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1 Melchart, D.; Linde, K.; Worku, F.; Sarkady, L.; Holzmann, M.; Jurcic, K.; Wagner, H.
Results of five randomized studies on the immunomodulatory activity of preparations of echinacea
J Altern Complement Med, 1995, 1(2), 145-160
Blood, Blood/Lymphatic system, Echinacea, Experiment, Basic Research, Homeopathy, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Human, Phytomedicine, Randomized trial
2 Lamm, S.; Sheng, Y.; Pero, R.W.
Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100
Phytomed, 2001, 8(4), 267-274
Inflammation, Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Uncaria, Uncaria tomentosa
3 Deak, G.; Muzes, G.; Lang, I.; Niederland, V.; Nekam, K.; Gonzalez-Cabello, R.; Gergely, P.; Feher, J.
Silymarin kezelés immunmodláns hatása krónikus alkoholos májbetegségben
(Immunomodulatory effects of silymarin treatment in chronic alcohol liver disease)
Orv Hetil, 1990, 131(24), 1295-1296
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
4 Lang, I.; Nekam, K.; Deak, G.; Muzes, G.; Gonzales-Cobello, R.; Gergely, P.; Cosmos, G.; Feher, J.
Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers
Ital J Gastroenterol, 1990, 22(5), 283-287
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
5 Satoh, N.; Sakai, S.; Kogure, T.; Tahara, E.; Origasa, H.; Shimada, Y.; Kohoda, K.; Okubo, T.; Terasawa, K.
A randomized double blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness N of one and responder restricted design
Phytomed, 2005, 12(8), 549-554
Angelica, Astragalus, Atractylodes, Bupleurum, Citrus, Citrus aurantium, Geriatrics, Glycyrrhiza, Hochuekkito, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Traditional Japanese medicine, ginger, Zizyphus, Zizyphus jujuba, Panax, Panax ginseng
6 Schwarz, E.; Parlesak, A.; Henneicke-von Zepelin, H.-H.; Bode, J.C.; Bode, C.
Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B- and T-lymphocytes in healthy volunteers
Results of a double-blind, placebo-controlled cross-over study
Phytomed, 2005, 12(9), 625-631
Echinacea, Echinacea purpurea, Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
7 Schink, M.; Tröger, W.; Dabidian, A.; Goyert, A.; Scheuerecker, H.; Meyer, J.; Fischer, I.U.; Glaser, F.
Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients
A randomized phase III trial
Forsch Komplementärmed, 2007, 14(1), 9-17
Surgery, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Randomized trial, Viscum, Viscum album, Iscador
8 Schink, M.; Tröger, W.; Dabidian, A.; Goyert, A.; Scheuerecker, H.; Meyer, J.; Fischer, I.U.; Glaser, F.
Effect of a perioperative infusion of mistletoe extract on surgery-induced immunosuppression in colorectal cancer patients
A controlled multicenter comparative cohort study
Phytomed, 2007, 14(S VII), 40 (Abstract; Symposiumsbeitrag)
Anthroposophic medicine, Bowel cancer, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Phytomedicine, Randomized trial, Colorectal cancer, Viscum, Viscum album
9 Rowe, C.A.; Nantz, M.P.; Bukowski, J.F.; Percival, S.S.
Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamm, delta T cell function
A randomized, double-blind, placebo-controlled study
J Am Coll Nutr, 2007, 26(5), 445-452
Respiratory diseases, Camellia, Camellia sinensis, Common cold, Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Tea
10 You, W.C.; Hsieh, C.C.; Huang, J.T.
Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis
J Altern Complement Med, 2009, 15(7), 771-778
Ear-nose-throat disorders, Immunomodulation, Immune system, Isatis, Isatis indigotica, Clinical research, Complementary and alternative medicine, Head and neck cancer, Cancer, Mucositis (oral), Phytomedicine, Randomized trial
11 Liu, J.Z.; Chen, S.G.; Zhang, B.; Wang, C.B.; Zhao, X.W.; Li, G.Y.; Wang, L.X.
Effect of haishengsu as an adjunct therapy for patients with advanced renal cell cancer
A randomized and placebo-controlled clinical trial
J Altern Complement Med, 2009, 15(10), 1127-1130
Chinese medicinal herbs, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Renal (cell) carcinoma, Phytomedicine, Placebo-controlled, Randomized trial, Tegillarca granosa, Traditional Chinese medicine
12 Chen, Y.Z.; Gao, Q.; Zhao, X.Z.; Chen, X.M.; Zhang, F.; Chen, J.; Xu, C.G.; Sun, L.L.; Mei, C.L.
Meta-analysis of Tripterygium wilfordii Hook F in the immunosuppressive treatment of IgA nephropathy
Intern Med, 2010, 49(19), 2049-2055
Urinary tract, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meta-analysis, Kidney, Phytomedicine, Tripterygium, Tripterygium wilfordii
13 Luna, L.A. Jr.; Bachi, A.L.; Novaes, E. Brito R.R.; Eid, R.G.; Suguri, V.M.; Oliveira, P.W.; Gregorio, L.C.; Vaisberg, M.
Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise
Modulation of secretory IgA, IL-6 and IL-15
Phytomed, 2011, 18(4), 303-308
Respiratory diseases, Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Pelargonium, Pelargonium sidoides, Phytomedicine, Placebo-controlled, Randomized trial, Sports medicine
14 Kim, S.H.; Kim, S.; Lee, S.H.; Park, H.W.; Chang, Y.S.; Min, K.U.; Cho, S.H.
The effects of PG102, a water-soluble extract from Actinidia arguta, on serum total IgE levels
A double-blind, randomized, placebo-controlled exploratory clinical study
Eur J Nutr, 2011, 50(7), 523-529
Actinidia, Actinidia arguta, Allergies, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
15 Kianbakht, S.; Ghazavi, A.
Immunomodulatory effects of saffron
A randomized double-blind placebo-controlled clinical trial
Phytother Res, 2011, 25(12), 1801-1805
Crocus, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
16 Chiva-Blanch, G.; Urpi-Sarda, M.; Llorach, R.; Rotches-Ribalta, M.; Guillén, M.; Casas, R.; Arranz, S.; Valderas-Martinez, P.; Portoles, O.; Corella, D.; Tinahones, F.; Lamuela-Raventos, R.M.; Andres-Lacueva, C.; Estruch, R.
Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis
A randomized clinical trial
Am J Clin Nutr, 2012, 95(2), 326-334
Andrology, Arteriosclerosis, Nutrition/diet, Cardiovascular diseases, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Vitis vinifera, Vitis
17 Müller, S.; März, R.; Schmolz, M.; Drewelow, B.; Eschmann, K.; Meiser, P.
Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration
New evidence on the antiinflammatory mode of action of bromelain
Phytother Res, 2013, 27(2), 199-204
Bromelain, Inflammation, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, posology, Randomized trial
18 Senti, G.; Moos, S. von; Tay, F.; Graf, N.; Sonderegger, T.; Johansen, P.; Kündig, T.M.
Epicutaneous allergen-specific immunotherapy ameliorates grass pollen-induced rhinoconjunctivitis
A double-blind, placebo-controlled dose escalation study
J Allergy Clin Immunol, 2012, 129(1), 128-135
Allergies, Hay fever, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Pollen, Randomized trial
19 Reyes, E.; Jaén, P.; Heras, E. de las; Carrión, F.; Alvarez-Mon, M.; Eusebio, E. de; Alvare, M.; Cuevas, J.; González, S.; Villarrubia, V.G.
Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generelized vitiligo
A pilot study
J Dermatol Sci, 2006, 41(3), 213-216
Skin diseases, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Polypodium leucotomos, Randomized trial, Vitiligo
20 Kim, K.-C.; Yook, J.-H.; Eisenbraun, J.; Kim, B.-S.; Huber, R.
Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma
A randomized, controlled pilot study
BMC Complement Altern Med, 2012, 12, 172; (1-7)
Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Mistletoe therapy, Phytomedicine, Randomized trial, Viscum, Viscum album
21 Rösler, D.; Fuchs, N.; Markolin, G.; Edler, B.; Kuklinski, B.; Kästenbauer, T.
Reduktion grippaler Infekte durch eine Phytoextrakt-Vitamin-Kombination
Eine randomisierte, doppelblinde, placebokontrollierte Studie
MMW Fortschr Med, 2012, 154 (Suppl. 4), 115-122
Nutrition/diet, Flu, Immun 44, Immunomodulation, Immune system, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Minerals, Dietary supplementation, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Trace elements, Vitamins
22 Huber, R.; Lüdtke, R.; Wieber, J.; Meyer, U.; Beckmann, C.
Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters
A placebo controlled clinical trial in healthy subjects
Merkurstab, 2013, 11, 116; (1-12)
Anthroposophic medicine, Healthy probands, Immunomodulation, Immune system, Iscucin, Clinical research, Complementary and alternative medicine, Mistletoe therapy, Phytomedicine, Placebo-controlled, Randomized trial, Viscum, Viscum album
23 Shetty, S.; Bose, A.; Sridharan, S.; Satyanarayana, A.; Rahul, A.
A clinico-biochemical evaluation of the role of a herbal (ayurvedic) immunomodulator in chronic periodontal disease
A pilot study
Oral Health Dent Manag, 2013, 12(2), 95-104
Ayurveda, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Parodontitis, Phytomedicine, Randomized trial, Septilin, Dental diseases
24 Rezapour-Firouzi, S.; Arefhosseini, S. R.; Mehdi, F.; Mehrangiz, E. M.; Baradaran, B.; Sadeghihokmabad, E.; Mostafaei, S.; Fazljou, S. M.; Torbati, M. A.; Sanaie, S.; Zamani, F.
Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients
Complement Ther Med, 2013, 21(5), 481-486
Cannabis, Cannabis sativa, Diet, Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Oil, Oenothera, Oenothera biennis, olive, green, Phytomedicine, Randomized trial, Olea
25 Khiewkhern, S.; Promthet, S.; Sukprasert, A.; Eunhpinitpong, W.; Bradshaw, P.
Effectiveness of aromatherapy with light thai massage for cellular immunity improvement in colorectal cancer patients receiving chemotherapy
Asian Pac J Cancer Prev, 2013, 14(6), 3903-3907
Aromatherapy, Cocos nucifera, Bowel cancer, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Phytomedicine, Randomized trial, ginger
26 Lee, A.-J.; Lee, H.J.; Kim, J.-D.; Jung, H.-J.; Bae, S.H.; Ryoo, H.M.; Kim, S.-G.
Changes of peripheral blood lymphocyte subtypes in patients with end stage cancer administered localized radiotherapy and Bojungikki-Tang
eCAM, 2014, Article ID 207613, (1-6)
Bojungikgitang, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Radiology, Randomized trial, Traditional Korean Medicine
27 Matsabisa, M.G.; Sekhoacha, M.P.; Ibrahim, O.; Moodley, P.; Faber, M.
Nutritional content and a phase-I safety clinical trial of a herbal-nutritional supplement (Muniti) with putative immune-modulating properties
Afr J Tradit Compl Altern Med, 2012, 9(3S), 19-23
Nutrition/diet, HIV, Immunomodulation, Immune system, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Minerals, Dietary supplementation, Phytomedicine, Placebo-controlled, Randomized trial, Vitamins
28 Panahi, Y.; Saadat, A.; Beiraghdar, F.; Sahebkar, A.
Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors
A randomized double-blind placebo-controlled trial
Phytother Res, 2014, 28(10), 1461-1467
Curcuma, Curcuma longa, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Randomized trial
29 Udani, J.K.
Immunomodulatory effects of ResistAid™
A randomized, double-blind, placebo-controlled, multidose study
J Am Coll Nutr, 2013, 32(5), 331-338
Immunomodulation, Immune system, Vaccination, Clinical research, Complementary and alternative medicine, Larix, Phytomedicine, Placebo-controlled, Randomized trial, Larix laricinia
30 Lewis, J.E.; Melillo, A.B.; Tiozzo, E.; Chen, L.; Leonard, S.; Howell, M.; Diaz, J.; Gonzalez, K.; Woolger, J.M.; Konefal, J.; Paterson, E.; Barnes, D.
A double-blind, randomized clinical trial of dietary supplementation on cognitive and immune functioning in healthy older adults
BMC Complement Altern Med, 2014, 14, 43; (1-9)
Nutrition/diet, Geriatrics, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Dietary supplementation, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Tokopherol, Gingivitis
31 Ho, C.K.; Choi, S.W.; Siu, P.M.; Benzie, I.F.
Effects of single dose and regular intake of green tea (Camellia sinensis) on DNA damage, DNA repair, and heme oxygenase-1 expression in a randomized controlled human supplementation study
Mol Nutr Food Res, 2014, 58(6), 1379-1383
Biology/Biological Sciences, Camellia, Camellia sinensis, Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Molecular biology, Phytomedicine, Placebo-controlled, Randomized trial, Tea
32 Singh, R.G.; Singh, P.; Singh, P.K.; Usha, -; Agrawal, A.; Upadhyay, B.N.; Soni, A.
Immunomodulating and antiproteinuric effect of Hippophae rhamnoides (Badriphal) in idiopathic nephrotic syndrome
J Assoc Physicians India, 2013, 61(6), 397-399
Urinary tract, Hippophae rhamnoides, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Nephrotisches Syndrom, Phytomedicine, Randomized trial, Hippophae
33 McAnulty, L.S.; Collier, S.R.; Landram, M.J.; Whittaker, D.S.; Isaacs, S.E.; Klemka, J.M.; Cheek, S.L.; Arms, J.C.; McAnulty, S.R.
Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females
Nutr Res, 2014, 34(7), 577-584
Arteries, Nutrition/diet, Cardiovascular diseases, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Randomized trial, Vaccinium, blueberry
34 Raus, K.; Pleschka, S.; Klein, P.; Schoop, R.; Fisher, P.
Effect of an echinacea-based hot drink versus olseltamivir in influenza treatment
A randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial
Curr Ther Res, 2015, 77, 66-72
Echinacea, Echinacea purpurea, Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
35 Zakay-Rones, Z.; Thom, E.; Wollan, T.; Wadstein, J.
Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza a and b virus infections
J Int Med Res, 2004, 32, 132-140
Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Sambucus, Viruses
36 Mahmoud, F.; Haines, D.; Al-Ozairi, E.; Dashti, A.
Effet of black tea consumption on intracellular cytokines, regulatory T cells and metabolic biomarkers in type 2 diabetes patients
Phytother Res, 2016, 30(3), 454-462
Camellia, Camellia sinensis, Diabetes mellitus, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Metabolic diseases, Tea
37 George, A.; Suzuki, N.; Abas, A.B.; Mohri, K.; Utsuyama, M.; Hirokawa, K.; Takara, T.
Immunomodulation in midde-aged humans via the ingestion of Physta® standardized root water extract of Eurycoma longifolia Jack
A randomized, double-blind, placebo-controlled, parallel study
Phytother Res, 2016, 30(4), 627-635
Eurycoma longifolia, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
38 Kheirouri, S.; Hadi, V.; Alizadeh, M.
Immunomodulatory effect of Nigella sativa oil on T lymphocytes in patients with rheumatoid arthritis
Immunol Invest, 2016, 45(4), 271-283
Arthritis, Muscoskeletal -/Connective tissue system, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Nigella sativa, Phytomedicine, Placebo-controlled, Randomized trial, Rheumatic diseases
39 Madineh, H.; Yadollahi, F.; Yadollahi, F.; Mofrad, E.P.; Kabiri, M.
Impact of garlic tablets on nosocomial infections in hospitalized patients in intensive care units
Electronic Physician, 2017, 9(4), 4064-4071
Allium, Allium sativum, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Intensivmedizin
40 Ra Cho, A.; Lee, S.Y.; Cho, Y.H.; Kim, C.M.; Kim, S.G.
Effects of 4-week intervention with Ulmus macrocarpa hance extract on immune function biomarkers in healthy adults
A randomized controlled trial
eCAM, 2018, Article ID 5690816, (1-6)
Healthy probands, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Ulmus, Ulmus macrocarpa
41 Magar, S.; Nayak, D.; Mahajan, U.B.; Patil, K.R.; Shinde, S.D.; Goyal, S.N.; Swaminarayan, S.; Patil, C.R.; Ojha, S.; Kundu, C.N.
Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats
Sci Rep, 2018, 8(1), 13562; (1-11)
Experiment, Basic Research, Homeopathy, Immunomodulation, Immune system, Complementary and alternative medicine, Nervous system, Neuropathy, Phytomedicine, Rhus, Rhus toxicodendron, Animal
42 Pelzer, F.; Tröger, W.; Nat, D.R.
Complementary treatment with mistletoe extracts during chemotherapy
Safety, neutropenia, fever, and quality of life assessed in a randomized study
J Altern Complement Med, 2018, 24(9-10), 954-961
Blood/Lymphatic system, Breast cancer, Fever, Gynaecology, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Neutropenia, Phytomedicine, Randomized trial