Quick search for therapies

2616 results (filtered)

Page 5 / 27
401 Fava, M.; Alpert, J.; Nierenberg, A.A.; Mischoulon, D.; Otto, M.W.; Zajecka, J., Murck, H.; Rosenbaum, J.F.
A double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
J Clin Psychopharmacol, 2005, 25(5), 441-447
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
402 Rog, D.J.; Nurmikko, T.J.; Friede, T.; Young, C.A.
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
Neurology, 2005, 65, 812-819
Cannabis, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Pain
403 Young, M. A.; Cook, J. L.; Webster, K. E.
The effect of topical wheatgrass cream on chronic plantar fasciitis
A randomized, double-blind, placebo-controlled trial
Complement Ther Med, 2006, 14(1), 3-9
Muscoskeletal -/Connective tissue system, Inflammation, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Triticum sativum, Triticum
404 Randlov, C.; Mehlsen, J.; Thomsen, C.F.; Hedman, C.; Fircks, H. von; Winther, K.
The efficacy of St. John's Wort in patients with minor depressive symptoms or dysthymia - a double-blind placebo-controlled study
Phytomed, 2006, 13(4), 215-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
405 Popa, G.; Hägele-Kaddour, H.; Walther, C.
Symptomatische Wirksamkeit eines Sabal-Urtica-Kombinationspräparats in der Therapie des benignen Prostatasyndroms
MMW Fortschr Med, 2005, 147(3), 103-108
Andrology, Urinary tract, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prostatic enlargement (benign), Randomized trial, Sabal serrulata, Urtica
406 Garrison, R.; Chambliss, W.G.
Effect of a proprietary Magnolia and Phellodendron extract on weight management
A pilot, double-blind, placebo-controlled clinical trial
Altern Ther Health Med, 2006, 12(1), 50-54
Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Magnolia, Magnolia officinalis, Dietary supplementation, Phellodendron, Phellodendron amurense, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases, Stress, Overweight
407 Heinen-Kammerer, T.; Motzkat, K.; Daniel, D.; Gertz, H.J.; Koller, M.; Lorenz, W.; Pilartz, H.; Zimmer, B.; Habs, M.; Driesch, V. von den; Rychlik, R.
Versorgungssituation von Demenzkranken kann durch Ginkgo biloba verbessert werden
Ergebnisse einer Studie zur Versorgungsforschung hinsichtlich der Leistungsfähigkeit der Demenzkranken, der Lebensqualität der Pflegenden und der Gesamtkosten der Behandlung
MMW Fortschr Med, 2005, 147(3), 127-133
Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Non-randomized trial, Economy, Phytomedicine, Cost-effectiveness
408 Bock, P.R.; Friedel, W.E.; Hanisch, J.; Karasmann, M.; Schneider, B.
Efficacy and safety of long-term complementary treatment with standardised European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncological therapy in patients with primary non-metastatic breast cancer
Arzneim Forsch, 2004, 54(8), 456-466; (1-10) (Sonderdruck)
Breast cancer, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Non-randomized trial, Phytomedicine, Retrolective design, Viscum, Viscum album, Iscador
409 Chung, T.K.H.; Yip, S.K.; Lam, P.; Chang, A.M.Z.; Haines, C.J.
A randomized, double-blind, placebo-controlled, crossover study on the effect of oral oestradiol on acute menopausal symptoms
Maturitas, 1996, 25, 115-123
Endocrinology, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Conventional medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Estrogen
410 McElhaney, J.E.; Goel, V.; Toane, B.; Hooten, J.; Shan, J.J.
Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults
A randomized, double-blinded, placebo controlled trial
J Altern Complement Med, 2006, 12(2), 153-157
Respiratory diseases, Common cold, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Panax, Panax quinquefolius
411 Chou, S.-C.; Chen, K.-W.; Hwang, J.-S.; Lu, W.-T.; Chu, Y.-Y.; Lin, J.-D.; Chang, H.-J.; See, L.-C.
The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease
Altern Ther Health Med, 2006, 12(3), 34-39
Nutrition/diet, Fatty liver, Gynostemma pentaphyllum, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Randomized trial, Metabolic diseases
412 Murphy, P.A.; Kern, S.E.; Stanczyk, F.Z.; Westhoff, C.L.
Interaction of St. John's Wort with oral contraceptives
Effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding
Contraception, 2005, 71, 402-408
Arzneimittelwechselwirkung, Healthy probands, Gynaecology, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Conventional medicine, Non-randomized trial, Pharmacology, Phytomedicine, Pharmacocinetics
413 Huyke, C.; Laszczyk, M.; Scheffler, A.; Ernst, R.; Schempp, C.M.
Behandlung aktinischer Keratosen mit Birkenkorkextrakt
Eine Pilotstudie
J Dtsch Dermatol Ges, 2006, 4, 132-137
Betula, Betula alba, Skin diseases, Keratosis, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine
414 Cucchini, F.; Donato, M. di; Ferrari, R.; Visioli, O.
Dynamic ventriculography with K-strophantin
Eur J Cardiol, 1978, 8(1), 75-84
Heart, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Strophantus
415 Schwarzbach, W.; Hermstein, N.
Ergebnisse der klinischen Prüfung eines enteral resorbierbaren Strophanthins
Med Klin, 1967, 62(1), 15-19
Heart, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Strophantus
416 Cucchini, F.; Bolognesi, R.; Javernaro, A.; Zeppelini, R.; Domenico, R.; Visioli, O.
Do inotropic drugs always induce a positive lusitropic effect?
A comparison between k-strophanthidin and dobutamine in patients with coronary artery disease
Eur Heart J, 1994, 15(12), 1666-1672
Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Phytomedicine, Randomized trial, Strophantus
417 Agostoni, P.G.; Doria, E.; Beri, M.; Guazzi, M.D.
Long-term use of K-strophanthin in advanced congestive heart failure due to dilated cardiomyopathy
A double-blind crossover evaluation versus digoxin
Clin Cardiol, 1994, 17(10), 536-541
Cardiovascular diseases, Cardiomyopathy, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Strophantus
418 Pidgeon, G.B.; Richards, A.M.; Nicholls, M.G.; Lewis, L.K.; Yandle, T.G.
Acute effects of intravenous ouabain in healthy volunteers
Clin Sci, 1994, 86(4), 391-397
Blood, Blood/Lymphatic system, Experiment, Clinical research, Complementary and alternative medicine, Human, Phytomedicine, Placebo-controlled, Randomized trial, Strophantus
419 Slany, J.; Mosslacher, H.
Einfluß von Spirolactone auf die myodardiale Kaliumbilanz unter Strophanthin beim Menschen
Klin Wschr, 1976, 54(14), 671-676
Cardiovascular diseases, Heart failure, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Strophantus
420 Baumgarten, G.; Beickert, A.; Berdow, J.; Fiehring, H.; Forster, W.; Haak, W.; Hafemeister, R.; Kiesewetter, R.; Klein, K.W.; Knappe, J.; Knorre, G. von; Krosch, H.; Lehmann, L.; Mann, D.; Menzel, B.; Noack, W.; Rosner, R.; Sundermann, A.
Strophanthin - Convallatoxol
Klinische Vergleichsuntersuchung im doppelten Blindversuch
Dt Ges Wesen, 1970, 25(20), 922-926
Convallaria, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Strophantus
421 Storz, H.
Über die quantitative Wirksamkeit von k-Strophanthin-alpha (Cymarin) bei intravenöser und oraler Applikation
Dtsch Med Wschr, 1969, 94(22), 1166-1169
Functional heart trouble, Cardiovascular diseases, Heart failure, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Strophantus
422 Nusser, E.; Eberl, R.
Vergleichende klinische Untersuchungen von Scillaglykosid A und k-Strophanthin
Med Welt, 1968, 9, 454-457
Cardiovascular diseases, Heart failure, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Strophantus
423 Schmidt, H.; Fiehring, H.; Assmann, I.; Hesse, P.; Banse, P.
Vergleichende Wirkungsanalyse kurzhaftender Herzglykoside (Convallatoxol, Cymarol und g-Strophanthin)
Z Gesamte Inn Med, 1970, 25(19), 902-904
Heart, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Strophantus
424 Zajicek, J.P.; Sanders, H.P.; Wright, D.E.; Vickery, P.J.; Ingram, W.M.; Reilly, S.M.; Nunn, A.J.; Teare, L.J.; Fox, P.J.; Thompson, A.J.
