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1 Murphy, J.J.; Heptinstall, S.; Mitchell, J.R.A.
Randomisierter und placebokontrollierter Doppelblindversuch zur Migräneprophylaxe mit Mutterkraut
Lancet, 1988, 2(11), 733-737

Clinical research, Complementary and alternative medicine, Matricaria, Migraine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/2899663

2 Brigo, B.
Le traitement homéopathique de la migraine
Une étude de 60 cas contrôlée en double aveugle - Remède homéopathique vs. placebo
LMHI (ed.) : 42nd Congress of the International Homeopathic Medical League, 29 March - 2 April, 1987, Arlington, Virginia, USA, 1987, 318-329

Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial

3 Brigo, B.; Serpelloni, G.
Homoeopathic Treatment of Migraines
A Randomized Double-blind Controlled Study of Sixty Cases - (Homoeopathic Remedy versus Placebo)
Berlin J Res Hom, 1991, 1(2), 98-106

Belladonna, Cyclamen, Gelsemium, Homeopathy, Ignatia, Clinical research, Complementary and alternative medicine, Lachesis, Migraine, Natrium, sodium chloride, Nervous system, Placebo-controlled, Randomized trial, Silicea, Sulfur

4 Walach, H.; Haag, G.; Gaus, W.
Klassisch-Homöopathische Therapie bei chronischen Kopfschmerzen
Eine randomisierte Doppelblindstudie
Schmerz, 1995, 1995(9), 9 (Abstract)

Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial

5 Whitmarsh, T.E.; Coleston, D.M.; Steiner, T.J.
Homoeopathic prophylaxis of migraine
Cephalalgia, 1993, 13(13), 178

Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Prevention, Randomized trial

6 Walach, H.; Haeusler, W.; Lowes, T.; Mussbach, D.; Schamell, U.; Springer, W.; Stritzl, G.; Gaus, W.; Haag, G.
Classical homeopathic treatment of chronic headaches
Cephalalgia, 1997, 17, 119-126

Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/9137850

7 Langer, H.
Ergebnisse der Behandlung der einfachen und klassischen Migräne
tpk, 1991, 5(3), 109-115

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Laserneedle acupuncture, Migraine, Nervous system, Traditional Chinese medicine

8 Stux, G.
Akupunkturtherapie der Migräne
tpk, 1988, 2(2), 89-93

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

9 Straumsheim, P.A.; Borchgrevink, C.F.; Mowinckel, P.; Kierulf, H.; Hafslund, O.
Homeopatisk behandling av migrene
En dobbelt-blind, placebokontrollert studie av 68 pasienter
Dynamis, 1997, 2, 18-22

Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial

10 Whitmarsh, T.E.; Coleston-Shields, D.M.; Steiner, T.J.
Double-blind randomised placebo-controlled study of homoeopathic prophylaxis of migraine
Cephalalgia, 1997, 17, 600-604

Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/9251877

11 Melchart, D.; Hager, S.; Liao, J.Z.; Weidenhammer, W.
Beobachtungsstudien im Rahmen eines naturheilkundlichen Klinikverbundes
Teil III: Zwischenergebnisse der diagnosespezifischen Dokumentation Migräne in der Klinik für Traditionelle Chinesische Medizin Kötzting
Forsch Komplementärmed, 1998, 5(3), 132-135

Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

Abstract: https://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=21093&Ausgabe=225782&ProduktNr=224242

12 Melchart, D.; Thormählen, J.; Hager, S.; Liao, J.; Weidenhammer, W.
Acupuncture versus Sumatriptan for Early Treatment of Acute Migraine Attacks - A Randomized Controlled Clinical Trial
Evidence-Based Complementary Medicine: International Congress on Clinical Research and Quality Management in Complementary Medicine, Munich, April 6 to 8, 2000
Forsch Komplementärmed, 2000, 7(1), 53 (Abstract)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

Abstract: https://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=57170&Ausgabe=228270&ProduktNr=224242&filename=57170.pdf

13 Walach, H.
Wissenschaftliche Untersuchungen zur Homöopathie
Die Münchener Kopfschmerzstudie - Arzneimittelprüfungen mit Belladonna
2000, 1-283 (Dissertation )

Belladonna, Drug proving, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial

14 Grossmann, M.; Schmidramsl, H.
An extract of petasites hybridus is effective in the prophylaxis of migraine
Int J Clin Pharmacol Ther, 2000, 38(10), 430-435

Clinical research, Complementary and alternative medicine, Migraine, Nervous system, butterbur, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/11020030

15 Brigo, B.
Homeopathic treatment of migraine
A sixty case, double-blind, controlled study (homeopathic remedy vs. placebo)
LMHI (ed.) : 42nd Congress of the International Homeopathic Medical League, 29 March - 2 April, 1987, Arlington, Virginia, USA, 1988, 318-329 (Symposiumsbeitrag)

Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Placebo-controlled, Randomized trial

16
Migräneprophylaxe mit Petasites hybribus
Petadolex-Studie international publiziert
EHK, 2001, 50(6), 368

Clinical research, Complementary and alternative medicine, Migraine, Nervous system, butterbur, Phytomedicine, Prevention, Randomized trial, Review (CR)

17 Melchart, D.; Weidenhammer, W.; Pollok-Müller, A.; Brand, J.; Saller, R.
Ergebnisqualität bei der Behandlung chronischer Kopfschmerzpatienten in einer Migräneklinik
Eine Kohortenstudie mit einjähriger Nachbeobachtung
Forsch Komplementärmed, 2001, 8(4), 219-227

Observational trial, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system

Abstract: https://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=57225&Ausgabe=228275&ProduktNr=224242

18 Muscari-Tomajoli, G.; Allegri, F.; Miali, E.; Pomposelli, R.; Tubai, P.; Targhetta, A.; Castellini, M.; Bellavite, P.
Observational study of quality of life in patients with headache, receiving homeopathic treatment
Brit Hom J, 2001, 90(4), 189-197

Observational trial, Homeopathy, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system

19 Grossmann, W.; Schmidramsl, H.
Effectiveness of Petasites extract in the prophylaxis of migraine
Chrubasik, S. et al. (eds.): Herbal medicinal products for the treatment of pain, 2000, 131-139

Clinical research, Complementary and alternative medicine, Migraine, Nervous system, butterbur, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

20 Pfaffenrath, V.; Diener, H.C.; Fisher, M.; Friede, M.; Henneicke-von Zeppelin, H.-H.
The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis - a double-blind, multicentre, randomized placebo-controlled dose-response study
Cephalalgia, 2002, 22, 523-532

Chrysanthemum, feverfew, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/12230594

21 Burke, B.E.; Olson, R.D.; Cusack, B.J.
Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine
Biomed Pharmacother, 2002, 56, 283-288

Gynaecology, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Phytomedicine, Premenstrual syndrome, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/12224599

22 Melchart, D.; Linde, K.; Streng, A.; Hoppe, A.; Brinkhaus, B.; Becker-Witt, C.; Pfaffenrath, V.; Hammes, M.; Willich, S.N.; Weidenhammer, W.; Reitmayr,S.; Wagenpfeil,S.
Acupuncture Randomized Trials (ART) in Patients with Migraine or Tension-Type Headache
Design and Protocols
Forsch Komplementärmed, 2003, 10(4), 179-184

Acupuncture, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ArtikelNr=73473&Ausgabe=229609&ProduktNr=224242

23 Bäcker, M.; Grossman, P.; Schneider, J.; Knoblauch, N.T.M.; Gareus, I.K.; Hammes, M.; Linde, K.; Melchart, D.; Dobos, G.J.
Vegetative reaction to acupuncture in migraineurs depends on the vagal tone before treatment: a randomised, controlled trial
FACT, 2003, 8(4), 477-478 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine, Vegetative nervous system

24 Friedrichs, E.M.
Qigong Yangsheng - Übungen der Traditionellen Chinesischen Medizin - als Begleittherapie bei Migräne und Spannungskopfschmerz
Eine multizentrische prospektive Pilotstudie
2003, 1-187 (Dissertation)

Observational trial, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Qi Gong, Traditional Chinese medicine

25 Linde, K.; Streng, A.; Reitmayr, S.; Hoppe, A.; Brinkhaus, B.; Becker-Witt, C.; Wagenpfeil, S.; Weidenhammer, W; Willich, S.N.; Melchart, D.
Efficacy of acupuncture in patients with migraine - the Acupuncture Randomised Trials (ART)
FACT, 2003, 8(4), 514-515 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/12972722

26 Vickers, A.J.; Rees, R.W.; Zollman, C.E.; McCarney, R.; Smith, C.; Ellis, N.; Fisher, P.A.G.; Haselen, R.A. van
Acupuncture for migraine and chronic tension headache in primary care: a large, pragmatic, randomised trial
FACT, 2003, 8(4), 546 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

27 Wonderling, D.; Vickers, A.J.; McCarney, R.; Grieve, R.
Cost effectiveness analysis of a randomised trial of acupuncture for chronic headache in primary care
BMJ, 2004, 328, (1-5)

Acupuncture, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Economy, Randomized trial, Traditional Chinese medicine, Cost-effectiveness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15023830

28 Vickers, A.J.; Rees, R.; Zollman, C.E.; McCarney, R.; Smith, C.; Ellis, N.; Fisher, P.; Haselen, R. van
Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial
BMJ, 2004, 328, 1-6 (744) (Internet)

Acupuncture, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15023828

29 Blum, J.M.; Marshall, P.
Herbal homeopathic support for the treatment of migraine-type headache symptoms
A prospective, randomized, double-blind clinical trial to test the efficacy and safety of MigraSpray
2001, 1-6 (Manuskript; Internet)

Chrysanthemum, feverfew, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial

30 Göbel, H.; Heinze, A.; Dworschak, M.; Heinze-Kuhn, K.; Stolze, H.
Oleum mentha x piperitae in der Akuttherapie von Migräne und Kopfschmerz vom Spannungstyp
Z Phytother, 2004, 25(3), 129-139

Clinical research, Complementary and alternative medicine, Headache, Mentha, peppermint, Migraine, Nervous system, Economy, Phytomedicine, Placebo-controlled, Randomized trial, Review (CR), Prevalence

31 Melchart, D.; Hager, S.; Hager, U.; Liao, J.; Weidenhammer, W.; Linde, K.
Treatment of patients with chronic headaches in a hospital for traditional Chinese medicine in Germany
A randomised, waiting list controlled trial
Complement Ther Med, 2004, 12(2-3), 71-78

Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15561516

32 Linde, K.; Streng, A.; Jürgens, S.; Hoppe, A.; Brinkhaus, B.; Witt, C.; Wagenpeil, S.; Pfaffenrath, V.; Hammes, M.G.; Weidenhammer, W.; Williche, S.N.; Melchart, D.
Acupuncture for patients with migraine
A randomized controlled trial
JAMA, 2005, 293(17), 2118-2125

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15870415

33 Maizels, M.; Blumenfeld, A.; Burchette, R.
A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis
A randomized trial
Headache, 2004, 44, 885-890

Chrysanthemum, feverfew, Nutrition/diet, Clinical research, Complementary and alternative medicine, Magnesium, Migraine, Minerals, Dietary supplementation, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial, Riboflavin

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15447697

34 Vickers, A.J.; Rees, R.W.; Zollman, C.E.; McCarney, R.; Smith, C.M.; Ellis, N.; Fisher, P.; Haselen, R. van; Wonderling, D.; Grieve, R.
Acupuncture of chronic headache disorders in primary care
Randomised controlled trial and economic analysis
Health Technol Assess, 2004, 8(48), 1-50

Acupuncture, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Economy, Randomized trial, Traditional Chinese medicine, Cost-effectiveness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15527670

35 Linde, M.; Fjell, A.; Carlsson, J.; Dahlof, C.
Role of needling per se in acupuncture as prophylaxis for menstrually related migraine
A randomised placebo-controlled study
Cephalalgia, 2005, 25, 41-47

Acupuncture, Gynaecology, Clinical research, Complementary and alternative medicine, Menstrual disorders, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15606569

36 Kaushik, R.; Kaushik, R.M.; Mahajan, S.K.; Rajesh, V.
Biofeedback assisted diaphragmatic breathing and systematic relaxation versus propranolol in long term prophylaxis of migraine
Complement Ther Med, 2005, 13(3), 165-174

Breathing therapy, Biofeedback, Clinical research, Complementary and alternative medicine, Migraine, Mind-body medicine, Nervous system, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16150370

37 Lipton, R.B.; Einhäupl, K.M.; Wilks, K.; Mauskop, A.
Petasites hybridus root (butterbur) is an effective preventive treatment for migraine
Neurology, 2004, 63, 2240-2244

Clinical research, Complementary and alternative medicine, Migraine, Nervous system, butterbur, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15623680

38 Sándor, P.S.; Di Clemente, L.; Coppola, G.; Saenger, U.; Fumal, A.; Magis, D.; Seidel, L.; Agosti, R.M.; Schoenen, J.
Efficacy of coenzyme Q10 in migraine prophylaxis
A randomized controlled trial
Neurology, 2005, 64, 713-715

Coenzyme, Nutrition/diet, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial

39 Bäcker, M.; Hammes, M.; Sander, D.; Funke, D.; Deppe, M.; Tölle, T.R.; Dobos, G.J.
Changes of cerebrovascular response to visual stimulation in migraineurs after repetitive sessions of somatosensory stimulation (acupuncture)
A pilot study
Headache, 2004, 44(1), 95-101

Acupuncture, Observational trial, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/14979891

40 Streng, A.; Linde, K.; Hoppe, A.; Pfaffenrath, V.; Hammes, M.; Wagenpfeil, S.; Weidenhammer, W.; Melchart, D.
Effectiveness and tolerability of acupuncture compared with metopolol in migraine prophylaxis
A randomised trial
FACT, 2005, 10(suppl. 1), 52 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/17115982

41 Diener, H.C.; Kronfeld, K.; Boewing, G.; Lungenhausen, M.; Maier, C.; Molsberger, A.; Tegenthoff, M.; Trampisch, H.-J.; Zenz, M.; Meinert, R.
Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial
Lancet (Neurology), 2006, 5(4), 310-316

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16545747

42 Diener, H.C.; Pfaffenrath, V.; Schnitker, J.; Friede, M.; Henneicke-von Zepelin, H.H.
Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention
Randomized double-blind, multicentre, placebo-controlled study
Cephalalgia, 2005, 25, 1031-1041

Clinical research, Complementary and alternative medicine, Matricaria, Migraine, Nervous system, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16232154

43 Kim, T.S.
A Study of the Use of Permanent Magnets in the Treatment of Chronical Primary Headache
Alternative Therapies in Health and Medicine (Inno Vision Communications) (eds.): Creating Integrative Healthcare. Fourth Annual Alternative Therapies Symposium, Proceedings, March 25-28, 1999, New York, NY, 1999, 92 (Symposiumsbeitrag; Abstract)

Clinical research, Complementary and alternative medicine, Headache, Magnetic field therapy, Migraine, Nervous system, Physical therapy, Placebo-controlled, Randomized trial

44 Chayasirisobhon, S.
Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication
Headache, 2006, 46, 788-793

Acidum ascorbicum, Antioxidants, Observational trial, Nutrition/diet, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Migraine, Nervous system, Phytomedicine, Pinus, Tokopherol, Vitamins

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16643582

45 Alecrim-Andrade, J.; Maciel-Junior, J.; Cladellas, X.; Correa-Filho, H.R.; Machado, H.C.
Acupuncture in migraine prophylaxis
A randomized sham-controlled trial
Cephalalgia, 2006, 26, 520-529

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/16674760

46 Lawler, S.P.; Cameron, L.D.
A randomized, controlled trial of massage therapy as a treatment for migraine
Ann Behav Med, 2006, 32, 50-59

Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Migraine, Nervous system, Randomized trial

47 Paterson, C.; Zheng, Z.; Xue, C.; Wang, Y.
'How is it for the patient?'
Participating in a sham-controlled acupuncture trial for migraine
FACT, 2006, 11(Suppl. 1), 35-36 (Symposiumsbeitrag; Abstract)

Acupuncture, Assesment, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Patient satisfaction, Placebo-controlled, Randomized trial, Traditional Chinese medicine

48 Pothmann, R.; Frankenberg, S. von; Lüdtke, R.; Thoiss, W.; Hoicke, C.; Bollig, G.
Ein randomisierter Vergleich verschiedener Modalitäten zur ernährungsmedizinischen Therapie bei Kindern mit Kopfschmerzen
Albrecht, H., Frühwald, M. (Hrsg.): Jahrbuch der Karl und Veronica Carstens-Stiftung, Band 10 (2003), 2004, 157-171

Nutrition/diet, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Pediatrics, Randomized trial

49 John, P.J.; Sharma, N.; Sharma, C.M.; Kankane, A.
Effectiveness of yoga therapy in the treatment of migraine without aura
A randomized controlled trial
Headache, 2007, 47(5), 654-661

Clinical research, Complementary and alternative medicine, Meditation, Migraine, Mind-body medicine, Nervous system, Randomized trial, Yoga

50 Streng, A.; Linde, K.; Hoppe, A.; Pfaffenrath, V.; Hammes, M.; Wagenpfeil, S.; Weidenhammer, W.; Melchart, D.
Effectiveness and tolerability of acupuncture compared with metoprolol in migraine prophylaxis
Headache, 2006, 46(10), 1492-1502

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://dx.doi.org/10.1111/j.1526-4610.2006.00598.x

51 Meyer-Wegener, J.
Migräneprophylaxe mit Mutterkraut
tpk, 1989, 3(3), 126-127

Clinical research, Complementary and alternative medicine, Matricaria, Migraine, Nervous system, Phytomedicine, Placebo-controlled, Randomized trial, Review (CR)

52 Baust, W.
Klinische Untersuchungen zur Wirksamkeit der Akupunkturbehandlung der Migräne
Dt Z Aku, 1979, 6, 132-135

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

53 Pongratz, W.; Dörr-Proske, H.; Wittchen, H.
Akupunktur in der Schmerztherapie im Vergleich mit einem psychologischen Verfahren am Beispiel des Migränekopfschmerzes
Rheuma-Schmerz und Entzündung, 1985, 4, 30-36

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

54 Schnorrenberger, C.C.; Baust, W.
Akupunkturbehandlung der Migräne im Doppelblindversuch
Vgl ds Z, 1979, 29(16), 425-428

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

55 Baischer, W.
Psychologische Aspekte als Prädiktoren für das Ansprechen auf Akupunktur bei Migränepatienten
Wien Klin Wochenschr, 1993, 105(7), 200-203

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo, Psychology/psychotherapy, Traditional Chinese medicine

56 Kubiena, G.; Nissel, H.; Porenta, G.; Veitl, M.; Wessely, P.
Akupunktur bei Migräne
Follow-up Studie
Dt Z Aku, 1992, 35(6), 140-148

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

57 Loh, L.; Nathan, P.W.; Schott, G.D.; Zilkha, K.H.
Acupuncture versus medical treatment for migraine and muscle tension headaches
J Neurol Neurosurg Psychiatry, 1984, 47, 333-337

Acupuncture, Clinical research, Complementary and alternative medicine, Conventional medicine, Headache, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

58 Lehmann, V.; Banzhaf, E.; Kunze, E.; Stübe, G.; Theil, G.; Schilling, C.; Möbius, M.; Wenzel, K.-P.; Hahn, D.
Randomisierte klinisch kontrollierte Studie der Effizienz der Akupunktur im Vergleich zur Elektroakupunktur sowie Pharmakotherapie mit Propanolol bei Patienten mit häufiger Migräne
Dt Z Aku, 1991, 34(2), 27-30

Acupuncture, Electroacupuncture, Electrotherapy, Clinical research, Complementary and alternative medicine, Conventional medicine, Migraine, Nervous system, Physical therapy, Randomized trial, Transcutaneous electrical nerve stimulation (TENS), Traditional Chinese medicine

59 Major, P.; Standnes, B.
Akupunkturbehandling ved migrene
Tidsskr Nor laegeforen, 1983, 103(7), 686-689

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

60 Marcus, P.
Treatment of migraine by acupuncture
Acupunct Electrother Res, 1979, 4, 137-147

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/6631882

61 Tukmachi, E.
Migraine and acupuncture
Clinical approach
Int J Altern Compl Med, 1994, 15-19

Acupuncture, General overview, Observational trial, Case report, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Pathologie, Practice, Theory, Traditional Chinese medicine

62 Kivellos, S.; Papatriantafyllou, J.; Papilas, K.; Vithoulkas, G.; Karagerorgiou, K.
Observational prospective study of homeopahtic treatment in patients with migraine, attending the Headache Clinic of Neurology Dpt. "G. Gennimatas" Athens General Hospital
8th Headache Congress of the European Headache Federation - EHF, Valencia, Spain, April 26-29, 2006, 2006, 1 (Internet; Abstract ; Symposiumsbeitrag)

Observational trial, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system

63 Alecrim-Andrade, J.; Maciel-Junior, J.A.; Carne, X.; Vasconcelos, G.M.S.; Correa-Filho, H.R.
Acupuncture in migraine prevention
A randomized sham controlled study
Clin J Pain, 2008, 24(2), 98-105

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/18209514

64 Facco, E.; Liguori, A.; Petti, F.; Zanette, G.; Coluzzi, F.; Nardin, M. De; Mattia, C.
Traditional acupuncture in migraine
A controlled, randomized study
Headache, 2008, 48, 398-407

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/17868354

65 Oelkers-Ax, R.; Leins, A.; Parzer, P.; Hillecke, T.; Bolay, H.V.; Fischer, J.; Bender, S.; Hermanns, U.; Resch, F.
Butterbur root extract and music therapy in the prevention of childhood migraine
An explorative study
Eur J Pain, 2008, 12(3), 301-313

Clinical research, Complementary and alternative medicine, Migraine, Music therapy, Nervous system, Pediatrics, butterbur, Phytomedicine, Placebo-controlled, Prevention, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/17659990

66 Paterson, C.; Zheng, Z.; Xue, C.; Wang, Y.
"Playing their parts"
The experiences of participants in a randomized sham-controlled acupuncture trial
J Altern Complement Med, 2008, 14(2), 199-208

Acupuncture, Assesment, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Patient satisfaction, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/18315508

67 Vas, J.; Rebollo, A., Perea-Milla, E.; Mendez, C.; Font, C.R.; Gomez-Rio, M.; Matrin-Avila, M.; Cabrera-Iboleon, J.; Caballero, M.D.; Olmos, M.A.; Aguilar, I.; Faus, V.; Martos, F.
Study protocol for a pragmatic randomised controlled trial in general practice investigating the effectiveness of acupuncture against migraine
BMC Complement Altern Med, 2008, 8(1), 12; (1-11) (Studienprotokoll)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/18410686

68 Ahmadi, A.; Schwebel, D.C.; Rezaei, M.
The efficacy of wet-cupping in the treatment of tension-type and migraine headache
Am J Chin Med, 2008, 36(1), 37-44

Purgative therapy, Observational trial, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Cupping

69 Li, Y.; Liang, F.; Yang, X.; Tain, X.; Yan, J.; Sun, G.; Chang, X.; Tang, Y.; Ma, T.; Zhou, L.; Lan, L.; Yao, W.; Zou, R.
Acupuncture for treating acute attacks of migraine
A randomized controlled trial
Headache, 2009, 49(6), 805-816

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19438740

70 Zhang, Y.; Wang, L.; Liu, H.; Li, N.; Li, J.; Yi, J.
The design and protocol of acupuncture for migraine prophylaxis
A multicenter randomized controlled trial
Trials, 2009, 10, 25; (1-7)

Acupuncture, Clinical research, Complementary and alternative medicine, Methodology, Migraine, Nervous system, Prevention, Randomized trial, Theory, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19389262

71 Böwing, G.; Zhou, J.; Endres, H.G.; Coeytaux, R.R.; Diener, H.C.; Molsberger, A.F.
Differences in Chinese diagnoses for migraine and tension-type headache
An analysis of the German acupuncture trials (GERAC) for headache
Cephalalgia, 2010, 30(2), 224-232

Diagnostics, Complementary and alternative medicine, Headache, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19614709

72 Elinoff, V.; Lynn, S.J.; Ochiai, H.; Hallquist, M.
The efficacy of Kiko exercises on the prevention of migraine headaches
A pilot study
Am J Chin Med, 2009, 37(3), 459-470

Observational trial, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Prevention, Traditional Japanese medicine

73 Ramos-Font, C.; Vas, J.; Rebollo-Aguirre, A.C.; Gomez-Rio, M.; Caballero, D.; Marin-Avila, M.; Cabrera-Iboleon, J.E.; Olmos-Raya, M.A.
Preliminary results of a pragmatic randomised controlled trial in general practice investigating the effectiveness of acupuncture against migraine
Qualitative analysis of brain perfusion SPECT
Eur J Integr Med, 2009, 1(4), 208-209 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://dx.doi.org/10.1016/j.eujim.2009.08.127

74 Lipton, R.B.; Dodick, D.W.; Silberstein, S.D.; Saper, J.R.; Aurora, S.K.; Pearlman, S.H.; Fischell, R.E.; Ruppel, P.L; Goodsby, P.J.
Single-pulse transcranial magnetic stimulation for accute treatment of migraine with aura
A randomised, double-blind, parallel-group, sham-controlled trial
Lancet (Neurology), 2010, (online, March 4, 2010), (1-8)

Clinical research, Complementary and alternative medicine, Magnetic field therapy, Migraine, Nervous system, Physical therapy, Placebo-controlled, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20206581

75 Whitmarsh, T.E.; Coleston, D.M.; Steiner, T.J.
Homoeopathic prophylaxis of migraine
Liga Medicorum Homoeopathica Internationalis (L.M.H.I.): 52nd Congress of the Liga Medicorum Homeopathica Internationalis, 28 May - 1 June 1997, Seattle, Washington, USA., 1997, 87 (Symposiumsbeitrag; Abstract)

Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial

76 Boutouyrie, P.; Corvisier, R.; Ong, K.T.; Vulser, C.; Lassalle, C.; Azizi, M.; Laloux, B.; Laurent, S.
Acute and chronic effects of acupuncture on radial artery
A randomized double blind study in migraine
Artery Res, 2010, 4(1), 7-14

Acupuncture, Arteries, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://dx.doi.org/10.1016/j.artres.2009.12.003

77 Witt, C.M.; Lüdtke, R.; Willich, S.N.
Homeopathic treatment of patients with migraine
A prospective observational study with a 2-year follow-up period
J Altern Complement Med, 2010, 16(4), 347-355

Observational trial, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20423206

78 Allais, G.; Romoli, M.; Rolando, S.; Castagnoli Gabellari, I.; Benedetto, C.
Ear acupuncture in unilateral migraine pain
Neurol Sci, 2010, 31(Suppl. 1), S185-S187

Acupuncture, Observational trial, Diagnostics, Gynaecology, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Ear acupuncture, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20464619

79 Kivellos, S.; Papatriantafyllou, J.; Papilas, K.; Vithoulkas, G.; Karagerorgiou, K.
Practising classical homeopathy in a headache clinic of a major public hospital in Athens, Greece
Four years experience in treating migraine patients
Liga Medicorum Homoeopathica Internationalis (L.M.H.I.): 63rd Congress of the Liga Medicorum Homeopathica Internationalis, 20. - 24. Mai 2008, Oostende, Belgien, Teil II, 2006, (1-8) (Symposiumsbeitrag)

Observational trial, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system

80 Nelson, C.F.; Bronfort, G.; Evans, R.; Boline, P.; Goldsmith, C.; Anderson, A.V.
The efficacy of spinal manipulation, amtiriptyline and the combination of both therapies for the prophylaxis of migraine headache
J Manipulative Physiol Ther, 1998, 21(8), 511-519

Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Migraine, Nervous system, Prevention, Randomized trial

81 Tuchin, P.J.; Pollard, H.; Bonello, R.
A randomized controlled trial of chiropractic spinal manipulative therapy for migraine
J Manipulative Physiol Ther, 2000, 23(2), 91-95

Chiropractic, Clinical research, Complementary and alternative medicine, Manual therapy, Migraine, Nervous system, Randomized trial

82 Usai, S.; Grazzi, L.; Andrasik, F.; Bussone, G.
An innovative approach for migraine prevention in young age
A preliminary study
Neurol Sci, 2010, 31(Suppl.1), 181-183

Observational trial, Ginkgo, Jugendmedizin, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Pediatrics, Phytomedicine, Prevention

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20464618

83 Voigt, K.; Liebnitzky, J.; Burmeister, U.; Sihvonen-Riemenschneider, H.; Beck, M.; Voigt, R.; Bergmann, A.
Efficacy of osteopathic manipulative treatment of female patients with migraine
Results of a randomized controlled trial
J Altern Complement Med, 2011, 17(3), 225-230

Gynaecology, Clinical research, Complementary and alternative medicine, Manual therapy, Migraine, Nervous system, Osteopathy, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21385086

84 Yang, J.; Liang, F.-R.; Fang, L.; Zeng, F.
A PET-CT study on cerebral glucose metabolism of migraine patients treated by acupuncture in attack stage
Eur J Integr Med, 2010, 2(4), 190 (Abstract; Symposiumsbeitrag)

Acupuncture, Electroacupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Neurophysiology, Physiology, Randomized trial, Traditional Chinese medicine

85 Zheng, H.; Liang, F.-R.; Li, Y.; Yan, J.; Chang, X.-R.; Wang, D.-J.
Cerebrovascular changes of migraineurs after different types of acupuncture treatment
A transcranial Doppler study
Eur J Integr Med, 2010, 2(4), 192 (Abstract; Symposiumsbeitrag)

Acupuncture, Brain, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

86 Sharma, N.; Sharma, S.; Verma, A.
Effectiveness of integrated yoga therapy in treatment of chronic migraine
Randomized controlled trail
Eur J Integr Med, 2010, 2(4), 194 (Abstract; Symposiumsbeitrag)

Depression, Clinical research, Complementary and alternative medicine, Meditation, Migraine, Mind-body medicine, Nervous system, Mental diseases, Randomized trial, Pain, Yoga, Chronic pain

87 Li, Y.; Liang, F.-R.; Zheng, H.; Witt, C.; Roll, S.; Yu, S.-G.; Yan, J.; Sun, G.; Huang, W.-J.; Chang, X.-R.; Zhao, L.; Zhang, H.-X.; Wang, D.-J.; Lan, L.; Zou, R.
Acupuncture to treat migraine
A multi-center randomized controlled trail
Eur J Integr Med, 2010, 2(4), 194-195 (Abstract; Symposiumsbeitrag)

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Randomized trial, Traditional Chinese medicine

88 Schmidt, S.; Simshäuser, K.; Aickin, M.; Lüking, C.; Schultz, C.; Kaube, H.
Mindfulness-based stress reduction is an effective intervention for patients suffering from migraine
Results from a controlled trail
Eur J Integr Med, 2010, 2(4), 196 (Abstract; Symposiumsbeitrag)

Mindfulness meditation, Clinical research, Complementary and alternative medicine, Meditation, Migraine, Mind-body medicine, Nervous system, Mental diseases, Randomized trial, Stress

89 Bijak, M.; Stockenhuber, D.; Wolkenstein, E.; Nissel, H.; Bischko, J.
Cephalea and migraine - a 6-month follow-up interrogation trial
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 95 (Symposiumsbeitrag; Abstract)

Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Headache, Migraine, Nervous system, Traditional Chinese medicine

90 Wang, L.-P.; Zhang, X.-Z.; Guo, J.; Liu, H.-L.; Zhang, Y.; Liu, C.-Z.; Yi, J.-H.; Wang, L.-P.; Zhao, J.-P.; Li, S.-S.
Efficacy of acupuncture for migraine prophylaxis
A single-blinded, double-dummy, randomized controlled trial
Pain, 2011, 152(8), 1864-1871

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21616596

91 Curtis, P.; Gaylord, S.A.; Park, J.; Faurot, K.R.; Coble, R.; Suchindran, C.; Coeytaux, R.R.; Wilkinson, L.; Mann, J.D.
Credibility of low-strength static magnet therapy as an attention control intervention for a randomized controlled study of CranioSacral Therapy for migraine headaches
J Altern Complement Med, 2011, 17(8), 711-721

Clinical research, Complementary and alternative medicine, Cranio-sacral therapy, Magnetic field therapy, Manual therapy, Migraine, Nervous system, Physical therapy, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21732734

92 Witt, C.M.; Lüdtke, R.; Willich, S.N.
Homeopathic treatment in patients with migraine
A prospective observational study with a 2-year follow-up period
Albrecht, H., Frühwald, M. (Hrsg.): Jahrbuch der Karl und Veronica Carstens-Stiftung, Band 17 (2010), 2011, 231-254

Observational trial, Homeopathy, Clinical research, Complementary and alternative medicine, Migraine, Nervous system

93 Conde, R.; Correa, V.S.; Carmona, F.; Contini, S. H.; Pereira, A.M.
Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine
Phytomed, 2011, 18(4), 1197-1201

Observational trial, Inhaltsstoffanalyse, Clinical research, Complementary and alternative medicine, Lippia, Lippia alba, Migraine, Nervous system, Phytomedicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21802924

94 Yang, C.P.; Chang, M.H.; Liu, P.E.; Li, T.C.; Hsieh, C.L.; Hwang, K.L.; Chang, H.H.
Acupuncture versus topiramate in chronic migraine prophylaxis
A randomized clinical trial
Cephalalgia, 2011, 31(15), 1510-1521

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22019576

95 San-Juan, D.; Pon, A.A.; Pohls, F.Z.; Castillo-Calcaneo, J. de D. Del; Perez-Neri, I.; Rios, C.
Peripheral pulsed electromagnetic fields may reduce the placebo effect in migraine patients that do not respond to the sham intervention in a randomized, placebo-controlled, double-blind, cross-over clinical trial
Complement Ther Med, 2012, 20(1-2), 31-37

Clinical research, Complementary and alternative medicine, Magnetic field therapy, Migraine, Nervous system, Physical therapy, Placebo, Placebo-controlled, Randomized trial

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22305246

96 Allais, G.; Romoli, M.; Rolando, S.; Airola, G.; Castagnoli Gabellari, I.; Allais, R.; Benedetto, C.
Ear acupuncture in the treatment of migraine attacks
A randomized trial on the efficacy of appropriate versus inappropriate acupoints
Neurol Sci, 2011, 32(Suppl.1), S173-S175

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Ear acupuncture, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21533739

97 Wang, L.P.; Zhang, X.Z.; Guo, J.; Liu, H.L.; Zhang, Y.; Liu, C.Z.; Yi, J.H.; Wang, L.P.; Zhao, J.P.; Li, S.S.
Efficacy of acupuncture for acute migraine attack
A multicenter single blinded, randomized controlled trial
Pain Med, 2012, 13(5), 623-630

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22536889

98 Li, Y.; Zheng, H.; Witt, C.M.; Roll, S.; Yu, S.G.; Yan, J.; Sun, G.J.; Zhao, L.; Huang, W.J.; Chang, X.R.; Zhang, H.X.; Wang, D.J.; Lan, L.; Zou, R.; Liang, F.R.
Acupuncture for migraine prophylaxis
A randomized controlled trial
CMAJ, 2012, 184(4), 401-410

Acupuncture, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Placebo-controlled, Prevention, Randomized trial, Traditional Chinese medicine

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22231691

99 Allais, G.; Rolando, S.; Castagnoli Gabellari, I.; Burzio, C.; Airola, G.; Borgogno, P.; Schiapparelli, P.; Allais, R.; Benedetto, C.
Acupressure in the control of migraine-associated nausea
Neurol Sci, 2012, 33(Suppl.1), 207-210

Acupressure, Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Migraine, Nervous system, Traditional Chinese medicine, Sickness

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22644205

100 Cohen, M.; Parker, S.; Taylor, D.; Smit, V. de; Ben-Meir, M.; Cameron, P.; Xue, C.
Acupuncture as analgesia for low bach pain, ankle sprain and migraine in emergency departements
Study protocol for a randomized controlled trial
Trials, 2011, 12, 241; (1-7) (Studienprotokoll)

Acupuncture, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Migraine, Nervous system, Emergency medicine/Intensive care, Randomized trial, Back pain (non-specific), Pain, Traditional Chinese medicine, Sprain

Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22085683

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