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1 Spasov, A.A.; Wikman, G.; Mandrikov, V.B.; Mironova, I.A.; Neumoin, V.V.
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen
Phytomed, 2000, 7(2), 85-89
Chronic fatigue syndrome, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
2 Darbinyan, V.; Kteyan, A.; Panossian, A.; Gabrielian, E.; Wikman, G.; Wagner, H.
Rhodiola rosea in stress induced fatigue
A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty
Phytomed, 2000, 7(5), 365-372
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
3 Shevtsov, V.A.; Zholus, B.I.; Shervarly, V.I.; Vol'skij, V.B.; Korovin, Y.P.; Khristich, M.P.; Roslyakova, N.A.; Wikman, G.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work
Phytomed, 2003, 10(2-3), 95-105
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
4 Johnson, S.K.; Diamond, B.J.; Rausch, S.; Kaufman, M.; Shiflett, S.C.; Graves, L.
The effect of Ginkgo biloba on functional measures in multiple sclerosis
A pilot randomized controlled trial
Explore, 2006, 2(1), 19-24
Anxiety, Chronic fatigue syndrome, Depression, Ginkgo, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
5 Baicus, C.; Baicus, A.
Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trials
Phytother Res, 2007, 21(6), 570-573
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Spirulina, Spirulina platensis
6 Olsson, E.M.G.; Schéele, B. von; Panossian, A.G.
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue
Planta Med, 2009, 75(2), 105-112
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
7 Cicero, A.F.; Derosa, G.; Brillante, R.; Bernardi, R.; Nascetti, S.; Gaddi, A.
Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life
A randomized clinical trial
Arch Gerontol Geriatr, 2004, 38(1), 69-73
Chronic fatigue syndrome, Eleutherococcus senticosus, Geriatrics, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
8 Hartz, A.J.; Bentler, S.; Noyes, R.; Hoehns, J.; Logemann, C.; Sinift, S.; Butani, Y.; Wang, W.; Brake, K.; Ernst, M.; Kautzman, H.
Randomized controlled trial of Siberian ginseng for chronic fatigue
Psychol Med, 2004, 34(1), 51-61
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
9 Cho, J.H.; Cho, C.K.; Shin, J.W.; Son, J.Y.; Kang, W.; Son, C.G.
Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue
A randomised, double-blind, controlled pilot study
Complement Ther Med, 2009, 17(3), 141-146
Astragalus, Astragalus membranaceus, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, sage, Salvia miltiorrhiza
10 Costa Miranda, V. da; Trufelli, D.C.; Santos, J.; Campos, M.P.; Nobuo, M.; Costa Miranda, M. da; Schlinder, F.; Riechelmann, R.; Giglio, A. del
Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression
Results of a pilot double-blind randomized study
J Altern Complement Med, 2009, 15(4), 431-433
Chronic fatigue syndrome, Depression, Guarana, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
11 Schutgens, F.W.G.; Neogi, P.; Wijk, E.P.A. van; Wijk, R. van; Wikman, G.; Wiegant, F.A.C.
The influence of adaptogens on ultraweak biophoton emission
A pilot-experiment
Phytother Res, 2009, 23, 1103-1108
Biophotons, Biophysics, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola rosea, Stress
12 Milesi, M.A.; Lacan, D.; Brosse, H.; Desor, D.; Notin, C.
Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel) on stress and fatigue in healthy people
A pilot, double-blind, placebo-controlled clinical trial
Nutrition J, 2009, 8, 40; (1-7)
Chronic fatigue syndrome, Nutrition/diet, Extramel, Healthy probands, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Juice/distillate, Stress
13 Barton, D.L.; Soor, G.S.; Bauer, B.A.; Sloan, J.A.; Johnson, P.A.; Figueras, C.; Duane, S.; Mattar, B.; Liu, H.; Atherton, P.J.; Christensen, B.; Loprinzi, C.L.
Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue
A randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA
Support Care Cancer, 2010, 18(2), 179-187
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, posology, Mental diseases, Randomized trial, Panax, Panax quinquefolius
14 Houghton, C.A.; Steels, E.L.; Fassett, R.G.; Coombes, J.S.
Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years
Phytomed, 2011, 18(6), 521-526
Chronic fatigue syndrome, Cucumis, Cucumis melo, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
15 Melzer, J.; Saller, R.
Pflanzliches Kombinationspräparat (Melissenblätter, Passionsblumenkraut, Pestwurz, Baldrianwurzel - Ze 185) bei Somatisierungsstörungen
Z Phytother, 2011, 32(2), 71-74
Chronic fatigue syndrome, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Melissa, maracuia, butterbur, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Stress, Valeriana
16 Oliveira Campos, M.P. de; Riechelmann, R.; Martins, L.C.; Hassan, B.J.; Casa, F.B.; Del Giglio A.
Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy
J Altern Complement Med, 2011, 17(6), 505-512
Anxiety, Breast cancer, Chronic fatigue syndrome, Depression, Guarana, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
17 Varney, E.; Buckle, J.
Effect of inhaled essential oils on mental exhaustion and moderate burnout
A small pilot study
J Altern Complement Med, 2013, 19(1), 69-71
Aromatherapy, Chronic fatigue syndrome, Helichrysum, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Mentha, peppermint, Ocimum, Ocimum basilicum, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
18 Lindheimer, J.B.; Loy, B.D.; O'Connor, P.J.
Short-term effects of black pepper (Piper nigrum) and rosemary (Rosmarinus officinalis and Rosmarinus eriocalyx) on sustained attention and on energy and fatigue mood states in young adults with low energy
J Med Food, 2013, 16(8), 765-771
Chronic fatigue syndrome, Jugendmedizin, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Piper nigrum, Placebo-controlled, Mental diseases, Randomized trial, rosemary, Rosmarinus eriocalyx
19 Kim, H.G.; Cho, J.H.; Yoo, S.R.; Lee, J.S.; Han, J.M.; Lee, N.H.; Ahn, Y.C.; Son, C.G.
Antifatigue effects of Panax ginseng C.A. Meyer
A randomised, double-blind, placebo-controlled trial
PLoS ONE, 2013, 8(4), e61271; (1-8)
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
20 Barton, D.L.; Liu, H.; Dakhil, S.R.; Linquist, B.; Sloan, J.A.; Nichols, C.R.; McGinn, T.W.; Stella, P.J.; Seeger, G.R.; Sood, A.; Loprinzi, C.L.
Wisconsin ginseng (Panax quinquefolius) to improve cancer-related fatigue
A randomized, double-blind trial, NO7C2
J Natl Cancer Inst, 2013, 105(16), 1230-1238
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Panax, Panax quinquefolius
21 Biswal, B.M.; Sulaiman, S.A.; Ismail, H.C.; Zakaria, H.; Musa, K.I.
Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients
Integr Cancer Ther, 2013, 12(4), 312-322
Breast cancer, Chronic fatigue syndrome, Gynaecology, Clinical research, Complementary and alternative medicine, Cancer, Non-randomized trial, Phytomedicine, Mental diseases, Withania, Withania somnifera
22 Noguchi, N.; Maruyama, I.; Yamada, A.
The influence of Chlorella and its hot water extract supplementation on quality of life in patients with breast cancer
eCAM, 2014, Article ID 704619, (1-7)
Breast cancer, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Mental diseases, Randomized trial
23 Schaffler, K.; Wolf, O.T.; Burkart, M.
No benefit adding Eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration
A randomized controlled study
Pharmacopsychiatry, 2013, 46(5), 181-190
Chronic fatigue syndrome, Eleutherococcus senticosus, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Stress
24 Vohra, S.; Punja, S.; Shamseer, L.; Olsen, K.
Rhodiola rosea for mental and physical fatigue in nurses on shift work
A randomized controlled trial
Forsch Komplementärmed, 2013, 20(suppl. 1), 112 (Abstract; Symposiumsbeitrag)
Occupational health, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
25 Punja, S.; Shamseer, L.; Olson, K.; Vohra, S.
Rhodiola rosea for mental and physical fatigue in nursing students
A randomized controlled trial
PLoS ONE, 2015, 9(9), e108416; (1-8)
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Rhodiola rosea
26 Cropley, M.; Banks, A.P.; Boyle, J.
The effects of Rhodolia rosea L. extract on anxiety, stress, cognition and other mood symptoms
Phytother Res, 2015, 29(12), 1934-1939
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
27 Bagheri-Nasemi, M.; Shorofi, S.A.; Nikkhah, A.; Espahbodi, F.; Koolaee, F.-S.G.
The effects of aromatherapy with lavender essential oil on fatigue levels in haemodialysis patients
A randomized clinical trial
Complement Ther Clin Pract, 2016, 22, 33-37
Aromatherapy, Chronic fatigue syndrome, Urinary tract, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Renal insufficiency, Phytomedicine, Mental diseases, Randomized trial
28 Lee, N.; Lee, S.-H.; Yoo, H.-R.; Yoo, H.S.
Anti-fatigue effects of enzyme-modified ginseng extract
A randomized, double-blind, placebo-controlled trial
J Altern Complement Med, 2016, 22(11), 859-864
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Panax, Panax ginseng
29 Bertoglio, J.C.; Baumgartner, M.; Palma, R.; Ciampi, E.; Carcamo, C.; Cáceres, D.D.; Acosta-Jamett, G.; Hancke, J.L.; Burgos, R.A.
Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis
A 12-month double-blind placebo-controlled pilot study
BMC Neurol, 2016, 16, 77; (1-8)
Andrographis paniculata, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
30 Gok Metin, Z.; Ozdemir, L.
The effects of aromatherapy massage and reflexology on pain and fatigue in patients with rheumatoid arthritis
A randomized controlled trial
Pain Manag Nurs, 2016, 17(2), 140-149
Aromatherapy, Arthritis, Muscoskeletal -/Connective tissue system, Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Reflexology, Rheumatic diseases, Pain
31 Vaziri, F.; Shiravani, M.; Najib, F.S.; Pourahmad, S.; Salehi, A.; Yazdanpanahi, Z.
Effect of lavender oil aroma in the early hours of postpartum period on maternal pains, fatigue, and mood
A randomized clinical trial
Int J Prev Med, 2017, 8, 29; (1-7)
Aromatherapy, Chronic fatigue syndrome, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula officinalis, Phytomedicine, Prevention, Mental diseases, Randomized trial, Pain, Obstetrics
32 Hassanzadeh, M.; Kiani, F.; Bouya, S.; Zarei, M.
Comparing the effects of relaxation technique and inhalation aromatherapy on fatigue in patients undergoing hemodialysis
Complement Ther Clin Pract, 2018, 31, 210-214
Aromatherapy, Chronic fatigue syndrome, Relaxation, Clinical research, Complementary and alternative medicine, Mind-body medicine, Phytomedicine, Mental diseases, Randomized trial
33 Muz, G.; Tasci, S.
Effect of aromatherapy via inhalation on the sleep quality and fatigue level in people undergoing hemodialysis
Appl Nurs Res, 2017, 37, 28-35
Aromatherapy, Chronic fatigue syndrome, Citrus, Citrus sinensis, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders
34 Belcaro, G.; Hosoi, M.; Feragalli, B.; Luzzi, R.; Dugall, M.
Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress
Minerva Med, 2018, 109(3), 211-217
Chronic fatigue syndrome, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Non-randomized trial, Phytomedicine, Mental diseases, Quercus, Quercus robur
35 Melo Sette, C.V. de; Ribas de Alcântara, b.B.; Schoueri, J.H.M.; Cruz, F.M.; Cubero, D.I.G.; Pianowski, L.F.; Peppone, L.J.; Fonseca, F.; Del Giglio, A.
Purified dry Paullinia cupana (PC-18) extract for chemotherapy-induced fatigue
Results of two double-blind randomized clinical trials
J Diet Suppl, 2018, 15(5), 673-683
Chronic fatigue syndrome, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
36 Baek, Y.; Kim, H.; Mun, S.; Lee, S.
Three-component herbal tea alleviates prolonged fatigue and improves sleep quality
A randomized controlled pilot study
Explore, 2018, 14(6), 420-423
Angelica, Angelica gigas, Astragalus, Astragalus mongholicus, Chronic fatigue syndrome, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Tea, Zizyphus, Zizyphus jujuba
37 Ardebili, F.M.
The effect of aromatherapy with bitter orange extract on anxiety and fatigue in type 2 diabetic patients
Adv Integr Med, 2019, epub ahead of print,
Anxiety, Aromatherapy, Chronic fatigue syndrome, Citrus, Citrus vulgaris, Diabetes mellitus, Complementary and alternative medicine, Phytomedicine, Mental diseases, Metabolic diseases
38 Wang, C.H.; Lin, C.Y.; Chen, J.S.; Ho, C.L.; Rau, K.M.; Tsai, J.T.; Chang, C.S.; Yeh, S.P.; Cheng, C.F.; Lai, Y.L.
Karnofsky performance status as a predictive factor for cancer-related fatigue treatment with Astragalus polysaccharides (PG2) injection
A double blind, multi-center, randomized phase IV study
Cancers, 2019, 11(2), 128; (1-13)
Applikationsform, Astragalus, Astragalus membranaceus, Chronic fatigue syndrome, Injektion, Clinical research, Complementary and alternative medicine, Cancer, Palliative care, Phytomedicine, posology, Mental diseases, Randomized trial