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401 Kim, H.S.; Kim, S.H.; Park, Y.S.; Kim, M.Y.
The effects of aroma massage and regular oil hand massage on the blood cortisol and serotonin level of elderly
Int J Bio Sci Bio Technol, 2016, 8(3), 119-126
Anxiety, Aromatherapy, Depression, Endocrinology, Geriatrics, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Serotonin, Cortisol
402 Eguchi, E.; Funakubo, N.; Tomooka, K.; Ohira, T.; Ogino, K.; Tanigawa, T.
The effects of aroma foot massage on blood pressure and anxiety in Japanese community-dwelling men and women
A crossover randomized controlled trial
PLoS ONE, 2016, 11(3), e0151712; (1-13)
Anxiety, Aromatherapy, Geriatrics, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
403 Bachmann, C.
Therapeutische Wirksamkeit und Sicherheit des Rosenwurz-Extraktes WS 1375
Resultate einer Anwendungsbeobachtung
Schweiz Z Ganzheitsmed, 2016, 28(4), 197-198
Observational trial, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola rosea, Stress
404 Moss, M.; Jones, R.; Moss, L.; Cutter, R.; Wesnes, K.
Acute consumption of peppermint and chamomile teas produce contrasting effects on cognition and mood in healthy young adults
Plant Sci Today, 2016, 3(3), 327-336
Chamomilla, Healthy probands, Clinical research, Complementary and alternative medicine, Mentha, peppermint, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Tea
405 Lopresti, A.L.; Drummond, P.D.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression
A randomised, double-blind, placebo-controlled study
J Affect Disord, 2017, 207, 188-196
Crocus, Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
406 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
407 Chamine, I.; Oken, B.S.
Aroma effects on physiologic and cognitive function following acute stress
A mechanism investigation
J Altern Complement Med, 2016, 22(9), 713-721
Aromatherapy, Healthy probands, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress, Vegetative nervous system
408 Lee, Y.-T.
A study of the effect of lavender floral-water eye-mask aromatherapy on the autonomous nervous system
Eur J Integr Med, 2016, 8(5), 781-788
Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Lavendula, Nervous system, Physical therapy, Phytomedicine, Mental diseases, Stress, Vegetative nervous system, Compress
409 Chen, M.C.; Fang, S.H.; Fang, L.
The effects of aromatherapy in relieving symptoms related to job stress among nurses
Int J Nurs Pract, 2015, 21(1), 87-93
Occupational health, Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Non-randomized trial, Phytomedicine, Mental diseases, Stress
410 Li, F.-D.; He, F.; Ye, X.-J.; Shen, W.; Wu, Y.-P.; Zhai, Y.-J.
Tea consumption is inversely associated with depressive symptoms in the elderly
A cross-sectional study in eastern China
J Affect Disord, 2016, 189, 157-162
Observational trial, Camellia, Camellia sinensis, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Tea, Green Tea, Black tea
411 Lee, N.; Lee, S.-H.; Yoo, H.-R.; Yoo, H.S.
Anti-fatigue effects of enzyme-modified ginseng extract
A randomized, double-blind, placebo-controlled trial
J Altern Complement Med, 2016, 22(11), 859-864
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Panax, Panax ginseng
412 Smith Lillehei, A.; Halcón, L.; Gross, C.R.; Savik, K.; Reis, R.
Well-being and self-assessment of change
Secondary analysis of an RCT that demonstrated benefit of inhaled lavender and sleep hygiene in college students with sleep problems
Explore, 2016, 12(6), 427-435
Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
413 Bertoglio, J.C.; Baumgartner, M.; Palma, R.; Ciampi, E.; Carcamo, C.; Cáceres, D.D.; Acosta-Jamett, G.; Hancke, J.L.; Burgos, R.A.
Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis
A 12-month double-blind placebo-controlled pilot study
BMC Neurol, 2016, 16, 77; (1-8)
Andrographis paniculata, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
414 Soto-Vásquez, M.R.; Alvarado-Garcia, P.A.
Aromatherapy with two essential oils from Satureja genre and mindfulness meditation to reduce anxiety in humans
J Tradit Complement Med, 2017, 7(1), 121-125
Mindfulness meditation, Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Meditation, Mind-body medicine, Phytomedicine, Mental diseases, Randomized trial, Satureja, Satureja brevicalyx, Satureja boliviana
