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1 Bertrand, M.; Doroshow, J.H.; Multhauf, P.; Blayney, D.; Carr, B.; Cecci, G.; Goldberg, D.; Emont, E.; Kogut, N.; Leong, L.; Margolin, K.
High dose folinic acid (HDFA) by continous infusion and IV bolus 5 FU in patients with advanced colorectal cancer
1985, 4, 77 (Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
2 Canobbio, L.; Nobile, M.T.; Galligioni, E.; Vidili, G.; Fassio, T.; Lo Re, G.; Rubagotti, A.; Rosso, R.
Randomized trial of 5-fluorouracil (5-FU) alone or combined with high dose folinic acid (FA) in advanced colorectal cancer patients (PTS)
1987, 6, 97 (Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
3 Ciura, P. La; Grotta, G. La; Nigra, E.; Comandone, A.; Grecchi, G.; Leria, G.; Calciati, A.
5-Methyltetrahydrofolic acid (MFH4)
An effective folate for the treatment of advanced colorectal cancer with 5-FU
Cancer Res, 1988, 110, 219-225
Observational trial, Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Vitamins
4 Costanzo, E. di; Bartolucci, B.; Sofra, M.; Calabresi, F.; Malacarne, P.; Belsanti, V.; Boni, C.; Bacchi, M.
5-fluorouracil (5-FU) alone vs. high dose folinic acid (FA) and 5-FU in advanced colorectal cancer (CA):
A randomized trial of the italian oncology group for clinical research (GOIRC).
Proceedings of American Society of Clinical Oncology, 1989, 106 (Symposiumsbeitrag; Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Randomized trial, Vitamins
5 Doroshow, J.H.; Bertrand, M.; Multhauf, P.; Leong, L.; Goldberg, D.; Margolin, K.; Carr, B.; Akman, S.; Hill, R.
Prospective randomized trial comparing 5-FU vs. 5-FU and high dose folinic acid (HDFA) for treatment of advanced colorectal cancer
Proceedings of American Society of Clinical Oncology, 1987, 96 (Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
6 Erlichman, C.; Fine, S.; Wong, A.; Elhakim, T.
A comparison of 5-fluorouracil (5FU) and folinic acid (FA) versus 5FU in metastatic colorectal carcinoma (MCC)
Proceedings of American Society of Clinical Oncology, Vol. V, 1986, 82 (Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
7 Erlichman, C.; Fine, S.; Wong, A.; Elhakim, T.
A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma
J Clin Oncol, 1988, 6(3), 469-475
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
8 Moertel, C.G.; Fleming, T.R.; Creagan, E.T.; Rubin, J.; O'Connell, M.J.; Ames, M.M.
High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy
A randomized double-blind comparison
New Engl J Med, 1985, 312(3), 137-141
Acidum ascorbicum, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Placebo-controlled, Randomized trial, Vitamins
9 Nobile, M.T.; Vidili, M.G.; Sobrero, A.; Sertoli, M.R.; Canobbio, L.; Fassio, T.; Rubagotti, A.; Gallo, L.; Lo Re, G.; Galligioni, E.; Rosso, R.
5-fluorouracil (FU) alone or combined with high dose folinic acid (FA) in advanced cologrectal cancer patients
A randomized trial
Proceedings of American Society of Clinical Oncology, 1988, 1988 (Abstract)
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
10 Tsavaris, N.; Bacoyanis, C.; Milonakis, N.; Sarafidou, M.; Zamanis, N.; Magoulas, D.; Kosmidis, P.
Folinic acid plus high-dose 5-fluorouracil with allopurinol protection in the treatment of advanced colorectal carcinoma
Eur J Cancer, 1990, 26(10), 1054-1056
Observational trial, Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Vitamins
11 Giovannucci, E.; Stampfer, M.J.; Colditz, G.A. et al.
Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
Ann Intern Med, 1998, 129, 517-524
Observational trial, Bowel cancer, Nutrition/diet, folic acid, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Oecotrophology, Vitamins
12 Paganelli, G.M.; Biasco, G.; Brandi, G.; Santucci, R.; Gizzi, G.; Villani, V.; Cianci, M.; Miglioli, M.; Barbara, L.
Effect of Vitamin A, C, and E Supplementation on Rectal Cell Proliferation in Patients with Colorectal Adenomas
J Natl Cancer Inst, 1992, 84(1), 47-51
Acidum ascorbicum, Axerophthol, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Placebo-controlled, Randomized trial, Tokopherol, Vitamins
13 Evans, W.K.; Nixon, D.W.; Daly, J.M.; Ellenberg, S.S.; Gardner, L.; Wolfe, E.; Shepherd, F.A.; Feld, R.; Gralla, R.; Fine, S.; Kemeny, N.; Jeejeebhoy, K.N.; Heymsfield, S.; Hoffman, F.A.
A Randomized Study of Oral Nutritional Support Versus Ad Lib Nutritional Intake During Chemotherapy for Advanced Colorectal and Non-Small-Cell Lung Cancer
J Clin Oncol, 1987, 5(1), 113-124
Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Magnesium, Randomized trial, Zincum
14 Greenberg, E.R.; Baron, J.A.; Tosteson, T.D.; Freeman, D.H.; Beck, G.J.; Bond, J.H.; Colacchio, T.A.; Coller, J.A.; Franki, H.D.; Haile, R.W.; Mandel, J.S.; Nierenberg, D.W.; Rothstein, R.; Snover, D.C.; Stevens, M.M.; Summers, R.W.; Stolk, R.U. van
A clinical trial of antioxidant vitamins to prevent colorectal adenoma
New Engl J Med, 1994, 331(3), 141-147
Acidum ascorbicum, Antioxidants, Carotin, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Prevention, Randomized trial, Tokopherol, Vitamins
15 MacLennan, R.; Macrae, F.; Bain, C.; Battistutta, D.; Chapuis, P.; Gratten, H.; Lambert, J.; Newland, R.C.; Ngu, M.; Russell, A.; Ward, M.; Wahlqvist, M.L.
Randomized Trial of Intake of Fat, Fiber, and Beta Carotene to Prevent Colorectal Adenomas
J Natl Cancer Inst, 1995, 87(23), 1760-1766
Beta-Carotin, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Prevention, Randomized trial, Vitamins
16 Mustacchi, G.; Pavesi, L.; Milani, S.; Iaffaioli, V.; Caraco, A.; Comella, G.; Contu, A.; Farris, A.; Attado-Parinello, G.; Narcisi, M.; Brema, F.; Beni, A.; Bumma, C.
High-Dose Folinic Acid (FA) and Fluorouracil (FU) Plus or Minus Thymostimulin (TS) for Treatment of Metastatic Colorectal Cancer
Results of a Randomized Multicenter Clinical Trial
Anticancer Res, 1994, 14, 617-620
Bowel cancer, Nutrition/diet, folic acid, Clinical research, Complementary and alternative medicine, Cancer, Orthomolecular medicine, Randomized trial, Vitamins
17 Wahlqvist, M.L.; Wattanapenpaiboon, N.; Macrae, F.A.; Lambert, J.R.; MacLennan, R.; Hsu-Hage, B.H.-H.
Changes in serum carotenoids in subjects with colorectal adenomas after 24 mo of beta-carotene supplementation
Am J Clin Nutr, 1994, 60, 936-943
Axerophthol, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Prevention, Randomized trial, Vitamins
18 Loprinzi, C.L.; Levitt, R.; Barton, D.L.; Sloan, J.A.; Atherton, P.J.; Smith, D.J.; Dakhil, S.R.; Moore, D.F. jr.; Krook, J.e.; Rowland, K.M. jr.; Mazurczak, M.A.; Berg, A.R.; Kim, G.P.
Evaluation of shark cartilage in patients with advanced cancer
A North Central Cancer Treatment Group Trial
Cancer, 2005, 104(1), gesamt
Breast cancer, Bowel cancer, Nutrition/diet, Haifisch, Clinical research, Complementary and alternative medicine, Cancer, Dietary supplementation, Placebo-controlled, Randomized trial
19 Yang, G.; Shu, X.O.; Li, H.; Chow, W.-H.; Ji, B.-T.; Zhang, X.; Gao, Y.T.; Zheng, W.
Prospective cohort study of green tea consumption and colorectal cancer risk in women
Cancer Epidemiology, Biomarkers & Prevention, 2007, 16(6), 1219-1223
Observational trial, Camellia, Camellia sinensis, Bowel cancer, Nutrition/diet, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Colorectal cancer, Tea
20 Peters, U.; Leitzmann, M.F.; Chatterjee, N.; Wang, Y.; Albanes, D.; Gelmann, E.P.; Friesen, M.D.; Riboli, E.; Hayes, R.B.
Serum lycopene, other carotenoids, and prostate cancer risk
A nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial
Cancer Epidemiology, Biomarkers & Prevention, 2007, 16(5), 962-968
Observational trial, Bowel cancer, Ovarian cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Lung cancer, Lycopene, Prevention, Prostate cancer, Solanum lycopersicum
21 Jiang, Z.M.; Wilmore, D.W.; Wang, X.R.; Wei, J.M.; Zhang, Z.T.; Gu, Z.Y.; Wang, S.; Han, S.M.; Jiang, H.; Yu, K.
Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery
Brit J Surg, 2010, 97(6), 804-809
Surgery, Bowel cancer, Nutrition/diet, Essential fatty acids, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Phaseolus, Phaseolus max, Phytomedicine, Randomized trial, fish oil
22 Burden, S.R.; Hill, J.; Shaffer, J.L.; Campbell, M.; Todd, C.
An unblinded randomised controlled trial in preoperative oral supplements in colorectal cancer patients
J Hum Nutr Diet, 2011, 24(5), 441-448
Surgery, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Dietary supplementation, Postoperative complaints, Prevention, Randomized trial
23 McCulloch, M.; Broffman, M.; Laan, M. van der; Hubbard, A.; Kushi, L.; Abrams, D.I.; Gao, J.; Colford, J.M. Jr.
Colon cancer survival with herbal medicine and vitamins combined with standard therapy in a whole-systems approach
Ten-year follow-up data analyzed with marginal structural models and propensity score methods
Integr Cancer Ther, 2011, 10(3), 240-259
Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Vitamins
24 Meyerhardt, J.A.; Sato, K.; Niedzwiecki, D.; Ye, C.; Saltz, L.B.; Mayer, R.J.; Mowat, R.B.; Whittom, R.; Hantel, A.; Benson, A.; Wigler, D.S.; Venook, A.; Fuchs, C.S.
Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer
Findings from CALGB 89803
J Natl Cancer Inst, 2012, 104(22), 1702-1711
Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Metabolic diseases
25 Mentor-Marcel, R.A.; Bobe, G.; Sardo, C.; Wang, L.S.; Kuo, C.T.; Stoner, G.; Colburn, N.H.
Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients
Nutr Cancer, 2012, 64(6), 820-825
Observational trial, Bowel cancer, Nutrition/diet, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Colorectal cancer, blackberry, raspberry
26 Anderson, A.S.; Craigie, A.M.; Caswell, S.; Treweek, S.; Stead, M.; Macleod, M.; Daly, F.; Belch, J.; Rodger, J.; Kirk, A.; Ludbrook, A.; Rauchhaus, P.; Norwood, P.; Thompson, J.; Wardle, J.; Steele, R.J.C.
The impact of a bodyweight and physical activity intervention (BeWEL) initiated through a national colorectal cancer screening programme
Randomised controlled trial
BMJ, 2014, 348, g1823; (1-13)
Exercise therapy, Bowel cancer, Diet, Nutrition/diet, Complementary and alternative medicine, Cancer, Physical therapy, Metabolic diseases, Overweight
27 Zhu, B.; Zhou, L.; Qi, L.; Zhong, R.; Miao, X.
Allium vegetables and garlic supplements do not reduce risk of colorectal cancer, based on meta-analysis of prospective studies
Clin Gastroenterol Hepatol, 2014, 12(12), 1991-2001
Allium, Allium sativum, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine, Prevention
28 Mego, M.; Chovanec, J.; Vochyanova-Andrezalova, I.; Konkolovsky, P.; Mikulova, M.; Reckova, M.; Miskovska, V.; Bystricky, B.; Beniak, J.; Medvecova, L.; Lagin, A.; Svetlovska, D.; Spanik, S.; Zajac, V.; Mardiak, J.; Drgona, L.
Prevention of irinotecan induced diarrhea by probiotics
A randomized double blind, placebo controlled pilot study
Complement Ther Med, 2015, 23(3), 356-362
Bowel cancer, Diarrhoeal disorder, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Placebo-controlled, Probiotics, Randomized trial
29 Guercio, B.J.; Sato, K.; Niedzwiecki, D.; Ye, X.; Saltz, L.B.; Mayer, R.J.; Mowat, R.B.; Whittom, R.; Hantel, A.; Benson, A.; Atienza, D.; Messino, M.; Kindler, H.; Venook, A.; Hu, F.B.; Ogino, S.; Wu, K.; Willett, W.C.; Giovannucci, E.L.; Meyerhardt, J.A.; Fuchs, C.S.
Coffee intake, recurrence, and mortality in stage III colon cancer
Results from CALGB 89803 (Alliance)
J Clin Oncol, 2015, 33(31), 3598-3607
Observational trial, Coffea, Coffea tosta, Bowel cancer, Dickdarmkrebs, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Prevention
30 Song, M.; Zhang, X.; Meyerhardt, J.A.; Giovannucci, E.L.; Ogino, S.; Fuchs, C.S.; Chan, A.T.
Marine omega-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis
Gut, 2016, epub ahead of print,
Observational trial, Bowel cancer, Nutrition/diet, Essential fatty acids, Clinical research, Complementary and alternative medicine, Cancer, fish oil, Cohort study, Omega-3 fatty acids
31 Nakamura, T.; Ishikawa, H.; Mutoh, M.; Wakabayashi, K.; Kawano, A.; Sakai, T.; Matsuura, N.
Coffee prevents proximal colorectal adenomas in Japanese men
A prospective cohort study
Eur J Cancer Prev, 2016, 25(5), 388-394
Andrology, Observational trial, Coffea, Coffea tosta, Bowel cancer, Dickdarmkrebs, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Colorectal cancer
32 Lance, P.; Alberts, D.S.; Thompson, P.A.; Fales, L.; Wang, F.; San Jose, J.; Jacobs, E.T.; Goodman, P.J.; Darke, A.K.; Yee, M.; Minasian, L.; Thompson, I.M.; Roe, D.J.
Colorectal adenomas in participants of the SELECT randomized trial of selenium and vitamin E for prostate cancer prevention
Cancer Prev Res, 2017, 10(1), 45-54
Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Dietary supplementation, Placebo-controlled, Prevention, Prostate cancer, Randomized trial, Selenium, Trace elements, Tokopherol, Vitamins
33 Hu, Y.; McIntosh, G.H.; Le Leu, R.K.; Somashekar, R.; Meng, X.Q.; Gopalsamy, G.; Bambaca, L.; McKinnon, R.A.; Young, G.P.
Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans
Br J Nutr, 2016, 116(11), 1901-1911
Camellia, Camellia sinensis, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Dietary supplementation, Randomized trial, Selenium, Brazil nut
34 Mehta, R.S.; Nishihara, R.; Cao, Y.; Song M.; Mima K.; Qian Z.R.; Nowak J.A.; Kosumi K.; Hamada T.; Masugi Y.; Bullman S.; Drew D.A.; Kostic A.D.; Fung T.T.; Garrett W.S.; Huttenhower C.; Wu K.; Meyerhardt J.A.; Zhang X.; Willett W.C.; Giovannucci E.L.; Fuchs C.S.; Chan A.T.; Ogino S.
Association of dietary patterns with risk of colorectal cancer subtypes classified by Fusobacterium nucleatum in tumor tissue
JAMA Oncol, 2017, 3(7), 921-927
Fiber, Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Microbiology, Microbiome
35 Moskal, A.; Freisling, H.; Byrnes, G.; Assi, N.; Fahey, M.T.; Jenab, M. et al.
Main nutrient patterns and colorectal cancer risk in the European prospective investigation into cancer and nutrition study
Brit J Cancer, 2016, 115, 1430-1440
Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Prevention
36 Borresen, E.C.; Brown, D.G.; Harbison, G.; Taylor, L.; Fairbanks, A.; O'Malia, J.; Bazan, M.; Rao, S.; Bailey, S.M.; Wdowik, M.; Weir, T.L.; Brown, R.J.; Ryan, E.P.
A randomized controlled trial to increase navy bean or rice bran consumption in colorectal cancer survivors
Nutr Cancer, 2016, 68(8), 1269-1280
Fiber, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Phaseolus, Phaseolus vulgaris, Phytomedicine, Randomized trial, Oryza sativa
37 Song, M.; Wu, K.; Meyerhardt, J.A.; Ogino, S.; Wang, M.; Fuchs, C.S.; Giovannucci, E.L.; Chan, A.T.
Fiber intake and survival after colorectal cancer diagnosis
JAMA Oncol, 2018, 4(1), 71-79
Fiber, Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer
38 Lu, D.; Pan, C.; Ye, C.; Duan, H.; Xu, F.; Yin, L.; Tian, W.; Zhang, S.
Meta-analysis of soy consumption and gastrointestinal cancer risk
Sci Reports, 2017, 7, 4048; (1-14)
Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Meta-analysis, Phaseolus, Phaseolus max, Phytomedicine
39 Tabung, F.K.; Liu, L.; Wang, W.; Fung, T.T.; Wu, K.; Smith-Warner, S.A.; Cao, Y.; Hu, F.B.; Ogino, S.; Fuchs, C.S.; Giovannucci, E.L.
Association of dietary inflammatory potential with colorectal cancer risk in men and women
JAMA Oncol, 2018, 4(3), 366-373
Observational trial, Bowel cancer, Inflammation, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer
40 Fadelu, T.; Zhang, S.; Niedzwiecki, D.; Ye, X.; Saltz, L.B.; Mayer, R.I.; Mowat, R.B.; Whittom, R.; Hantel, A.; Benson, A.B.; Atienza, D.M.; Messino, M.; Kindler, H.L.; Venook, A.; Ogino, S.; Ng, K.; Wu, K.; Willett, W.; Giovannucci, E.; Meyerhardt, J.; Bao, Y.; Fuchs, C.S.
Nut consumption and survival in patients with stage III colon cancer
Results from CALGB 89803 (Alliance)
J Clin Oncol, 2018, 36(11), 1112-1120
Observational trial, Bowel cancer, Nutrition/diet, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Prevention