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1 Brinkeborn, R.M.; Shah, D.V.; Degenring, F.H.
Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold
A randomized, placebo controlled, double-blind clinical trial
Phytomed, 1999, 6(1), 1-5
Respiratory diseases, Echinacea, Common cold, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
2 Cáceres, D.D.; Hancke, J.L.; Burgos, R.A.; Sandberg, F.; Wikman, G.K.
Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the sypmtoms of common cold
A randomized double-blind placebo study
Phytomed, 1999, 6(4), 217-223
Andrographis paniculata, Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial
3 Grimm, W.; Müller, H.-H.
A Randomized Controlled Trial of the Effect of Fluid Extract of Echinacea Purpurea on the Incidence and Severity of Colds and Respiratory Infections
Am J Med, 1999, 106(2), 138-143
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial
4 Henneicke-von Zeppelin, H.-H.; Hentschel, C.; Schnitker, J.; Kohnen, R.; Köhler, G.; Wüstenberg, P.
Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection)
Results of a randomised, double blind, placebo controlled, multicentre study
Curr Med Res Opinion, 1999, 15(3), 214-227
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
5 Lindenmuth, G.F.; Lindenmuth, E.B.
The efficacy of Echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms
A randomized, double-blind placebo-controlled study
J Altern Complement Med, 2000, 6(4), 327-334
Respiratory diseases, Echinacea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Tea
6 Melchior, J.; Spasov, A.A.; Ostrovskij, O.V.; Bulanov, A.E.; Wikman, G.
Double-blind, placebo-controlled pilot and Phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-repiratory tract infection
Phytomed, 2000, 7(5), 341-350
Andrographis paniculata, Respiratory diseases, Common cold, Infections, Kan Jang (Komplex), Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial
7 Josling, P.
Preventing the common cold with a garlic supplement
A double-blind, placebo-controlled survey
Adv Ther, 2001, 18, 189-193
Allicin, Allium, Respiratory diseases, Common cold, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
8 Barrett, B.P.; Brown, R.L.; Locken, K.; Maberry, R.; Bobula, J.A.; Alessio, D. d'
Treatment of the common cold with unrefined echinacea
Ann Intern Med, 2002, 137, 939-946
Respiratory diseases, Echinacea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
9 Yale, S.H.; Liu, K.
Echinacea purpurea therapy for the treatment of the common cold
A randomized, double-blind, placebo-controlled clinical trial
Arch Intern Med, 2004, 164, 1237-1241
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
10 Cohen, H.A.; Varsano, I.; Kahan, E.; Sarrell, M.; Uziel, Y.
Effectiveness of an herbal preparation containing Echinacea, Propolis, and Vitamin C in preventing respiratory tract infections in children
Arch Ped Adolesc Med, 2004, 158, 217-221
Acidum ascorbicum, Apitherapy, Respiratory diseases, Echinacea, Common cold, Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Prevention, Propolis, Randomized trial, Vitamins
11 Sperber, S.J.; Shah, L.P.; Gilbert, R.D.; Ritchey, T.W.; Monto, A.S.
Echinacea purpurea for prevention of experimental rhinovirus colds
Clin Infect Dis, 2004, 38, 1367-1371
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Healthy probands, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Viruses
12 Predy, G.N.; Goel, V.; Lovlin, R.; Donner, A.; Stitt, L.; Basu, T.K.
Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper repiratory tract infections
A randomized controlled trial
CMAJ, 2005, 173(9), 1043-1048
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Panax, Panax ginseng
13 Naser, B.; Lund, B.; Henneicke-von Zepelin, H.-H.; Köhler, G.; Lehmacher, W.; Scaglione, F.
A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold
Phytomed, 2005, 12(10), 715-722
Respiratory diseases, Baptisia, Echinacea, Echinacea pallida, Echinacea purpurea, Common cold, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Thuja
14 Weber, W.; Taylor, J.A.; Stoep, A.V.; Weiss, N.S.; Standish, L.J.; Calabrese, C.
Echinacea purpurea for Prevention of Upper Respiratory Tract Infections in Children
J Altern Complement Med, 2005, 11(6), 1021-1026
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
15 McElhaney, J.E.; Goel, V.; Toane, B.; Hooten, J.; Shan, J.J.
Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults
A randomized, double-blinded, placebo controlled trial
J Altern Complement Med, 2006, 12(2), 153-157
Respiratory diseases, Common cold, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Panax, Panax quinquefolius
16 Kamin, W.; Kieser, M.
Pinimenthol Erkältungssalbe bei Patienten mit Erkältungskrankheiten der Luftwege
Eine Kohortenstudie
Z Phytother, 2006, 27(Kongressband), S10
Respiratory diseases, Observational trial, Common cold, Eucalyptus, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Mentholum, Phytomedicine, Pinimenthol, Pinus, Pinus mugo, Adverse effect
17 Shah, S.A.; Sander, S.; White, C.M.; Rinaldi, M.; Coleman, C.I.
Evaluation of echinacea for the prevention and treatment of the common cold
A meta-analysis
Lancet Infect Dis, 2007, 7(7), 473-480
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine
18 Kamin, W.; Kieser, M.
Pinimenthol((R)) ointment in patients suffering from upper respiratory tract infections
A post-marketing observational study
Phytomed, 2007, 14(12), 787-791
Respiratory diseases, Observational trial, Common cold, Eucalyptus, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Mentholum, Oil, Phytomedicine, Pinimenthol, Pinus, Pinus mugo, Pinus sylvestris, Adverse effect
19 Rowe, C.A.; Nantz, M.P.; Bukowski, J.F.; Percival, S.S.
Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamm, delta T cell function
A randomized, double-blind, placebo-controlled study
J Am Coll Nutr, 2007, 26(5), 445-452
Respiratory diseases, Camellia, Camellia sinensis, Common cold, Flu, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Tea
20 Lizogub, V.G.; Riley, D.S.; Heger, M.
Efficacy of a Pelargonium sidoides preparation in patients with the common cold
A randomized, double blind, placebo-controlled clinical trial
Explore, 2007, 3(6), 573-584
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Pelargonium, Pelargonium sidoides, Phytomedicine, Placebo-controlled, Randomized trial
21 Vohra, S.; Johnston, B.C.; Laycock, K.L.; Midodzi, W.K.; Dhunnoo, I.; Harris, E.; Baydala, L.
Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection
A phase II randomized, controlled trial of 2 dosing schedules
Pediatrics, 2008, 122(2), E-402-410
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax quinquefolius
22 Kalus, U.; Kiesewetter, H.; Radtke, H.
Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract
Phytother Res, 2010, 24(1), 96-100
Respiratory diseases, Camellia, Camellia sinensis, Cistus, Cistus incanus, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Tea
23 Saxena, R.C.; Singh, R.; Kumar, P.; Yadav, S.C.; Negi, M.P.; Saxena, V.S.; Joshua, A.J.; Vijayabalaji, V.; Goudar, K.S.; Venkateshwarlu, K.; Amit, A.
A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection
Phytomed, 2010, 17(3-4), 178-185
Andrographis paniculata, Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
24 Ross, S.M.
A standardized Echinacea extract demonstrates efficacy in the prevention and treatment of colds in athletes
Holist Nurs Pract, 2010, 24(2), 107-109
Respiratory diseases, Observational trial, Echinacea, Echinacea purpurea, Common cold, Complementary and alternative medicine, Phytomedicine, Prevention, Sports medicine
25 Barrett, B.; Brown, R.; Rakel, D.; Mundt, M.; Bone, K.; Barlow, S.; Ewers, T.
Echinacea for treating the common cold
A randomized trial
Ann Intern Med, 2010, 153(12), 769-777
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
26 Roll, S.; Nocon, M.; Willich, S.N.
Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables
A randomised, double-blind, placebo-controlled trial
Br J Nutr, 2011, 105(1), 118-122
Respiratory diseases, Common cold, Nutrition/diet, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Randomized trial
27 Stauss-Grabo, M.; Atiye, S.; Warnke, A.; Wedemeyer, R.S.; Donath, F.; Blume, H.H.
Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan((R)) Cough Tablets) in the treatment of colds accompanied by coughing
Phytomed, 2011, 18(6), 433-436
Respiratory diseases, Observational trial, Common cold, Hedera, Hedera helix, Cough, Clinical research, Complementary and alternative medicine, Phytomedicine, Prospan
28 Minetti, A.M.; Forti, S.; Tassone, G.; Torretta, S.; Pignataro, L.
Efficacy of complex herbal compound of Echinacea angustifolia (Imoviral Junior) in recurrent upper respiratory tract infections during pediatric age
Preliminary results
Minerva Pediatr, 2011, 63(3), 177-182
Acidum, Acidum ascorbicum, Arabinogalaktan, Respiratory diseases, Observational trial, Echinacea, Common cold, Ear-nose-throat disorders, Imoviral, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Quinsy, Middle ear inflammation, Pediatrics, Phytomedicine, Zincum
29 Ross, S.M.
African geranium (EPs 7630), Part I
A proprietary root extract of Pelargonium sidoides (EPs 7630) is found to be effective in resolving symptoms associated with the common cold in adults
Holist Nurs Pract, 2012, 26(2), 106-109 (Zweitveröffentlichung)
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Pelargonium, Pelargonium sidoides, Phytomedicine, Placebo-controlled, Randomized trial
30 Patiroglu, T.; Tunc, A.; Eke Gungor, H.; Unal, E.
The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy
Phytomed, 2012, 19(11), 958-961
Respiratory diseases, Common cold, Immune system, Clinical research, Complementary and alternative medicine, Pediatrics, Pelargonium, Pelargonium sidoides, Phytomedicine, Placebo-controlled, Randomized trial
31 Jawad, M.; Schoop, R.; Suter, A.; Klein, P.; Eccles, R.
Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes
A randomized, double-blind, placebo-controlled trial
eCAM, 2012, 2012, 841315; (1-7)
Respiratory diseases, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
32 Guay, J.; Champagne, P.; Guibord, P.; Gruenwald, J.
The efficacy and safety of a patent pending combination of ginger and goldenrod extracts on the management of cold symptoms
A randomized, double-blind controlled trial
Food Nutr Sci, 2012, 3, 1651-1657
Respiratory diseases, Echinacea, Common cold, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, Solidago, Solidago virgaurea, ginger
33 Tahan, F.; Yaman, M.
Can the Pelargonium sidoides root extract EPs((R)) 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?
Phytomed, 2013, 20(2), 148-150
Asthma, Respiratory diseases, Common cold, Infections, Clinical research, Complementary and alternative medicine, Pediatrics, Pelargonium, Pelargonium sidoides, Phytomedicine, Randomized trial, Umckaloabo, Viruses
34 Zou, C.; Su, G.; Wu, Y.; Lu, F.; Mao, W.; Liu, X.
Astragalus in the prevention of upper respiratory tract infection in children with nephrotic syndrome
Evidence-based clinical practice
eCAM, 2013, Article ID 352130, (1-10)
Astragalus, Respiratory diseases, Common cold, Cough, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Prevention, Cold, Review (CR)
35 Paul, I.M.; Beiler, J.S.; Vallati, J.R.; Duda, L.M.; King, T.S.
Placebo effect in the treatment of acute cough in infants and toddlers
A randomized clinical trial
JAMA Pediatr, 2014, epub ahead of print,
century plant, Respiratory diseases, Common cold, Cough, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Placebo-controlled, Randomized trial
36 Michalsen, A.; Uehleke, B.; Stange, R.
Safety and compliance of a complex homeopathic drug (Contramutan N Saft) in the treatment of acute respiratory tract infections
A large oberservational (non-interventional) study in children and adults focussing on homeopathy specific adverse reactions versus adverse drug reactions
Regul Toxicol Pharmacol , 2015, 72(2), 179-184
Respiratory diseases, Observational trial, Contramutan, Echinacea, Common cold, Eupatorium, Ear-nose-throat disorders, Sore throat, Homeopathy, Cough, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Potentization, Cold, Mother tincture, Hoarseness
37 Okabayashi, S.; Goto, M.; Kawamura, T.; Watanabe, H.; Kimura, A.; Uruma, R.; Takahashi, Y.; Taneichi, S.; Musashi, M.; Miyaki, K.
Non-superiority of Kakkonto, a Japanese herbal medicine, to a representative multiple cold medicine with respect to anti-aggravation effects on the common cold
A randomized controlled trial
Intern Med, 2014, 53, 949-956
Respiratory diseases, Common cold, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, Traditional Japanese medicine, Kakkonto
38 Duijker, G.; Bertsias, A.; Symvoulakis, E.K.; Moschandreas, J.; Malliaraki, N.; Derdas, S.P.; Tsikalas, G.K.; Katerinopoulos, H.E.; Pirintsos, S.A.; Sourvinos, G.; Castanas, E.; Lionis, C.
Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection
Results from a double-blind randomized controlled trial
J Ethnopharmacol, 2015, 163, 157-166
Aromatherapy, Respiratory diseases, Common cold, Ethnomedicine, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Origanum, Phytomedicine, Placebo-controlled, Randomized trial, sage, Corydothymus capitatus, Origanum dictamnus, Salvia fruticosa
39 Hartleb, H.; Lang, C.; Wegener, T.; Staiger, C.
Erkältungsbedingte Anwendung einer Kombination aus Isländisch Moos, Hyaluronsäure und Hydrogelkomplex
Z Phytother, 2016, 37(1), 4-8
Respiratory diseases, Observational trial, Cetraria islandica, Common cold, Ear-nose-throat disorders, Sore throat, Hyaluronsäure, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Isla med hydro
40 Tiralongo, E.; Wee, S.S.; Lea, R.A.
Elderberry supplementation reduces cold duration and symptoms in air-travellers
A randomized, double-blind placebo-controlled clinical trial
Nutrients, 2016, 8, 182; (1-15)
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Sambucus
41 Schaefer, A.; Kehr, M.S.; Giannetti, B.M.; Bulitta, M.; Staiger, C.
A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575®) vs. placebo in the treatment of adults with acute cough
Pharmazie, 2016, 71, 504-509
Respiratory diseases, Common cold, Hedera, Hedera helix, Cough, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
42 Eccles, R.; Jawad, M.; Ramsey, D.L.; Hull, J.D.
Efficacy of a topical aromatic rub (Vicks VapoRub®)-speed of action of subjective nasal cooling and relief from nasal congestion
Open J Respir Dis, 2015, 5, 10-18
Applikationsform, Respiratory diseases, Camphora, Common cold, Eucalyptus, Ear-nose-throat disorders, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Mentholum, Oleum, Oleum terebinthinae, Phytomedicine, Randomized trial, Salbe, Cold, Inhalation
43 Ahmad, S.M.; Azhar, I.; Ahmad, N.; Masroor, S.D.
Pharmacoeconomic evaluations and comparison of licorice (Glycyrrhiza glabra L.) with triaminic DM based therapies for common cold in the city of Karachi
Retrospective burden of illness, cost and budget impact analysis
J Pharmacogn Phytochem, 2017, 6(1), 258-270
Respiratory diseases, Observational trial, Common cold, Clinical research, Complementary and alternative medicine, Economy, Phytomedicine, Retrospective design, Cost-effectiveness
44 Anastasaki, M.; Bertsias, A.; Pirintsos, S.A.; Castanas, E.; Lionis, C.
Post-market outcome of an extract of traditional Cretan herbs on upper respiratory tract infections
A pragmatic, prospective observational study
BMC Complement Altern Med, 2017, 17, 466; (1-5)
Respiratory diseases, Observational trial, Common cold, Ear-nose-throat disorders, Sore throat, Cough, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Herbs, Sinusitis, Origanum, Phytomedicine, sage, Thymus, Thymus vulgaris, Origanum dictamnus, Salvia fruticosa
45 Riley, D.S.; Lizogub, V.G.; Zimmermann, A.; Funk, P.; Lehmacher, W.
Efficacy and tolerability of high-dose Perlargonium extract in patients with the common cold
Altern Ther Health Med, 2018, 24(2), 16-26
Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Umckaloabo
46 Cohen, H.A.; Hoshen, M.; Gur, S.; Bahir, A.; Laks, Y.; Blau, H.
Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds
A randomized, single-blinded, multicenter study
World J Pediatr, 2017, 13(1), 27-33
Apitherapy, Respiratory diseases, Common cold, Grindelia, Grindelia robusta, Helichrysum, Helichrysum italicum, Honey, Cough, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Pediatrics, Phytomedicine, Plantago, Plantago lanceolata, Polysaccharide, Randomized trial, Grintuss
47 Hawkins, J.; Baker, C.; Cherry, L.; Dunne, E.
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms
A meta-analysis of randomized, controlled clinical trials
Complement Ther Med, 2019, 42, 361-365
Respiratory diseases, Common cold, Flu, Infections, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Sambucus
48 Schulten, B.; Bulitta, M.; Ballering-Brühl, B.; Köster, U.; Schäfer, M.
Efficacy of Echinacea purpurea in patients with a common cold
A placebo-controlled, randomised, double-blind clinical trial
Arzneim Forsch, 2001, 51(7), 563-568
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial