Res, 2016, 30(10), 1775-1784
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Trifolium, fenugreek
331 Meng, S.; Deng, Q.; Feng, C.; Pan, Y.; Chang, Q.
Effects of massage treatment combined with topical cactus and aloe on puerperal milk stasis
Breast Dis, 2015, 35(3), 173-178
Aloe, Cactus, Galactostasia, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Randomized trial
332 Schloss, J.; Steel, A.
Medical synopsis
Can plant-based therapies assist menopausal symptoms?
Adv Integr Med, 2016, 3(2), 66-67
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Phytomedicine, Systematic review
333 Gartoulla, P.; Han, M.M.
Red clover extract for alleviating hot flushes in postmenopausal women
A meta-analysis
Maturitas, 2014, 79(1), 58-64
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Phytomedicine, Trifolium, Trifolium pratense
334 Aalami-Harandi, R.; Karamali, M.; Asemi, Z.
The favorable effects of garlic intake on metabolic profiles, hs-CRP, biomarkers of oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampcsia
Randomized, double-blind, placebo-controlled trial
J Matern Fetal Neonatal Med, 2015, 28(17), 2020-2027
Allium, Allium sativum, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Pre-eclampsia, Prevention, Randomized trial, Obstetrics
335 Yaralizadeh, M.; Abedi, P.; Najar, S.; Namjoyan, F.; Saki, A.
Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women
A double-blind randomized placebo-controlled trial
Maturitas, 2016, 84, 75-80
Applikationsform, Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Salbe, Vaginal atrophy
336 Yazdkhasti, M.; Pirak, A.
The effect of aromatherapy with lavender essence on severity of labor pain and duration of labor in primiparous women
Complement Ther Clin Pract, 2016, 25, 81-86
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Randomized trial, Obstetrics, Tedious labour, Geburtsschmerz
337 Dongre, S.; Langade, D.; Bhattacharyya, S.
Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women
A pilot study
BioMed Res Int, 2016, Article ID 284154, (1-9)
Ayurveda, Healthy probands, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Withania, Withania somnifera
338 Tara, F.; Zand-Kargar, Z.; Rajabi, O.; Berenji, F.; Akhlaghi, F.; Shakeri, M.T.; Azizi, H.
The effects of ozonated olive oil and clotrimazole cream for treatment of vulvovaginal candidiasis
Altern Ther Health Med, 2016, 22(4), 44-49
Candidiasis, Gynaecology, Infections, Clinical research, Complementary and alternative medicine, Oil, Oleum, Oleum oliva, Ozon therapy, Phytomedicine, Randomized trial, Oxygen therapy, Vaginalinfektion
339 Tröger, W.; Zdrale, Z.; Stankovic, N.
Fünf-Jahres-Nachbeobachtung von Patientinnen mit Brustkrebs nach einer randomisierten Studie mit Viscum album (L.) Exrakt
Dt Z Onkol, 2016, 48(3), 105-110
Breast cancer, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Phytomedicine, Randomized trial, Viscum, Viscum album
340 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
341 Vannabhum, M.; Poopong, S.; Wongwananuruk, T.; Nimmannit, A.; Suwannatrai, U.; Dangrat, C.; Apichartvorakit, A.; Booranasubkajorn, S.; Laohapand, T.; Akaraserenont, P.
The efficacy of Thai herbal Prasaplai formula for treatment of primary dysmenorrhea
A short-term randomized controlled trial
eCAM, 2016, Article ID 2096797, (1-7)
Dysmenorrhea, Gynaecology, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, Traditional Thai Medicine
342 Juthani-Mehta, M.; Van Ness, P.H.; Bianco, L.
Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes
A randomized clinical trial
JAMA, 2016, 316(18), 1879-1887
Geriatrics, Gynaecology, Urinary tract, Urinary tract infection, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Vaccinium, cranberry
343 Haghighian, M.K.; Rafraf, M.; Moghaddam, A.; Hemmati, S.; Jafarabadi, M.A.; Gargari, P.
Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia
A double blind, randomized, placebo controlled pilot study
Eur J Integr Med, 2016, 8(5), 676-682
Dyslipidämie, Obesitiy, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Punica granatum, Randomized trial, Metabolic diseases
344 Gutierrez, J.L.; Bowden, R.G.; Willoughby, D.S.
Cassia cinnamon supplementation reduces peak blood glucose responses but does not improve insulin resistance and sensitivity in young, sedentary, obese women
J Diet Suppl, 2016, 13(4), 461-471
Cinnamomum, Cinnamomum cassia, Diabetes mellitus, Obesitiy, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Metabolic diseases
345 Sadeghi Aval Shahr, H.; Saadat, M.; Kheirkhah, M.; Saadat, E.
The effect of self-aromatherapy massage of the abdomen on the primary dysmenorrhoea
J Obstet Gynaecol, 2015, 35(4), 382-385
Aromatherapy, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Placebo-controlled, Randomized trial, Rosa, Rosa damascena
346 Marzouk, T.; Barakat, R.; Ragab, A.; Badria, F.; Badawy, A.
Lavender-thymol as a new topical aromatherapy preparation for episiotomy
A randomised clinical trial
J Obstet Gynaecol, 2015, 35(5), 472-475
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Phytomedicine, Placebo-controlled, Randomized trial, Obstetrics, thyme camphor, Wound healing, episiotomy
347 Banaszewska, B.; Wrotynska-Barczynska, J.; Spaczynski, R.Z.; Pawelczyk, L.; Duleba, A.J.
Effect of resveratrol on polycystic ovary syndrome
A double-blind, randomized, placebo-controlled trial
J Clin Endocrinol Metab, 2016, 101, 3575-3581
Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Polycystic ovary syndrome, Randomized trial, Resveratrol
348 Shirooye, P.; Hasehm-Dabaghian, F.; Hamzeloo-Moghadam, M.; Afrakhteh, M.; Bioos, S.; Mokaberinejad, R.
A clinical comparative study of oral and topical ginger on severity and duration of primary dysmenorrhea
Res J Pharmacogn, 2017, 4(1), 23-32
Applikationsform, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, ginger, Lotion, Kapsel
349 Yuan, L.J.; Qin, Y.; Wang, L.; Zeng, Y.; Chang, H.; Wang, J.; Wang, B.; Wan, J.; Che, S.H.; Zhang, Q.Y.; Zhu, J.D.; Zhou, Y.; Mi, M.T.
Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women with gestational diabetes mellitus and lowered the incidence of large-for-gestational-age newborns
Clin Nutr, 2016, 35(2), 388-393
Capsicum, Diabetes mellitus, Gynaecology, Clinical research, Complementary and alternative medicine, Neonatologie, Pediatrics, Phytomedicine, Placebo-controlled, Randomized trial, Obstetrics, Metabolic diseases
350 Ghazanfarpour, M.; Sadeghi, R.; Roudsari, R.L.
The application of soy isoflavones for subjective symptoms and objective signs of vaginal atrophy in menopause
A systematic review of randomised controlled trials
J Obstet Gynaecol, 2016, 36(2), 160-171
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phaseolus, Phaseolus max, Phytomedicine, Systematic review, Vaginal atrophy
351 Ghazanfarpour, M.; Sadeghi, R.; Roudsari, R.L.; Khorsand, I.; Khadivzadeh, T.; Muoio, B.
Red clover for treatment of hot flashes and menopausal symptoms
A systematic review and meta-analysis
J Obstet Gynaecol, 2016, 36(3), 301-311
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Phytomedicine, Systematic review, Trifolium, Trifolium pratense
352 Lee, H.W.; Choi, J.; Lee, Y.; Kil, K.J.; Lee, M.S.
Ginseng for managing menopausal woman's health
A systematic review of double-blind, randomized, placebo-controlled trials
Medicine, 2016, 95(38), e4914; (1-7)
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Systematic review, Panax, Panax ginseng
353 Mombaini, E.; Jafarirad, S.; Husain, D.; Hossein-Haghighizadeh, M.; Padfar, P.
The impact of green tea supplementation on anthropometric indices and inflammatory cytokines in women with polycystic ovary syndrome
Phytother Res, 2017, 31(5), 747-754
Camellia, Camellia sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Polycystic ovary syndrome, Randomized trial
354 Ghazanfarpour, M.; Sadeghi, R.; Abdolahian, S.; Roudsari, R.L.
The efficacy of Iranian herbal medicines in alleviating hot flashes
A systematic review
Int J Reprod Biomed, 2016, 14(3), 155-166
Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Systematic review
355 Nikniaz, Z.; Mahdavi, R.; Nikniaz, L.; Ebrahimi, A.; Ostadrahimi, A.;
Effects of Elaeagnus angustifolia L. on lipid profile and atherogenic indices in obese females
A randomized controlled clinical trial
J Diet Suppl, 2016, 13(6), 595-606
Obesitiy, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Elaeagnus angustifolia
356 Abdi, F.; Alimoradi, Z.; Haqi, P.; Mahdizad, F.
Effects of phytoestrogens on bone mineral density during the menopause transition
A systematic review of randomized, controlled trials
Climacteric, 2016, 19(6), 535-545
Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Osteoporosis, Phytomedicine, Systematic review
357 Razali, N.; Nahwari, S.H.M.; Sulaiman, S.; Hassan, J.
Date fruit consumption at term
Effect on length of gestation, labour and delivery
J Obstet Gynaecol, 2017, 37(5), 595-600
Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Phoenix, Phoenix dactylifera, Phytomedicine, Randomized trial, Obstetrics
358 Romero-Cerecero, O.; Islas-Garduno, A.L.; Zamilpa, A.; Tortoriello, J.
Effectiveness of Ageratina pichinchensis extract in patients with vulvovaginal candidiasis
A randomized, double-blind, and controlled pilot study
Phytother Res, 2017, 31(6), 885-890
Ageratina pichinchensis, Candidiasis, Gynaecology, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Vaginalinfektion
359 Kashani, L.; Eslatmanesh, S.; Saedi, N.; Niroomand, N.; Ebrahimi, M.; Hosseinian, M.; Foroughifar, T.; Salimi, S.; Akhondzadeh, S.
Comparison of saffron versus fluoxetine in treatment of mild to moderate postpartum depression
A double-blind, randomized clinical trial
Pharmacopsychiatry, 2017, 50(2), 64-68
Crocus, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Obstetrics, Postpartum depression
360 Myers, S.P.; Vigar, V.
Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes
A systematic review and meta-analysis
Phytomed, 2017, 24, 141-147
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Phytomedicine, Systematic review, Trifolium, Trifolium pratense
361 Sut, N.; Kahyaoglu-Sut, H.
Effect of aromatherapy massage on pain in primary dysmenorrhea
A meta-analysis
Complement Ther Clin Pract, 2017, 27, 5-10
Aromatherapy, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Meta-analysis, Phytomedicine
362 Fatima, L.; Sultana, A.
Efficacy of Tribulus terrestris L. (fruits) in menopausal transition symptoms
A randomized placebo controlled study
Adv Integr Med, 2017, 4(2), 56-65
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Tribulus terrestris
363 Rahimi-kian, F.; Bekhradi, R.; Rhimi, R.; Golzareh, P.; Mehran, A.
Evaluating the effect of fennel soft capsules on the quality of life and its different aspects in menopausal women
A randomized clinical trial
Nurs Pract Today, 2017, 4(2), 87-95
Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
364 Rahimikian, F.; Rahimi, R.; Golzareh, P.; Bekhradi, R.; Mehran, A.
Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women
A randomized, triple-blind, placebo-controlled trial
Menopause, 2017, 24(9), 1017-1021
Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
365 Kirichenko, T.V.; Myasoedova, V.A.; Orekhova, V.A.; Ravanai, A.L.; Nikitina, N.A.; Grechko, A.V.; Sobenin, I.A.; Orekhov, A.N.
Phytoestrogen-rich natural preparation for treatment of climacteric syndrome and atherosclerosis prevention in perimenopausal women
Phytother Res, 2017, 31(8), 1209-1214
Allium, Allium sativum, Arteriosclerosis, Camellia, Camellia sinensis, Gynaecology, Cardiovascular diseases, hop, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Vitis vinifera, Vitis
366 Maki, K.C.; Kaspar, K.L.; Khoo, C.; Derrig, L.H.; Schild, A.L.; Gupta, K.
Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection
Am J Clin Nutr, 2016, 103(6), 1434-1442
Gynaecology, Urinary tract, Urinary tract infection, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Juice/distillate, Vaccinium, cranberry
367 Jafari-Dehkordi, E.; Hashem-Dabaghian, F.; Aliasl, F.; Aliasl, J.; Taghavi-Shirazi, M.; Sadeghpour, O.
Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy
A randomised clinical trial
J Obstet Gynaecol, 2017, 37(8), 1048-1052
Cydonia, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Pyridoxin, Randomized trial, Obstetrics, Morning sickness, Vitamins, Quince
368 Vaziri, F.; Shiravani, M.; Najib, F.S.; Pourahmad, S.; Salehi, A.; Yazdanpanahi, Z.
Effect of lavender oil aroma in the early hours of postpartum period on maternal pains, fatigue, and mood
A randomized clinical trial
Int J Prev Med, 2017, 8, 29; (1-7)
Aromatherapy, Chronic fatigue syndrome, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Phytomedicine, Prevention, Mental diseases, Randomized trial, Pain, Obstetrics
369 Kamalifard, M.; Delazar, A.; Satarzade, N.; Mirghafourvand, M.; Dousti, R.
The comparison of the impact of lavender and Valerian aromatherapy on reduction of the active phase among nulliparous women
A double blind randomized controlled trial
Int J Med Res Health Sci, 2017, 5(9S), 532-538
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Randomized trial, Pain, Obstetrics, Valeriana, Tedious labour
370 Shirvani, M.A.; Motahari-Tabari, N.; Alipour, A.
Use of ginger versus stretching exercises for the treatment of primary dysmenorrhea
A randomized controlled trial
J Integr Med, 2017, 15(4), 295-301
Muscoskeletal -/Connective tissue system, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Physical therapy, Phytomedicine, Randomized trial, ginger, Stretching
371 Sharifzadeh, F.; Kashanian, M.; Koohpayehzadeh, J.; Rezaian, F.; Sheikhansari, N.; Eshraghi, N.
A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP)
J Matern Fetal Neonatal Med, 2018, 31(19), 2509-2514
Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Pyridoxin, Randomized trial, Obstetrics, Morning sickness, Sickness (pregnancy), Vitamins, ginger
372 Kao, Y.H.; Huang, Y.C.; Chung, U.L.; Hsu, W.N.; Tang, Y.T.; Liao, Y.H.
Comparisons for effectiveness of aromatherapy and acupressure massage on quality of life in career women
A randomized controlled trial
J Altern Complement Med, 2017, 23(6), 451-460
Acupressure, Acupuncture, Occupational health, Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Origanum, Origanum majorana, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, sage, Salvia sclarea, Stress, Traditional Chinese medicine
373 Matsumoto, T.; Kimura, T.; Hayashi, T.
Does Japanese citrus fruit Yuzu (Citrus junos Sieb. ex Tanaka) fragrance have lavender-like therapeutic effects that alleviate premenstrual emotional symptoms?
A single-blind randomized crossover study
J Altern Complement Med, 2017, 23(6), 461-470
Aromatherapy, Citrus, Citrus junos, Gynaecology, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Premenstrual syndrome, Mental diseases, Randomized trial, Vegetative nervous system
374 Arentz, S.; Smith, C.A.; Abbott, J.; Fahey, P.; Cheema, B.S.; Bensoussan, A.
Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS)
A randomized controlled trial
Phytother Res, 2017, 31(9), 1330-1340
Cinnamomum, Glycyrrhiza, liquorice root, Gynaecology, Hypericum, St John's wort, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lifestyle modification, Mind-body medicine, Paeonia, Paeonia lactiflora, Phytomedicine, Polycystic ovary syndrome, Randomized trial, Metabolic diseases, Tribulus terrestris, Overweight
375 Steels, E.; Steele, M.L.; Harold, M.; Coulson, S.
Efficacy of a proprietary Trigonella foenum-graecum L. de-husked seed extract in reducing menopausal symptoms in otherwise healthy women
A double-blind, randomized, placebo-controlled study
Phytother Res, 2017, 31(9), 1316-1322
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Trifolium, fenugreek
376 Pasta, V.; Dinicola, S.; Giuliani, A.; Harrath, A.H.; Alwasel, S.H.; Tartaglia, F.; Cucina, A.; Bizzarri, M.
A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas
Eur Rev Med Pharmacol Sci, 2016, 20, 1860-1865
Boswellia, Fibroadenom, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
377 Verkaik, S.; Kamperman, A.M.; Westrhenen, R. van; Schulte, P.F.J.
The treatment of premenstrual syndrome with preparations of Vitex agnus castus
A systematic review and meta-analysis
Am J Obstet Gynecol, 2017, 217(2), 150-166
Agnus castus, Gynaecology, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Premenstrual syndrome, Systematic review
378 Lambert, M.N.T.; Thybo, C.B.; Lykkeboe, S.; Rasmussen, L.M.; Frette, X.; Christensen, L.P.; Jeppesen, P.B.
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women
A randomized controlled trial
Am J Clin Nutr, 2017, 106(3), 909-920
Muscoskeletal -/Connective tissue system, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Probiotics, Randomized trial, osteopenia
379 Lambert, M.N.T.; Hu, L.M.; Jeppesen, P.B.
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
Am J Clin Nutr, 2017, 106(3), 801-811
Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Osteoporosis, Phytomedicine, Systematic review
380 Rao, S.; Hegde, S.K.; Baliga-Rao, M.P.; Lobo, J.; Palatty, P.L.; George, T.; Baliga, M.S.
Sandalwood oil and turmeric-based cream prevents ionizing radiation-induced dermatitis in breast cancer patients
Clinical study
Medicines, 2017, 4(3), 43; (1-8)
Applikationsform, Breast cancer, Curcuma, Curcuma longa, Dermatitis, Gynaecology, Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Randomized trial, Salbe, Santalum album, Santalum
381 Hassan, N.H.
Effect of cinnamon on hemoglobin level after menstruation
Sci J Med Res, 2017, 1(3), 92-95
Blood/Lymphatic system, Cinnamomum, Gynaecology, Hyphema, Clinical research, Complementary and alternative medicine, Menstrual disorders, Phytomedicine, Randomized trial
382 Kazemzadeh, R.; Nikjou, R.; Rostamnegad, M.; Norouzi, H.
Effect of lavender aromatherapy on menopause hot flushing
A crossover randomized clinical trial
J Chin Med Assoc, 2016, 79, 489-492
Aromatherapy, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Menopause, Phytomedicine, Randomized trial
383 Seifi, M.; Abbasalizadeh, S.; Mohammad‐Alizadeh‐Charandabi, S.; Khodaie, L.; Mirghafourvand, M.
The effect of Rosa (L. Rosa canina) on the incidence of urinary tract infection in the puerperium
A randomized placebocontrolled trial
Phytother Res, 2018, 32(1), 76-83
Bladder infection, Gynaecology, Urinary tract, Urinary tract infection, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Rosa, Rosa canina, Obstetrics, Kaiserschnitt
384 Postigo, S.; Lima, S.M.R.R.; Yamada, S.S.; Reis, B.F. dos; Silva, G.M.D.; Aoki, T.
Assessment of the effects of Tribulus terrestris on sexual function of menopausal women
Rev Bras Ginecol Obstet, 2016, 38, 140-146
Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Tribulus terrestris, Sexual dysfunktion (female)
385 Thamlikitkul, L.; Srimuninnimit, V.; Akewanlop, C. Ithimakin, S.; Techawathanawanna, S.; Korphaisarn, K.; Chantharasamee, J.; Danchaivijitr, P.; Soparattanapaisarn, N.
Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen
A randomized, double-blind, placebo-controlled, crossover study
Support Care Cancer, 2017, 25(2), 459-464
Breast cancer, Vomiting, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Sickness, ginger
386 Nikjou, R.; Kazemzadeh, R.; Rostamnegad, M.; Moshfegi, S.; Karimollahi, M.; Salehi, H.
The effect of lavender aromatherapy on the pain severity of primary dysmenorrhea
A triple-blind randomized clinical trial
Ann Med Health Sci Res, 2016, 6(4), 211-215
Aromatherapy, Dysmenorrhea, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Placebo-controlled, Randomized trial
387 Penny, B.L.; Razlog, R.; Deroukakis, M.; Johnston, G.
A comparative study of Klimakt-Heel® and Femolene Ultra in the management of typical climacteric symptoms
Health SA Gesondh, 2009, 14(1), 144-148
Gynaecology, Homeopathy, Climacteric, Klimakt-Heel, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, Femolene Ultra
388 Chen, P.J.; Chou, C.C.; Yang, L.; Tsai, Y.L.; Chang, Y.C.; Liaw, J.J.
Effects of aromatherapy massage on pregnant women's stress and immune function
A longitudinal, prospective, randomized controlled trial
J Altern Complement Med, 2017, 23(10), 778-786
Aromatherapy, Gynaecology, Immune system, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Phytomedicine, Mental diseases, Randomized trial, Obstetrics, Stress
389 Rezazadeh, K.; Rahmati-Yamchi, M.; Mohammadnejad, L.; Ebrahimi-Mameghani, M.; Delazar, A.
Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome
Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms
Phytother Res, 2018, 32(1), 84-93
Cynara cardunculus subsp. flavescens, Gynaecology, Clinical research, Complementary and alternative medicine, Metabolic syndrome, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
390 Khan, T.M.; Wu, D.B.; Dolzhenko, A.V.
Effectiveness of fenugreek as a galactagogue
A network meta-analysis
Phytother Res, 2018, 32(3), 402-412
Gynaecology, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Obstetrics, Systematic review, Trifolium, fenugreek
391 Ahmed, M.; Hwang, J.H.; Choi, S.; Han, D.
Safety classification of herbal medicines used among pregnant women in Asian countries
A systematic review
BMC Complement Altern Med, 2017, 17(1), 489; (1-11)
Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Obstetrics, Systematic review, Adverse effect
392 Trambert, R.; Kowalski, M.O.; Wu, B.; Mehta, N.; Friedman, P.
A randomized controlled trial provides evidence to support aromatherapy to minimize anxiety in women undergoing breast biopsy
Worldviews Evid Based Nurs, 2017, 14(5), 394-402
Anxiety, Aromatherapy, Breast, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
393 Nadadur, M.; Stanczyk, F.Z.; Tseng, C.C.; Kim, L.; Wu, A.H.
The effect of reduced dietary fat and soy supplementation on circulating adipocytokines in postmenopausal women
A randomized controlled 2-month trial
Nutr Cancer, 2016, 68(4), 554-559
Breast cancer, Diet, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Menopause, Dietary supplementation, Phaseolus, Phaseolus max, Phytomedicine, Prevention, Randomized trial, Low Fat
394 Tamaki, K.; Fukuyama, A.K.; Terukina, S.; Kamada, Y.; Uehara, K.; Arakaki, M.; Yamashiro, K.; Miyashita, M.; Ishida, T.; McNamara, K.M.; Ohuchi, N.; Tamaki, N.; Sasano, H.
Randomized trial of aromatherapy versus conventional care for breast cancer patients during perioperative periods
Breast Cancer Res Treat, 2017, 162(3), 523-531
Aromatherapy, Breast cancer, Citrus, Citrus sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Lavendula, Phytomedicine, Postoperative complaints, Randomized trial, Ylang ylang
395 Shahrahmani, H.; Kariman, N..; Jannesari, S.; Rafieian-Kopaei, M.; Mirzaei, M.; Ghalandari, S.; Shahrahmani, N.; Mardani, G.
The effect of green tea ointment on episiotomy pain and wound healing in primiparous women
A randomized, double-blind, placebo-controlled clinical trial
Phytother Res, 2018, 32(3), 522-530
Applikationsform, Camellia, Camellia sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Salbe, Pain, Obstetrics, Wound healing, episiotomy
396 Taavoni, S.; Ekbatani, N.N.; Haghani, H.
Effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms
A randomised, placebo-controlled clinical trial
Menopause Rev, 2017, 16(1), 19-22
Cinnamomum, Crocus, Spices, Gynaecology, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Tribulus terrestris, ginger
397 Hajimonfarednejad, M.; Nimrouzi, M.; Heydari, M.; Zarshenas, M.M.; Raee, M.J.; Jahromi, B.N.
Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome
A randomized double‐blind placebo controlled clinical trial
Phytother Res, 2018, 32(2), 276-283
Cinnamomum, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Polycystic ovary syndrome, Randomized trial, Metabolic diseases
398 Mirzaei, N.; Moghaddam, F.S.; Ozgoli, G.; Sahranavard, S.; Ghasemi, E.
Purslane (Portulaca oleracea) effect on heavy menstrual bleeding (menorrhagia) in Iranian women
Adv Integr Med, 2018, 5(2), 56-62
Gynaecology, Clinical research, Complementary and alternative medicine, Menorrhagie, Menstrual disorders, Phytomedicine, Placebo-controlled, Portulaca oleracea, Randomized trial
399 Joulaeerad, N.; Ozgoli, G.; Hajimehdipoor, H.; Ghasemi, E.; Salehimoghaddam, F.
Effect of aromatherapy with peppermint oil on the severity of nausea and vomiting in pregnancy
A single-blind, randomized, placebo-controlled trial
J Reprod Infertil, 2018, 19(1), 32-38
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Mentha, peppermint, Phytomedicine, Placebo-controlled, Randomized trial, Morning sickness, Sickness (pregnancy)
400 Ghanbari-Niaki, A.; Saeidi, A.; Ahmadian, M.; Gharahcholo, L.; Naghavi, N.; Fazelzadeh, M.; Mahjoub, S.; Myers, S.; Williams, A.
The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women
Integr Med Res, 2018, 7(1), 44-52
Exercise therapy, Endocrinology, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Physical therapy, Phytomedicine, Randomized trial