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1
Warshafsky, S.; Kamer, R.S.; Sivak, S.L.
Effect of Garlic on Total Serum Cholesterol
A Meta-analysis
Ann Intern Med, 1993, 119, 599-605
Effect of Garlic on Total Serum Cholesterol
A Meta-analysis
Ann Intern Med, 1993, 119, 599-605
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases
2
Silagy, C.A.; Neil, A.
Garlic as a lipid lowering agent
A meta-analysis
J Royal College Phys London, 1994, 28(1), 39-45
Garlic as a lipid lowering agent
A meta-analysis
J Royal College Phys London, 1994, 28(1), 39-45
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases
3
Stevinson, C.; Pittler, M.H.; Ernst, E.
Garlic for treating hypercholesterolemia
A meta-analysis of randomized clinical trials
Ann Intern Med, 2000, 133(6), 420-429
Garlic for treating hypercholesterolemia
A meta-analysis of randomized clinical trials
Ann Intern Med, 2000, 133(6), 420-429
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases
4
Wolfram, R.M.; Kritz, H.; Efthimiou, Y.; Stomatopoulos, J.; Sinzinger, H.
Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia
A pilot study
Wien Klin Wochenschr, 2002, 114(19-20), o.A. (Abstract)
Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia
A pilot study
Wien Klin Wochenschr, 2002, 114(19-20), o.A. (Abstract)
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Opuntia, prickly pear, Phytomedicine, Metabolic diseases
5
Somogyi, A.; Ecsedi, G.G.; Blazovics, A.; Miskolczi, K.; Gergely, P.; Feher, J.
Short term treatment of type II hyperlipoproteinaemia with silymarin
Acta Med Hung, 1989, 46(4), 289-295
Short term treatment of type II hyperlipoproteinaemia with silymarin
Acta Med Hung, 1989, 46(4), 289-295
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, milk thistle, Metabolic diseases
6
Agarwal, R.; Singh, S.P.; Saran, R.K.; Das, S.K.; Asthana, N.S.O.P.; Gupta, P.P.; Nityanand, S.; Dhawan, B.N.; Agarwal, S.S.
Clinical trials of gugulipid
A new hypolipidemic agent of plant origin in primary hyperlipidemia
Ind J Med Res, 1986, 84, 626-634
Clinical trials of gugulipid
A new hypolipidemic agent of plant origin in primary hyperlipidemia
Ind J Med Res, 1986, 84, 626-634
Ayurveda, Observational trial, High blood pressure, Cammophora, Cammophora mukul, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
7
Gopal, K.; Saran, R.K.; Nityanand, S.; Gupta, P.P.; Hasan, M.; Das, S.K.; Agarwal, S.S.
Clinical trials of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipedemia
J Assoc Phys Ind, 1986, 34(4), 249-251
Clinical trials of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipedemia
J Assoc Phys Ind, 1986, 34(4), 249-251
Angina pectoris, Ayurveda, Observational trial, High blood pressure, Cammophora, Cammophora mukul, Heart attack, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
8
Malhotra, S.C.; Ahuja, M.M.S.; Sundaram, K.R.
Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and Clofibrate
Ind J Med Res, 1977, 65, 390-395
Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and Clofibrate
Ind J Med Res, 1977, 65, 390-395
Ayurveda, Observational trial, Cammophora, Cammophora mukul, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
9
Sundaram, V.; Hanna, A.N.; Lubow, G.P.; Koneru, L; Falko, J.M.; Sharma, H.M.
Inhibition of low-density-lipoprotein oxidation by oral herbal mixture MAK 4 and MAK 5 in hyperlipidemic patients
Am J Med Sci, 1997, 314(5), 303-310
Inhibition of low-density-lipoprotein oxidation by oral herbal mixture MAK 4 and MAK 5 in hyperlipidemic patients
Am J Med Sci, 1997, 314(5), 303-310
Ayurveda, Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
10
Agarwal, O.P.
Prevention of Atheromatous Heart Disease
J Vasc Dis, 1985, 36(8), 485-492
Prevention of Atheromatous Heart Disease
J Vasc Dis, 1985, 36(8), 485-492
Aloe, Arteriosclerosis, Ayurveda, Observational trial, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
11
Soni, K.B.
Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers
Ind J Physiol Pharmacol, 1992, 36(4), 273-275
Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers
Ind J Physiol Pharmacol, 1992, 36(4), 273-275
Observational trial, Curcuma, Curcuma longa, Healthy probands, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
12
Mathur, K.S.; Khan, M.A.
Hypocholsterolaemic of Bengal gram
A long-term study in man
BMJ, 1968, 1, 30-31
Hypocholsterolaemic of Bengal gram
A long-term study in man
BMJ, 1968, 1, 30-31
Observational trial, Nutrition/diet, Healthy probands, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Lathyrus, Lathyrus sativus, Phytomedicine, Metabolic diseases
13
Rosell, M.S.; Appleby, P.N.; Spencer, E.A.; Key, T.J.
Soy intake and blood cholesterol concentrations
A cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition
Am J Clin Nutr, 2004, 80, 1391-1396
Soy intake and blood cholesterol concentrations
A cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition
Am J Clin Nutr, 2004, 80, 1391-1396
Observational trial, Nutrition/diet, Gynaecology, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phaseolus, Phaseolus max, Phytomedicine, Prevention, Metabolic diseases
14
Lupattelli, G.; Marchesi, S., Lombardini, R.; Roscini, A.R.; Trinca, F.; Gemelli, F.; Vaudo, G.; Mannarino, E.
Artichoke juice improves endothelial function in hyperlipemia
Life Sci, 2004, 76, 775-782
Artichoke juice improves endothelial function in hyperlipemia
Life Sci, 2004, 76, 775-782
Observational trial, Cynara cardunculus subsp. flavescens, Nutrition/diet, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases
15
Ulbricht, C.; Basch, E.; Szapary, P.; Hammerness, P.; Axentsev, S.; Boon, H.; Kroll, D.; Garraway, L.; Vora, M.; Woods, J.
Guggul for hyperlipidemia
A review by the Natural Standard Research Collaboration
Complement Ther Med, 2005, 13(4), 279-290
Guggul for hyperlipidemia
A review by the Natural Standard Research Collaboration
Complement Ther Med, 2005, 13(4), 279-290
Cammophora, Cammophora mukul, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
16
Thompson Coon, J.S.; Ernst, E.
Herbs for serum cholesterol reduction
A systematic review
J Fam Pract, 2003, 52(6), 468-478
Herbs for serum cholesterol reduction
A systematic review
J Fam Pract, 2003, 52(6), 468-478
Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
17
Uehleke, B.; Ortiz, M.; Stange, R.
Cholesterol reduction using psyllium husks
Do gastrointestinal adverse effects limit compliance? Results of a specific observational study
Phytomed, 2008, 15(3), 153-159
Cholesterol reduction using psyllium husks
Do gastrointestinal adverse effects limit compliance? Results of a specific observational study
Phytomed, 2008, 15(3), 153-159
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Plantago, Plantago ovata, Metabolic diseases, Adverse effect
18
Uehleke, B.; Ortiz, M.; Stange, R.
Cholesterol reduction using psyllium husks - Do gastrointestinal adverse effects limit compliance?
Results of a specific observational study
Z Phytother, 2008, 29(Suppl 1, Kongressband), S17 (Abstract; Symposiumsbeitrag)
Cholesterol reduction using psyllium husks - Do gastrointestinal adverse effects limit compliance?
Results of a specific observational study
Z Phytother, 2008, 29(Suppl 1, Kongressband), S17 (Abstract; Symposiumsbeitrag)
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Plantago, Plantago ovata, Metabolic diseases, Adverse effect
19
Wider, B.; Pittler, M.H.; Thompson-Coon, J.; Ernst, E.
Artichoke leaf extract for treating hypercholesterolaemia (Review)
Cochrane Database Syst Rev, 2009, 3(CD003335), 1-27
Artichoke leaf extract for treating hypercholesterolaemia (Review)
Cochrane Database Syst Rev, 2009, 3(CD003335), 1-27
Cynara cardunculus subsp. flavescens, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
20
Kassaian, N.; Azadbakht, L.; Forghani, B.; Amini, M.
Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients
Int J Vitam Nutr Res, 2009, 79(1), 34-39
Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients
Int J Vitam Nutr Res, 2009, 79(1), 34-39
Observational trial, Diabetes mellitus, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Trifolium, fenugreek
21
Mensink, R.; Zock, P.; Kester,
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins
A meta-analysis of 60 controlled trials
Am J Clin Nutr, 2003, 77(5), 1146-1155
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins
A meta-analysis of 60 controlled trials
Am J Clin Nutr, 2003, 77(5), 1146-1155
Arteriosclerosis, Brassica, Brassica napus, Nutrition/diet, Essential fatty acids, Helianthus, sunflower, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Coronary heart disease, Meta-analysis, Oil, olive, green, Phytomedicine, Prevention, Metabolic diseases, Olea
22
Talati, R.; Sobieraj, D.M.; Makanji, S.S.; Phung, O.J.; Coleman, C.I.
The comparative efficacy of plant sterols and stanols on serum lipids
A systematic review and meta-analysis
J Am Diet Assoc, 2010, 110(5), 719-726
The comparative efficacy of plant sterols and stanols on serum lipids
A systematic review and meta-analysis
J Am Diet Assoc, 2010, 110(5), 719-726
Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases, Systematic review
23
Fa-lin, Z.; Zhen-yu, W.; Yan, H.; Tao, Z.; Kang, L.
Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment
Phytother Res, 2010, 24(S2), S209-S213
Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment
Phytother Res, 2010, 24(S2), S209-S213
Observational trial, Chinese medicinal herbs, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Ribes, black currant, Metabolic diseases, Traditional Chinese medicine
24
Aramwit, P.; Petcharat, K.; Supasyndh, O.
Efficacy of mulberry leaf tablets in patients with mild dyslipidemia
Phytother Res, 2011, 25(3), 365-369
Efficacy of mulberry leaf tablets in patients with mild dyslipidemia
Phytother Res, 2011, 25(3), 365-369
Observational trial, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Morus, Morus alba, Phytomedicine, Metabolic diseases
25
Hasani-Ranjbar, S.; Nayebi, N.; Moradi, L.; Mehri, A.; Larijani, b.; Abdollahi, M.
The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia
A systematic review
Curr Pharm Des, 2010, 16(26), 2935-2947
The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia
A systematic review
Curr Pharm Des, 2010, 16(26), 2935-2947
Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
26
Khadem-Ansari, M.H.; Rasmi, Y.; Ramezani, F.
Effects of red grape juice consumption on high density lipoprotein-cholesterol, apolipoprotein AI, apolipoprotein B and homocysteine in healthy human volunteers
Open Biochem J, 2010, 4, 96-99
Effects of red grape juice consumption on high density lipoprotein-cholesterol, apolipoprotein AI, apolipoprotein B and homocysteine in healthy human volunteers
Open Biochem J, 2010, 4, 96-99
Observational trial, Nutrition/diet, Healthy probands, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Juice/distillate, Metabolic diseases, Vitis vinifera, Vitis
27
Zeng, T.; Guo, F.F.; Zhang, C.L.; Song, F.Y.; Zhao, X.L., Xie, K.Q.
A meta-analysis of randomzed, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
J Sci Food Agric, 2012, 92(9), 1892-1902
A meta-analysis of randomzed, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles
J Sci Food Agric, 2012, 92(9), 1892-1902
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases
28
Zeng, T.; Zhang, C.L.; Zhao, X.L.; Xie, K.Q.
The roles of garlic on the lipid parameters
A systematic review of the literature
Crit Rev Food Sci Nutr, 2013, 53(3), 215-230
The roles of garlic on the lipid parameters
A systematic review of the literature
Crit Rev Food Sci Nutr, 2013, 53(3), 215-230
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
29
Ried, K.; Toben, C.; Fakler, P.
Effect of garlic on serum lipids
An updated meta-analysis
Nutrition Rev, 2013, 71(5), 282-299
Effect of garlic on serum lipids
An updated meta-analysis
Nutrition Rev, 2013, 71(5), 282-299
Allium, Allium sativum, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases
30
Wider, B.; Pittler, M.H.; Thompson-Coon, J.; Ernst, E.
Artichoke leaf extract for treating hypercholesterolaemia (Review)
Cochrane Database Syst Rev, 2013, 3(CD003335), 1-30
Artichoke leaf extract for treating hypercholesterolaemia (Review)
Cochrane Database Syst Rev, 2013, 3(CD003335), 1-30
Cynara cardunculus subsp. flavescens, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
31
Stuglin, C.; Prasad, K.
Effect of flaxseed consumption on blood pressure, serum lipids, hemopoietic system and liver and kidney enzymes in healthy humans
J Cardiovasc Pharmacol Ther, 2005, 10(1), 23-27
Effect of flaxseed consumption on blood pressure, serum lipids, hemopoietic system and liver and kidney enzymes in healthy humans
J Cardiovasc Pharmacol Ther, 2005, 10(1), 23-27
Observational trial, High blood pressure, Nutrition/diet, Healthy probands, Urinary tract, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Liver, Linum usitatissimum, Gastrointestinal tract, Kidney, Phytomedicine, Metabolic diseases
32
Sahebkar, A.
Effects of resveratrol supplementation on plasma lipids
A systematic review and meta-analysis of randomized controlled trials
Nutrition Rev, 2013, 71(12), 822-835
Effects of resveratrol supplementation on plasma lipids
A systematic review and meta-analysis of randomized controlled trials
Nutrition Rev, 2013, 71(12), 822-835
Nutrition/diet, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Dietary supplementation, Phytomedicine, Resveratrol, Metabolic diseases, Systematic review
33
Zhu, Y.; Miao, Y.; Meng, Z.; Zhong, Y.
Effects of Vaccinium berries on serum lipids
A meta-analysis of randomized controlled trials
eCAM, 2015, Article ID 790329, (1-11)
Effects of Vaccinium berries on serum lipids
A meta-analysis of randomized controlled trials
eCAM, 2015, Article ID 790329, (1-11)
Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases, Vaccinium
34
Phimarn, W.; Wichalyo, K.; Silpsavikul, K.; Sungthong, B.; Saramunee, K.
A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile
Eur J Nutr, 2017, 56(4), 1509-1521
A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile
Eur J Nutr, 2017, 56(4), 1509-1521
Diabetes mellitus, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Morus, Morus alba, Phytomedicine, Metabolic diseases
35
Ried, K.
Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity
An updated meta-analysis and review
J Nutr, 2016, 146(2), 389S-396S
Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity
An updated meta-analysis and review
J Nutr, 2016, 146(2), 389S-396S
Allium, Allium sativum, High blood pressure, Cardiovascular diseases, Hypercholesterolemia, Hyperlipoproteinemia, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases, Systematic review
36
Zarvandi, N.; Rakhshandeh, H.; Abazari, M.; Shafiee-Nick, R.; Ghorbani, A.
Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes
Biomed Pharmacother, 2017, 89, 69-75
Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes
Biomed Pharmacother, 2017, 89, 69-75
Allium, Allium sativum, Aloe, Aloe vera, Observational trial, Diabetes mellitus, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nigella sativa, Phytomedicine, Plantago, Metabolic diseases, Trifolium, fenugreek
37
Momose, Y.; Maeda-Yamamoto, M.; Nabetani, H.
Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans
Int J Food Sci Nutr, 2016, 67(6), 606-613
Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans
Int J Food Sci Nutr, 2016, 67(6), 606-613
Camellia, Camellia sinensis, Healthy probands, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review
38
Tshongo Muhindo, C.; Ahn, S.A.; Rousseau, M.F.; Dierckxsens, Y.; Hermans, M.P.
Efficacy and safety of a combination of red yeast rice and olive extract in hypercholesterolemic patients with and without statin-associated myalgia
Complement Ther Med, 2017, 35, 140-144
Efficacy and safety of a combination of red yeast rice and olive extract in hypercholesterolemic patients with and without statin-associated myalgia
Complement Ther Med, 2017, 35, 140-144
Observational trial, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, red yeast rice, olive, green, Phytomedicine, Metabolic diseases, Olea
39
Akbari-Fakhrabadi, M.; Heshmati, J.; Sepidarkish, M.; Shidfar, F.
Effect of sumac (Rhus Coriaria) on blood lipids
A systematic review and meta-analysis
Complement Ther Med, 2018, 40, 8-12
Effect of sumac (Rhus Coriaria) on blood lipids
A systematic review and meta-analysis
Complement Ther Med, 2018, 40, 8-12
Cardiovascular diseases, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Rhus, Metabolic diseases, Systematic review, Rhus coriaria
40
Kang, S.; Song, S.; Lee, J.; Chang, H.; Lee, S.
Clinical investigatoins of the effect of Citrus unshiu peel pellet on obesity and lipid profile
eCAM, 2018, Article ID 4341961, (1-6)
Clinical investigatoins of the effect of Citrus unshiu peel pellet on obesity and lipid profile
eCAM, 2018, Article ID 4341961, (1-6)
Observational trial, Citrus, Citrus unshiu, Dyslipidämie, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Overweight
41
Eslami, O.; Shidfar, F.
Soy milk: A functional beverage with hypocholesterolemic effects?
A systematic review of randomized controlled trials
Complement Ther Med, 2019, 42, 82-88
Soy milk: A functional beverage with hypocholesterolemic effects?
A systematic review of randomized controlled trials
Complement Ther Med, 2019, 42, 82-88
Dyslipidämie, Nutrition/diet, Hypercholesterolemia, Hyperlipoproteinemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Metabolic diseases, Systematic review