415 Ng, Q.X.; Venkatanarayanan, N.; Ho, C.Y.
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
416 Gok Metin, Z.; Ozdemir, L.
The effects of aromatherapy massage and reflexology on pain and fatigue in patients with rheumatoid arthritis
A randomized controlled trial
Pain Manag Nurs, 2016, 17(2), 140-149
Aromatherapy, Arthritis, Muscoskeletal -/Connective tissue system, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Reflexology, Rheumatic diseases, Pain
417 Field, T.; Field, T.; Cullen , C.; Largie, S.; Diego, M.; Schanberg, S.; Kuhn, C.
Lavender bath oil reduces stress and crying and enhances sleep in very young infants
Early Hum Develop, 2008, 84, 399-401
Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Pediatrics, Phytomedicine, Mental diseases, Sleep disorders, Stress
418 Jafarzadeh, M.; Arman, S.; Pour, F.F.
Effect of aromatherapy with orange essential oil on salivary cortisol and pulse rate in children during dental treatment
A randomized controlled clinical trial
Adv Biomed Res, 2013, 2, 10; (1-12)
Anxiety, Aromatherapy, Citrus, Citrus sinensis, Endocrinology, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases, Randomized trial, Stress, Dental diseases, Cortisol
419 Lee, C.H.; Lai, C.L.; Sung, Y.H.; Lai, M.Y.; Lin, C.Y.; Lin, L.Y.
Comparing effects between music intervention and aromatherapy on anxiety of patients undergoing mechanical ventilation in the intensive care unit
A randomized controlled trial
Qual Life Res, 2017, 26(7), 1819-1829
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Music therapy, Phytomedicine, Mental diseases, Randomized trial, Intensivmedizin
420 Lekomtseva, Y.; Zhukova, I.; Wacker, A.
Rhodiola rosea in subjects with prolonged or chronic fatigue symptoms
Results of an openl label clinical trial
Complement Med Res, 2017, 24(1), 46-52
Observational trial, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola, Rhodiola rosea
421 Rother, C.; Schnelle, M.
Cardiodoron® bei Patienten mit Schlafstörungen - Ergebnisse einer prospektiven Beobachtungsstudie
Complement Med Res, 2017, 24(1), 15-25
Observational trial, Cardiodoron, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Sleep disorders, Stress
422 Rother, C.; Schnelle, M.
Cardioron® bei Patienten mit Schlafstörungen
Ergebnisse einer prospektiven Beobachtungsstudie
Merkurstab, 2017, 70(1), 48-58 (Zweitveröffentlichung)
Observational trial, Cardiodoron, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Sleep disorders
423 Romain, C.; Alcaraz, P.E.; Chung, L.H.; Cases, J.
Regular consumption of HolisFiit, a polyphenol-rich extract-based food supplement, improves mind and body well-being of overweight and slightly obese volunteers
A randomized, double-blind, parallel trial
Int J Food Sci Nutr, 2017, 68(7), 840-848
Nutrition/diet, Obesitiy, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases, Overweight
424 Sayeed, M.S.B.; Shams, T.; Hossain, S.F.; Rahman, R.; Mostofa, A.G.M.; Kadir, M.F.; Mahmood, S.; Asaduzzaman, -
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
J Ethnopharmacol, 2014, 152, 156-162
Anxiety, Depression, Brain, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Nigella sativa, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
425 Han, X.; Gibson, J.; Eggett, D.L.; Parker, T.L.
Bergamot (Citrus bergamia) essential oil inhalation improves positive feelings in the waiting room of a mental health treatment center
A pilot study
Phytother Res, 2017, 31(5)nt, 812-816
Aromatherapy, Observational trial, Citrus, Citrus bergamia, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases
426 Takeda, A.; Watanuki, E.; Koyama, S.
Effects of inhalation aromatherapy on symptoms of sleep disturbances in the elderly with dementia
eCAM, 2017, Article ID 1902807, (1-7)
Aromatherapy, Observational trial, Cedrus, Citrus, Citrus sinensis, Cupressus, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Phytomedicine, Pinus, Mental diseases, Sleep disorders
427 Huang, L.; Capdevila, L.
Aromatherapy improves work performance through balancing the autonomic nervous system
J Altern Complement Med, 2017, 23(3), 214-221
Occupational health, Aromatherapy, Citrus, Citrus aurantium, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Stress, Vegetative nervous system
428 Sharifi, A.; Motaghi, M.; Borji, M.; Moradi, M.
The effect of orange essence aromatherapy on anxiety in school-age children with diabetes
Biomed Pharmacol J, 2017, 10(1), 159-164
Anxiety, Aromatherapy, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Oleum, Pediatrics, Phytomedicine, Mental diseases, Randomized trial, Metabolic diseases, Oleum aurantii
429 Gibbert, J.; Kreimendahl, F.; Lebert, J.; Rychlik, R.; Trompetter, I.
Improvement of stress resistance and quality of life of adults with nervous restlessness after treatment with a passion flower dry extract
Forsch Komplementärmed, 2017, 24(2), 83-89
Observational trial, Clinical research, Complementary and alternative medicine, maracuia, Passiflora incarnata, Phytomedicine, Mental diseases, Stress
430 Vaziri, F.; Shiravani, M.; Najib, F.S.; Pourahmad, S.; Salehi, A.; Yazdanpanahi, Z.
Effect of lavender oil aroma in the early hours of postpartum period on maternal pains, fatigue, and mood
A randomized clinical trial
Int J Prev Med, 2017, 8, 29; (1-7)
Aromatherapy, Chronic fatigue syndrome, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Phytomedicine, Prevention, Mental diseases, Randomized trial, Pain, Obstetrics
431 Chang, Y.Y.; Lin, C.L.; Chang, L.Y.
The effects of aromatherapy massage on sleep quality of nurses on monthly rotating night shifts
eCAM, 2017, Article ID 3861273, (1-8)
Aromatherapy, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Pflege
432 Kao, Y.H.; Huang, Y.C.; Chung, U.L.; Hsu, W.N.; Tang, Y.T.; Liao, Y.H.
Comparisons for effectiveness of aromatherapy and acupressure massage on quality of life in career women
A randomized controlled trial
J Altern Complement Med, 2017, 23(6), 451-460
Acupressure, Acupuncture, Occupational health, Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Origanum, Origanum majorana, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, sage, Salvia sclarea, Stress, Traditional Chinese medicine
433 Matsumoto, T.; Kimura, T.; Hayashi, T.
Does Japanese citrus fruit Yuzu (Citrus junos Sieb. ex Tanaka) fragrance have lavender-like therapeutic effects that alleviate premenstrual emotional symptoms?
A single-blind randomized crossover study
J Altern Complement Med, 2017, 23(6), 461-470
Aromatherapy, Citrus, Citrus junos, Gynaecology, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Premenstrual syndrome, Mental diseases, Randomized trial, Vegetative nervous system
434 Seo, E.-Y.
Effects of aroma mouthwash on stress level, xerostomia, and halitosis in healthy nurses
A non-randomized controlled clinical trial
Eur J Integr Med, 2017, 10, 82-89
Applikationsform, Aromatherapy, Citrus, lime leaves [kaffir-], Halitosis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Melaleuca, Melaleuca alternifolia, Mentha, peppermint, Dry mouth, Mundwasser, Non-randomized trial, Phytomedicine, Mental diseases, Stress, Ylang ylang
435 Kell, G.; Rao, A.; Beccaria, G.; Clayton, P.; Inarejos-García, A.M.; Prodanov, M.
affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.
Complement Ther Med, 2017, 33, 58-64
Crocus, Depression, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
436 Tugut, N.; Demirel, G.; Baser, M.; Ata, E.E.; Karakus, S.
Effects of lavender scent on patients' anxiety and pain levels during gynecological examination
Complement Ther Clin Pract, 2017, 28, 65-69
Anxiety, Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial, Pain
437 Firoozabadi, A.; Kolouri, S.; Zarshenas, M.M.; Salehi, A.; Mosavat, S.H.; Dastgheib, S.A.
Efficacy of a freeze-dried aqueous extract of Nepeta menthoides Boiss. and Buhse in the treatment of anxiety in patients with depression
A double-blind, randomized, controlled trial
J Herbal Med, 2017, 10, 17-23
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Nepeta menthoides
438 Keefe, J.R.; Amsterdam, J.; Li, Q.S.; Soeller, I.; DeRubeis, R.; Mao, J.J.
Specific expectancies are associated with symptomatic outcomes and side effect burden in a trial of chamomile extract for generalized anxiety disorder
J Psychiatr Res, 2017, 84, 90-97
Anxiety, Observational trial, Chamomilla, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Adverse effect
439 Hozumi, H.; Hasegawa, S.; Tsunenari, T.; Sanpei, N.; Arashina, Y.; Takahashi, K.; Konnno, A.; Chida, E.; Tomimatsu, S.
Aromatherapies using Osmanthus fragrans oil and grapefruit oil are effective complementary treatments for anxious patients undergoing colonoscopy
A randomized controlled study
Complement Ther Med, 2017, 34, 165-169
Anxiety, Aromatherapy, Citrus, Citrus paradisi, Clinical research, Complementary and alternative medicine, Lavendula, Gastrointestinal tract, Phytomedicine, Mental diseases, Randomized trial, Fragrant olive
440 Johnson, K.; West, T.; Diana, S.; Todd, J.; Haynes, B.; Bernhardt, J.; Johnson, R.
Use of aromatherapy to promote a therapeutic nurse environment
Int Crit Care Nurs, 2017, 40, 18-25
Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Hospital, Lavendula, Lavendula angustifolia, Phytomedicine, Practice, Mental diseases, Stress
441 Kasper, S.; Dienel, A.
Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms
Neuropsychiatr Dis Treat, 2017, 13, 889-898
Observational trial, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola, Rhodiola rosea
442 Stevens, N.; Dorsett, J.; DaBell, A.; Eggett, D.L. Han, X.; Parker, T.L.
Subjective assessment of the effects of an herbal supplement containing lavender essential oil on sleep quality
A randomized, double-blind, placebo-controlled crossover study
Cogent Med, 2017, 4(1), 1380871; (1-11)
Aromatherapy, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
443 Lee, M.-k.; Lim, S.; Song, J.-A.; Kim, M.-E.; Hur, M.-H.
The effects of aromatherapy essential oil inhalation on stress, sleep quality and immunity in healthy adults
Randomized controlled trial
Eur J Integr Med, 2017, 12, 79-86
Aromatherapy, Healthy probands, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Stress
444 Neto, G.C.; Braga, J.E.F.; Alves, M.F.; Morais Pordeus, L.C. de; Santos, S.G. dos; Scotti, M.T.; Almeida, R.N.; Fátima Formiga Melo Diniz, M. de
Anxiolytic effect of Citrus aurantium L. in crack users
eCAM, 2017, Article ID 7217619, (1-8)
Anxiety, Aromatherapy, Observational trial, Citrus, Citrus vulgaris, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Addiction, Drug addiction
445 Yahya, H.M.; Shahar, S.; Ismail, S.N.A.; Aziz, A.F.; Din, N.C.; Hakim, B.N.A.
Mood, cognitive function and quality of life improvements in middle aged women following supplementation with Polygonum minus extract
Sains Malaysiana, 2017, 46(2), 245-254
Anxiety, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Polygonum, Polygonum minus, Mental diseases, Randomized trial, Postpartum depression
446 Mineo, L.; Concerto, C.; Patel, D.; Mayorga, T.; Paula, M.; Chusid, E.; Aguglia, E.; Battaglia, F.
Valeriana officinalis root extract modulates cortical excitatory circuits in humans
Neuropsychobiology, 2017, 75, 46-51
Anxiety, Biology/Biological Sciences, Brain, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Neurobiology, Phytomedicine, Placebo-controlled, Mental diseases, Sleep disorders, Valeriana
447 Franciscis, P. de; Grauso, F.; Luisi, A.; Schettino, M.T.
Adding Agnus castus and Magnolia to soy isoflavones relieves sleep disturbances besides postmenopausal vasomotor symptoms
Long term safety and effectiveness
Nutrients, 2017, 9, 129; (1-8)
Agnus castus, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Magnolia, Menopause, Non-randomized trial, Phaseolus, Phaseolus max, Phytomedicine, Mental diseases, Sleep disorders
448 Adib-Hajbaghery, M.; Mousavi, S.N.
The effects of chamomile extract on sleep quality among elderly people
A clinical trial
Complement Ther Med, 2017, 35, 109-114
Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
449 Chen, P.J.; Chou, C.C.; Yang, L.; Tsai, Y.L.; Chang, Y.C.; Liaw, J.J.
Effects of aromatherapy massage on pregnant women's stress and immune function
A longitudinal, prospective, randomized controlled trial
J Altern Complement Med, 2017, 23(10), 778-786
Aromatherapy, Gynaecology, Immune system, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Phytomedicine, Mental diseases, Randomized trial, Obstetrics, Stress
450 Baldinger, P.; Höflich, A.S.; Mitterhauser, M.; Hahn, A.; Rami-Mark, C.; Spies, M.; Wadsak, W.; Lanzenberger, R.; Kasper, S.
Effects of silexan on the serotonin-1A receptor and microstructure of the human brain
A randomized, placebo-controlled, double-blind, cross-over study with molecular and structural neuroimaging
Int J Neuropsychopharmacol, 2015, 18(4), pyu063; (1-9)
Anxiety, Aromatherapy, Brain, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
451 Yang, Y.P.; Lee, F.P.; Chao, H.C.; Hsu, F.Y.; Wang, J.J.
Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia
J Am Med Dir Assoc, 2016, 17(8), 719-724
Aromatherapy, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases
452 Trambert, R.; Kowalski, M.O.; Wu, B.; Mehta, N.; Friedman, P.
A randomized controlled trial provides evidence to support aromatherapy to minimize anxiety in women undergoing breast biopsy
Worldviews Evid Based Nurs, 2017, 14(5), 394-402
Anxiety, Aromatherapy, Breast, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
453 Martin, T.J.; Mist, S.; Lektsok, T.; Trent, N.L.
Tibetan herbal tea Agar-35 reduces negative affect and anxiety
A placebo-controlled pilot study
Explore, 2017, 13(6), 367-370
Anxiety, Aquilaria, Aquilaria agallocha, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Tea, Traditional Tibetan medicine, Agar-35
454 Hekmatpou, D.; Pourandish, Y.; Farahani, P.V.; Parvizrad, R.
The effect of aromatherapy with orange essential oil on anxiety and pain in patients with fractured limbs admitted to an emergency ward
A randomized clinical trial
Central Eur J Nurs Midwif, 2017, 8(4), 717-722
Anxiety, Aromatherapy, Muscoskeletal -/Connective tissue system, Citrus, Citrus sinensis, Clinical research, Fracture, Complementary and alternative medicine, Emergency medicine/Intensive care, Phytomedicine, Mental diseases, Randomized trial, Pain
455 Cheon, C.; Yoo, J.-E.; Yoo, H.-S.; Cho, C.-K.; Kang, S.; Kim, M.; Jang, B.-H.; Shin, Y.-C.; Ko, S.-G.
Efficacy and safety of Sipjeondaebo-Tang for anorexia in patients with cancer
A pilot, randomized, double-blind, placebo-controlled trial
eCAM, 2017, Article-ID 8780325, (1-10)
Eating disorders, Juzen-Taiho-To, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Traditional Korean Medicine, Appetitlosigkeit
456 Shara, M.; Kakish, E.; Stohs, S.J.
Effect of an adaptogen-based supplement on stress parameters in healthy volunteers
Int J Complement Altern Med, 2017, 10(1), 00321; (1-5)
Eleutherococcus senticosus, Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Schizandra, Stress
457 Um, M.Y.; Kim, J.Y.; Han, J.K.; Kim, J.; Yang, H.; Yoon, M.; Kim, J.; Kang, S.W.; Cho, S.
Phlorotannin supplement decreases wake after sleep onset in adults with self-reported sleep disturbance
A randomized, controlled, double-blind clinical and polysomnographic study
Phytother Res, 2018, 32(4), 698-704
Ecklonia, Ecklonia cava, Clinical research, Complementary and alternative medicine, Sea remedies, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
458 Cho, E.H.; Lee, M.-Y.; Hur, M.-H.
The effects of aromatherapy on intensive care unit patient's stress and sleep quality
A nonrandomised controlled trial
eCAM, 2017, Article ID 2856592, (1-10)
Aromatherapy, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Sleep disorders, Stress, Pflege, Intensivmedizin
459 Farnia, V.; Tatari, F.; Alikhani, M.; Shakeri, J.; Taghizadeh, M.; Karbaizadeh, H.; Sadeghi Bahmani, D.; Holsboer-Trachsler, E.; Brand, S.
Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy
Results from a double-blind, randomized, placebo-controlled clinical trial
Drug Alcohol Depend, 2017, 176, 117-125
Andrology, Aromatherapy, Erectile disorder, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rosa, Rosa damascena, Addiction, Sexual dysfunction (male), Drug addiction
460 Yang, Y.-P.; Wang, C.-J.; Wang, J.-J.
Effect of aromatherapy massage on agitation and depressive mood in individuals with dementia
J Gerontol Nurs, 2016, 42(9), 38-46
Aromatherapy, Chamomilla, Citrus, Citrus sinensis, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Nervous system, Phytomedicine, Mental diseases, Randomized trial
461 Fung, K.M.; Kamen, J.
Management of behavioural and psychological symptoms of dementia (BPSD) by complementary and alternative medicine (CAM) approaches
2018, 1-163 (Dissertation)
Acupressure, Acupuncture, Aromatherapy, Dementia, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Traditional Chinese medicine, Review (CR), Conduct disorder
462 Nematolahi, P.; Mehrabani, M.; Karami-Mohajeri, S.; Dabaghzadeh, F.
Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students
A randomized clinical trial
Complement Ther Clin Pract, 2018, 30, 24-28
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, rosemary, Sleep disorders
463 Ayik, C.; Özden, D.
The effects of preoperative aromatherapy massage on anxiety and sleep quality of colorectal surgery patients
A randomized controlled study
Complement Ther Med, 2018, 36, 93-99
Anxiety, Aromatherapy, Surgery, Clinical research, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, hybrid lavender
464 Iokawa, K.; Kohzuki, M.; Sone, T.; Ebihara, S.
Effect of olfactory stimulation with essential oils on cardiovascular reactivity during the moving beans task in stroke patients with anxiety
Complement Ther Med, 2018, 36, 20-24
Anxiety, Aromatherapy, Observational trial, Citrus, Citrus paradisi, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lavendula, Nervous system, Phytomedicine, Mental diseases, Rehabilitation, Stroke, Vegetative nervous system
465 Risi, O.; Manica, M.; Lisanti, R.C.; Manfredi, A.; Tecci, G.R.
Effectiveness on mild stress and mixed urinary incontinence and impact on Quality of Life of a phytotherapic product containing astragalus, thyme, lavender, hop, equisetum, red clover, cypress and agrimonia at titrated concentrations
Results from a monocentric study
Arch Ital Urol Androl, 2017, 89(4), 293-295
Observational trial, Gynaecology, Urinary tract, Incontinence, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Stress, IncontinenzaMEV®
466 Ghajar, A.; Neishabouri, S.M.; Velayati, N.; Jahangard, L.; Matinnia, N.; Haghighi, M.; Ghaleiha, A.; Afarideh, M.; Salimi, S.; Meysamie, A.; Akhondzadeh, S.
Crocus sativus L. versus Citalopram in the treatment of major depressive disorder with anxious distress
A double-blind, controlled clinical trial
Pharmacopsychiatry, 2017, 50(4), 152-160
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
467 Hamdamina, S.; Nazarpour, S.; Simbar, M.; Hajian, S.; Mojab, F.; Talebi, A.
Effects of aromatherapy with Rosa damascena on nulliparous women's pain and anxiety of labor during first stage of labor
J Integr Med, 2018, 16, 120-125
Anxiety, Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rosa, Rosa damascena, Obstetrics, Geburtsschmerz
468 Feyzabadi, Z.; Rezaeitalab, F.; Badiee, S.; Taghipour, A.; Moharari, F.; Soltanifar, A.; Ahmadpour, M.R.
Efficacy of violet oil, a traditional Iranian formula, in patients with chronic insomnia
A randomized, double-blind, placebo-controlled study
J Ethnopharmacol, 2018, 214, 22-28
Aromatherapy, Clinical research, Complementary and alternative medicine, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Viola, Viola odorata, Traditionelle Persische Medizin
469 Soler, J.; Elices, M.; Dominguez-Clavé, E.; Pascual, J.C.; Feilding, A.; Navarro-Gil, M.; García-Campayo, J.; Riba, J.
Four weekly Ayahuasca sessions lead to increases in "acceptance" capacities
A comparison study with a standard 8-week mindfulness training program
Front Pharmacol, 2018, 9, 224; (1-8)
Mindfulness meditation, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Meditation, Mind-body medicine, Non-randomized trial, Phytomedicine, Mental diseases, Stress, Tea, Ayahuasca
470 Dantas, L.-P.; Oliveira-Ribeiro, A. de
Effects of Passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction
Med Oral Patol Oral Cir Bucal, 2017, 22(1), e95-e101
Anxiety, Clinical research, Complementary and alternative medicine, maracuia, Passiflora incarnata, Phytomedicine, Mental diseases, Randomized trial, Tooth extraction, Dental diseases
471 Farshbaf-Khalili, A.; Kamalifard, M.; Namadian, M.
Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women
A triple-blind, randomized, controlled clinical trial
Complement Ther Clin Pract, 2018, 31, 132-138
Anxiety, Citrus, Citrus aurantiifolia, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
472 Hassanzadeh, M.; Kiani, F.; Bouya, S.; Zarei, M.
Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis
Complement Ther Clin Pract, 2018, 31, 210-214
Aromatherapy, Chronic fatigue syndrome, Relaxation, Clinical research, Complementary and alternative medicine, Mind-body medicine, Phytomedicine, Mental diseases, Randomized trial
473 Bush, J.A.; Ratamess, N.A.; Stohs, S.J.; Ellis, N.L.; Vought, I.T.; O'Grady, E.A.; Kuper, J.D.; Kang, J.; Faigenbaum, A.D.
Acute hematological and mood perception effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine
A placebo-controlled, double-blind study
Phytother Res, 2018, 32(8), 1593-1607
Blood, Blood/Lymphatic system, Citrus, Citrus aurantium, Coffeinum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
474 Ng, Q.X.; Koh, S.S.H.; Chan, H.W.; Ho, C.Y.X.
Clinical use of curcumin in depression
A meta-analysis
J Am Med Dir Assoc, 2017, 18(6), 503-508
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
475 Moazen-Zadeh, E.; Abbasi, S.H.; Safi-Aghdam, H.; Shahmansouri, N.; Arjmandi-Beglar, A.; Hajhosseinn Talasaz, A.; Salehiomran, A.; Forghani, S.; Akhondzadeh, S.
Effects of saffron on cognition, anxiety, and depression in patients undergoing coronary artery bypass grafting
A randomized double-blind placebo-controlled trial
J Altern Complement Med, 2018, 24(4), 361-368
Anxiety, Surgery, Crocus, Depression, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
476 Yang, X.; Chen, X.; Fu, Y.; Luo, Q.; Du, L.; Qiu, H.; Qiu, T.; Zhang, L.; Meng, H.
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults
A meta-analysis of randomized controlled trials
Neuropsychiatr Dis Treat, 2018, 14, 1297-1305
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
477 Faydali, S.; Cetinkaya, F.
The effect of aromatherapy on sleep quality of elderly people residing in a nursing home
Holist Nurs Pract, 2018, 32(1), 8-16
Aromatherapy, Observational trial, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Sleep disorders
478 Muz, G.; Tasci, S.
Effect of aromatherapy via inhalation on the sleep quality and fatigue level in people undergoing hemodialysis
Appl Nurs Res, 2017, 37, 28-35
Aromatherapy, Chronic fatigue syndrome, Citrus, Citrus sinensis, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
479 Keefe, J.R.; Mao, J.J.; Soeller, I.; Li, Q.S.; Amsterdam, J.D.
Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder
Phytomed, 2016, 23(12), 1699-1705
Anxiety, Chamomilla, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
480 Mao, J.J.; Xie, S.X.; Keefe, J.R.; Soeller, I.; Li, Q.S.; Amsterdam, J.D.
Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder
A randomized clinical trial
Phytomed, 2016, 23(12), 1735-1742
Anxiety, Chamomilla, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
481 Meier, S.; Haschke, M.; Zahner, C.; Kruttschnitt, E.; Drewe, J.; Liakoni, E.; Hammann, F.; Gaab, J.
Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men
An explorative randomized placebo-controlled double-blind study
Phytomed, 2018, 39, 85-92
Andrology, Healthy probands, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Melissa, lemon balm, maracuia, Passiflora incarnata, butterbur, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress, Valeriana, Petasites hybridus
482 Belcaro, G.; Hosoi, M.; Feragalli, B.; Luzzi, R.; Dugall, M.
Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress
Minerva Med, 2018, 109(3), 211-217
Chronic fatigue syndrome, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Non-randomized trial, Phytomedicine, Mental diseases, Quercus, Quercus robur
483 Bahrami, T.; Rejeh, N.; Heravi-Karimooi, M.; Vaismoradi, M.; Tadrisi, S.D.; Sieloff, C.
Effect of aromatherapy massage on anxiety, depression, and physiologic parameters in older patients with the acute coronary syndrome
A randomized clinical trial
Int J Nurs Pract, 2017, 23(6), e12601; (1-10)
Anxiety, Aromatherapy, Depression, Geriatrics, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Lavendula, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
484 Keefe, J.R.; Guo, W.; Li, Q.S.; Amsterdam, J.D.; Mao, J.J.
An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder
J Psychiatr Res, 2018, 96, 189-195
Anxiety, Observational trial, Chamomilla, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases
485 Shirzadegan, R.; Gholami, M.; Hasanvand, S.; Birjandi, M.; Beiranvand, A.
Effects of geranium aroma on anxiety among patients with acute myocardial infarction
A triple-blind randomized clinical trial
Complement Ther Clin Pract, 2017, 29, 201-206
Anxiety, Aromatherapy, Heart attack, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
486 Tóth, B.; Hegyi, P.; Lantos, T.; Szakács, Z.; Kerémi, B.; Varga, G.; Tenk, J.; Pétervári, E.; Balaskó, M.; Rumbus, Z.; Rakonczay, Z.; Bálint, E.R.; Kiss, T.; Csupor, D.
The efficacy of saffron in the treatment of mild to moderate depression
A meta-analysis
Planta Med, 2019, 85(1), 24-31
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
487 Paolo, B.; Massimo, B.; Stefano, S.
Complementary treatment of mood disturbances in terminally ill oncological patients with the aphanziomenon flos aquae extract Klamin®
Adv Complement Altern Med, 2018, 1(3), (1-5)
Anxiety, Observational trial, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Cancer, sea kelp, Sea remedies, Phytomedicine, Mental diseases
488 Saritaş, S.; Kavak, F.; Savaş, B.
The effect of lavender oil on anxiety levels of patients before laparoscopic cholecystectomy
Complement Ther Clin Pract, 2018, 32, 51-54
Anxiety, Aromatherapy, Surgery, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Phytomedicine, Mental diseases, Randomized trial
489 Ranjbar, M.; Firoozabadi, A.; Salehi, A.; Ghorbanifar, Z.; Zarshenas, M.M.; Sadeghniiat-Haghighi, K.; Rezaeizadeh, H.
Effects of herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. and Buhse) on insomnia severity, anxiety and depression in insomniacs
Randomized placebo controlled trial
Integr Med Res, 2018, 7(4), 328-332
Anxiety, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, lemon balm, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Nepeta menthoides
490 Ghazanfarpour, M.; Mohammadzadeh, F.; Shokrollahi, P.; Khadivzadeh, T.; Najaf Najafi, M.; Hajirezaee, H.; Afiat, M.
Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women
A double-blind randomised controlled trial
J Obstet Gynaecol, 2018, 38(1), 121-126
Anxiety, Depression, Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
491 Xiong, M.; Li, Y.; Tang, P.; Zhang, Y.; Cao, M.; Ni, J.; Xing, M.
Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults
J Altern Complement Med, 2018, 24(7), 717-724
Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Citrus sinensis, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Inhalation
492 Jaruzel, C.B.; Gregoski, M.; Mueller, M.; Faircloth, A.; Kelechi, T.
Aromatherapy for preoperative anxiety
A pilot study
J Perianesth Nurs, 2018, epub ahead of print,
Anxiety, Aromatherapy, Observational trial, Surgery, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases
493 Romero-Cerecero, O.; Islas-Garduño, A.L.; Zamilpa, A.; Pérez-Garcia, M.D.; Tortoriello, J.
Therapeutic effectiveness of Galphimia glauca in young people with social anxiety disorder
A pilot study
eCAM, 2018, Article ID 1716939, (1-8)
Anxiety, Ginkgo, Jugendmedizin, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases, Randomized trial, Social phobia
494 Fung, J.K.K.; Tsang, H.W.
Management of behavioural and psychological symptoms of dementia by an aroma-massage with acupressure treatment protocol
A randomised clinical trial
J Clin Nurs, 2018, 27(9-10), 1812-1825
Acupressure, Acupuncture, Aromatherapy, Dementia, Geriatrics, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Traditional Chinese medicine, Conduct disorder
495 Melo Sette, C.V. de; Ribas de Alcântara, b.B.; Schoueri, J.H.M.; Cruz, F.M.; Cubero, D.I.G.; Pianowski, L.F.; Peppone, L.J.; Fonseca, F.; Del Giglio, A.
Purified dry Paullinia cupana (PC-18) extract for chemotherapy-induced fatigue
Results of two double-blind randomized clinical trials
J Diet Suppl, 2018, 15(5), 673-683
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
496 Zwanzger, P.; Wacker, A.
Silexan bei somatischen Angstsymptomen
Z Phytother, 2017, 38 (Suppl.1), 44 (Abstract (Poster))
Anxiety, Depression, Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Meta-analysis, Ear noises, Phytomedicine, Mental diseases, Silexan
497 Afrasiabian, F.; Mirabzadeh Ardakani, M.; Rahmani, K.; Azadi, N.A.; Alemohammad, Z.B.; Bidaki, R.; Karimi, M.; Emtiazy, M.; Hashempur, M.H.
Aloysia citriodora Palau (lemon verbena) for insomnia patients
A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety
Phytother Res, 2019, 33(2), 350-359
Aloysia, Aloysia triphylla, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
498 Fernandez, M.L.F.; Ferrer, M.V.P.; Flores, K.A.B.; Florido, A.I.A.; Foronda, K.I.L.; Lazalita, L.A.M.
The effect of lavender aromatherapy to junior nursing students' anxiety, concentratioin and memory retention
Arch Nurs Health Care Res, 2018, 102(1), (1-10)
Anxiety, Aromatherapy, Observational trial, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Nervous system, Phytomedicine, Mental diseases, Pflege
499 Umigai, N.; Takeda, R.; Mori, A.
Effect of crocetin on quality of sleep
A randomized, double-blind, placebo-controlled, crossover study
Complement Ther Med, 2018, 41, 47-51
Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
500 Milajerdi, A.; Jazayeri, S.; Shirzadi, E.; Hashemzadeh, N.; Azizgol, A.; Djazayery, A.; Esmaillzadeh, A.; Akhondzadeh, S.
The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus
A double-blind, randomized and placebo-controlled clinical trial
Complement Ther Med, 2018, 41, 196-202
Anxiety, Crocus, Depression, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases