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1 Batey, R.G.; Bensoussan, A.; Yang, Y.F.; Bollip, S.; Hossain, M.A.
Preliminary report of a randomized, double-blind placebo controlled trial of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C
J Gastroenterol Hepatol, 1998, 13, 244-247
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Traditional Chinese medicine
2 Huber, R.; Lüdtke, R.; Klassen, M.; Müller-Buscher, G.; Wolff-Vorbeck, G.; Scheer, R.
Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C
An individually controlled cohort study
Eur J Med Res, 2001, 6, 399-405
Observational trial, Hepatitis, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Viscum, Viscum album
3 Liu, J.; Lin, H.; McIntosh, H.
Genus phyllanthus for chronic hepatitis B virus infection
A systematic review
J Viral Hepatitis, 2001, 8, 358-366
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phyllanthus, Phytomedicine
4 Guptan, R.C.; Prakash, B.; Mukherjee, A.; Sarin, S.K.
Double blind ranomized trial of Prak-20, an ayurvedic drug, in acute viral hepatitis
J Gastroenterol Hepatol, 1994, 9(3), A44 (Abstract)
Ayurveda, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Prak-20, Randomized trial
5 Das, D.G.
A double-blind clinical trial of kamalahar, an indigenous compound preparation, in acute viral hepatitis
Ind J Gastroenterol, 1993, 12(4), 126-8
Embelia, Embelia ribes, Hepatitis, Kamalahar, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Nyctanthes arbor-tristis, Phyllanthus, Phytomedicine, Placebo-controlled, Randomized trial, Taraxacum, Tecoma undulata, Terminalia, Terminalia arjuna
6 Kainuma, M.; Ogata, N.; Kogure, T.; Kohta, K.; Hattori, N.; Mitsuma, T.; Teresawa, K.
The efficacy of a herbal medicine (Mao-to) in combination with intravenous natural interferon-ß for patients with chronic hepatitis C, genotype 1b and high viral load: a pilot study
Phytomed, 2002, 9(5), 365-372
Observational trial, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine, Traditional Japanese medicine
7 Salmi, H.A.; Sarna, S.
Effect of silymarin on chemical, functional and morphological alterations of the liver
A double-blind controlled study
Scand J Gastroenterol, 1982, 17, 517-521
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
8 Trinchet, J.C.; Coste, T.; Levy, V.G.
Traitement de l´hepatite alcoolique par la silymarine
Une etude comparative en double insu chez 116 malades (Treatment of alcoholic hepatitis with silymarin. A double-blind comparative study in 116 patients)
Gastroenterol Clin Biol, 1989, 13, 120-124
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
9 Tanasescu, C.; Petrea, S.; Baldescu, R.; Macarie, E.; Chiriloiu, C.; Purice, S.
Use of the Romanian product Silimarina in the treatment of chronic liver disease
Rev Roum Méd Int, 1988, 26, 311-322
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
10 Magliulo, E.; Gagliardi, B.; Fiori, G.P.
Zur Wirkung von Silymarin bei der Behandlung der akuten Virushepatitis
Med Klin, 1978, 79, 1060-1065
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
11 Buzzelli, G.; Moscarella, S.; Giusti, A.; Duchini, A.; Marena, C.; Lampertico, M.
A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB 1016) in chronic acitve hepatitis
Int J Clin Pharmacol Ther Toxicol, 1993, 31, 456-460
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
12 Kiesewetter, E.; Leodolter, I.; Thaler, H.
Ergebnisse zweier Doppelblindstudien zur Wirksamkeit von Silymarin bei chronischer Hepatitis
Leber Magen Darm, 1977, 7, 318-323
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
13 Martiis, M. de ; Fontana, M.; Assogna, G.; Ottavi, R. d'; Ottavi, O. d'
I derivati del cardo mariano nella terapia delle epatopatie croniche
Clin Ter, 1980, 94(3), 283-315
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
14 Schmidt, U.; Dürr, H.K.; Bode, J.C.
Zur Therapie der akuten Virushepatitis mit Silymarin
Bericht über eine kontrollierte Studie
Verh Dt Ges Inn Med, 1977, 83, 563-565
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
15 Realini, S.; Gonvers, J.J.; Hofstetter, J.R.
Essai clinique de la silymarine dans les affections chroniques du foie
Schweiz Rundsch Med Prax, 1975, 64(19), 595-598
Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
16 Reutter, F.W.; Haase, W.
Klinische Erfahrungen mit Silymarin bei chronischen Lebererkrankungen
Schweiz Rundsch Med Prax, 1975, 64(36), 1145-1151
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle
17 Bode, J.C.; Schmidt, U.; Dürr, H.K.
Zur Behandlung der akuten Virushepatitis mit Silymarin
Ergebnisse einer kontrollierten Studie
Med Klin, 1977, 72, 513-518
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, milk thistle
18 Musso, A.; Giacchino, M.; Vietti, M.; Vaccino, P.; Cerutti, A.
Considerazioni sull´uso della Silimarina e della SAMe nel trattamento dell´epatite infettiva acute dell´infanzia
(Remarks on the use of Silimarine and SAMe in the treatment of acute infectious hepatitis in infancy)
Minerva Pediatr, 1980, 32, 363-367
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Pediatrics, Phytomedicine, milk thistle
19 Kainuma, M.; Sakai, S.; Sekiya, N.; Mantani, N.; Ogata, N.; Shimada, Y.; Terasawa, K.
The effects of a herbal medicine (Mao-to) in patients with chronic hepatitis C after injection of IFN-ß
Phytomed, 2004, 11(1), 5-10
Observational trial, Hepatitis, Interferon, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine
20 Jakkula, M.; Boucher, T.A.; Beyendorff, U.; Ac, L.; Conn, S.M.; Johnson,J.E.; Nolan, C.J.; Peine, C.J.; Albrecht, J.H.
A randomized trial of chinese herbal medicines for the treatment jof symptomatic hepatitis C
Arch Intern Med, 2004, 164(12), 1341-1346
Chinese medicinal herbs, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine
21 Kainuma, M.; Hikiami, H.; Nozaki, K.; Hayashi, K.; Shimada, Y.; Terasawa, K.
The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C
A pilot study
Hum Psychopharmacol, 2004, 19, 235-241
Observational trial, Depression, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Mao-to, Phytomedicine, Mental diseases, Traditional Japanese medicine
22 Weisser, L.
Das Verhalten der Serum-Eiweiß-Konstellation bei Leberschädigung während der Behandlung mit Mariendistel- und Löwenzahnextrakten
Aus unserer Arbeit, 1955, 1(10), 19-20
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle, Taraxacum
23 Orlent, H.; Hansen, B.E.; Willems, M.; Brouwer, J.T.; Huber, R.; Kullak, Ublick, G.A.; Gerken, G.; Zeuzem, S.; Nevens, F.; Tielemans, C.M.; Zondervan, P.E.; Lagging, M.; Westin, J.; Schalm, S.W.
Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C
A randomized phase II trial
J Hepatol, 2006, 45(4), 539-546
Biochemistry, Glycyrrhiza, liquorice root, Glycyrrhizinsäure, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial
24 Hartleb, H.; Traczyk, Z.; Zacharewicz, A.; Zacharewicz, M.
Therapie von Leber- und Gallenwegserkrankungen mit einem Pflanzenextrakt
Wirksamkeit von Hepabene bei chronischer Cholelithiasis und Virushepatitis
Natur- und GanzheitsMedizin, 1991, 4(11), 628-635
Fumaria, Fumaria officinalis, Gall stones, Hepabene, Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, milk thistle
25 El-Kamary, S.S.; Shardell, M.D.; Abdel-Hamid, M.; Ismail, S.; El-Ateek, M.; Metwally, M.; Mikhail, N.; Hashem, M.; Mousa, A.; Aboul-Fotouh, A.; El-Kassas, M.; Esmat, G.; Strickland, G.T.
A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis
Phytomed, 2009, 16(5), 391-400
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
26 Ferenci, P.; Scherzer, T.M.; Kerschner, H.; Rutter, K.; Beinhardt, S.; Hofer, H.; Schöniger-Hekele, M.; Holzmann, H.; Steindl-Munda, P.
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
Gastroenterol, 2008, 135(5), 1561-1567
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, milk thistle
27 Huber, R.; Müller, M.; Naumann, J.; Schenk, T.; Lüdtke, R.
Artichoke leave extract for chronic hepatitis C
A pilot study
Phytomed, 2009, 16(9), 801-804
Observational trial, Cynara cardunculus subsp. flavescens, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
28 Bierner, M.; Berg, T.
Silibin besitzt hohe antivirale Aktivität bei Hepatitis C und stellt eine neue, dringend erwartete Therapieoption für schwer zu behandelnde Fälle dar
Z Phytother, 2009, 30(Suppl.1 Kongressband), S6 (Abstract; Symposiumsbeitrag)
Case report, Hepatitis, Complementary and alternative medicine, Legalon, Gastrointestinal tract, Phytomedicine, Practice
29 Lin, Y.; Dong, X.; Chen, Z.; Chen, Y.; Zhang, S.
Observation of T cell receptor Vbeta gene usage in the peripheral blood of patients with chronic hepatitis B after being treated by Hejie decoction
Spatula DD, 2011, 1(1), 17-22
Observational trial, Bupleurum, Codonopsis, Codonopsis pilosula, Glycyrrhiza, Chinese medicinal herbs, Hejie, Hepatitis, Immunomodulation, Immune system, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Morinda, Morinda officinalis, Phytomedicine, Pinellia Tuber, Polygonum, Polygonum cuspidatum, Scutellaria, Traditional Chinese medicine, Zizyphus, Zizyphus jujuba
30 Zaky, S.; Kamel, S.E.; Hassan, M.S.; Sallam, N.A.; Shahata, M.A.; Helal, S.R.; Mahmoud, H.
Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C
J Altern Complement Med, 2011, 17(3), 259-263
Nutrition/diet, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Ozon therapy, Phytomedicine, Oxygen therapy, milk thistle, Vitamins
31 Patki, P.; Tandon, M.
Evauation of safety and efficacy of herbal extract HD03-ES in HBeAg negative chronic hepatitis B
An open clinical study
Eur J Integr Med, 2010, 2(4), 211 (Abstract, Symposiumsbeitrag)
Hepatitis, Clinical research, Complementary and alternative medicine, Herbs, Gastrointestinal tract, Phytomedicine, Randomized trial
32 Patki, P.; Tandon, M.
A phase II prospective clinical study to evaluate the efficacy and safety of a herbal extract HD-03/ES in HBeAg negative chronic hepatitis B
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 102-103 (Symposiumsbeitrag; Abstract)
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial
33 Freedman, N.D.; Curto, T.M.; Morishima, C.; Seeff, L.B.; Goodman, Z.D.; Wright, E.C.; Sinha, R.; Everhart, J.E.
Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial
Aliment Pharmacol Ther, 2011, 33(1), 127-137
Observational trial, Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Hepatic fibrosis, Liver cirrhosis, Gastrointestinal tract, Phytomedicine, milk thistle, Viruses
34 Freedman, N.D.; Curto, T.M.; Lindsay, K.L.; Wright, E.C.; Sinha, R.; Everhart, J.E.;
Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C
Gastroenterol, 2011, 140(7), 1961-1969
Coffea, Coffea tosta, Nutrition/diet, Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Conventional medicine, Gastrointestinal tract, Non-randomized trial, Phytomedicine, Viruses
35 Shikov, A.N.; Djachuk, G.I.; Sergeev, D.V.; Pozharitskaya, O.N.; Esaulenko, E.V.; Kosman, V.M.; Makarov, V.G.
Birch bark extract as therapy for chronic hepatitis C - A pilot study
Phytomed, 2011, 18(10), 807-810
Observational trial, Betula, Betula alba, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
36 Fried, M.W.; Navarro, V.J.; Afdhal, N.; Belle, S.H.; Wahed, A.S.; Hawke, R.L.; Doo, E.; Meyers, C.M.; Reddy, K.R.
Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy
A randomized controlled trial
JAMA, 2012, 308(3), 274-282
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
37 Reddy, K.R.; Belle, S.H.; Fried, M.W.; Afdhal, N.; Navarro, V.J.; Hawke, R.L.; Wahed, A.S.; Doo, E.; Meyers, C.M.
Rationale, challenges, and participants in a phase II trial of a botanical product for chronic hepatitis C
Clin Trials, 2012, 9(1), 102-112
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle
38 Wong, V.W.-S.; Wong, G.L.-H.; Chan, A.W.-H.; Chu, W.C.-W.; Choi, P.C.-L.; Chim, A.M.-L.; Yiu, K.K.-L.; Yu, J.; Chan, F.K.-L.; Chan, H.L.-Y.
Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria
A randomized trial
J Gastroenterol Hepatol, 2013, 28, 57-62
Hepatitis, Clinical research, Complementary and alternative medicine, Liver cirrhosis, Gastrointestinal tract, Phyllanthus, Phyllanthus urinaria, Phytomedicine, Randomized trial
39 Dashtdar, M.; Bagheri, F.; Dashtdar, M.R.
Treatment of Hepatitis B by TCAM herbal medicine (Hepato-Persica)
Dashtdar, M. et al. (Eds.): Integrated clinial approach to intractable dieseases. A series of clinical research by integrative medicine, 2011, 30-50
Hepatitis, Hepato-Persica, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
40 Barakat, E.M.F.; El Wakeel, L.M.; Hagag, R.S.
Effects of Nigella sativa on outcome of hepatitis C in Egypt
World J Gastroenterol, 2013, 19(16), 2529-2536
Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nigella sativa, Phytomedicine
41 Yang, Z.; Zhuang, L.; Lu, Y.; Xu, Q.; Chen, X.
Effects and tolerance of Silymarin (milk thistle) in chronic hepatitis C virus infection patients
A meta-analysis of randomized controlled trials
Biomed Res Int, 2014, 2014, 941085; (1-9)
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Meta-analysis, Phytomedicine, milk thistle
42 Shawkat, H.; Yakoot, M.; Shawkat, T.; Helmy, S.
Efficacy and safety of a herbal mixture (Viron® tablets) in the treatment of patients with chronic hepatitis C virus infection
A prospective, randomized, open-label, proof-of-concept study
Drug Design Devel Ther, 2015, 9, 799-804
Hepatitis, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Viron
43 Choi, S.H.; Yang, K.J.; Lee, D.S.
Effects of complementary combination therapy of Korean red ginseng and antiviral agents in chronic hepatitis B
J Altern Complement Med, 2016, 22(12), 964-969
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Randomized trial, Viruses, Panax, Panax ginseng
44 Abdel-Moneim, A.; Morsy, B.M.; Mahmoud, A.M.; Abo-Seif, M.A.
Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt
EXCLI J, 2013, 12, 943-955
Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Non-randomized trial, Nigella sativa, Phytomedicine, ginger
45 Carrieri, M.P.; Protopopescu, C.; Marcellin, F.; Salmon-Ceron, D.; Dabis, F.; Spire, B.
Protective effect of coffee consumption on all-cause mortality of French HIV-HCV co-infected patients
J Hepatol, 2017, 67(6), 1157-1167
Observational trial, Coffea, Hepatitis, HIV, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
46 Iqbal, O.; Nazar, H.; Afzal, S.; Usmanghani, K.
Alternative treatment in Hepatitis B by using polyherbal formulation
Pak J Pharm Sci, 2017, 30(1), 49-54
Artemisia, Artemisia absinthium, Hepatitis, Kaempferol, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Millefolium, Phytomedicine, Quercetin, Randomized trial, Rosa, Rosa damascena
47 Philips, C.A.; Paramaguru, R.; Joy, A.K.; Antony, K.L.; Augustine, P.
Clinical outcomes, histopathological patterns, and chemical analysis of Ayurveda and herbal medicine associated with severe liver injury
A single-center experience from southern India
Indian J Gastroenterol, 2018, 37(1), 9-17
Ayurveda, Observational trial, Hepatitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine
48 Baiguera, C.; Boschetti, A.; Raffetti, E.; Zanini, B.; Puoti, M.; Donato, F.
Phyllanthus niruri versus placebo for chronic hepatitis B virus infection
A randomized controlled trial
Complement Med Res, 2018, 25(6), 376-382
Hepatitis, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phyllanthus, Phyllanthus niruri, Phytomedicine, Placebo-controlled, Randomized trial