Cannabinoids in multiple sclerosis (CAMS) study
Safety and efficacy data for 12 months follow up
J Neurol Neurosurg Psychiatry, 2005, 76, 1664-1669
Cannabis, Cannabis sativa, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
425 Diepvens, K.; Kovacs, E.M.; Vogels, N.; Westerterp-Plantenga, M.S.
Metabolic effects of green tea and of phases of weight loss
Physiol Behav, 2006, 87, 185-191
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Tea, Overweight
426 Chan, C.C.W.; Koo, M.W.; Ng, E.H.; Tang, O.S.; Yeung, W.S.; Ho, P.C.
Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome
A randomized placebo-controlled trial
J Soc Gynecol Investig, 2006, 13, 63-68
Camellia, Camellia sinensis, Gynaecology, Clinical research, Complementary and alternative medicine, Ovarialzyste, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Tea, Overweight
427 Diener, H.C.; Pfaffenrath, V.; Schnitker, J.; Friede, M.; Henneicke-von Zepelin, H.H.
Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention
Randomized double-blind, multicentre, placebo-controlled study
Cephalalgia, 2005, 25, 1031-1041
Clinical research, Complementary and alternative medicine, Matricaria, Migraine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial
428 Agarwal, A.; Dhiraaj, S.; Tandon, M.; Singh, P.K.; Singh, U.; Pawar, S.
Evaluation of capsaicin ointment at the Korean hand acupressure point K-D2 for prevention of postoperative nausea and vomiting
Anaesthesia, 2005, 60, 1185-1188
Acupressure, Acupuncture, Capsicum, Surgery, Vomiting, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Pain, Traditional Chinese medicine, Sickness
429 Bettuzzi, S.; Brausi, M.; Rizzi, F.; Castagnetti, G.; Peracchia, G.; Corti, A.
Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia
A preliminary report from a one-year proof-of-principle study
Cancer Res, 2006, 66, 1234-1240
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Prostate cancer, Randomized trial, Tea
430 Bui, L.T.; Nguyen, D.T.; Ambrose, P.J.
Blood pressure and heart rate effects following a single dose of bitter orange
Ann Pharmacother, 2006, 40, 53-57
Nutrition/diet, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Adverse effect
431 McCulloch, M.; See, C.; Shu, X.J.; Broffman, M.; Kramer, A.; Fan, W.-Y.; Gao, J.; Lieb, W.; Shieh, K.; Colford, J.M. jr.
Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer
Meta-analysis of randomized trials
J Clin Oncol, 2006, 24, 419-430
Astragalus, Astragalus membranaceus, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Meta-analysis, Phytomedicine, Randomized trial, Traditional Chinese medicine
432 Saab, B.R.; Pashayan, N.; El-Chemaly, S.; Sabra, R.
Sesame oil use in ameliorating cough in children
A randomised controlled trial
Complement Ther Med, 2006, 14(2), 92-99
Respiratory diseases, Cough, Clinical research, Complementary and alternative medicine, Oil, Pediatrics, Phytomedicine, Randomized trial, Sesamum indicum
433 Rapp, A.; Grohmann, G.; Oelzner, P.; Uehleke, B.; Uhlemann, C.
Beeinflusst Knoblauch die Blutfliesseigenschaften und die Durchblutung bei progressiver systemischer Sklerose?
Forsch Komplementärmed, 2006, 13(3), 141-146
Allium, Allium sativum, Arteriosclerosis, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
434 Pidgeon, G.B.; Richards, A.M.; Nicholls, M.G.; Bailey, R.R.; Lynn, K.L.; Lewis, L.K.; Yandle, T.G.
Effect of ouabain on pressor responsiveness in normal man
Am J Physiol, 1994, 267, E642-E647
High blood pressure, Healthy probands, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Strophantus
435 Jünemann, P.
Beitrag zur medikamentösen Behandlung der Stenocardie
Aus unserer Arbeit, 1955, 1(8), 20-21
Crataegus, Case report, Cardiovascular diseases, Heart failure, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Practice, Stenocrat
436 Osmers, R.; Friede, M.; Liske, E.; Schnitker, J.; Freudenstein, J.; Zepelin, H.-H. Heneicke von
Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms
Obstet Gynecol, 2005, 105, 1074-1083
Black cohosh, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
437 Han, S.H.; Hur, M.H.; Buckle, J.; Choi, J.; Lee, M.S.
Effect of aromatherapy on symptoms of dysmenorrhea in college students
A randomized placebo-controlled clinical trial
J Altern Complement Med, 2006, 12(6), 543-548
Aromatherapy, Dysmenorrhea, Gynaecology, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Manual therapy, Massage, Phytomedicine, Placebo-controlled, Prunus, Prunus dulcis, Randomized trial, Rosa, Rosa centifolia, sage, Salvia sclarea
438 Hsu, C.H.; Hwang, K.C.; Chao, C.L.; Chang, S.G.; Ho, M.S.; Chou, P.
Can herbal medicine assist against avian flu?
Learning from the experience of using supplementary treatment with chinese medicine on SARS or SARS-like infectious disease in 2003
J Altern Complement Med, 2006, 12(6), 505-509
Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, SARS - Severe acute respirotary syndrome, Review (CR)
439 Murali, P.M.; Rajasekaran, S.; Paramesh, P.; Krishnarajasekar, O.R.; Vasudevan, S.; Nalini, K.; Lakshmisubramanian, S.; Deivanayagam, C.N.
Plant-based formulation in the management of chronic obstructive pulmonary disease
A randomized double-blind study
Respir Med, 2006, 100, 39-45
Respiratory diseases, Bryonia, Bryonia alba, Drosera, Drosera peltata, Emphysema, Ipecacuanha, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial
440 Engelmann, U.; Walther, C.; Bondarenko, B.; Funk, P.; Schlafke, S.
Efficacy and safety of a combination of sabal and urtica extract in lower urinary tract symptoms
A randomized, double-blind study versus tamsulosin
Arzneim Forsch, 2006, 56, 222-229
Urinary tract, Urinary tract infection, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Prostagutt (forte), Prostatic enlargement (benign), Randomized trial, Sabal serrulata, Urtica
441 Uebelhack, R.; Blohmer, J.U.; Graubaum, H.J.; Busch, R.; Gruenwald, J.; Wernecke, K.D.
Black cohosh and St John's wort for climacteric complaints
A randomized trial
Obstet Gynecol, 2006, 107, 247-255
Black cohosh, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
442 Blake, D.R.; Robson, P.; Ho, M.; Jubb, R.W.; McCabe, C.S.
Preliminary assessment of the efficacy, tolerability and saftey of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
Rheumatol, 2006, 45, 50-52
Arthritis, Muscoskeletal -/Connective tissue system, Cannabis, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Pain
443 Moreno, R.A.; Teng, C.T.; Almeida, K.M.; Tavares Junior, H.
Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression
A randomized double-blind trial in a Brazilian sample
Rev Bras Psiquiatr, 2006, 28, 29-32
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
444 Yamada, H.; Takuma, N.; Daimon, T.; Hara, Y.
Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents
A prospective clinical study
J Altern Complement Med, 2006, 12(7), 669-672
Camellia, Camellia sinensis, Geriatrics, Flu, Infections, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Tea
445 Jocher, A.; Hornstein, S.; Schulte-Mönting, J.; Schempp, C.M.
Antiinflammatorische Wirkung von Salvia officinalis im UV-Erythemtest
Z Phytother, 2006, 27(Kongressband), S10
Allergies, Inflammation, Erythema, Healthy probands, Skin diseases, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, sage
446 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Dienel, A.; Kieser, M.
Multizentrische, doppelblinde, plazebokontrollierte und randomisierte Studie zur Wirksamkeit von Johanniskrautextrakt WS 5570 bei Patienten mit leichten oder mittelschweren Formen einer Depression
Z Phytother, 2006, 27(Kongressband), S10
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
447 Kaszik-Bettag, M.; Rettenberger, R.; Heger, P.M.
Efficacy and safety of the special Extract Rheum rhaponticum (ERr 731) in perimenopausal women with climateric complaints
Z Phytother, 2006, 27(Kongressband), S11
Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Rheum, Rheum rhaponticum
448 Koetter, U.; Butterwerk, V.; Brattström, A.
Hops contribute to the clinical efficacy of a fixed valerian hops extract combination in patients with primary insomnia
A placebo controlled, double-blind, randomized and prospective clinical trial
Z Phytother, 2006, 27(Kongressband), S11
hop, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
449 Staiger, C.
Beinwellwurzelextrakt - so wirksam wie Diclofenac
Ergebnisse einer multizentrischen Studie bei Sprunggelenksdistorsionen
Z Phytother, 2006, 27(Kongressband), S15
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Symphytum, Sprain
450 Uebelhack, R.; Blohmer, J.U.; Graubaum, H.J.; Busch, R.; Grünwald, J.; Wernecke, K.D.
Remifemin plus - ein wirksames Therapeutikum bei klimakterischen Beschwerden mit deutlich psychischer Komponente
Z Phytother, 2006, 27(Kongressband), S15-S16
Black cohosh, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
451 Widrig, R.; Suter, A.; Saller, R.; Melzer, J.
Arnika-Gel versus Ibuprofen-Gel zur topischen Behandlung der Osteoarthritis der Hand
Z Phytother, 2006, 27(Kongressband), S16
Arnica, Arthrosis, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial
452 Yancheva, S.; Ihl, R.; Schlaefke, S.; Hoerr, R.
Ginkgo-biloba-Extract EGb 761, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features
A randomised, double-blind trial
Z Phytother, 2006, 27(Kongressband), S17
Alzheimer's disease, Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial
453 Dimpfel, W.
Akute Wirksamkeit eines Baldrian-Trockenextraktes auf die Schlaftiefe beim Menschen
Eine doppelblinde, randomisierte, plazebokontrollierte Studie im parallelen Design
Z Phytother, 2006, 27(Kongressband), S20
Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Valeriana
454 Orlent, H.; Hansen, B.E.; Willems, M.; Brouwer, J.T.; Huber, R.; Kullak, Ublick, G.A.; Gerken, G.; Zeuzem, S.; Nevens, F.; Tielemans, C.M.; Zondervan, P.E.; Lagging, M.; Westin, J.; Schalm, S.W.
Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C
A randomized phase II trial
J Hepatol, 2006, 45(4), 539-546
Biochemistry, Glycyrrhiza, liquorice root, Glycyrrhizinsäure, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial
455 Dave, U.P.; Chauvan, V.; Dalvi, J.
Evaluation of BR-16 A (Mentat) in cognitive and behavioural dysfunction of mentally retarded children
A placebo-controlled study
Ind J Pediatr, 1993, 60, 423-428
Ayurveda, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nervous system, Pediatrics, Phytomedicine, Placebo-controlled, Randomized trial
456 Grossarth-Maticek, R.; Ziegler, R.
Prospective controlled cohort studies on long-term therapy of breast cancer patients with a mistletoe preparation (Iscador)
Forsch Komplementärmed, 2006, 13(5), 285-292
Breast cancer, Clinical research, Complementary and alternative medicine, Cancer, Mistletoe therapy, Phytomedicine, Randomized trial, Viscum, Viscum album, Iscador
457 Oben, J.; Kuate, D.; Agbor, G.; Momo, C.; Talla, X.
The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome
BMC Complement Altern Med, 2006, 5(24), (1-7)
Camellia, Camellia sinensis, Chromium, Cissus, Cissus quadrangularis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phaseolus, Phaseolus max, Phytomedicine, Placebo-controlled, Randomized trial, Selenium, Metabolic diseases, Overweight
458 Anghelescu, I.G.; Kohnen, R.; Szegedi, A.; Klement, S.; Kieser, M.
Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression
Results from a randomized multicenter study
Pharmacopsychiatry, 2006, 39(6), 213-219
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
459 Moshiri, E.; Basti, A.A.; Noorbala, A.A.; Jamshidi, A.H.; Hesameddin, Abbasi S.; Akhondzadeh, S.
Crocus sativus L. (petal) in the treatment of mild-to-moderate depression
A double-blind, randomized and placebo-controlled trial
Phytomed, 2006, 13(9-10), 607-611
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
460 Sun, C.L.; Yuan, J.M.; Koh, W.P.; Yu, M.C.
Green tea, black tea and breast cancer risk
A meta-analysis of epidemiological studies
Carcinogenesis, 2006, 27(7), 1310-1315
Breast cancer, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prevention, Tea
461 Sun, C.L.; Yuan, J.M.; Koh, W.P.; Yu, M.C.
Green tea, black tea and colorectal cancer risk
A meta-analysis of epidemiologic studies
Carcinogenesis, 2006, 27(7), 1301-1309
Camellia, Camellia sinensis, Bowel cancer, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prevention, Colorectal cancer, Tea
462 Kucera, M.; Barna, M.; Horácek, O.; Kováriková, J.; Kucera, A.
Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion
Results of a randomized controlled clinical double blind study
Wien Med Wochenschr, 2004, 154(21-22), 498-507
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Symphytum, Sprain
463 Newton, K.M.; Reed, S.D.; LaCroix, A.Z.; Grothaus, L.C.; Ehrlich, K.; Guiltinan, J.
Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo
Ann Intern Med, 2006, 145, 869-879
Black cohosh, Nutrition/diet, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Menopause, Phaseolus, Phaseolus max, Phytomedicine, Placebo-controlled, Randomized trial
464 Davis, K.; Philpott, S.; Kumar, D.; Mendall, M.
Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome
Int J Clin Pract, 2006, 60, 1080-1086
Aloe, Aloe vera, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome
465 DeKosky, S.T.; Fitzpatrick, A.; Ives, D.G.; Saxton, J.; Williamson, J.; Lopez, O.L.; Burke, G.; Fried, L.; Kuller, L.H.; Robbins, J.; Tracy, R., Woolard, N.; Dunn, L.; Kronmal, R.; Nahin, R.; Furberg, C.
The Ginkgo Evaluation of Memory (GEM) study
Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
Contemp Clin Trials, 2006, 27, 238-253
Dementia, Ginkgo, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Prevention, Randomized trial
466 Stavro, P.M.; Woo, M.; Leiter, L.A.; Heim, T.F.; Sievenpiper, J.L.; Vuksan, V.
Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function
Hypertension, 2006, 47, 791-796
High blood pressure, Urinary tract, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Kidney, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax quinquefolius
467 Gundermann, K.-J.; Godehardt, E.; Ulbrich, M.
Wirksamkeit eines pflanzlichen Kombinationspräparats bei funktioneller Dyspepsie
Metaanalyse randomisierter Doppelblindstudien auf Basis eines validen gastrointestinalen Symptomprofils
MMW Fortschr Med, 2004, 146, 71-76
Dyspepsia, Iberogast, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, Randomized trial
468 Kasper, S.; Anghelescu, I.G.; Szegedi, A.; Szegedi, A.; Dienel, A.; Kieser, M.
Superior efficacy of St Johns wort extract WS(R) 5570 compared to placebo in patients with major depression
A randomized, double-blind, placebo-controlled, multi-center trial
BMC Med, 2006, 4, 14; (1-13)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
469 Kim, J.-H.; Park, C.Y.; Lee, S.-J.
Effects of sun ginseng on subjective quality of life in cancer patients
A double-blind, placebo-controlled pilot trial
J Clin Pharm Ther, 2006, 31, 331-334
Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Psychology/psychotherapy, Randomized trial, Panax, Panax ginseng
470 Grube, B.; Grunwald, J.; Krug, L.; Staiger, C.
Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee
Results of a double-blind, randomised, bicenter, placebo-controlled trial
Phytomed, 2007, 14(1), 2-10
Arthrosis, Muscoskeletal -/Connective tissue system, Geriatrics, Clinical research, Knee arthrosis, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Symphytum
471 Hanai, H.; Iida, T.; Takeuchi, K.; Watanabe, F.; Maruyama, Y.; Andoh, A. et al.
Curcumin maintenance therapy for ulcerative colitis
Randomized, multicenter, double-blind, placebo-controlled trial
Clin Gastroenterol Hepatol, 2006, 4(12), 1502-1506
Ulcerative colitis, Curcuma, Curcuma longa, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
472 Becker, B.; Kuhn, U.; Hardewig-Budny, B.
Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea
Arzneim Forsch, 2006, 56(6), 387-393
Chamomilla, Diarrhoeal disorder, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Malus, Pediatrics, Phytomedicine, Randomized trial
473 Dalais, F.S.; Ebeling, P.R.; Kotsopoulos, D.; McGrath, B.P.; Teede, H.J.
The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women
Clin Endocrinol, 2003, 58, 704-709
Muscoskeletal -/Connective tissue system, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Osteoporosis, Phaseolus, Phaseolus max, Physiology, Phytomedicine, Placebo-controlled, Randomized trial
474 Chen, Y.M.; Ho, S.C.; Lam, S.S.; Ho, S.S.; Woo, J.L.
Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake
A double-blind, randomized, controlled trial
Menopause, 2004, 11(3), 246-254
Muscoskeletal -/Connective tissue system, Calcium, Nutrition/diet, Gynaecology, Clinical research, Bones, Complementary and alternative medicine, Menopause, Minerals, Osteoporosis, Phytomedicine, Randomized trial
475 Omer, B.; Krebs, S.; Omer, H.; Noor, T.O.
Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease
A double-blind placebo-controlled study
Phytomed, 2007, 14(2-3), 87-95
Artemisia, Artemisia absinthium, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
476 Kubo, T.; Nishimura, H.
Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children
Phytomed, 2007, 14(2-3), 96-101
Flu, Infections, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Mao-to, Pediatrics, Phytomedicine, Randomized trial, Traditional Japanese medicine
477 Gardner, C.D.
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia
Arch Intern Med, 2007, 167, 346-353
Allium, Allium sativum, Nutrition/diet, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
478 Bull, L.
Sunflower therapy for children with specific learning difficulties (dyslexia)
A randomised, controlled trial
Complement Ther Clin Pract, 2007, 13, 15-24
Bioenergetics, Homeopathy, Kinesiology, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Pediatrics, Phytomedicine, Psychology/psychotherapy, Randomized trial
479 Schink, M.; Tröger, W.; Dabidian, A.; Goyert, A.; Scheuerecker, H.; Meyer, J.; Fischer, I.U.; Glaser, F.
Mistletoe extract reduces the surgical suppression of natural killer cell activity in cancer patients
A randomized phase III trial
Forsch Komplementärmed, 2007, 14(1), 9-17
Surgery, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Randomized trial, Viscum, Viscum album, Iscador
480 Hsu, C.H.; Liao, Y.L.; Lin, S.C.; Hwang, K.C.; Chou, P.
The Mushroom Agaricus Blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes
A Randomized, Double-blinded, and Placebo-Controlled Clinical Trial
J Altern Complement Med, 2007, 13(1), 97-102
Agaricus, Agaricus blazei, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
481 Guala, A.; Oberle, D.; Ramos, M.
Efficacy and safety of two baby creams in children with diaper dermatitis: results of a postmarketing surveillance study
J Altern Complement Med, 2007, 13(1), 16-18
marigold, Chamomilla, Dermatitis, Skin diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, over-the-counter-medicines, Pediatrics, Phytomedicine, Randomized trial, Review (CR)
482 Hubbert, M.; Sievers, H.; Lehnfeld, R.; Kehrl, W.
Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis
A randomised, double-blind, placebo-controlled study with adaptive design and interim analysis
Eur J Med Res, 2006, 11, 20-26
Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Pharyngitis, Phytomedicine, Placebo-controlled, Randomized trial, sage
483 Heger, M.; Ventoskovskiy, B.M.; Borzenko, I.; Kneis, K.C.; Rettenberger, R.; Kaszkin-Bettag, M.; Heger, P.W.
Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints
A 12-week randomized, double-blind, placebo-controlled trial
Menopause, 2006, 13, 744-759
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial, Rheum, Rheum rhaponticum
484 Shin, B.C.; Lee, M.S.
Effects of aromatherapy acupressure on hemiplegic shoulder pain and motor power in stroke patients
A pilot study
J Altern Complement Med, 2007, 13(2), 247-251
Acupressure, Acupuncture, Aromatherapy, Muscoskeletal -/Connective tissue system, Hemiplegia, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Randomized trial, Stroke, Pain, Schulterschmerz (unspezifisch), Traditional Chinese medicine
485 Martirosyan, D.M.; Miroshnichenko, L.A.; Kulakova, S.N.; Pogojeva, A.V.; Zoloedo, V.I.
Amaranth oil application for coronary heart disease and hypertension
Lipids Health Dis, 2007, 6, 1; (1-12)
Amaranthus, High blood pressure, Cardiovascular diseases, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Coronary heart disease, Oil, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
486 Huseini, H.F.; Larijani, B.; Heshmat, R.; Fakhrzadeh, H.; Radjabipour, B.; Toliat, T.
The efficacy of Silybum marianum (L.) Gaertn. (Sylimarin) in the treatment of type II diabetes
A randomized, double-blind, placebo-controlled, clinical trial
Phytother Res, 2006, 20, 1036-1039
Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle, Metabolic diseases
487 Bernstein, S.; Donsky, H.; Gulliver, W.; Hamilton, D.; Nobel, S.; Norman, R.
Treatment of mild to moderate psoriasis with Reliéva, a Mahonia aquifolium extract
A double-blind, placebo-controlled study
Am J Ther, 2006, 13, 121-126
Berberis aquifolium, Skin diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Psoriasis vulgaris
488 Liu, Y.F.; Yu, H.M.; Zhang, C.; Yang, R.X.; Yan, F.F.; Liu, Y.; Zhang, Y.; Zhao, Y.X.
Effects of Quyu xiaoban capsules on clinical outcomes and platelet activation and aggregation in patients with unstable angina pectoris
J Altern Complement Med, 2007, 13(3), 369-374
Angina pectoris, Crataegus, Crataegus cuneata, Curcuma, Curcuma zedoaria, Cardiovascular diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Quyu Xiaoban, Randomized trial, Rheum, Rheum palmatum, Sargassum, Sargassum pallidum, Traditional Chinese medicine, Whitmania pigra
489 Blohmer, J.-U.; Graubaum, H.-J.; Busch, R.; Grünwald, J.; Wernecke, K.-D.; Uebelhack, R.
Cimicifuga und Hypericum als fixe Kombination gegen psychische Wechseljahresbeschwerden
Placebokontrollierte Doppelblindstudie mit 301 Patientinnen
Z Phytother, 2007, 28(2), 67-70
Black cohosh, Depression, Gynaecology, Hypericum, St John's wort, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
490 Vuksan, V.; Sung, M.K.; Sievenpiper, J.L.; Stavro, P.M.; Jenkins, A.L.; Di Buono, M.; Lee, K.S.; Leiter, L.A.; Nam, K.Y.; Arnason, J.T.; Coi, M.; Naeem, A.
Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes
Results of a randomized, double-blind, placebo-controlled study of efficacy and safety
Nutr Metabol Cardiovasc Dis, 2008, 18(1), 46-56
Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Metabolic diseases, Panax, Panax ginseng
491 Strasser, F.; Luftner, D.; Possinger, K.; Ernst, G.; Ruhstaller, T.; Meissner, W.; Ko, Y.-D.; Schnelle, M.; Reif, M.; Cerny, T.
Comparison of orally administered cannabis extract and delta-9-tetrahydrocannibol in treating patients with cancer-related anorexia-cachexia
A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the cannabis-in-cachexia-study-group
J Clin Oncol, 2006, 24(21), 3394-3400
Cannabis, Eating disorders, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Kachexie
492 Sammartino, A.; Tommaselli, G.A.; Gargano, V.; Carlo, C.di; Attianese, W.; Nappi, C.
Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women
A double-blind, randomized, placebo-controlled trial
Gynecol Endocrinol, 2006, 22(11), 646-650
Actaea, Black cohosh, Gynaecology, Climacteric, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
493 Shah, S.A.; Sander, S.; White, C.M.; Rinaldi, M.; Coleman, C.I.
Evaluation of echinacea for the prevention and treatment of the common cold
A meta-analysis
Lancet Infect Dis, 2007, 7(7), 473-480
Respiratory diseases, Echinacea, Echinacea purpurea, Common cold, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine
494 Lovera, J.; Bagert, B.; Smoot, K.; Morris, C.D.; Frank, R.; Bogardus, K.; Wild, K.; Oken, B.; Whitham, R.; Bourdette, D.
Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis
A randomized, placebo-controlled trial
Multiple Sclerosis, 2007, 13(3), 376-385
Ginkgo, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial
495 Steptoe, A.; Gibson, E.L.; Vuononvirta, R.; Hamer, M.; Wardle, J.; Rycroft, J.A.; Martin, J.F.; Erusalimsky, J.D.
The effects of chronic tea intake on platelet activation and inflammation
A double-blind placebo controlled trial
Atherosclerosis, 2007, 193, 277-282
Camellia sinensis, Inflammation, Healthy probands, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Phytomedicine, Placebo-controlled, Randomized trial, Tea, Black tea
496 Chainani-Wu, N.; Silverman, S. Jr; Reingold, A.; Bostrom, A.; McCulloch, C.; Lozada-Nur, F.; Weintraub, J.
A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus
Phytomed, 2007, 14(7-8), 427-446
Ayurveda, Curcuma, Curcuma longa, Ear-nose-throat disorders, Immune system, Clinical research, Complementary and alternative medicine, Mouth, Phytomedicine, Placebo-controlled, Randomized trial
497 Widrig, R.; Suter, A.; Saller, R.; Melzer, J.
Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study
Rheumatol Int, 2007, 27(6), 585-591
Arnica, Arthrosis, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial
498 Greenlee, H.; Atkinson, C.; Stanczyk, F.Z.; Lampe, J.W.
A pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women
Cancer Epidemiology, Biomarkers & Prevention, 2007, 16(8), 1601-1609
Curcuma, Curcuma longa, Cynara cardunculus subsp. flavescens, Endocrinology, Nutrition/diet, Gynaecology, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, rosemary, Schizandra, Schizandra chinensis, milk thistle, Taraxacum
499 Kishida, Y.; Miki, H.; Nishii, T.; Inoue, T.; Nishida, S.; Yoshikawa, H.; Sugano, N.
Therapeutic effects of Saireito (TJ-114), a traditional Japanese herbal medicine, on postoperative edema and inflammation after total hip arthroplasty
Phytomed, 2007, 14(9), 581-586
Alisma orientale, Atractylodes, Muscoskeletal -/Connective tissue system, Blood/Lymphatic system, Bupleurum, Surgery, Cinnamomum, Inflammation, Glycyrrhiza, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Edema, Phytomedicine, Pinellia Tuber, Polyporus umbellatus, Poria, Poria cocos, Randomized trial, Saireito, Scutellaria, Traditional Japanese medicine, ginger, Zizyphus, Zizyphus jujuba, Polyporus, Panax, Panax ginseng
500 Udani, J.; Singh, B.B.
Blocking carbohydrate absorption and weight loss
A clinical trial using a proprietary fractionated white bean extract
Altern Ther Health Med, 2007, 13(4), 32-37
Healthy probands, Clinical research, Complementary and alternative medicine, Phaseolus, Phaseolus vulgaris, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Overweight