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1 Linde, K.; Ramirez, G.; Mulrow, C.D.; Pauls, A.; Weidenhammer, W.; Melchart, D.
St John's wort for depression - an overview and meta-analysis of randomised clinical trials
BMJ, 1996, 313, 253-258
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
2 Volz, H.-P.; Kieser, M.
Kava-kava Extract WS 1490 versus Placebo in Anxiety Disorders
A Randomized Placebo-controlled 25-week Outpatient Trial
Pharmacopsychiatry, 1997, Artikel 765, Kittelberger (1), 1-5
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
3 Panossian, A.; Oganessian, A.S.; Ambartsumian, M.; Gabrielian, E.S.; Wagner, H.; Wikman, G.
Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva
Phytomed, 1999, 6(1), 17-26
Exercise therapy, Bryonia, Clinical research, Complementary and alternative medicine, Mind-body medicine, Lifestyle therapy, Physical therapy, Phytomedicine, Mental diseases, Randomized trial, Schizandra, Schizandra chinensis, Stress
4 Lenoir, S.; Degenring, F.H.; Saller, R.
A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hyericum perforatum L.
Phytomed, 1999, 6(3), 141-146
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
5 Philipp, M.; Kohnen, R.; Hiller, K.-O.
Hypericum extract versus imipramine or placebo in patients with moderate depression
Randomised multicentre study of treatment for eigth weeks
BMJ, 1999, 319, 1534-1539
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
6 Spasov, A.A.; Wikman, G.; Mandrikov, V.B.; Mironova, I.A.; Neumoin, V.V.
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen
Phytomed, 2000, 7(2), 85-89
Chronic fatigue syndrome, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
7 Pittler, M.H.; Ernst, E.
The Efficacy of Kava Extracts for Anxiety. A Systematic Review and Meta-Analysis
Evidence-Based Complementary Medicine: International Congress on Clinical Research and Quality Management in Complementary Medicine, Munich, April 6 to 8, 2000
Forsch Komplementärmed, 2000, 7(1), 49-50 (Abstract)
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Piper, Mental diseases, Review (CR)
8 Woelk, H.
Comparison of St John's wort and imipramine for treating depression
Randomised controlled trial
BMJ, 2000, 321, 536-539
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
9 Darbinyan, V.; Kteyan, A.; Panossian, A.; Gabrielian, E.; Wikman, G.; Wagner, H.
Rhodiola rosea in stress induced fatigue
A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty
Phytomed, 2000, 7(5), 365-372
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
10 Shebek, J.; Rindone, J.P.
A pilot study exploring the effect of kudzu root on the drinking habits of patients with chronic alcoholism
J Altern Complement Med, 2000, 6(1), 45-48
Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Addiction
11 Shelton, R.C.; Keller, M.B.; Gelenberg, A.; Dunner, D.L.; Hirschfeld, R.; Thase, M.E.; Russell, J.; Bruce Lydiard, R.; Crits-Christoph, P.; Gallop, R.; Todd, L.; Hellerstein, D.; Goodnick, P.; Keitner, G.; Stahl, S.M.; Halbreich, U.
Effectiveness of St. John's wort in major depression
A randomized controlled trial
JAMA, 2001, 285(15), 1978-1986
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
12 Dorn, M.
Wirksamkeit und Verträglichkeit von Baldrian versus Oxazepam bei nichtorganischen und nicht-psychiatrischen Insomnien: Eine randomisierte, doppelblinde, klinische Vergleichsstudie
Forsch Komplementärmed, 2000, 7, 79-84
Clinical research, Complementary and alternative medicine, Oxazeptan, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
13 Bradwejn, J.; Zhou, Y.; Koszycki, D.; Shlik, J.
A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
J Clin Psychopharmacol, 2000, 20, 680-684
Anxiety, Healthy probands, Hydrocotyle, Hydrocotyle asiatica, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
14 Francis, A.J.P.; Dempster, R.J.W.
Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial
Phytomed, 2002, 9(4), 273-279
ADHD, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Valeriana
15 Lecrubier, Y.; Clerc, G.; Didi, R.; Kieser, M.
Efficacy of St. John´s Wort Extract WS 5570 in Major Depression
A Double-Blind, Placebo-Controlled Trial
Am J Psych, 2002, 159 (8), 1361-1366
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
16 Wolfson, P.; Hoffmann, D.L.
An Investigation into the Efficacy of Scutellaria Lateriflora in Healthy Volunteers
Altern Ther Health Med, 2003, 9(2), 74-78
Anxiety, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Scutellaria, Scutellaria lateriflora
17 Shevtsov, V.A.; Zholus, B.I.; Shervarly, V.I.; Vol'skij, V.B.; Korovin, Y.P.; Khristich, M.P.; Roslyakova, N.A.; Wikman, G.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work
Phytomed, 2003, 10(2-3), 95-105
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
18 Boerner, R.J.; Sommer, H.; Berger, W.; Kuhn, U.; Schmidt, U.; Mannel, M.
Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in generalised anxiety disorder - An 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients
Phytomed, 2003, 10(suppl. IV), 38-49
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Mental diseases, Randomized trial
19 Kasper, S.; Dienel, A.
Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients
A meta-analysis of data from three randomized, placebo-controlled trials
Psychopharmacol, 2002, 164, 301-308
Chemistry, Cluster, Depression, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Physical Chemistry, Phytomedicine, Mental diseases
20 Cagnacci, A.; Arangino, S.; Renzi, A.; Zanni, A.L.; Malmusi, S.; Volpe, A.
Kava-kava administration reduces anxiety in perimenopausal women
Maturitas, 2003, 44, 103-109
Anxiety, Gynaecology, Kava, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Mental diseases, Randomized trial
21 Akhondzadeh, S.; Kashani, L.; Fotouhi, A.; Jarvandi, S.; Mobaseri, M.; Moin, M.; Khani, M.; Jamshidi, A.H.; Baghalian, K.; Taghizadeh, M.
Comparison of Lavandula angustifolia Mill. tincture and imiopramine in the treatment of mild to moderate depression
A double-blind, randomized trial
Prog Neuropsychopharmacol Biol Psychiatry, 2003, 27, 123-127
Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
22 Gastpar, M.; Klimm, H.D.
Treatment of anxiety, tension and restlessness states with Kava special extract WL 1490 in general practice: a randomized placebo-controlled double-blind multicenter trial
Phytomed, 2003, 10(8), 631-639
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
23 Coxeter, P.D.; Schluter, P.J.; Eastwood, H.L.; Nikles, C.J.; Glasziou, P.P.
Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials
Complement Ther Med, 2003, 11(4), 215-222
Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana, n-of-1 trial
24 Farag, N.H.; Mills, P.J.
A randomized-controlled trial of the effects of a traditional herbal supplement on sleep onset insomnia
Complement Ther Med, 2003, 11(4), 223-225
Ayurveda, aloeweed, Glycyrrhiza, liquorice root, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nardostachys jatamansi, Phytomedicine, Piper, Piper nigrum, Placebo-controlled, Mental diseases, Randomized trial, Rosa, Rosa centifolia, Sleep disorders, Tinospora, Tinospora cordifolia, Valeriana, Withania, Withania somnifera, ginger
25 Kennedy, D.O.; Wake, G.; Savelev, S.; Tildesley, N.T.J.;Perry, E.K.; Wesnes, K.A.; Scholey, A.B.
Modulation of mood and cognitive performance following acute administration of single doses of Melissa ofiicinalis (lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties
Neuropsychopharmacology, 2003, 28, 1871-1881
Experiment, Healthy probands, Basic Research, In vitro, Clinical research, Complementary and alternative medicine, Melissa, lemon balm, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
26 Hanus, M.; Lafon, J.; Mathieu, M.
Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders
Curr Med Res Opinion, 2004, 20, 63-71
Anxiety, Crataegus, Eschscholtzia californica, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Magnesium, Magnesium oxydatum, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
27 Lehrl, S.
Clinical efficacy of kava extract WS 1490 in sleep disturbances associated with anxiety disorders
Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial
J Affect Disord, 2004, 78, 101-110
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
28 Abraham, K.; Connor, K.M.; Davidson, J.R.T.
Explanatory attributions of anxiety and recovery in a study of Kava
J Altern Complement Med, 2004, 10(3), 556-559
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
29 Akhondzadeh, S.; Fallah-Pour, H.; Afkham, K.; Jamshidi, A.-H.; Khalighi-Cigaroudi, F.
Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression
A pilot double-blind randomized trial
BMC Complement Altern Med, 2004, 4(12), 1-17 (Internet)
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
30 Röder, C.; Schaefer, M.; Leucht, S.
Meta-Analyse zu Wirksamkeit und Verträglichkeit der Behandlung der leichten und mittelschweren Depression mit Johanniskraut
Fortschr Neurol Psychiatr, 2004, 72(6), 330-343
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Adverse effect
31 Thompson, R.; Ruch, W.; Hasenöhrl, R.U.
Enhanced cognitive performance and cheerful mood by standardised extracts of Piper methysteticum (Kava-kava)
Hum Psychopharmacol, 2004, 19, 243-250
Depression, Healthy probands, Kava, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
32 Werneke, U.; Horn, O.; Taylor, D.M.
How effective is St John's wort?
The evidence revisited
J Clin Psych, 2004, 65, 611-617
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
33 Murck, H.; Fava, M.; Alpert, J.; Nierenberg, A.A.; Mischoulon, D.; Otto, M.W.; Zajecka, J.; Mannel, M.; Rosenbaum, J.F.
Hypericum extract in patients with MDD and reversed vegetative signs
Re-analysis form data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
Int J Neuropsychopharmacol, 2004, 7, 1-7
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
34 Trautmann-Sponsel, R.D.; Dinel, A.
Safety of Hypericum extract in mildly to moderately depressed outpatients
A review on data from three randomized, placebo-controlled trials
J Affect Disord, 2004, 82, 303-307
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Review (CR)
35 Gelenberg, A.J.; Shelton, R.C.; Crits-Christoph, P.; Keller, M.B.; Dunner, D.L.; Hirschfeld, R.M.A.; Thase, M.E.; Russell, J.M.; Lydiard, R.B.; Gallop, R.J.; Todd, L.; Hellerstein, D.J.; Goodnick, P.J.; Keitner, G.I.; Stahl, S.M.; Halbreich, U.; Hopkins H.S.
The effectiveness of St.John's Wort in major depressive disorder
A naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
J Clin Psych, 2004, 65(8), 1114-1119
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
36 Szegedi, A.; Kohnen, R.; Dienel, A.; Kieser, M.
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St. John's wort): randomised controlled double blind non-inferiority trial versus paroxetine
BMJ, 2005, 330, 503-507
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
37 Linde, K.; Berner, M.; Egger, M.; Mulrow, C.
St John's wort for depression
Meta-analysis of randomised controlled trials
Brit J Psychiatry, 2005, 186, 99-107
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
38 Kobak, K.A.; Taylor, L.V.; Warner, G.; Futterer, R.
St. John's wort versus placebo in social phobia
Results from a placebo-controlled pilot study
J Clin Psychopharmacol, 2005, 25(1), 51-58
Anxiety, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Social phobia
39 Soden, K.; Vincent, K.; Craske, S.; Lucas, C.; Ashley, S.
A randomized controlled trial of aromatherapy massage in a hospice setting
Palliative Med, 2004, 18, 87-92
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Palliative care, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Pain
40 Noorbala, A.A.; Akhondzadeh, S.; Tahmacebi-Poura, N.; Jamshidib, A.H.
Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression
A double-blind, randomized pilot trial
J Ethnopharmacol, 2005, 97, 281-284
Crocus, Depression, Ethnopharmacology, Clinical research, Complementary and alternative medicine, Pharmacology, Phytomedicine, Mental diseases, Randomized trial
41 Lewith, G.T.; Godfrey, A.D.; Prescott, P.
A single-blinded, randomized pilot study evaluating the aroma of Lavendula angustifolia as a treatment for mild insomnia
J Altern Complement Med, 2005, 11(4), 631-637
Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
42 Bjerkenstedt, L.; Edman, G.V.; Alken, R.G.; Mannel, M.
Hypericum extract LI 160 and fluoxetine in mild to moderate depression
A randomized, placebo-controlled multi-center study in outpatients
Eur Arch Psychiatry Clin Neurosci, 2005, 255, 40-47
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
43 Jacobs, B.P.; Bent, S.; Tice, J.A.; Blackwell, T.; Cummings, S.R.
An Internet-based randomized, placebo-controlled trial of Kava and Valerian for anxiety and insomnia
Medicine, 2005, 84, 197-207
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
44 Johnson, S.K.; Diamond, B.J.; Rausch, S.; Kaufman, M.; Shiflett, S.C.; Graves, L.
The effect of Ginkgo biloba on functional measures in multiple sclerosis
A pilot randomized controlled trial
Explore, 2006, 2(1), 19-24
Anxiety, Chronic fatigue syndrome, Depression, Ginkgo, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
45 Kobak, K.A.; Taylor, L.V.; Bystritsky, A.; Kohlenberg, C.J.; Greist, J.H.; Tucker, P.; Warner, G.; Futterer, R.; Vapnik, T.
St John's wort versus placebo in obsessive-compulsive disorder
Results from a double-blind study
Int Clin Psychopharmacol, 2005, 20, 299-304
Anxiety, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Mania, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
46 Fava, M.; Alpert, J.; Nierenberg, A.A.; Mischoulon, D.; Otto, M.W.; Zajecka, J., Murck, H.; Rosenbaum, J.F.
A double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
J Clin Psychopharmacol, 2005, 25(5), 441-447
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
47 Randlov, C.; Mehlsen, J.; Thomsen, C.F.; Hedman, C.; Fircks, H. von; Winther, K.
The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia - a double-blind placebo-controlled study
Phytomed, 2006, 13(4), 215-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
48 Garrison, R.; Chambliss, W.G.
Effect of a proprietary Magnolia and Phellodendron extract on weight management
A pilot, double-blind, placebo-controlled clinical trial
Altern Ther Health Med, 2006, 12(1), 50-54
Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Magnolia, Magnolia officinalis, Dietary supplementation, Phellodendron, Phellodendron amurense, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases, Stress, Overweight
49 Moreno, R.A.; Teng, C.T.; Almeida, K.M.; Tavares Junior, H.
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression
A randomized double-blind trial in a Brazilian sample
Rev Bras Psiquiatr, 2006, 28, 29-32
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
50 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Dienel, A.; Kieser, M.
Multizentrische, doppelblinde, plazebokontrollierte und randomisierte Studie zur Wirksamkeit von Johanniskrautextrakt WS 5570 bei Patienten mit leichten oder mittelschweren Formen einer Depression
Z Phytother, 2006, 27(Kongressband), S10
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
51 Koetter, U.; Butterwerk, V.; Brattström, A.
Hops contribute to the clinical efficacy of a fixed valerian hops extract combination in patients with primary insomnia
A placebo controlled, double-blind, randomized and prospective clinical trial
Z Phytother, 2006, 27(Kongressband), S11
hop, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
52 Uebelhack, R.; Blohmer, J.U.; Graubaum, H.J.; Busch, R.; Grünwald, J.; Wernecke, K.D.
Remifemin plus - ein wirksames Therapeutikum bei klimakterischen Beschwerden mit deutlich psychischer Komponente
Z Phytother, 2006, 27(Kongressband), S15-S16
Black cohosh, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
53 Dimpfel, W.
Akute Wirksamkeit eines Baldrian-Trockenextraktes auf die Schlaftiefe beim Menschen
Eine doppelblinde, randomisierte, plazebokontrollierte Studie im parallelen Design
Z Phytother, 2006, 27(Kongressband), S20
Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
54 Anghelescu, I.G.; Kohnen, R.; Szegedi, A.; Klement, S.; Kieser, M.
Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression
Results from a randomized multicenter study
Pharmacopsychiatry, 2006, 39(6), 213-219
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
55 Moshiri, E.; Basti, A.A.; Noorbala, A.A.; Jamshidi, A.H.; Hesameddin, Abbasi S.; Akhondzadeh, S.
Crocus sativus L. (petal) in the treatment of mild-to-moderate depression
A double-blind, randomized and placebo-controlled trial
Phytomed, 2006, 13(9-10), 607-611
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
56 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Szegedi, A.; Dienel, A.; Kieser, M.
Superior efficacy of St Johns wort extract WS(R) 5570 compared to placebo in patients with major depression
A randomized, double-blind, placebo-controlled, multi-center trial
BMC Med, 2006, 4, 14; (1-13)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
57 Omer, B.; Krebs, S.; Omer, H.; Noor, T.O.
Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease
A double-blind placebo-controlled study
Phytomed, 2007, 14(2-3), 87-95
Artemisia, Artemisia absinthium, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
58 Blohmer, J.-U.; Graubaum, H.-J.; Busch, R.; Grünwald, J.; Wernecke, K.-D.; Uebelhack, R.
Cimicifuga und Hypericum als fixe Kombination gegen psychische Wechseljahresbeschwerden
Placebokontrollierte Doppelblindstudie mit 301 Patientinnen
Z Phytother, 2007, 28(2), 67-70
Black cohosh, Depression, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
59 Strasser, F.; Luftner, D.; Possinger, K.; Ernst, G.; Ruhstaller, T.; Meissner, W.; Ko, Y.-D.; Schnelle, M.; Reif, M.; Cerny, T.
Comparison of orally administered cannabis extract and delta-9-tetrahydrocannibol in treating patients with cancer-related anorexia-cachexia
A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the cannabis-in-cachexia-study-group
J Clin Oncol, 2006, 24(21), 3394-3400
Cannabis, Eating disorders, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Kachexie
60 Wilkinson, S.M.; Love, S.B.; Westcombe, A.M.; Gambles, M.A.; Burgess, C.C.; Cargill, A.; Young, T.; Maher, J.; Ramirez, A.J.
Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer
A multicenter randomized controlled trial
J Clin Oncol, 2007, 25(5), 532-539
Anxiety, Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
61 Herrera-Arellano, A.; Jiménez-Ferrer, E.; Zamilpa, A.; Morales-Valdéz, M.; García-Valencia, C.E.; Tortoriello, J.
Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder
A randomized, double-blind clinical trial controlled with Lorazepam
Planta Med, 2007, 73(8), 713-717
Anxiety, Galphimia, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
62 Eckmann, F.
Hirnleistungsstörungen - Behandlung mit Ginkgo-biloba-Extrakt
Zeitpunkt des Wirkungseintritts in einer Doppelblindstudie mit 60 stationären Patienten
Fortschr Med, 1990, 108(29), 557-560
Depression, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
63 Scripnikov, A.; Khomenko, A.; Napryeyenko, O.
Effects of Ginkgo biloba Extract EGb 761 on neuropsychiatric symptoms of dementia
Findings from a randomised controlled trial
WMW, 2007, 157(13-14), 295-300
Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial
64 Kasper, S.; Anghelescu, I.-G.; Szegedi, A.; Dienel, A.; Kieser, M.
Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode
WMW, 2007, 157(13-14), 362-366
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
65 Baicus, C.; Baicus, A.
Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trials
Phytother Res, 2007, 21(6), 570-573
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Spirulina, Spirulina platensis
66 Napryeyenko, O.; Borzenko, I.
Ginkgo biloba special extract in dementia with neuropsychiatric features
A randomised, placebo-controlled, double-blind clinical trial
Arzneim Forsch, 2007, 57, 4-11
Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
67 Dimpfel, W.; Suter, A.A.
Sleep improving effects of a single dose administration of a valerian/hops fluid extract
A double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using the electrohypnogram
Z Phytother, 2008, 29(Suppl 1, Kongressband), S23 (Abstract; Symposiumsbeitrag)
hop, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
68 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.P.; Dienel, A.; Kieser, M.
Efficacy of St. John's wort extract WS 5570 in acute treatment of mild depression
A reanalysis of data from controlled clinical trials
Eur Arch Psychiatry Clin Neurosci, 2008, 258(1), 59-63
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
69 Papakostas, G.I.; Crawford, C.M.; Scalia, M.J.; Fava, M.
Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder
A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine
Neuropsychobiology, 2007, 56(2-3), 132-137
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
70 Kalman, D.S.; Feldman, S.; Feldman, R.; Schwartz, H.I.; D.R. Krieger; Garrison, R.
Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women
A pilot, double-blind, placebo-controlled clinical trial
Nutrition J, 2008, 7, (1-16) (Internet)
Anxiety, Healthy probands, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Magnolia, Magnolia officinalis, Menopause, Phellodendron, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Stress
71 Weber, W.; Vander Stoep, A.; McCarty, R.L.; Weiss, N.S.; Biederman, J.; McClellan, J.
Hypericum perforatum (St John's wort) for attention-deficit/hyperactivity disorder in children and adolescents
A randomized controlled trial
JAMA, 2008, 299(22), 2633-2641
ADHD, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
72 Calabrese, C.; Gregory, W.L.; Leo, M.; Kraemer, D.; Bone, K.; Oken, B.
Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly
A randomized, double-blind, placebo-controlled trial
J Altern Complement Med, 2008, 14(6), 707-713
Anxiety, Bacopa monnieri, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
73 Stringer, J.; Swindell, R.; Dennis, M.
Massage in patients undergoing intensive chemotherapy reduces serum cortisol and prolactin
Psychooncol, 2008, 17(10), 1024-1031
Aromatherapy, Clinical research, Complementary and alternative medicine, Cancer, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Stress
74 Li, L.T.; Wang, S.H.; Ge, H.Y.; Chen, J.; Yue, S.W.; Yu, M.
The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) and fluoxetine on post-stroke depression
J Altern Complement Med, 2008, 14(7), 841-846
Angelica, Angelica sinensis, Atractylodes, Atractylodes macrocephala, Bupleurum, Bupleurum chinense, Depression, Glycyrrhiza, Glycyrrhiza uralensis, Cardiovascular diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lilium, Lilium brownii var. colchesteri, Mentha, Mentha haplocalyx, Paeonia, Paeonia lactiflora, Phytomedicine, Placebo-controlled, Poria, Poria cocos, Mental diseases, Randomized trial, Rehmannia glutinosa, sage, Salvia miltiorrhiza, Stroke, ginger
75 Doruk, A.; Uzun, O.; Ozsahin, A.
A placebo-controlled study of extract of Ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia
Int Clin Psychopharmacol, 2008, 23(4), 223-227
Ginkgo, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Schizophrenia
76 Taibi, D.M.; Vitiello, M.V.; Barsness, S.; Elmer, G.W.; Anderson, G.D.; Landis C.A.
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia
Sleep Med, 2009, 10(3), 319-328
Geriatrics, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
77 Uebelhack, R.; Gruenwald, J.; Graubaum, H.J.; Busch, R.
Efficacy and tolerability of Hypericum extract STW 3-VI in patients with moderate depression
A double-blind, randomized, placebo-controlled clinical trial
Adv Ther, 2004, 21(4), 265-275
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
78 Cuellar, N.G.; Ratcliffe, S.J.
Does valerian improve sleepiness and symptom severity in people with restless legs syndrome?
Altern Ther Health Med, 2009, 15(2), 22-28
Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Restless legs syndrome, Sleep disorders, Valeriana
79 Gastpar, M.; Singer, A.; Zeller, K.
Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression
A double-blind, randomised, multicentre, placebo-controlled study
Pharmacopsychiatry, 2006, 39(2), 66-75
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Conventional medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
80 Rahimi, R.; Nikfar, S.; Abdollahi, M.
Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors
A meta-analysis
Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33(1), 118-127
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
81 Olsson, E.M.G.; Schéele, B. von; Panossian, A.G.
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue
Planta Med, 2009, 75(2), 105-112
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
82 Koetter, U.; Schrader, E.; Käufeler, R.; Brattström, A.
A randomized, double blind, placebo controlled, prospective clincal study to demonstrate clinical efficacy of a fixed Valerian Hops extract combination (ZE91019) in patients suffering from non-organic sleep disorder
Phytother Res, 2007, 21(9), 847-851
hop, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
83 Darbinyan, V.; Aslanyan, G.; Amroyan, E.; Gabrielyan, E.; Malmström, C.; Panossian, A.
Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression
Nord J Psychiatry, 2007, 61(5), 343-348
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
84 Cicero, A.F.; Derosa, G.; Brillante, R.; Bernardi, R.; Nascetti, S.; Gaddi, A.
Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life
A randomized clinical trial
Arch Gerontol Geriatr, 2004, 38(1), 69-73
Chronic fatigue syndrome, Eleutherococcus senticosus, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
85 Hartz, A.J.; Bentler, S.; Noyes, R.; Hoehns, J.; Logemann, C.; Sinift, S.; Butani, Y.; Wang, W.; Brake, K.; Ernst, M.; Kautzman, H.
Randomized controlled trial of Siberian ginseng for chronic fatigue
Psychol Med, 2004, 34(1), 51-61
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
86 Sarris, J.; Kavanagh, D. J.; Adams, J.; Bone, K.; Byrne, G.
Kava Anxiety Depression Spectrum Study (KADSS)
A mixed methods RCT using an aqueous extract of Piper methysticum
Complement Ther Med, 2009, 17(3), 176-178
Anxiety, Depression, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
87 Cho, J.H.; Cho, C.K.; Shin, J.W.; Son, J.Y.; Kang, W.; Son, C.G.
Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue
A randomised, double-blind, controlled pilot study
Complement Ther Med, 2009, 17(3), 141-146
Astragalus, Astragalus membranaceus, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, sage, Salvia miltiorrhiza
88 Taibi, D.M.; Bourguignon, C.; Taylor, A.
A feasibility study of valerian extract for sleep disturbance in person with arthritis
Biol Res Nurs, 2009, 10(4), 409-417
Arthritis, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
89 Costa Miranda, V. da; Trufelli, D.C.; Santos, J.; Campos, M.P.; Nobuo, M.; Costa Miranda, M. da; Schlinder, F.; Riechelmann, R.; Giglio, A. del
Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression
Results of a pilot double-blind randomized study
J Altern Complement Med, 2009, 15(4), 431-433
Chronic fatigue syndrome, Depression, Guarana, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
90 Schutgens, F.W.G.; Neogi, P.; Wijk, E.P.A. van; Wijk, R. van; Wikman, G.; Wiegant, F.A.C.
The influence of adaptogens on ultraweak biophoton emission
A pilot-experiment
Phytother Res, 2009, 23, 1103-1108
Biophotons, Biophysics, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola rosea, Stress
91 Bann, C.M.; Parker, C.B.; Bradwejn, J.; Davidson, J.R.; Vitiello, B.; Gadde, K.M.
Assessing patient beliefs in a clinical trial of Hypericum perforatum in major depression
Depress Anxiety, 2004, 20(3), 114-122
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
92 Milesi, M.A.; Lacan, D.; Brosse, H.; Desor, D.; Notin, C.
Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel) on stress and fatigue in healthy people
A pilot, double-blind, placebo-controlled clinical trial
Nutrition J, 2009, 8, 40; (1-7)
Chronic fatigue syndrome, Nutrition/diet, Extramel, Healthy probands, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Juice/distillate, Stress
93 Barton, D.L.; Soor, G.S.; Bauer, B.A.; Sloan, J.A.; Johnson, P.A.; Figueras, C.; Duane, S.; Mattar, B.; Liu, H.; Atherton, P.J.; Christensen, B.; Loprinzi, C.L.
Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue
A randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA
Support Care Cancer, 2010, 18(2), 179-187
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, posology, Mental diseases, Randomized trial, Panax, Panax quinquefolius
94 Sayyah, M.; Boostani, H.; Pakseresht, S.; Malaieri, A.
Efficacy of aqueous extract of Echium amoenum in treatment of obsessive-compulsive disorder
Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33(8), 1513-1516
Echium, Echium amoenum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Obsessive-compulsive disorder
95 Parsons, A.; Ingram, J.; Inglis, J.; Aveyard, P.; Johnstone, E.; Brown, K.; Franklin, M.; Bermudez, I.
A proof of concept randomized placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to prevent weight gain on smoking cessation
Drug Alcohol Depend, 2009, 102(1-3), 116-122
Chromium, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Addiction
96 Woelk, H.; Schläfke, S.
A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder
Phytomed, 2010, 17(2), 94-99
Anxiety, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Oil, Phytomedicine, Mental diseases, Randomized trial
97 Sayyah, M.; Boostani, H.; Pakseresht, S.; Malayeri, A.
Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of obsessive-compulsive disorder
Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34, 362-365
Clinical research, Complementary and alternative medicine, Mania, Phytomedicine, Mental diseases, Randomized trial, milk thistle
98 Sarris, J.; Kavanagh, D.J.; Byrne, G.; Bone, K.M.; Adams, J.; Deed, G.
The Kava Anxiety Depression Spectrum Study (KADSS)
A randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
Psychopharmacol, 2009, 205(3), 399-407
Anxiety, Depression, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
99 Salehi, B.; Imani, R.; Mohammadi, M.R.; Fallah, J.; Mohammadi, M.; Ghanizadeh, A.; Tasviechi, A.A.; Vossoughi, A.; Rezazadeh, S.; Akhondzadeh, S.
Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents
A double blind, randomized controlled trial
Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(1), 76-80
Ginkgo, ADHD, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases, Randomized trial
100 Atmaca, M.; Tezcan, E.; Kuloglu, M.; Ustundag, B.; Kirtas, O.
The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia
Psych Clin Neurosci, 2005, 59, 652-656
Ginkgo, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Schizophrenia