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101 Terauchi, M.; Hiramitsu, S.; Akiyoshi, M.; Owa, Y.; Kato, K.; Obayashi, S.; Matsushima, E.; Kubota, T.
Effects of the Kampo formula Tokishakuyakusan on headaches and concomitant depression in middle-aged women
eCAM, 2014, Article ID 593560, (1-8)
Observational trial, Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Headache, Menopause, Nervous system, Phytomedicine, Mental diseases, Toki-shakuyaku-san, Traditional Japanese medicine
102 Sanmukhani, J.; Satodia, V.; Trivedi, J.; Patel, T.; Tiwari, D.; Pachal, B.; Goel, A.; Tripathi, C.B.
Efficacy and safety of curcumin in major depressive disorder
A randomized controlled trial
Phytother Res, 2014, 28, 579-585
Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
103 Nishimatsu, H.; Kitamura, T.; Yamada, D.; Nomiya, A.; Niimi, A.; Suzuki, M.; Fujimura, T.; Fukuhara, H.; Nakagawa, T.; Enomoto, Y.; Kume, H.; Igawa, Y.; Homma, Y.
Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic exract and other five of natural medicines
Comparison with traditional herbal medicines (Kampo)
Aging Male, 2014, 17(2), 112-116
Andrology, Depression, Erectile disorder, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
104 Stojanovska, L.; Law, C.; Lai, B.; Chung, T.; Nelson, K.; Day, S.; Apostolopoulos, V.; Haines, C.
Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Climacteric, 2015, 18(1), 69-78
High blood pressure, Depression, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
105 Fißler, M.; Quante, A.
A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety
Complement Ther Med, 2014, 22(1), 63-69
Anxiety, Aromatherapy, Observational trial, Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Retrospective design, Sleep disorders
106 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.-P.; Möller, H.-J.; Schläfke, S.; Dienel, A.
Lavender oil preparation Silexan is effective in generalized anxiety disorder
A randomized, double-blind comparison to placebo and paroxetine
Int J Neuropsychopharmacol, 2014, epub ahead of print,
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
107 Shahmansouri, N.; Farokhnia, M.; Abbasi, S.H.; Kassaian, S.E.; Noorbala Tafti, A.A.; Gougol, A.; Yekehtaz, H.; Forghani, S.; Mahmoodian, M.; Saroukhani, S.; Arjmandi-Beglar, A.; Akhondzadeh, S.
A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients
J Affect Disord, 2014, 155, 216-222
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
108 Firoozabadi, A.; Salehi, A.; Jahanbin, S.; Mohagheghzadeh, A.
Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression
A triple-blind randomized controlled trial study
J Evid Based Compl Altern Med, 2015, 20(2), 94-97
Cuscuta, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Cuscuta planiflora, Nepeta menthoides
109 Mao, J.J.; Li, Q.S.; Soeller, I.; Xie, S.X.; Amsterdam, J.D.
Rhodiola rosea therapy for major depressive disorder
A study protocol for a randomized, double-blind, placebo-controlled trial
J Clin Trials, 2014, 4(3), 170; (1-7) (Studienprotokoll)
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
110 Dording, C.M.; Schettler, P.J.; Dalton, E.D.; Parkin, S.R.; Walker, R.S.W.; Fehling, K.B.; Fava, M.; Mischoulon, D.
A double-blind placebo-controlled trial of Maca root as treatment for antidepressant-induced sexual dysfunction in women
eCAM, 2015, Article ID 949036, (1-9)
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sexual dysfunktion (female)
111 Mao, J.J.; Xie, S.X.; Zee, J.; Soeller, I.; Li, Q.S.; Rockwell, K.; Amsterdam, J.D.
Rhodiola rosea versus sertraline for major depressive disorder
A randomized placebo-controlled trial
Phytomed, 2015, 22(3), 394-399
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
112 Talaei, A.; Hassanpour Moghadam, M.; Sajadi Tabassi, S.A.; Mohajeri, S.A.
Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder
A randomized, double-blind, placebo-controlled, pilot clinical trial
J Affect Disord, 2015, 174, 51-56
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
113 Panahi, Y.; Badeli, R.; Karami, G.R.; Badeli, Z.; Sahebkar, A.
A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder
Complement Ther Med, 2015, 23(4), 598-602
Antioxidants, Chlorella, Chlorella vulgaris, Depression, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Mental diseases, Randomized trial
114 Osório, F. de L.; Sanches, R.F.; Macedo, L.R.; Santos, R.G.; Maia-de-Oliveira, J.P.; Wichert-Ana, L.; Araujo, D.B. de; Riba, J.; Crippa, J.A.; Hallak, J.E.
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression
A preliminary report
Rev Bras Psiquiatr, 2015, 37, 13-20
yage, Observational trial, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases
115 Chen, S.-L.; Chen, C.-H.
Effects of lavender tea on fatigue, depression, and maternal-infant attachement in sleep-disturbed postnatal women
Worldviews Evid Based Nurs, 2015, 12(6), 370-379
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
116 Cropley, M.; Banks, A.P.; Boyle, J.
The effects of Rhodolia rosea L. extract on anxiety, stress, cognition and other mood symptoms
Phytother Res, 2015, 29(12), 1934-1939
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
117 Lopresti, A.L.; Maes, M.; Maker, G.L.; Hood, S.D.; Drummond, P.D.
Curcumin for the treatment of major depression
A randomised, double-blind, placebo controlled study
J Affect Disord, 2014, 167, 368-375
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
118 Lopresti, A.L.; Maes, M.; Meddens, M.J.M.; Maker, G.L.; Arnoldussen, E.; Drummond, P.D.
Curcumin and major depression
A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change
Eur Neuropsychopharmacol, 2015, 25, 38-50
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Mechanism of action
119 Al-Karawi, D.; Al Mamoori, D.A.; Tayyar, Y.
The role of curcumin administration in patients with major depressive disorder
Mini meta-analysis of clinical trials
Phytother Res, 2016, 30(2), 175-183
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
120 Mosaffa-Jahromi, M.; Tamaddon, A.-M.; Afsharypuor, S.; Salehi, S.H.; Pasalar, M.; Jafari, P.; Lankarani, K.B.
Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome
A randomized active and placebo-controlled clinical trial
J Evid Based Compl Altern Med, 2017, 22(1), 41-46
Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Pimpinella, Pimpinella anisum, Placebo-controlled, Mental diseases, Randomized trial, Irritable bowel syndrome
121 Mazidi, M.; Shemshian, M.; Mousavi, S.H.; Norouzy, A.; Kermani, T.; Moghiman, T.; Sadeghi, A.; Mokhber, N.; Ghayour-Mobarhan, M.; Ferns, G.A.A.
A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression
J Complement Integr Med, 2016, 13(2), 195-199
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
122 Lopresti, A.L.; Drummond, P.D.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression
A randomised, double-blind, placebo-controlled study
J Affect Disord, 2017, 207, 188-196
Crocus, Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
123 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
124 Li, F.-D.; He, F.; Ye, X.-J.; Shen, W.; Wu, Y.-P.; Zhai, Y.-J.
Tea consumption is inversely associated with depressive symptoms in the elderly
A cross-sectional study in eastern China
J Affect Disord, 2016, 189, 157-162
Observational trial, Camellia, Camellia sinensis, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Tea, Green Tea, Black tea
125 Ng, Q.X.; Venkatanarayanan, N.; Ho, C.Y.
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
126 Sayeed, M.S.B.; Shams, T.; Hossain, S.F.; Rahman, R.; Mostofa, A.G.M.; Kadir, M.F.; Mahmood, S.; Asaduzzaman, -
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
J Ethnopharmacol, 2014, 152, 156-162
Anxiety, Depression, Brain, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Nigella sativa, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
127 Kell, G.; Rao, A.; Beccaria, G.; Clayton, P.; Inarejos-García, A.M.; Prodanov, M.
affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.
Complement Ther Med, 2017, 33, 58-64
Crocus, Depression, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
128 Firoozabadi, A.; Kolouri, S.; Zarshenas, M.M.; Salehi, A.; Mosavat, S.H.; Dastgheib, S.A.
Efficacy of a freeze-dried aqueous extract of Nepeta menthoides Boiss. and Buhse in the treatment of anxiety in patients with depression
A double-blind, randomized, controlled trial
J Herbal Med, 2017, 10, 17-23
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Nepeta menthoides
129 Yang, Y.-P.; Wang, C.-J.; Wang, J.-J.
Effect of aromatherapy massage on agitation and depressive mood in individuals with dementia
J Gerontol Nurs, 2016, 42(9), 38-46
Aromatherapy, Chamomilla, Citrus, Citrus sinensis, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Nervous system, Phytomedicine, Mental diseases, Randomized trial
130 Nematolahi, P.; Mehrabani, M.; Karami-Mohajeri, S.; Dabaghzadeh, F.
Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students
A randomized clinical trial
Complement Ther Clin Pract, 2018, 30, 24-28
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, rosemary, Sleep disorders
131 Ghajar, A.; Neishabouri, S.M.; Velayati, N.; Jahangard, L.; Matinnia, N.; Haghighi, M.; Ghaleiha, A.; Afarideh, M.; Salimi, S.; Meysamie, A.; Akhondzadeh, S.
Crocus sativus L. versus Citalopram in the treatment of major depressive disorder with anxious distress
A double-blind, controlled clinical trial
Pharmacopsychiatry, 2017, 50(4), 152-160
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
132 Ng, Q.X.; Koh, S.S.H.; Chan, H.W.; Ho, C.Y.X.
Clinical use of curcumin in depression
A meta-analysis
J Am Med Dir Assoc, 2017, 18(6), 503-508
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
133 Moazen-Zadeh, E.; Abbasi, S.H.; Safi-Aghdam, H.; Shahmansouri, N.; Arjmandi-Beglar, A.; Hajhosseinn Talasaz, A.; Salehiomran, A.; Forghani, S.; Akhondzadeh, S.
Effects of saffron on cognition, anxiety, and depression in patients undergoing coronary artery bypass grafting
A randomized double-blind placebo-controlled trial
J Altern Complement Med, 2018, 24(4), 361-368
Anxiety, Surgery, Crocus, Depression, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
134 Yang, X.; Chen, X.; Fu, Y.; Luo, Q.; Du, L.; Qiu, H.; Qiu, T.; Zhang, L.; Meng, H.
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults
A meta-analysis of randomized controlled trials
Neuropsychiatr Dis Treat, 2018, 14, 1297-1305
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
135 Bahrami, T.; Rejeh, N.; Heravi-Karimooi, M.; Vaismoradi, M.; Tadrisi, S.D.; Sieloff, C.
Effect of aromatherapy massage on anxiety, depression, and physiologic parameters in older patients with the acute coronary syndrome
A randomized clinical trial
Int J Nurs Pract, 2017, 23(6), e12601; (1-10)
Anxiety, Aromatherapy, Depression, Geriatrics, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Lavendula, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
136 Tóth, B.; Hegyi, P.; Lantos, T.; Szakács, Z.; Kerémi, B.; Varga, G.; Tenk, J.; Pétervári, E.; Balaskó, M.; Rumbus, Z.; Rakonczay, Z.; Bálint, E.R.; Kiss, T.; Csupor, D.
The efficacy of saffron in the treatment of mild to moderate depression
A meta-analysis
Planta Med, 2019, 85(1), 24-31
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
137 Paolo, B.; Massimo, B.; Stefano, S.
Complementary treatment of mood disturbances in terminally ill oncological patients with the aphanziomenon flos aquae extract Klamin®
Adv Complement Altern Med, 2018, 1(3), (1-5)
Anxiety, Observational trial, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Cancer, sea kelp, Sea remedies, Phytomedicine, Mental diseases
138 Ranjbar, M.; Firoozabadi, A.; Salehi, A.; Ghorbanifar, Z.; Zarshenas, M.M.; Sadeghniiat-Haghighi, K.; Rezaeizadeh, H.
Effects of herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. and Buhse) on insomnia severity, anxiety and depression in insomniacs
Randomized placebo controlled trial
Integr Med Res, 2018, 7(4), 328-332
Anxiety, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, lemon balm, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Nepeta menthoides
139 Ghazanfarpour, M.; Mohammadzadeh, F.; Shokrollahi, P.; Khadivzadeh, T.; Najaf Najafi, M.; Hajirezaee, H.; Afiat, M.
Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women
A double-blind randomised controlled trial
J Obstet Gynaecol, 2018, 38(1), 121-126
Anxiety, Depression, Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
140 Xiong, M.; Li, Y.; Tang, P.; Zhang, Y.; Cao, M.; Ni, J.; Xing, M.
Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults
J Altern Complement Med, 2018, 24(7), 717-724
Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Citrus sinensis, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Inhalation
141 Zwanzger, P.; Wacker, A.
Silexan bei somatischen Angstsymptomen
Z Phytother, 2017, 38 (Suppl.1), 44 (Abstract (Poster))
Anxiety, Depression, Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Meta-analysis, Ear noises, Phytomedicine, Mental diseases, Silexan
142 Milajerdi, A.; Jazayeri, S.; Shirzadi, E.; Hashemzadeh, N.; Azizgol, A.; Djazayery, A.; Esmaillzadeh, A.; Akhondzadeh, S.
The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus
A double-blind, randomized and placebo-controlled clinical trial
Complement Ther Med, 2018, 41, 196-202
Anxiety, Crocus, Depression, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases
143 Palhano-Fontes, F.; Barreto, D.; Onias, H.; Andrade, K.C.; Novaes, M.M.; Pessoa, J.A.; Mota-Rolim, S.A.; Osório, F.L.; Sanches, R.; Santos, R.G. dos; Tófoli, L.F.; Silveira, G.O. de; Yonamine, M.; Riba, J.; Santos, F.R.; Silva-Junior, A.A.; Alchieri, J.C.; Galvão-Coelho, N.L.; Lobão-Soares, B.; Hallak, J.C.; Arcoverde, E.; Maia-de-Oliveira, J.P.; Araújo, D.B.
Rapid antidrepressant effects of the psychedelic ayahuasca in treatment-resistant depression
A randomized placebo-controlled trial
Psychol Med, 2018, epub ahead of print, (epub)
yage, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial