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1 Linde, K.; Ramirez, G.; Mulrow, C.D.; Pauls, A.; Weidenhammer, W.; Melchart, D.
St John's wort for depression - an overview and meta-analysis of randomised clinical trials
BMJ, 1996, 313, 253-258
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
2 Schmidt, U.; Harrer, G.; Kuhn, U.; Biller, A.
Äquivalenzvergleich: Johanniskrautextrakt LoHyp-57 vs. Fluoexetin-HCI
Beitrag des Symposiums "Phytopharmaka 2000", Bonn Nov. 1998
Z Phytother, 1999, 20(2), 89-90
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases
3 Lenoir, S.; Degenring, F.H.; Saller, R.
A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hyericum perforatum L.
Phytomed, 1999, 6(3), 141-146
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
4 Philipp, M.; Kohnen, R.; Hiller, K.-O.
Hypericum extract versus imipramine or placebo in patients with moderate depression
Randomised multicentre study of treatment for eigth weeks
BMJ, 1999, 319, 1534-1539
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
5 Linde, K.; Mulrow, C.D.
St John's wort for depression
Cochrane Database Syst Rev, 2000, 1(CD000448), 1-17
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
6 Woelk, H.
Comparison of St John's wort and imipramine for treating depression
Randomised controlled trial
BMJ, 2000, 321, 536-539
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
7 Shelton, R.C.; Keller, M.B.; Gelenberg, A.; Dunner, D.L.; Hirschfeld, R.; Thase, M.E.; Russell, J.; Bruce Lydiard, R.; Crits-Christoph, P.; Gallop, R.; Todd, L.; Hellerstein, D.; Goodnick, P.; Keitner, G.; Stahl, S.M.; Halbreich, U.
Effectiveness of St. John's wort in major depression
A randomized controlled trial
JAMA, 2001, 285(15), 1978-1986
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
8 Whiskey, E.; Werneke, U.; Taylor, D.
A systematic review and meta-analysis of Hypericum perforatum in depression
A comprehensive clinical review
Int Clin Psychopharmacol, 2001, 16, 239-252
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Systematic review
9 Lecrubier, Y.; Clerc, G.; Didi, R.; Kieser, M.
Efficacy of St. John´s Wort Extract WS 5570 in Major Depression
A Double-Blind, Placebo-Controlled Trial
Am J Psych, 2002, 159 (8), 1361-1366
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
10 Kasper, S.; Dienel, A.
Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients
A meta-analysis of data from three randomized, placebo-controlled trials
Psychopharmacol, 2002, 164, 301-308
Chemistry, Cluster, Depression, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Physical Chemistry, Phytomedicine, Mental diseases
11 Akhondzadeh, S.; Kashani, L.; Fotouhi, A.; Jarvandi, S.; Mobaseri, M.; Moin, M.; Khani, M.; Jamshidi, A.H.; Baghalian, K.; Taghizadeh, M.
Comparison of Lavandula angustifolia Mill. tincture and imiopramine in the treatment of mild to moderate depression
A double-blind, randomized trial
Prog Neuropsychopharmacol Biol Psychiatry, 2003, 27, 123-127
Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
12 Hammerness, P.; Brasch, E.; Ulbricht, E.; Barrette, E.P.; Foppa, I.; Basch, S.; Bent, S.; Boon, H.; Ernst, E.
St. John's wort: A systematic review of adverse effects and drug interactions for the consultation psychiatrist
Psychosomatics, 2003, 44(4), 271-282
Anxiety, Arzneimittelwechselwirkung, Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review, Adverse effect
13 Akhondzadeh, S.; Fallah-Pour, H.; Afkham, K.; Jamshidi, A.-H.; Khalighi-Cigaroudi, F.
Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression
A pilot double-blind randomized trial
BMC Complement Altern Med, 2004, 4(12), 1-17 (Internet)
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
14 Röder, C.; Schaefer, M.; Leucht, S.
Meta-Analyse zu Wirksamkeit und Verträglichkeit der Behandlung der leichten und mittelschweren Depression mit Johanniskraut
Fortschr Neurol Psychiatr, 2004, 72(6), 330-343
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Adverse effect
15 Linde, K.; Knüppel, L.
Large-scale observational studies of hypericum extracts in patients with depressive disorders
A systematic review
Phytomed, 2005, 12(1-2), 148-157
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
16 Thompson, R.; Ruch, W.; Hasenöhrl, R.U.
Enhanced cognitive performance and cheerful mood by standardised extracts of Piper methysteticum (Kava-kava)
Hum Psychopharmacol, 2004, 19, 243-250
Depression, Healthy probands, Kava, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
17 Werneke, U.; Horn, O.; Taylor, D.M.
How effective is St John's wort?
The evidence revisited
J Clin Psych, 2004, 65, 611-617
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
18 Murck, H.; Fava, M.; Alpert, J.; Nierenberg, A.A.; Mischoulon, D.; Otto, M.W.; Zajecka, J.; Mannel, M.; Rosenbaum, J.F.
Hypericum extract in patients with MDD and reversed vegetative signs
Re-analysis form data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
Int J Neuropsychopharmacol, 2004, 7, 1-7
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
19 Trautmann-Sponsel, R.D.; Dinel, A.
Safety of Hypericum extract in mildly to moderately depressed outpatients
A review on data from three randomized, placebo-controlled trials
J Affect Disord, 2004, 82, 303-307
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Review (CR)
20 Gelenberg, A.J.; Shelton, R.C.; Crits-Christoph, P.; Keller, M.B.; Dunner, D.L.; Hirschfeld, R.M.A.; Thase, M.E.; Russell, J.M.; Lydiard, R.B.; Gallop, R.J.; Todd, L.; Hellerstein, D.J.; Goodnick, P.J.; Keitner, G.I.; Stahl, S.M.; Halbreich, U.; Hopkins H.S.
The effectiveness of St.John's Wort in major depressive disorder
A naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
J Clin Psych, 2004, 65(8), 1114-1119
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
21 Szegedi, A.; Kohnen, R.; Dienel, A.; Kieser, M.
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St. John's wort): randomised controlled double blind non-inferiority trial versus paroxetine
BMJ, 2005, 330, 503-507
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
22 Linde, K.; Berner, M.; Egger, M.; Mulrow, C.
St John's wort for depression
Meta-analysis of randomised controlled trials
Brit J Psychiatry, 2005, 186, 99-107
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
23 Knüppel, L.; Linde, K.
Adverse effects of St. John's wort
A systematic review
J Clin Psych, 2004, 65, 1470-1479
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review, Adverse effect
24 Noorbala, A.A.; Akhondzadeh, S.; Tahmacebi-Poura, N.; Jamshidib, A.H.
Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression
A double-blind, randomized pilot trial
J Ethnopharmacol, 2005, 97, 281-284
Crocus, Depression, Ethnopharmacology, Clinical research, Complementary and alternative medicine, Pharmacology, Phytomedicine, Mental diseases, Randomized trial
25 Bjerkenstedt, L.; Edman, G.V.; Alken, R.G.; Mannel, M.
Hypericum extract LI 160 and fluoxetine in mild to moderate depression
A randomized, placebo-controlled multi-center study in outpatients
Eur Arch Psychiatry Clin Neurosci, 2005, 255, 40-47
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
26 Johnson, S.K.; Diamond, B.J.; Rausch, S.; Kaufman, M.; Shiflett, S.C.; Graves, L.
The effect of Ginkgo biloba on functional measures in multiple sclerosis
A pilot randomized controlled trial
Explore, 2006, 2(1), 19-24
Anxiety, Chronic fatigue syndrome, Depression, Ginkgo, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
27 Fava, M.; Alpert, J.; Nierenberg, A.A.; Mischoulon, D.; Otto, M.W.; Zajecka, J., Murck, H.; Rosenbaum, J.F.
A double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
J Clin Psychopharmacol, 2005, 25(5), 441-447
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
28 Randlov, C.; Mehlsen, J.; Thomsen, C.F.; Hedman, C.; Fircks, H. von; Winther, K.
The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia - a double-blind placebo-controlled study
Phytomed, 2006, 13(4), 215-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
29 Moreno, R.A.; Teng, C.T.; Almeida, K.M.; Tavares Junior, H.
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression
A randomized double-blind trial in a Brazilian sample
Rev Bras Psiquiatr, 2006, 28, 29-32
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
30 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Dienel, A.; Kieser, M.
Multizentrische, doppelblinde, plazebokontrollierte und randomisierte Studie zur Wirksamkeit von Johanniskrautextrakt WS 5570 bei Patienten mit leichten oder mittelschweren Formen einer Depression
Z Phytother, 2006, 27(Kongressband), S10
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
31 Anghelescu, I.G.; Kohnen, R.; Szegedi, A.; Klement, S.; Kieser, M.
Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression
Results from a randomized multicenter study
Pharmacopsychiatry, 2006, 39(6), 213-219
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
32 Moshiri, E.; Basti, A.A.; Noorbala, A.A.; Jamshidi, A.H.; Hesameddin, Abbasi S.; Akhondzadeh, S.
Crocus sativus L. (petal) in the treatment of mild-to-moderate depression
A double-blind, randomized and placebo-controlled trial
Phytomed, 2006, 13(9-10), 607-611
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
33 Pilkington, K.; Boshnakova, A.; Richardson, J.
St. John's wort for depression
Time for a different perspective?
Complement Ther Med, 2006, 14(4), 268-281
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
34 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Szegedi, A.; Dienel, A.; Kieser, M.
Superior efficacy of St Johns wort extract WS(R) 5570 compared to placebo in patients with major depression
A randomized, double-blind, placebo-controlled, multi-center trial
BMC Med, 2006, 4, 14; (1-13)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
35 Omer, B.; Krebs, S.; Omer, H.; Noor, T.O.
Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease
A double-blind placebo-controlled study
Phytomed, 2007, 14(2-3), 87-95
Artemisia, Artemisia absinthium, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
36 Blohmer, J.-U.; Graubaum, H.-J.; Busch, R.; Grünwald, J.; Wernecke, K.-D.; Uebelhack, R.
Cimicifuga und Hypericum als fixe Kombination gegen psychische Wechseljahresbeschwerden
Placebokontrollierte Doppelblindstudie mit 301 Patientinnen
Z Phytother, 2007, 28(2), 67-70
Black cohosh, Depression, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
37 Wilkinson, S.M.; Love, S.B.; Westcombe, A.M.; Gambles, M.A.; Burgess, C.C.; Cargill, A.; Young, T.; Maher, J.; Ramirez, A.J.
Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer
A multicenter randomized controlled trial
J Clin Oncol, 2007, 25(5), 532-539
Anxiety, Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
38 Eckmann, F.
Hirnleistungsstörungen - Behandlung mit Ginkgo-biloba-Extrakt
Zeitpunkt des Wirkungseintritts in einer Doppelblindstudie mit 60 stationären Patienten
Fortschr Med, 1990, 108(29), 557-560
Depression, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
39 Kasper, S.; Anghelescu, I.-G.; Szegedi, A.; Dienel, A.; Kieser, M.
Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode
WMW, 2007, 157(13-14), 362-366
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
40 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.P.; Dienel, A.; Kieser, M.
Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression
A reanalysis of data from controlled clinical trials
Eur Arch Psychiatry Clin Neurosci, 2008, 258(1), 59-63
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
41 Papakostas, G.I.; Crawford, C.M.; Scalia, M.J.; Fava, M.
Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder
A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine
Neuropsychobiology, 2007, 56(2-3), 132-137
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
42 Calabrese, C.; Gregory, W.L.; Leo, M.; Kraemer, D.; Bone, K.; Oken, B.
Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly
A randomized, double-blind, placebo-controlled trial
J Altern Complement Med, 2008, 14(6), 707-713
Anxiety, Bacopa monnieri, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
43 Li, L.T.; Wang, S.H.; Ge, H.Y.; Chen, J.; Yue, S.W.; Yu, M.
The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) and fluoxetine on post-stroke depression
J Altern Complement Med, 2008, 14(7), 841-846
Angelica, Angelica sinensis, Atractylodes, Atractylodes macrocephala, Bupleurum, Bupleurum chinense, Depression, Glycyrrhiza, Glycyrrhiza uralensis, Cardiovascular diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lilium, Lilium brownii var. colchesteri, Mentha, Mentha haplocalyx, Paeonia, Paeonia lactiflora, Phytomedicine, Placebo-controlled, Poria, Poria cocos, Mental diseases, Randomized trial, Rehmannia glutinosa, sage, Salvia miltiorrhiza, Stroke, ginger
44 Linde, K.; Berner, M.M.; Kriston, L.
St. John's wort for major depression
Cochrane Database Syst Rev, 2008, 4(CD000448), 1-147
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
45 Uebelhack, R.; Gruenwald, J.; Graubaum, H.J.; Busch, R.
Efficacy and tolerability of Hypericum extract STW 3-VI in patients with moderate depression
A double-blind, randomized, placebo-controlled clinical trial
Adv Ther, 2004, 21(4), 265-275
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
46 Gastpar, M.; Singer, A.; Zeller, K.
Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression
A double-blind, randomised, multicentre, placebo-controlled study
Pharmacopsychiatry, 2006, 39(2), 66-75
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Conventional medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
47 Rahimi, R.; Nikfar, S.; Abdollahi, M.
Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors
A meta-analysis
Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33(1), 118-127
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
48 Darbinyan, V.; Aslanyan, G.; Amroyan, E.; Gabrielyan, E.; Malmström, C.; Panossian, A.
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression
Nord J Psychiatry, 2007, 61(5), 343-348
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
49 Sarris, J.; Kavanagh, D. J.; Adams, J.; Bone, K.; Byrne, G.
Kava Anxiety Depression Spectrum Study (KADSS)
A mixed methods RCT using an aqueous extract of Piper methysticum
Complement Ther Med, 2009, 17(3), 176-178
Anxiety, Depression, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
50 Costa Miranda, V. da; Trufelli, D.C.; Santos, J.; Campos, M.P.; Nobuo, M.; Costa Miranda, M. da; Schlinder, F.; Riechelmann, R.; Giglio, A. del
Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression
Results of a pilot double-blind randomized study
J Altern Complement Med, 2009, 15(4), 431-433
Chronic fatigue syndrome, Depression, Guarana, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
51 Sarris, J.; Kavanagh, D.J.
Kava and St. John's Wort
Current evidence for use in mood and anxiety disorders
J Altern Complement Med, 2009, 15(8), 827-836
Anxiety, Depression, Hypericum, St John's wort, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Mental diseases, Systematic review
52 Bann, C.M.; Parker, C.B.; Bradwejn, J.; Davidson, J.R.; Vitiello, B.; Gadde, K.M.
Assessing patient beliefs in a clinical trial of Hypericum perforatum in major depression
Depress Anxiety, 2004, 20(3), 114-122
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
53 Sarris, J.; Kavanagh, D.J.; Byrne, G.; Bone, K.M.; Adams, J.; Deed, G.
The Kava Anxiety Depression Spectrum Study (KADSS)
A randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
Psychopharmacol, 2009, 205(3), 399-407
Anxiety, Depression, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
54 Lipovac, M.; Chedraui, P.; Gruenhut, C.; Gocan, A.; Stammler, M.; Imhof, M.
Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extract
Maturitas, 2010, 65(3), 258-261
Anxiety, Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Mental diseases, Randomized trial, Trifolium, Trifolium pratense
55 Wan, H.; Chen, Y.
Effects of antidepressive treatment of Saint John's wort extract related to autonomic nevous function in women with irritable bowel syndrome
Int J Psychiatry Med, 2010, 40(1), 45-56
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases, Irritable bowel syndrome, Vegetative nervous system
56 Kasper, S.; Gastpar, M.; Möller, H.J.; Müller, W.E.; Volz, H.P.; Dienel, A.; Kieser, M.
Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs
A reanalysis of data from controlled clinical trials in acute major depression
Int Clin Psychopharmacol, 2010, 25(4), 204-213
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
57 Zubeldia, J.M.; Nabi, H.A.; Jiménez, del Rio, M.; Genovese, J.
Exploring new applications for Rhodiola rosea
Can we improve the quality of life of patients with short-term hypothyroidism induced by hormone withdrawal?
J Med Food, 2010, 13(6), 1287-1292
Depression, Hypothyreodism, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Thyroid cancer, Metabolic diseases
58 Dwyer, A.V.; Whitten, D.L.; Hawrelak, J.A.
Herbal medicines, other than St. John's Wort, in the treatment of depression
A systematic review
Altern Med Rev, 2011, 16(1), 40-49
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
59 Honarmand, K.; Tierney, M.C.; O'Connor, P.; Feinstein, A.
Effects of cannabis on cognitive function in patients with multiple sclerosis
Neurology, 2011, 76(13), 1153-1160
Anxiety, Cannabis, Depression, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases
60 Singer, A.; Schmidt, M.; Hauke, W.; Stade, K.
Duration of response after treatment of mild to moderate depression with Hypericum extract STW 3-VI, citalopram and placebo
A reanalysis of data from a controlled clinical trial
Phytomed, 2011, 18(8-9), 739-742
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
61 Ulbricht, C.; Chao, W.; Tanguay-Colucci, S.; Conquer, J.; Costa, D.; Culwell, S.; Giese, N.; Higdon, E.R.B.; Isaac, R.; Kaltenbach, M.; Kligler, B.; Laster, R.; Liu, Y.; McCarthy, M.; Nachum, B.; Nummy, K.; Redwanski, J.; Rusie, E.; Windsor, R.; Wojcik, G.J.; Zhou, S.
Rhodiola (Rhodiola spp.)
An evidence-based systematic review by the Natural Standard Research Collaboration
Altern Compl Ther, 2011, 17(2), 110-119
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola, Systematic review
62 Oliveira Campos, M.P. de; Riechelmann, R.; Martins, L.C.; Hassan, B.J.; Casa, F.B.; Del Giglio A.
Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy
J Altern Complement Med, 2011, 17(6), 505-512
Anxiety, Breast cancer, Chronic fatigue syndrome, Depression, Guarana, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
63 Akhondzadeh Basti, A.; Moshiri, E.; Noorbala, A.A.; Jamshidi, A.H.; Abbasi, S.H.; Akhondzadeh, S.
Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients
A pilot double-blind randomized trial
Prog Neuropsychopharmacol Biol Psychiatry, 2007, 31(2), 439-442
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
64 Akhondzadeh, S.; Tahmacebi-Pour, N.; Noorbala, A.A.; Amini, H.; Fallah-Pour, H.; Jamshidi, A.H.; Khani, M.
Crocus sativus L. in the treatment of mild to moderate depression
A double-blind, randomized and placebo-controlled trial
Phytother Res, 2005, 19(2), 148-151
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
65 Rapaport, M.H.; Nierenberg, A.A.; Howland, R.; Dording, C.; Schettler, P.J.; Mischoulon, D.
The treatment of minor depression with St. John's wort or citalopram
Failure to show benefit over placebo
J Psychiatr Res, 2011, 45(7), 931-941
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
66 Hongratanaworakit, T.
Aroma-therapeutic effects of massage blended essential oils on humans
Nat Prod Commun, 2011, 6(8), 1199-1204
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Nervous system, Non-randomized trial, Phytomedicine, Placebo-controlled, Mental diseases, Vegetative nervous system
67 Dimpfel, W.; Koch, K.; Weiss, G.
Early effect of NEURAPAS ((R)) balance on current source density (CSD) of human EEG
BMC Psychiatry, 2011, 11, 123; (1-15)
Anxiety, Depression, Brain, Healthy probands, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Neurapas balance, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress
68 Agosta, C.; Atlante, M.; Benvenuti, C.
Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause
Minerva Ginecol, 2011, 63(1), 11-18
Anxiety, Borderline syndrome, Calciferol, Calcium, Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lactobacillus spec., Lactobacillus sporogenes, Magnolia, Magnolia officinalis, Menopause, Microbiological therapy, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
69 Conrad, P.; Adams, C.
The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman
A pilot study
Complement Ther Clin Pract, 2012, 18(3), 164-168
Anxiety, Aromatherapy, Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Obstetrics
70 Serfaty, M.; Wilkinson, S.; Freeman, C.; Mannix, K.; King, M.
The ToT study: helping with Touch or Talk (ToT)
A pilot randomised controlled trial to examine the clinical effectiveness of aromatherapy massage versus cognitive behaviour therapy for emotional distress in patients in cancer/palliative care
Psychooncol, 2012, 21(5), 563-569
Anxiety, Aromatherapy, Depression, Clinical research, Cognitive behavioral therapy, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Palliative care, Phytomedicine, Mental diseases, Psychology/psychotherapy, Randomized trial, Stress
71 Amsterdam, J.D.; Shults, J.; Soeller, I.; Mao, J.J.; Rockwell, K.; Newberg, A.B.
Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans
An exploratory study
Altern Ther Health Med, 2012, 18(5), 44-49
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
72 Taavoni, S.; Darsareh, F.; Joolaee, S.; Haghani, H.
The effect of aromatherapy massage on the psychological symptoms of postmenopausal Iranian women
Complement Ther Med, 2013, 21(3), 158-163
Anxiety, Aromatherapy, Depression, Geranium, Gynaecology, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Menopause, Phytomedicine, Mental diseases, Randomized trial, Rosa, rosemary
73 Hausenblas, H.A.; Saha, D.; Dubyak, P.J.; Anton, S.D.
Saffron (Crocus sativus L.) and major depressive disorder
A meta-analysis of randomized clinical trials
J Integr Med, 2013, 11(6), 377-383
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
74 Nell, H.; Siebert, M.; Chellan, P.; Gericke, N.
A randomized, double-blind, parallel-group, placebo-controlled trial of extract Sceletium tortuosum (Zembrin) in healthy adults
J Altern Complement Med, 2013, 19(11), 898-904
Anxiety, Depression, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, posology, Mental diseases, Randomized trial, Sceletium tortuosum
75 Sanmukhani, J.; Satodia, V.; Trivedi, J.; Patel, T.; Tiwari, D.; Pachal, B.; Goel, A.; Tripathi, C.B.
Efficacy and safety of curcumin in major depressive disorder
A randomized controlled trial
Phytother Res, 2014, 28, 579-585
Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
76 Nishimatsu, H.; Kitamura, T.; Yamada, D.; Nomiya, A.; Niimi, A.; Suzuki, M.; Fujimura, T.; Fukuhara, H.; Nakagawa, T.; Enomoto, Y.; Kume, H.; Igawa, Y.; Homma, Y.
Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic exract and other five of natural medicines
Comparison with traditional herbal medicines (Kampo)
Aging Male, 2014, 17(2), 112-116
Andrology, Depression, Erectile disorder, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
77 Stojanovska, L.; Law, C.; Lai, B.; Chung, T.; Nelson, K.; Day, S.; Apostolopoulos, V.; Haines, C.
Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Climacteric, 2015, 18(1), 69-78
High blood pressure, Depression, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
78 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.-P.; Möller, H.-J.; Schläfke, S.; Dienel, A.
Lavender oil preparation Silexan is effective in generalized anxiety disorder
A randomized, double-blind comparison to placebo and paroxetine
Int J Neuropsychopharmacol, 2014, epub ahead of print,
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
79 Liu, L.-Y.; Feng, B.; Chen, J.; Tan, Q.-R.; Chen, Z.-X.; Chen, W.-S.; Wang, P.-R.; Zhang, Z.-J.
Herbal medicine for hospitalized patients with severe depressive episode
A retrospective controlled study
J Affect Disord, 2015, 170, 71-77
Depression, Clinical research, Complementary and alternative medicine, Hospital, Non-randomized trial, Phytomedicine, Practice, Mental diseases, Retrospective design
80 Shahmansouri, N.; Farokhnia, M.; Abbasi, S.H.; Kassaian, S.E.; Noorbala Tafti, A.A.; Gougol, A.; Yekehtaz, H.; Forghani, S.; Mahmoodian, M.; Saroukhani, S.; Arjmandi-Beglar, A.; Akhondzadeh, S.
A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients
J Affect Disord, 2014, 155, 216-222
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
81 Firoozabadi, A.; Salehi, A.; Jahanbin, S.; Mohagheghzadeh, A.
Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression
A triple-blind randomized controlled trial study
J Evid Based Compl Altern Med, 2015, 20(2), 94-97
Cuscuta, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Cuscuta planiflora, Nepeta menthoides
82 Mao, J.J.; Li, Q.S.; Soeller, I.; Xie, S.X.; Amsterdam, J.D.
Rhodiola rosea therapy for major depressive disorder
A study protocol for a randomized, double-blind, placebo-controlled trial
J Clin Trials, 2014, 4(3), 170; (1-7) (Studienprotokoll)
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
83 Dording, C.M.; Schettler, P.J.; Dalton, E.D.; Parkin, S.R.; Walker, R.S.W.; Fehling, K.B.; Fava, M.; Mischoulon, D.
A double-blind placebo-controlled trial of Maca root as treatment for antidepressant-induced sexual dysfunction in women
eCAM, 2015, Article ID 949036, (1-9)
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sexual dysfunktion (female)
84 Mao, J.J.; Xie, S.X.; Zee, J.; Soeller, I.; Li, Q.S.; Rockwell, K.; Amsterdam, J.D.
Rhodiola rosea versus sertraline for major depressive disorder
A randomized placebo-controlled trial
Phytomed, 2015, 22(3), 394-399
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
85 Tang, S.K.; Tse, M.Y.M.
Aromatherapy: Does it help to relieve pain, depression, anxiety, and stress in community-dwelling older persons?
Biomed Res Int, 2014, Article ID 430195, (1-12)
Anxiety, Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Non-randomized trial, Phytomedicine, Mental diseases, Pain, Stress, Inhalation
86 Talaei, A.; Hassanpour Moghadam, M.; Sajadi Tabassi, S.A.; Mohajeri, S.A.
Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder
A randomized, double-blind, placebo-controlled, pilot clinical trial
J Affect Disord, 2015, 174, 51-56
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
87 Panahi, Y.; Badeli, R.; Karami, G.R.; Badeli, Z.; Sahebkar, A.
A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder
Complement Ther Med, 2015, 23(4), 598-602
Antioxidants, Chlorella, Chlorella vulgaris, Depression, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Mental diseases, Randomized trial
88 Chen, S.-L.; Chen, C.-H.
Effects of lavender tea on fatigue, depression, and maternal-infant attachement in sleep-disturbed postnatal women
Worldviews Evid Based Nurs, 2015, 12(6), 370-379
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
89 Cropley, M.; Banks, A.P.; Boyle, J.
The effects of Rhodolia rosea L. extract on anxiety, stress, cognition and other mood symptoms
Phytother Res, 2015, 29(12), 1934-1939
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
90 Lopresti, A.L.; Maes, M.; Maker, G.L.; Hood, S.D.; Drummond, P.D.
Curcumin for the treatment of major depression
A randomised, double-blind, placebo controlled study
J Affect Disord, 2014, 167, 368-375
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
91 Lopresti, A.L.; Maes, M.; Meddens, M.J.M.; Maker, G.L.; Arnoldussen, E.; Drummond, P.D.
Curcumin and major depression
A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change
Eur Neuropsychopharmacol, 2015, 25, 38-50
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Mechanism of action
92 Al-Karawi, D.; Al Mamoori, D.A.; Tayyar, Y.
The role of curcumin administration in patients with major depressive disorder
Mini meta-analysis of clinical trials
Phytother Res, 2016, 30(2), 175-183
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
93 Mosaffa-Jahromi, M.; Tamaddon, A.-M.; Afsharypuor, S.; Salehi, S.H.; Pasalar, M.; Jafari, P.; Lankarani, K.B.
Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome
A randomized active and placebo-controlled clinical trial
J Evid Based Compl Altern Med, 2017, 22(1), 41-46
Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Pimpinella, Pimpinella anisum, Placebo-controlled, Mental diseases, Randomized trial, Irritable bowel syndrome
94 Mazidi, M.; Shemshian, M.; Mousavi, S.H.; Norouzy, A.; Kermani, T.; Moghiman, T.; Sadeghi, A.; Mokhber, N.; Ghayour-Mobarhan, M.; Ferns, G.A.A.
A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression
J Complement Integr Med, 2016, 13(2), 195-199
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
95 Prichard, C.; Newcomb, P.
Benefit to family members of delivering hand massage with essential oils to critically ill patients
Am J Crit Care, 2015, 24(5), 446-449
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Non-randomized trial, Phytomedicine, Mental diseases, Intensivmedizin
96 Lopresti, A.L.; Drummond, P.D.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression
A randomised, double-blind, placebo-controlled study
J Affect Disord, 2017, 207, 188-196
Crocus, Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
97 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
98 Apaydin, E.A.; Maher, A.r.; Shanman, R.; Booth, M.S.; Miles, J.N.V.; Sorbero, M.E.; Hempel, S.
A systematic review of St. John’s wort for major depressive disorder
Syst Rev, 2016, 5, 148; (1-25)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
99 Ng, Q.X.; Venkatanarayanan, N.; Ho, C.Y.
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
100 Sayeed, M.S.B.; Shams, T.; Hossain, S.F.; Rahman, R.; Mostofa, A.G.M.; Kadir, M.F.; Mahmood, S.; Asaduzzaman, -
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
J Ethnopharmacol, 2014, 152, 156-162
Anxiety, Depression, Brain, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Nigella sativa, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial