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301 Arai, Y.-C.; Kawanishi, J.; Sakakima, Y.; Sueoka, S.; Ito, A.; Tawada, Y.; Maruyama, Y.; Banno, S.; Takayama, H.; Nishihara, M.; Kawai, T.; Ikemoto, T.
The effect of Kampo medicine Yokukansan on preoperative anxiety and sedation levels
eCAM, 2014, Article ID 965045, (1-4)
Anxiety, Surgery, Clinical research, Complementary and alternative medicine, Phytomedicine, Prevention, Mental diseases, Randomized trial, Traditional Japanese medicine, Yokukansan
302 Hajibagheri, A.; Babaii, A.; Adib-Hajbaghery, M.
Effect of Rosa damascene aromatherapy on sleep quality in cardiac patients
A randomized controlled trial
Complement Ther Clin Pract, 2014, 20(3), 159-163
Aromatherapy, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rosa, Rosa damascena, Sleep disorders
303 Sanmukhani, J.; Satodia, V.; Trivedi, J.; Patel, T.; Tiwari, D.; Pachal, B.; Goel, A.; Tripathi, C.B.
Efficacy and safety of curcumin in major depressive disorder
A randomized controlled trial
Phytother Res, 2014, 28, 579-585
Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
304 Dave, U.P.; Dingankar, S.R.; Saxena, V.S.; Joseph, J.A.; Bethapudi, B.; Agarwal, A.; Kudiganti, V.
An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children
Adv Mind-Body Med, 2014, 28(2), 10-15
Bacopa monnieri, Observational trial, ADHD, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases
305 Sarris, J.; Stough, C.; Bousman, C.A.; Wahid, Z.T.; Murray, G.; Teschke, R.; Savage, K.M.; Dowell, A.; Ng, C.; Schweitzer, I.
Kava in the treatment of generalized anxiety disorder
A double-blind, randomized, placebo-controlled study
J Clin Psychopharmacol, 2013, 2013, 643-648
Anxiety, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
306 Thomas, G.; Lucas, P.; Capler, N.R.; Tupper, K.W.; Martin, G.
Ayahuasca-assisted therapy for addiction
Results from a preliminary observational study in Canada
Curr Drug Abuse Rev, 2013, 6(1), 30-42
yage, Observational trial, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Psychotria, Stress, Addiction, Psychotria viridis, Drug addiction
307 Agnihotri, A.P.; Sontakke, S.D.; Thawani, V.R.; Saoji, A.; Goswami, V.S.S.
Effects of Withania somnifera in patients of schizophrenia
A randomized, double blind, placebo controlled pilot trial study
Ind J Pharmacol, 2013, 45(4), 427-418
Ayurveda, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Schizophrenia, Withania, Withania somnifera
308 Kim, K.Y.; Seo, H.J.; Min, S.S.; Park, M.; Seol, G.H.
The effect of 1,8-cineole inhalation on preoperative anxiety
A randomized clinical trial
eCAM, 2014, Article ID 820126, (1-7)
Anxiety, Aromatherapy, Surgery, Eucalyptus, Clinical research, Complementary and alternative medicine, Oil, Phytomedicine, Mental diseases, Randomized trial
309 Choi, S.Y.; Kang, P.; Lee, H.S.; Seol, G.H.
Effects of inhalation of essential oil of Citrus aurantium L.var. amara on menopausal symptoms, stress, and estrogen in postmenopausal women
A randomized controlled trial
eCAM, 2014, Article ID 796518, (1-7)
Aromatherapy, Citrus, Citrus aurantium, Endocrinology, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Mental diseases, Randomized trial, Stress
310 Pinheiro, M.L.; Alcantara, C.E.P.; Moraes, M. de; Andrade, E.D. de
Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery
A randomized, double-blind, placebo-controlled split-mouth study
J Pharm Bioallied Sci, 2014, 6(2), 109-114
Anxiety, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Valeriana, Wisdom teeth, Tooth extraction, Dental diseases
311 Nishimatsu, H.; Kitamura, T.; Yamada, D.; Nomiya, A.; Niimi, A.; Suzuki, M.; Fujimura, T.; Fukuhara, H.; Nakagawa, T.; Enomoto, Y.; Kume, H.; Igawa, Y.; Homma, Y.
Improvement of symptoms of aging in males by a preparation LEOPIN ROYAL containing aged garlic exract and other five of natural medicines
Comparison with traditional herbal medicines (Kampo)
Aging Male, 2014, 17(2), 112-116
Andrology, Depression, Erectile disorder, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
312 Stojanovska, L.; Law, C.; Lai, B.; Chung, T.; Nelson, K.; Day, S.; Apostolopoulos, V.; Haines, C.
Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Climacteric, 2015, 18(1), 69-78
High blood pressure, Depression, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
313 Wu, J.J.; Cui, Y.; Yang, Y.S.; Kang, M.S.; Jung, S.C.; Park, H.K.; Yeun, H.Y.; Jang, W.J.; Lee, S.; Kwak, Y.S.; Eun, S.Y.
Modulatory effects of aromatherapy massage intervention on electroencephalogram, psychological assessments, salivary cortisol and plasma brain-derived neurotrophic factor
Complement Ther Med, 2014, 22(3), 456-462
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Stress
314 Fißler, M.; Quante, A.
A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety
Complement Ther Med, 2014, 22(1), 63-69
Anxiety, Aromatherapy, Observational trial, Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Retrospective design, Sleep disorders
315 Matsumoto, T.; Asakura, H.; Hayashi, T.
Effects of olfactory stimulation from the fragrance of the Japanese citrus fruit yuzu (Citrus junos Sieb. ex Tanaka) on mood states and salivary chromogranin A as an endocrinologic stress marker
J Altern Complement Med, 2014, 20(6), 500-506
Aromatherapy, Citrus, Citrus junos, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Stress
316 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.-P.; Möller, H.-J.; Schläfke, S.; Dienel, A.
Lavender oil preparation Silexan is effective in generalized anxiety disorder
A randomized, double-blind comparison to placebo and paroxetine
Int J Neuropsychopharmacol, 2014, epub ahead of print,
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
317 Liu, L.-Y.; Feng, B.; Chen, J.; Tan, Q.-R.; Chen, Z.-X.; Chen, W.-S.; Wang, P.-R.; Zhang, Z.-J.
Herbal medicine for hospitalized patients with severe depressive episode
A retrospective controlled study
J Affect Disord, 2015, 170, 71-77
Depression, Clinical research, Complementary and alternative medicine, Hospital, Non-randomized trial, Phytomedicine, Practice, Mental diseases, Retrospective design
318 Lytle, J.; Mwatha, C.; Davis, K.K.
Effect of lavender aromatherapy on vital signs and perceived quality of sleep in the intermediate care unit
A pilot study
Am J Crit Care, 2014, 23(1), 24-29
Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
319 Shahmansouri, N.; Farokhnia, M.; Abbasi, S.H.; Kassaian, S.E.; Noorbala Tafti, A.A.; Gougol, A.; Yekehtaz, H.; Forghani, S.; Mahmoodian, M.; Saroukhani, S.; Arjmandi-Beglar, A.; Akhondzadeh, S.
A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients
J Affect Disord, 2014, 155, 216-222
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
320 Johnson, C.E.
Effect of aromatherapy on cognitive test anxiety among nursing students
Altern Compl Ther, 2014, 20(2), 84-87
Anxiety, Aromatherapy, Citrus, lime leaves [kaffir-], Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
321 Rother, C.; Weyers, G.; Hufnagel, R.
Administration of Cardiodoron ((R)) in patients with functional cardiovascular disorders and/or sleep disorders
Results of a non-interventional study
Forsch Komplementärmed, 2013, 20(Suppl 3), 3 (Symposiumsbeitrag; Abstract)
Observational trial, Cardiodoron, Functional heart trouble, Cardiovascular diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Sleep disorders
322 Schaffler, K.; Wolf, O.T.; Burkart, M.
No benefit adding Eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration
A randomized controlled study
Pharmacopsychiatry, 2013, 46(5), 181-190
Chronic fatigue syndrome, Eleutherococcus senticosus, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Stress
323 Ko, H.J.; Kim, I.; Kim, J.B.; Moon, Y.; Whang, M.C.; Lee, K.M.; Jung, S.P.
Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity
A double-blind randomized placebo-controlled trial
J Child Adolesc Psychopharmacol, 2014, 24(9), 501-508
ADHD, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Panax, Panax ginseng
324 Gnatta, J.R.; Piason, P.P.; Lion Botero Couto Lopes, C. de; Rogenski, M.B.; Silva, M.J.P.
Aromatherapy with ylang ylang for anxiety and self-esteem
A pilot study
Rev Esc Enferm USP, 2014, 48(3), 492-499
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Ylang ylang
325 Firoozabadi, A.; Salehi, A.; Jahanbin, S.; Mohagheghzadeh, A.
Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression
A triple-blind randomized controlled trial study
J Evid Based Compl Altern Med, 2015, 20(2), 94-97
Cuscuta, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Cuscuta planiflora, Nepeta menthoides
326 Rangaswamy, P.A.; Sultana, A.; Rahman, K.; Nagapattinam, S.
Efficacy of Boswellia serrata L. and Cyperus scariosus L. plus pelvic floor muscle training in stress incontinence in women of reproductive age
Complement Ther Clin Pract, 2014, 20, 230-236
Exercise therapy, Urinary tract, Incontinence, Clinical research, Complementary and alternative medicine, Physical therapy, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress, Pelvic floor exercises
327 Mao, J.J.; Li, Q.S.; Soeller, I.; Xie, S.X.; Amsterdam, J.D.
Rhodiola rosea therapy for major depressive disorder
A study protocol for a randomized, double-blind, placebo-controlled trial
J Clin Trials, 2014, 4(3), 170; (1-7) (Studienprotokoll)
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
328 Panozzo, M.; Rossi, E.G.; Bartoli, P.; Da Fre, M.
Integrative treatment for women diseases in a public homeopathic clinic (2002-2011) and multidisciplinary approach to personal and family crisis
Forsch Komplementärmed, 2013, 20(suppl. 1), 98 (Abstract; Symposiumsbeitrag)
Observational trial, Gynaecology, Homeopathy, Clinical research, Complementary and alternative medicine, Menopause, Menstrual disorders, Phytomedicine, Mental diseases
329 Vohra, S.; Punja, S.; Shamseer, L.; Olsen, K.
Rhodiola rosea for mental and physical fatigue in nurses on shift work
A randomized controlled trial
Forsch Komplementärmed, 2013, 20(suppl. 1), 112 (Abstract; Symposiumsbeitrag)
Occupational health, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
330 Seyyed-Rasooli, E.; Amiri, M.-R.; Zamanzadeh, V.; Peron, K.; Aghakeshizadeh, M.
Effect of aromatherapy on anxiety and pain in patients undergoing cholecystectomy
Adv Herbal Med, 2014, 1(1), 1-7
Anxiety, Aromatherapy, Surgery, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rosa, Pain
331 Chamine, I.; Oken, B.S.
Expectancy of stress-reducing aromatherapy effect and performance on a stress-sensitive cognitive task
eCAM, 2015, Article ID 324360, (1-11)
Aromatherapy, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress
332 Bock, P.R.; Hanisch, J.; Matthes, H.; Zänker, K.S.
Targeting inflammation in cancer-related fatigue
A rationale for mistletoe therapy as supportive care in colorectal cancer patients
Inflamm Allergy Drug Targets, 2014, 13, 105-111
Observational trial, Chronic fatigue syndrome, Bowel cancer, Inflammation, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Phytomedicine, Mental diseases, Viscum, Viscum album, Iscador
333 Vigl, S.
Rhodiola rosea bei Chronic Fatigue Syndrom
Achtwöchige, dokumentierte Anwendungsbeobachtung mit 28 Teilnehmern
EHK, 2014, 63(6), 325-331
Observational trial, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola, Rhodiola rosea
334 Paula, L.C. de; Fonseca, F.; Perazzo, F.; Cruz, F.M.; Cubero, D.; Trufelli, D.C.; Martins, S.P.; Santi, P.X.; Silva, E.A. da; Del Giglio, A.
Uncaria tomentosa (Cat's Claw) improves quality of life in patients with advanced solid tumors
J Altern Complement Med, 2015, 21(1), 22-30
Observational trial, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Palliative care, Phytomedicine, Mental diseases, Sleep disorders, Uncaria
335 Dording, C.M.; Schettler, P.J.; Dalton, E.D.; Parkin, S.R.; Walker, R.S.W.; Fehling, K.B.; Fava, M.; Mischoulon, D.
A double-blind placebo-controlled trial of Maca root as treatment for antidepressant-induced sexual dysfunction in women
eCAM, 2015, Article ID 949036, (1-9)
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sexual dysfunktion (female)
336 Punja, S.; Shamseer, L.; Olson, K.; Vohra, S.
Rhodiola rosea for mental and physical fatigue in nursing students
A randomized controlled trial
PLoS ONE, 2015, 9(9), e108416; (1-8)
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rhodiola rosea
337 Mao, J.J.; Xie, S.X.; Zee, J.; Soeller, I.; Li, Q.S.; Rockwell, K.; Amsterdam, J.D.
Rhodiola rosea versus sertraline for major depressive disorder
A randomized placebo-controlled trial
Phytomed, 2015, 22(3), 394-399
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
338 Tang, S.K.; Tse, M.Y.M.
Aromatherapy: Does it help to relieve pain, depression, anxiety, and stress in community-dwelling older persons?
Biomed Res Int, 2014, Article ID 430195, (1-12)
Anxiety, Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Non-randomized trial, Phytomedicine, Mental diseases, Pain, Stress, Inhalation
339 Gurevich, M.I.; Robinson, C.L.
Medication-free alternatives for long-term maintenance of bipolar disorder
A case series
Global Adv Health Med, 2015, 4(2), 53-60
Anxiety, Observational trial, Nutrition/diet, Clinical research, Complementary and alternative medicine, Lifestyle modification, Meditation, Mind-body medicine, Phytomedicine, Mental diseases, Psychology/psychotherapy, Retrospective design, Sleep disorders, Bipolare Störung
340 Yang, M.H.; Lin, L.C.; Wu, S.C.; Chiu, J.H.; Wang, P.N.; Lin, J.G.
Comparison of the efficacy of aroma-acupressure and aromatherapy for the treatment of dementia-associated agitation
BMC Complement Altern Med, 2015, 15(1), 93; (1-8)
Acupressure, Acupuncture, Aromatherapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Traditional Chinese medicine, Conduct disorder
341 Simoes-Wüst, A.P.; Hassani, T.A.; Müller-Hübenthal, B.; Pittl, S.; Kuck, A.; Meden, H.; Eberhard, J.; Decker, M.; Fürer, K.; Mandach, U. von
Sleep quality improves during treatment with Bryophyllum pinnatum
An observational study on cancer patients
Integr Cancer Ther, 2015, 14(5), 452-459
Observational trial, Bryophyllum, Bryophyllum pinnatum, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Mental diseases, Sleep disorders
342 Shakibaei, F.; Radmanesh, M.; Salari, E.; Mahaki, B.
Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents
A randomized, placebo-controlled, trial
Complement Ther Clin Pract, 2015, 21, 61-67
Ginkgo, ADHD, Jugendmedizin, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
343 Országhová, Z.; Waczuliková, I.; Burki, C.; Rohdewald, P.; Duracková, Z.
An effect of oak-wood extract (Robuvit®) on energy state of healthy adults
A pilot study
Phytother Res, 2015, 29(8), 1219-1224
Observational trial, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Quercus, Quercus robur
344 Chagas, M.H.; Eckeli, A.L.; Zuardi, A.W.; Pena-Pereira, M.A.; Sobreira-Neto, M.A.; Sobreira, E.T.; Camilo, M.R.; Bergamaschi, M.M.; Schenk, C.H.; Hallak, J.E.; Tumas, V.; Crippa, J.A.
Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parikinson's diesease patients
A case series
J Clin Pharm Ther, 2014, 39(5), 564-566
Observational trial, Cannabis, Cannabis sativa, Clinical research, Complementary and alternative medicine, Nervous system, Parkinson's disease, Phytomedicine, Mental diseases, Sleep disorders
345 Redstone, L.
Mindfulness meditation and aromatherapy to reduce stress and anxiety
Arch Psychiatr Nurs, 2015, 29(3), 192-193
Mindfulness meditation, Anxiety, Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Phytomedicine, Mental diseases, Stress
346 Kyle, G.
Evaluating the effectiveness of aromatherapy in reducing levels of anxiety in palliative care patients
Results of a pilot study
Complement Ther Clin Pract, 2006, 12, 148-155
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Palliative care, Phytomedicine, Prunus, Prunus dulcis, Mental diseases, Randomized trial, Santalum album, Santalum
347 Namazi, M.; Akbari, S.A.A.; Mojab, F.; Talebi, A.; Majd, H.A.; Jannesari, S.
Aromatherapy with Citrus aurantium oil and anxiety during the first stage of labor
Iran Red Crescent Med J, 2014, 16(6), e18371; (1-6)
Anxiety, Aromatherapy, Citrus, Citrus vulgaris, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Obstetrics
348 Silveira-Souto, M.-L.; São-Mateus, C.-R.; Almeida-Souza, L.-M.; Groppo, F.-C.
Effect of Erythrina mulungu on anxiety during extraction of third molars
Med Oral Patol Oral Cir Bucal, 2014, 19(5), e518-e524
Anxiety, Erythrina, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Tooth extraction, Dental diseases
349 Bikmoradi, A.; Seifi, Z.; Poorolajal, J.; Araghchian, M.; Safiaryan, R.; Oshvandi, K.
Effect of inhalation aromatherapy with lavender essential oil on stress and vital signs in patients undergoing coronary artery bypass surgery
A single-blinded randomized clinical trial
Complement Ther Med, 2015, 23(3), 331-338
Aromatherapy, Surgery, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Phytomedicine, Placebo-controlled, Postoperative complaints, Mental diseases, Randomized trial, Stress
350 Burns, E.; Blamey, C.; Ersser, S.J.; Lloyd, A.J.; Barnetson, L.
The use of aromatherapy in intrapartum midwifery practice
An observational study
Complement Ther Nurs Midwif, 2000, 6(1), 33-34
Anxiety, Aromatherapy, Observational trial, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Obstetrics
351 ZImmermann-Viehoff, F.; Steckhan, N.; Meissner, K.; Deter, H.-C.; Kirschbaum, C.
Influence of suggestive placebo intervention on psychobiological responses to social stress
A randomized controlled trial
J Evid Based Compl Altern Med, 2016, 21(1), 3-9
Healthy probands, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo, Placebo-controlled, Mental diseases, Randomized trial, Stress
352 Lillehei, A.S.; Halcón, L.L.; Savik, K.; Reis, R.
Effect of inhaled lavender and sleep hygiene on self-reported sleep issues
A randomized controlled trial
J Altern Complement Med, 2015, 21(7), 430-438
Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
353 Zeinalzadeh, S.; Akbarzadeh, M.; Mohagheghzadeh, A.; Faridi, P.; Sayadi, M.
Comparison of the effects of Elaeagnus angustifolia flower capsule and sildenafil citrate tablet on anxiety resulting from sexual dysfunction in women referring to the selected clinics of Shiraz University of Medical Sciences
J Evid Based Compl Altern Med, 2016, 21(3), 186-193
Anxiety, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Elaeagnus angustifolia
354 Watanabe, E.; Kuchta, K.; Kimura, M.; Rauwald, H.W.; Kamei, T.; Imanishi, J.
Effects of bergamot (Citrus bergamia (Risso) Wright & Arn.) essential oil aromatherapy on mood states, parasympathetic nervous system activity, and salivar cortisol levels in 41 healthy females
Forsch Komplementärmed, 2015, 22(1), 43-49
Aromatherapy, Citrus, Citrus bergamia, Endocrinology, Healthy probands, Gynaecology, Internal medicine, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Vegetative nervous system, Cortisol
355 Karadag, E.; Samancioglu, S.; Ozden, d.; Bakir, E.
Effects of aromatherapy on sleep quality and anxiety of patients
Nurs Crit Care, 2017, 22(2), 105-112
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Intensivmedizin
356 Talaei, A.; Hassanpour Moghadam, M.; Sajadi Tabassi, S.A.; Mohajeri, S.A.
Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder
A randomized, double-blind, placebo-controlled, pilot clinical trial
J Affect Disord, 2015, 174, 51-56
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
357 Steflitsch, W.; Steiner, D.; Peinhaupt, W.; Riedler, B.; Smuc, M.; Diewald, G.
Gesundheitsförderung durch Stress- und Burnout-Prophylaxe mit ätherischen Ölen für alle Berufsgruppen im Wiener Otto-Wagner-Spital
Forsch Komplementärmed, 2015, 22(3), 185-194
Occupational health, Aromatherapy, Observational trial, Chronic fatigue syndrome, Citrus, Citrus sinensis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Prevention, Mental diseases, Santalum album, Stress, Santalum
358 Panahi, Y.; Badeli, R.; Karami, G.R.; Badeli, Z.; Sahebkar, A.
A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder
Complement Ther Med, 2015, 23(4), 598-602
Antioxidants, Chlorella, Chlorella vulgaris, Depression, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Mental diseases, Randomized trial
359 Osório, F. de L.; Sanches, R.F.; Macedo, L.R.; Santos, R.G.; Maia-de-Oliveira, J.P.; Wichert-Ana, L.; Araujo, D.B. de; Riba, J.; Crippa, J.A.; Hallak, J.E.
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression
A preliminary report
Rev Bras Psiquiatr, 2015, 37, 13-20
yage, Observational trial, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases
360 Chen, S.-L.; Chen, C.-H.
Effects of lavender tea on fatigue, depression, and maternal-infant attachement in sleep-disturbed postnatal women
Worldviews Evid Based Nurs, 2015, 12(6), 370-379
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
361 Cropley, M.; Banks, A.P.; Boyle, J.
The effects of Rhodolia rosea L. extract on anxiety, stress, cognition and other mood symptoms
Phytother Res, 2015, 29(12), 1934-1939
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
362 Hanprasertpong, T.; Kor-anantakul, O.; Leetanaporn, R.; Suwanrath, C.; Suntharasaj, T.; Pruksanusak, N.; Pranpanus, S.
Reducing pain and anxiety during second trimester genetic amniocentesis using aromatic therapy
A randomized trial
J Med Assoc Thai, 2015, 98(8), 734-738
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Mentholum, Phytomedicine, Mental diseases, Randomized trial, Pain, Obstetrics
363 Shakibaei, F.; Radmanesh, M.; Salari, E.; Mahaki, B.
Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents
A randomized, placebo-controlled, trial
Complement Ther Clin Pract, 2015, 21, 61-67
Ginkgo, ADHD, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
364 Chen, C.-J.; Kumar, K.J.; Chen, Y.T.; Tsao, N.W.; Chien, S.C.; Chang, S.T.; Chu, F.H.; Wang, S.Y.
Effect of Hinoki and Meniki essential oils on human autonomic nervous system activity and mood states
Nat Prod Commun, 2015, 10(7), 1305-1308
Aromatherapy, Observational trial, Chamaecyparis, Chamaecyparis formosensis, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Vegetative nervous system, Chamaecyparis obtusa
365 Lopresti, A.L.; Maes, M.; Maker, G.L.; Hood, S.D.; Drummond, P.D.
Curcumin for the treatment of major depression
A randomised, double-blind, placebo controlled study
J Affect Disord, 2014, 167, 368-375
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
366 Lopresti, A.L.; Maes, M.; Meddens, M.J.M.; Maker, G.L.; Arnoldussen, E.; Drummond, P.D.
Curcumin and major depression
A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change
Eur Neuropsychopharmacol, 2015, 25, 38-50
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Mechanism of action
367 Cheng, L.; Pan, G.-F.; Wang, W.; Liang, R.-X.; Sunk X.-B.; Huang, Y.-X.; Peng, Y.-S.; Ma, S.
Aqueous extract of asparagus (Instant Asparagus Powder®) reduces psychological and physiological stress
SM J Pharmacol Ther, 2015, 1(2), 1006; (1-6)
Asparagus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress
368 Klement, S.; Kasper, S.
Silexan bei generalisierten Angststörungen - günstige Wirkung auf alltagsrelevante Endpunkte, gute Verträglichkeit
Z Phytother, 2015, 36(Suppl. 1), S33-S34 (Abstract; Symposiumsbeitrag)
Anxiety, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
369 Trompetter, I.; Gibbert, J.; Kreimendahl, F.; Lebert, J.; Weiss, G.; Rychlik, R.
Passionsblumenextrakt erhöht die Resilienz und steigert die Lebensqualität von Patienten mit nervösen Unruhezuständen
Z Phytother, 2015, 36(Suppl. 1), S39 (Abstract; Symposiumsbeitrag)
Observational trial, Clinical research, Complementary and alternative medicine, maracuia, Passiflora incarnata, Phytomedicine, Mental diseases, Stress
370 Toolika, E.; Bhat, N.P.; Shetty, S.K.
A comparative clinical study on the effect of Tagara (Valeriana wallichii DC.) and Jatamansi (Nardostachys jatamansi DC.) in the management of Anidra (primary insomnia)
Ayu, 2015, 36(1), 46-49
Ayurveda, Clinical research, Complementary and alternative medicine, Nardostachys jatamansi, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Valeriana, Valeriana wallichii
371 Fernandes Pimenta, F.C.; Feitosa Alves, M.; Fernandes Pimenta, M.B.; Linhares Melo, S.A.; Figueirêdo de Almeida, A.A.; Leite, J.R.; Morais Pordeus, L.C. de; Fátima Formiaga Melo Diniz, M. de; Almeida, R.N. de
Anxiolytic effect of Citrus aurantium L. on patients with chronic myeloid leukemia
Phytother Res, 2016, 30(4), 613-617
Anxiety, Aromatherapy, Citrus, Citrus aurantium, Clinical research, Complementary and alternative medicine, Cancer, Leukaemia, Phytomedicine, Mental diseases, Randomized trial
372 Yoshiyama, K.; Arita, H.; Suzuki, J.
The effect of aroma hand massage therapy for people with dementia
J Altern Complement Med, 2015, 21(12), 759-765
Abies, Abies nigra, Aromatherapy, Citrus, Citrus aurantium, Citrus paradisi, Cymbopogon, Dementia, Geriatrics, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Melissa, lemon balm, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rosa, Rosa damascena, Cymbopogon martinii
373 Bagheri-Nasemi, M.; Shorofi, S.A.; Nikkhah, A.; Espahbodi, F.; Koolaee, F.-S.G.
The effects of aromatherapy with lavender essential oil on fatigue levels in haemodialysis patients
A randomized clinical trial
Complement Ther Clin Pract, 2016, 22, 33-37
Aromatherapy, Chronic fatigue syndrome, Urinary tract, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Renal insufficiency, Phytomedicine, Mental diseases, Randomized trial
374 Dyer, J.; Cleary, L.; McNeill, S.; Ragsdale-Lowe, M.; Osland, C.
The use of aromasticks to help with sleep problems
A patient experience survey
Complement Ther Clin Pract, 2016, 22, 51-58
Aromatherapy, Observational trial, Boswellia, Boswellia sacra, Citrus, Citrus bergamia, Citrus reticulata, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Sleep disorders, Santalum
375 Bang, J.S.; Chung, Y.H.; Chung, S.J.; Lee, H.S.; Song, E.H.; Shin, Y.K.; Lee, Y.J.; Kim, H.C.; Nam, Y.; Jeong, J.H.
Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover
Pharmazie, 2015, 70(4), 269-273
Acanthopanax, Acanthopanax senticosus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Addiction, Alcohol Addiction
376 Mosaffa-Jahromi, M.; Tamaddon, A.-M.; Afsharypuor, S.; Salehi, S.H.; Pasalar, M.; Jafari, P.; Lankarani, K.B.
Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome
A randomized active and placebo-controlled clinical trial
J Evid Based Compl Altern Med, 2017, 22(1), 41-46
Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Pimpinella, Pimpinella anisum, Placebo-controlled, Mental diseases, Randomized trial, Irritable bowel syndrome
377 Hongratanaworakit, T.
Relaxing effect of rose oil on humans
Nat Prod Commun, 2009, 4(2), 261-266
Aromatherapy, Observational trial, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Oil, Phytomedicine, Mental diseases, Rosa, Rosa damascena, Stress, Vegetative nervous system
378 Lamport, D.J.; Lawton, C.L.; Merat, N.; Jamson, H.; Myrissa, K.; Hofman, D.; Chadwick, H.K.; Quadt, F.; Wightman, J.D.; Dye, L.
Concord grape juice, cognitive function, and driving performance
A 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children
Am J Clin Nutr, 2016, 103, 775-783
Brain, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Juice/distillate, Stress, Vitis, Vitis labrusca
379 Karaman, T.; Karaman, S.; Dogru, S.; Tapar, H.; Sahin, A.; Suren, M.; Arici, S.; Kaya, Z.
Evaluating the efficacy of lavender aromatherapy on peripheral venous cannulation pain and anxiety
A prospective, randomized study
Complement Ther Clin Pract, 2016, 23, 64-68
Anxiety, Aromatherapy, Surgery, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial, Chronic pain
380 Biswas, T.K.; Chakrabarti, S.; Pandit, S.; Jana, U.; Dey, S.K.
Pilot study evaluating the use of Emblica officinalis standardized fruit extract in cardio-respiratory improvement and antioxidant status of volunteers with smoking history
J Herbal Med, 2014, 4, 188-194
Respiratory diseases, Indian gooseberry, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Addiction
381 Jiang, K.; Jin, Y.; Huang, L.; Feng, S.; Hou, X.; Du, B.; Zheng, J.; Li, L.
Black cohosh improves objective sleep in postmenopausal women with sleep disturbance
Climacteric, 2015, 18(4), 559-567
Black cohosh, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
382 Choudhary, D.; Bhattacharyya, S.; Joshi, K.
Body weight managment in adults under chronic stress through treatment with Ashwagandha root extract
A double-blind, randomized, placebo-controlled trial
J Evid Based Compl Altern Med, 2017, 22(1), 96-106
Obesitiy, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases, Stress, Withania, Withania somnifera
383 Johnson, J.R.; Rivard, R.L.; Griffin, K.H.; Kolste, A.K.; Joswiak, D.; Kinney, M.E.; Dusek, J.A.
The effectiveness of nurse-delivered aromatherapy in an acute care setting
Complement Ther Med, 2016, 25, 164-169
Anxiety, Aromatherapy, Observational trial, Citrus, Citrus reticulata, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Gastrointestinal tract, Origanum, Origanum majorana, Phytomedicine, Mental diseases, Retrospective design, Pain, Sickness, ginger, Pflege
384 Matsumoto, T.; Kimura, T.; Hayashi, T.
Aromatic effects of a Japanese citrus fruit -yuzu (Citrus junos Sieb. ex Tanaka)- on psychoemotional states and autonomic nervous system activity during the menstrual cycle
A single-blind randomized controlled crossover study
Biopsychosoc Med, 2016, 10, 11; (1-11)
Aromatherapy, Citrus, Citrus junos, Gynaecology, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Vegetative nervous system
385 Mirghafourvand, M.; Charandabi, S.M.-A.; Hakimi, S.; Khodaie, L.; Galeshi, M.
Effect of orange peel essential oil on postpartum sleep quality
A randomized controlled clinical trial
Eur J Integr Med, 2016, 8(1), 62-66
Aromatherapy, Citrus, Citrus sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Obstetrics
386 Franco, L.; Blanck, T.J.J.; Dugan, K.; Kline, R.; Shanmugam, G.; Galotti, A.; Bergen Granell, A. von; Wajda, M.
Both lavender fleur oil and unscented oil aromatherapy reduce preoperative anxiety in breast surgery patients
A randomized trial
J Clin Anesth, 2016, 33, 243-249
Anxiety, Aromatherapy, Breast cancer, Surgery, Clinical research, Complementary and alternative medicine, Cancer, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial
387 Mazidi, M.; Shemshian, M.; Mousavi, S.H.; Norouzy, A.; Kermani, T.; Moghiman, T.; Sadeghi, A.; Mokhber, N.; Ghayour-Mobarhan, M.; Ferns, G.A.A.
A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression
J Complement Integr Med, 2016, 13(2), 195-199
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
388 Prichard, C.; Newcomb, P.
Benefit to family members of delivering hand massage with essential oils to critically ill patients
Am J Crit Care, 2015, 24(5), 446-449
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Non-randomized trial, Phytomedicine, Mental diseases, Intensivmedizin
389 Kim, H.S.; Kim, S.H.; Park, Y.S.; Kim, M.Y.
The effects of aroma massage and regular oil hand massage on the blood cortisol and serotonin level of elderly
Int J Bio Sci Bio Technol, 2016, 8(3), 119-126
Anxiety, Aromatherapy, Depression, Endocrinology, Geriatrics, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Serotonin, Cortisol
390 Eguchi, E.; Funakubo, N.; Tomooka, K.; Ohira, T.; Ogino, K.; Tanigawa, T.
The effects of aroma foot massage on blood pressure and anxiety in Japanese community-dwelling men and women
A crossover randomized controlled trial
PLoS ONE, 2016, 11(3), e0151712; (1-13)
Anxiety, Aromatherapy, Geriatrics, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
391 Bachmann, C.
Therapeutische Wirksamkeit und Sicherheit des Rosenwurz-Extraktes WS 1375
Resultate einer Anwendungsbeobachtung
Schweiz Z Ganzheitsmed, 2016, 28(4), 197-198
Observational trial, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola rosea, Stress
392 Moss, M.; Jones, R.; Moss, L.; Cutter, R.; Wesnes, K.
Acute consumption of peppermint and chamomile teas produce contrasting effects on cognition and mood in healthy young adults
Plant Sci Today, 2016, 3(3), 327-336
Chamomilla, Healthy probands, Clinical research, Complementary and alternative medicine, Mentha, peppermint, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Tea
393 Lopresti, A.L.; Drummond, P.D.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression
A randomised, double-blind, placebo-controlled study
J Affect Disord, 2017, 207, 188-196
Crocus, Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
394 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
395 Chamine, I.; Oken, B.S.
Aroma effects on physiologic and cognitive function following acute stress
A mechanism investigation
J Altern Complement Med, 2016, 22(9), 713-721
Aromatherapy, Healthy probands, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress, Vegetative nervous system
396 Lee, Y.-T.
A study of the effect of lavender floral-water eye-mask aromatherapy on the autonomous nervous system
Eur J Integr Med, 2016, 8(5), 781-788
Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Lavendula, Nervous system, Physical therapy, Phytomedicine, Mental diseases, Stress, Vegetative nervous system, Compress
397 Chen, M.C.; Fang, S.H.; Fang, L.
The effects of aromatherapy in relieving symptoms related to job stress among nurses
Int J Nurs Pract, 2015, 21(1), 87-93
Occupational health, Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Non-randomized trial, Phytomedicine, Mental diseases, Stress
398 Li, F.-D.; He, F.; Ye, X.-J.; Shen, W.; Wu, Y.-P.; Zhai, Y.-J.
Tea consumption is inversely associated with depressive symptoms in the elderly
A cross-sectional study in eastern China
J Affect Disord, 2016, 189, 157-162
Observational trial, Camellia, Camellia sinensis, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Tea, Green Tea, Black tea
399 Lee, N.; Lee, S.-H.; Yoo, H.-R.; Yoo, H.S.
Anti-fatigue effects of enzyme-modified ginseng extract
A randomized, double-blind, placebo-controlled trial
J Altern Complement Med, 2016, 22(11), 859-864
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Panax, Panax ginseng
400 Smith Lillehei, A.; Halcón, L.; Gross, C.R.; Savik, K.; Reis, R.
Well-being and self-assessment of change
Secondary analysis of an RCT that demonstrated benefit of inhaled lavender and sleep hygiene in college students with sleep problems
Explore, 2016, 12(6), 427-435
Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders