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1701 Wang, B.S.; Wang, H.; Song, Y.Y.; Qi, H.; Rong, Z.X.; Wang, B.S.; Zhang, L.; Chen, H.Z.
Effectiveness of standardized Ginkgo biloba extract on cognitive symptoms of dementia with a six-month treatment
A bivariate random effect meta-analysis
Pharmacopsychiatry, 2010, 43(3), 86-91
Dementia, Geriatrics, Ginkgo, Clinical research, Complementary and alternative medicine, Meta-analysis, Nervous system, Phytomedicine
1702 Tissera, M.H.A.; Kadudunkorala, K.M.M.; Whitanarachchi, K.
Chapter 57: A preliminary study on the lowering of cholesterol levels by a combination of black seed and garlic
De Silva, T. et al. (Eds.): Traditional and alternative medicine. Research and policy perspectives., 2009, 575-579
Allium, Allium sativum, Observational trial, Hypercholesterolemia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Nigella sativa, Phytomedicine, Metabolic diseases
1703 Wasif Saif, M.; Lansigan, F.; Ruta, S.; Lamb, L.; Mezes, M.; Elligers, K.; Grant, N.; Jiang, Z.L.; Liu, S.H.; Cheng, Y.C.
Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies
Phytomed, 2010, 17(3-4), 161-169
Pancreatic cancer, Observational trial, Bowel cancer, Glycyrrhiza, Glycyrrhiza uralensis, Chinese medicinal herbs, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Cancer, Stomach cancer, Paeonia, Paeonia lactiflora, Phytomedicine, Traditional Chinese medicine, Zizyphus, Zizyphus jujuba
1704 Saxena, R.C.; Singh, R.; Kumar, P.; Yadav, S.C.; Negi, M.P.; Saxena, V.S.; Joshua, A.J.; Vijayabalaji, V.; Goudar, K.S.; Venkateshwarlu, K.; Amit, A.
A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection
Phytomed, 2010, 17(3-4), 178-185
Andrographis paniculata, Respiratory diseases, Common cold, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial
1705 Dabos, K.J.; Sfika, E.; Vlatta, L. J.; Giannikopoulos, G.
The effect of mastic gum on Helicobacter pylori
A randomized pilot study
Phytomed, 2010, 17(3-4), 296-299
Helicobacter pylori, Infections, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, pistachio, Pistacia lentiscus, Randomized trial
1706 Beltran-Debon, R.; Alonso-Villaverde, C.; Aragones, G.; Rodriguez-Medina, I.; Rull, A.; Micol, V.; Segura-Carretero, A.; Fernandez-Gutierrez, A.; Camps, J.; Joven, J.
The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans
Phytomed, 2010, 17(3-4), 186-191
Observational trial, Healthy probands, Hibiscus, Hibiscus sabdariffa, Immunomodulation, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine
1707 Fang, Y.; Zhao, L.; Yan, F.; Xia, X.; Xu, D.; Cui, X.
Escin improves sperm quality in male patients with varicocele-associated infertility
Phytomed, 2010, 17(3-4), 192-196
Aesculus hippocastanum, Andrology, Infertility, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial
1708 Park, J.J.; Kang, M.; Shin, S.; Choi, E.; Kwon, S.; Wee, H.; Nam, B.; Kaptchuk, T.J.
Unexplained infertility treated with acupuncture and herbal medicine in Korea
J Altern Complement Med, 2010, 16(2), 193-198
Acupuncture, Observational trial, Gynaecology, Infertility, Clinical research, Complementary and alternative medicine, Phytomedicine, Traditional Chinese medicine
1709 Saito, Y.A.; Rey, E.; Almazar-Elder, A.E.; Harmsen, W.S.; Zinsmeister, A.R.; Locke, G.R.; Talley, N.J.
A randomized, double-blind, placebo-controlled trial of St John's wort for treating irritable bowel syndrome
Am J Gastroenterol, 2010, 105(1), 170-177
Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Irritable bowel syndrome
1710 Melzer, J.; Brignoli, R.; Keck, M.E.; Saller, R.
A Hypericum extract in the treatment of depressive symptoms in outpatients
An open study
Forsch Komplementärmed, 2010, 17(1), 7-14
Observational trial, Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Adverse effect
1711 Thiel, M.T.; Sitzmann, F.; Längler, A.
The potential role of thyme in the treatment of pyodermia in newborn infants
A retrospective analysis
Forsch Komplementärmed, 2010, 17(1), 29-31
Observational trial, Skin diseases, Clinical research, Complementary and alternative medicine, Neonatologie, Pediatrics, Phytomedicine, Pyodermia, Retrospective design, Thymus, Thymus vulgaris
1712 Grünwald, J.; Bitterlich, N.; Nauert, C.; Schmidt, M.
Anwendung und Verträglichkeit von Beinwellcreme (Symphyti herba) bei Kindern mit akuten stumpfen Traumen
Z Phytother, 2010, 31(1), 61-65
Observational trial, Muscoskeletal -/Connective tissue system, Blood/Lymphatic system, Hematoma, Clinical research, Complementary and alternative medicine, Muscle strain, Pediatrics, Phytomedicine, Sports medicine, Symphytum, Sprain
1713 Krebs, S.; Omer, T. N.; Omer, B.
Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn's disease
A controlled clinical trial
Phytomed, 2010, 17(5), 305-309
Artemisia, Artemisia absinthium, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Crohn's disease, Phytomedicine, Randomized trial
1714 Fioravanti, A.; Bellisai, B.; Capitani, S.; Manica, P.; Paolazzi, G.; Galeazzi, M.
Phytothermotherapy
A possible complementary therapy for fibromyalgia patients
Clin Exp Rheumatol, 2009, 27(5 Suppl. 56), S29-S32
Muscoskeletal -/Connective tissue system, Fibromyalgia, Clinical research, Complementary and alternative medicine, Physical therapy, Phytomedicine, Randomized trial, Rheumatic diseases, Thermotherapy
1715 Ladas, E.J.; Kroll, D.J.; Oberlies, N.H.; Cheng, B.; Ndao, D.H.; Rheingold, S.R.; Kelly, K.M.
A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL)
Cancer, 2010, 116(2), 506-513
Clinical research, Complementary and alternative medicine, Cancer, Liver, Leukaemia, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, milk thistle, Adverse effect
1716 Kim, E.J.; Jang, M.K.; Yoon, E.H.; Jung, C.Y.; Nam, D.W.; Lee, S.D.; Kim, K.S.
Efficacy of pharmacopuncture using root bark of Ulmus davidiana Planch in patients with knee osteoarthritis
A double-blind randomized controlled trial
J Acupunct Meridian Stud, 2010, 3(1), 16-23
Acupuncture, Arthrosis, Muscoskeletal -/Connective tissue system, Clinical research, Knee arthrosis, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Rheumatic diseases, Traditional Chinese medicine, Ulmus, Ulmus davidiana, Pharmacopuncture
1717 Abdali, K.; Khajehei, M.; Tabatabaee, H.R.
Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women
A randomized, double-blind, placebo-controlled study
Menopause, 2010, 17(2), 326-331
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
1718 Ngamjarus, C.; Pattanittum, P.; Somboonporn, C.
Roselle for hypertension in adults
Cochrane Database Syst Rev, 2010, 1(CD007894), 1-16
High blood pressure, Cardiovascular diseases, Hibiscus, Hibiscus sabdariffa, Clinical research, Complementary and alternative medicine, Phytomedicine, Systematic review
1719 Tan Garcia, J.; Gonzaga, F.; Tan, D.; Ng, T.Y.; Oei, P.L.; Chan, C.W.
Use of a multibotanical (Nutrafem) for the relief of menopausal vasomotor symptoms
A double-blind, placebo-controlled study
Menopause, 2010, 17(2), 303-308
Eucommia ulmoides, Gynaecology, Cardiovascular diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Menopause, Nutrafem, Phytomedicine, Placebo-controlled, Randomized trial, Vigna, Vigna radiata
1720 Loo, W.T.Y.; Jin, L.J.; Chow, L.W.C.; Cheung, M.N.B.; Wang, M.
Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients
Expert Opin Investig Drugs, 2010, 19(Suppl.1), S91-S100
Breast cancer, Experiment, Basic Research, Ear-nose-throat disorders, In vitro, Clinical research, Complementary and alternative medicine, Cancer, Human, Mucositis (oral), Phytomedicine, Placebo-controlled, Randomized trial, Rhodiola, Rhodiola algida, Animal
1721 Mbah, A.U.; Udeinya, I.J.; Shu, E.N.; Chijioke, C.P.; Nubila, T.; Udeinya, F.; Muobuike, A.; Mmuobieri, A., Obioma, M.S.
Fractionated neem leaf extract is safe and increases CD4+ cell levels in HIV/AIDS patients
Am J Ther, 2007, 14(4), 369-374
Azadirachta indica, Observational trial, HIV, Immunomodulation, Immune system, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine
1722 Waheed, A.; Miana, G.A.; Ahmad, S.I.
Clinical investigation of hypoglycemic effect of seeds of Azadirachta indica in type-2 (NIDDM) diabetes mellitus
Pak J Pharm Sci, 2006, 19(4), 322-325
Azadirachta indica, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Metabolic diseases
1723 Abdel-Ghaffar, F.; Semmler, M.
Efficacy of neem seed extract shampoo on head lice of naturally infected humans in Egypt
Parasitol Res, 2007, 100(2), 329-332
Azadirachta indica, Observational trial, Skin diseases, Clinical research, Complementary and alternative medicine, Lice, Phytomedicine
1724 Bandyopadhyay, U.; Biswas, K.; Sengupta, A.; Moitra, P.; Dutta, P.; Sarkar, D.; Debnath, P.; Ganguly, C.K.; Banerjee, R.K.
Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer
Life Sci, 2004, 75(24), 2867-2878
Azadirachta indica, Observational trial, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Gastric ulcer, Phytomedicine, Duodenal ulcer
1725 Pai, M.R.; Acharya, L.D.; Udupa, N.
Evaluation of antiplaque activity of Azadirachta indica leaf extract gel
A 6-week clinical study
J Ethnopharmacol, 2004, 90(1), 99-133
Azadirachta indica, Observational trial, Clinical research, Complementary and alternative medicine, Phytomedicine, Dental diseases, Dental plaque
1726 Vanka, A.; Tandon, S.; Rao, S.R.; Udupa, N.; Ramkumar, P.
The effect of indigenous Neem (Azadirachta indica) [correction of (Adirachta indica)] mouth wash on Streptococcus mutans and Lactobacilli growth
Indian J Dent Res, 2001, 12(3), 133-144
Azadirachta indica, Bacteria, Ear-nose-throat disorders, Infections, Clinical research, Complementary and alternative medicine, Lactobacillus spec., Pediatrics, Phytomedicine, Randomized trial
1727 Kim, N.K.; Lee, D.H.; Lee, J.H.; Oh, Y.L.; Yoon, I.H.; Seo, E.S., Lee, C.H.
Bojungikgitang and banhabaekchulchonmatang in adult patients with tinnitus
A randomized, double-blind, three-arm, placebo-controlled trial - study protocol
Trials, 2010, 11(1), 34; (1-7)
Banhabaekchulchonmatang, Bojungikgitang, Ethnomedicine, Ear-nose-throat disorders, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Ear noises, Phytomedicine, Placebo-controlled, Randomized trial
1728 Sayyah, M.; Boostani, H.; Pakseresht, S.; Malayeri, A.
Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of obsessive-compulsive disorder
Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34, 362-365
Clinical research, Complementary and alternative medicine, Mania, Phytomedicine, Mental diseases, Randomized trial, milk thistle
1729 Erkkola, R.; Vervarcke, S.; Vansteelandt, S.; Rompotti, P.; Keukeleire, D. de; Heyerick, A.
A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts
Phytomed, 2010, 17(6), 389-396
Gynaecology, hop, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Randomized trial
1730 Herrera-Arellano, A.; Jimenez-Ferrer, E.; Zamilpa, A.; Martínez-Rivera, M. de los A.; Rodríguez-Tovar, A.V.; Herrera-Alvarez, S.; Salas-Andonaegui, M.L.; Nava-Xalpa, M.Y.; Méndez-Salas, A.; Tortoriello, J.
Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection
Planta Med, 2009, 75(5), 466-471
Candidiasis, Gynaecology, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Solanum, Solanum chrysotrichum, Vaginalinfektion
1731 Schapowal, A.; Berger, D.; Klein, P.; Suter, A.
Eine Kombination von Salbei/Echinacea oder Chlorhexidin/Lidocain zu Behandlung akuter Halsschmerzen
Z Phytother, 2009, 30(6), 275-284
Echinacea, Echinacea purpurea, Ear-nose-throat disorders, Sore throat, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lidocain, Phytomedicine, Randomized trial, sage
1732 Kamin, W.; Kieser, M.
Pinimenthol Erkältungssalbe bei Patienten mit Infekten der oberen Atemwege
Eine Kohortenstudie
Z Phytother, 2009, 30(6), 285-288
Respiratory diseases, Observational trial, Common cold, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Pinimenthol
1733 Tsai, C.H.; Chiu, W.C.; Yang, N.C.; Ouyang, C.M.; Yen, Y.H.
A novel green tea meal replacement formula for weight loss among obese individuals
A randomised controlled clinical trial
Int J Food Sci Nutr, 2009, 60(s6), 1512-159
Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Metabolic diseases, Tea, Overweight
1734 Moretti, M.E.; Maxson, A.; Hanna, F.; Koren, G.
Evaluating the safety of St John's wort in human pregnancy
Reprod Toxicol, 2009, 28(1), 96-99
Gynaecology, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Obstetrics, Adverse effect
1735 Geller, S.E.; Shulman, L.P.; Breemen, R.B. van; Banuvar, S.; Zhou, Y.; Epstein, G.; Hedayat, S.; Nikolic, D.; Krause, E.C.; Piersen, C.E.; Bolton, J.L.; Pauli, G.F.; Farnsworth, N.R.
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms
A randomized controlled trial
Menopause, 2009, 16(6), 1156-1166
Black cohosh, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Trifolium, Trifolium pratense
1736 Sarris, J.; Kavanagh, D.J.; Byrne, G.; Bone, K.M.; Adams, J.; Deed, G.
The Kava Anxiety Depression Spectrum Study (KADSS)
A randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
Psychopharmacol, 2009, 205(3), 399-407
Anxiety, Depression, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Placebo-controlled, Mental diseases, Randomized trial
1737 Salehi, B.; Imani, R.; Mohammadi, M.R.; Fallah, J.; Mohammadi, M.; Ghanizadeh, A.; Tasviechi, A.A.; Vossoughi, A.; Rezazadeh, S.; Akhondzadeh, S.
Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents
A double blind, randomized controlled trial
Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(1), 76-80
Ginkgo, ADHD, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Mental diseases, Randomized trial
1738 Romero-Cerecero, O.; Roman-Ramos, R.; Zamilpa, A.; Jiménez-Ferrer, J.E.; Rojas-Bribiesca, G.; Tortoriello, J.
Clinical trial to compare the effectiveness of two concentrations of the Ageratina pichinchensis extract in the topical treatment of onychomycosis
J Ethnopharmacol, 2009, 126(1), 74-78
Ageratina pichinchensis, Skin diseases, Fungal skin infection, Clinical research, Complementary and alternative medicine, Phytomedicine, posology, Randomized trial
1739 Graz, B.; Willcox, M.L.; Diakite, C.; Falquet, J.; Dackuo, F.; Sidibe, O.; Giani, S.; Diallo, D.
Argemone mexicana decoction versus artesunate-amodiaquine for the managment of malaria in Mali
Policy and public-health implications
Trans R Soc Trop Med Hyg, 2010, 104(1), 33-41
chicalote, Infections, Clinical research, Complementary and alternative medicine, Malaria, Phytomedicine, Randomized trial
1740 Chevassus, H.; Molinier, N.; Costa, F.; Galtier, F.; Renard, E.; Petit, P.
A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers
Eur J Clin Pharmacol, 2009, 65(12), 1175-1178
Nutrition/diet, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Trifolium, fenugreek
1741 Sartore, G.; Reitano, R.; Barison, A.; Magnanini, P.; Cosma, C.; Burlina, S.; Manzato, E.; Fedele, D.; Lapolla, A.
The effects of psyllium on lipoproteins in type II diabetic patients
Eur J Clin Nutr, 2009, 63, 1269-1271
Diabetes mellitus, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Plantago, Plantago ovata, Metabolic diseases
1742 Hozawa, A.; Kuriyama, S.; Nakaya, N.; Ohmori-Matsuda, K.; Kakizaki, M.; Sone, T.; Nagai, M.; Sugawara, Y.; Nitta, A.; Tomata, Y.; Niu, K.; Tsuji, I.
Green tea consumption is associated with lower psychological distress in a general population
The Ohsaki Cohort 2006 Study
Am J Clin Nutr, 2009, 90(5), 1390-1396
Observational trial, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Stress, Tea
1743 Kawahara, H.; Mitani, Y.; Nomura, M.; Nose, K.; Yoneda, A.; Hasegawa, T.; Kubota, A.; Fukuzawa, M.
Impact of rikkunshito, an herbal medicine, on delayed gastric emptying in profoundly handicapped patients
Pediatr Surg Int, 2009, 25(11), 987-990
Observational trial, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Pediatrics, Phytomedicine, Rikkunshi-to, Traditional Japanese medicine
1744 Gurrola-Diaz, C.M.; Garcia-Lopez, P.M.; Sanchez-Enriquez, S.; Troyo-Sanroman, R.; Andrade-Gonzalez, I.; Gomez-Leyva, J.F.
Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)
Phytomed, 2010, 17(7), 500-505
Hibiscus, Hibiscus sabdariffa, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Metabolic syndrome, Phytomedicine, Randomized trial, Metabolic diseases
1745 Canning, S.; Waterman, M.; Orsi, N.; Ayres, J.; Simpson, N.; Dye, L.
The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome
A randomized, double-blind, placebo-controlled trial
CNS Drugs, 2010, 24(3), 207-225
Gynaecology, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Premenstrual syndrome, Randomized trial
1746 Singh, K.; Pannu, M.S.; Singh, P.; Singh, J.
Effect of wheat grass tablets on the frequency of blood transfusions in Thalassemia Major
Indian J Pediatr, 2010, 77(1), 90-91
Observational trial, Blood/Lymphatic system, Clinical research, Complementary and alternative medicine, Pediatrics, Phytomedicine, Thalassaemia
1747 Picon, P.D.; Picon, R.V.; Costa, A.F.; Sander, G.B.; Amaral, K.M.; Aboy, A.L.; Henriques, A.T.
Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation
BMC Complement Altern Med, 2010, 10(1), 17; (1-9)
Cassia, Cassia angustifolia, Foeniculum vulgare, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Pimpinella, Pimpinella anisum, Placebo-controlled, Randomized trial, Sambucus, Constipation
1748 Talati, R.; Sobieraj, D.M.; Makanji, S.S.; Phung, O.J.; Coleman, C.I.
The comparative efficacy of plant sterols and stanols on serum lipids
A systematic review and meta-analysis
J Am Diet Assoc, 2010, 110(5), 719-726
Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Metabolic diseases, Systematic review
1749 De, B.K.; Dutta, D.; Pal, S.K.; Gangopadhyay, S.; Das Baksi, S.; Pani, A.
The role of garlic in hepatopulmonary syndrome
A randomized controlled trial
Can J Gastroenterol, 2010, 24(3), 183-188
Allium, Allium sativum, Respiratory diseases, Clinical research, Complementary and alternative medicine, Liver, Lung, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial
1750 Taku, K.; Melby, M.K.; Takebayashi, J.; Mizuno, S.; Ishimi, Y.; Omori, T.; Watanabe, S.
Effect of soy isoflavone extract supplements on bone mineral density in menopausal women
Meta-analysis of randomized controlled trials
Asian Pacific J Clin Nutr, 2010, 19(1), 33-42
Muscoskeletal -/Connective tissue system, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Meta-analysis, Osteoporosis, Phaseolus, Phaseolus max, Phytomedicine
1751 Ziegler, R.; Grossarth-Maticek, R.
Individual patient data meta-analysis of survival and psychosomatic self-regulation from published prospective controlled cohort studies for long-term therapy of breast cancer patients with a mistletoe preparation (Iscador)
eCAM, 2010, 7(2), 157-166
Breast cancer, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Mistletoe therapy, Phytomedicine, Viscum, Viscum album, Iscador
1752 Lee, Y.L.; Najm, W.I.; Owens, J.; Thrupp, L.; Baron, S.; Shanbrom, E.; Cesario, T.
Anti-microbial activity of urine after ingestion of cranberry
A pilot study
eCAM, 2010, 7(2), 227-232
Bacteria, Healthy probands, Urinary tract, Urinary tract infection, Infections, Clinical research, Complementary and alternative medicine, Phytomedicine, Vaccinium, cranberry
1753 Park, J.J.; Shin, J.; Choi, Y.; Youn, Y.; Lee, S.; Kwon, S.R.; Lee, H.; Kang, M.H.; Ha, I.H.; Shin, I.
Integrative package for low back pain with leg pain in Korea
A prospective cohort study
Complement Ther Med, 2010, 18(2), 78-86
Acupuncture, Apitherapy, Observational trial, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Manual therapy, Phytomedicine, Traditional Chinese medicine
1754 Arslan, G.G.; Eser, I.
An examination of the effect of castor oil packs on constipation in the elderly
A randomized controlled trial
Complement Ther Clin Pract, 2011, 17(1), 58-62
Geriatrics, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Oil, Physical therapy, Phytomedicine, Randomized trial, Rizinus communis, Constipation, Compress
1755 Li, L.
The effect of Neuragen PN ((R)) on neuropathic pain
A randomized, double blind, placebo controlled clinical trial
BMC Complement Altern Med, 2010, 10, 22; (1-7)
Homeopathy, Clinical research, Complementary and alternative medicine, Nervous system, Neuragen PN, Neuropathy, Oil, Phytomedicine, Placebo-controlled, Randomized trial
1756 Sannia, A.
Un'esperienza di fitoterapia con una asociazione di fitocomplessi ad attività epatoprotettrice contenente un estratto di foglie di carciofo per il controllo dei sintomi della dispepsia funzionale
[Phytotherapy with a mixture of dry extracts with heapto-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms]
Minerva Gastroenterol Dietol, 2010, 56(2), 93-99
Observational trial, Curcuma, Curcuma longa, Cynara cardunculus subsp. flavescens, Dyspepsia, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Taraxacum
1757 Ross, S.M.
A standardized Echinacea extract demonstrates efficacy in the prevention and treatment of colds in athletes
Holist Nurs Pract, 2010, 24(2), 107-109
Respiratory diseases, Observational trial, Echinacea, Echinacea purpurea, Common cold, Complementary and alternative medicine, Phytomedicine, Prevention, Sports medicine
1758 George, J.; Hedge, S.; Rajesh, K.S.; Kumar, A.
The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis
A clinico-biochemical study
Indian J Dent Res, 2009, 20(4), 480-482
Applikationsform, Cammophora, Chamomilla, Eucalyptus, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, sage, Gingivitis, Dental diseases, Dental plaque, toothpaste
1759 Chiummariello, S.; De Gado, F.; Monarca, C.; Ruggiero, M.; Carlesimo, B.; Scuderi, N.; Alfano, C.
Studio multicentrico su un preparato topico ad azione linfodrenante nel trattamento dell'ulcera flebostatica degli arti inferiori
G Chir, 2009, 30(11-12), 497-501
Ulcer, Skin diseases, Cardiovascular diseases, Idrastin, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Randomized trial, Vein disorders
1760 Ferrari, A.
Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms
J Obstet Gynaecol Res, 2009, 35(6), 1083-1090
Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phaseolus, Phaseolus max, Phytomedicine, Placebo-controlled, Randomized trial
1761 Björk-Eriksson, T.; Gunnarsson, M.; Holmström, M.; Nordqvist, A.; Petruson, B.
Fewer problems with dry nasal mucous membranes following local use of sesame oil
Rhinology, 2000, 38(4), 200-203
Observational trial, Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Nose, Oil, Phytomedicine, Sesamum indicum, Adverse effect
1762 Johnsen, J.; Bratt, B.-M.; Michel-Barron, O.; Glennow, C.; Petruson, B.
Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa
Arch Otolaryngol Head Neck Surg, 2001, 127, 1353-1356
Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Oil, Phytomedicine, Randomized trial, Cold, Sesamum indicum
1763 Atmaca, M.; Tezcan, E.; Kuloglu, M.; Ustundag, B.; Kirtas, O.
The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia
Psych Clin Neurosci, 2005, 59, 652-656
Ginkgo, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Schizophrenia
1764 Zhang, X.Y.; Zhou, D.F.; Cao, L.Y.; Wu, G.Y.
The effects of Ginkgo biloba extract added to haloperidol on pheripheral T cell subsets in drug-free schizophrenia
A double-blind, placebo-controlled trial
Psychopharmacol, 2006, 188, 12-17
Ginkgo, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Schizophrenia
1765 Giannetti, B.M.; Staiger, C.; Bulitta, M.; Predel, H.G.
Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain
Results of a double-blind, randomised, placebo controlled, multicentre trial
Brit J Sports Med, 2010, 44(9), 637-641
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Back pain (non-specific), Symphytum
1766 Vyas, A.P.; Rastogi, P.K.; Jaiswal, V.; Dave, D.
HERBAVATE an alternative approach for the management of eczema?
J Complement Integr Med, 2010, 7(1), 16; (1-7)
Observational trial, Calotropis, Calotropis gigantea, Curcuma, Curcuma longa, Eczema, Skin diseases, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Phytomedicine, Pongamia, Pongamia glabra, Solanum, Solanum xanthocarpum
1767 Chen, S.; Li, Z.; Krochmal, R.; Abrazado, M.; Kim, W.; Cooper, C.B.
Effect of Cs-4 ((R)) (Cordyceps sinensis) on exercise performance in healthy older subjects
A double-blind, placebo-controlled trial
J Altern Complement Med, 2010, 16(5), 585-590
Muscoskeletal -/Connective tissue system, Cordyceps, Cordyceps sinensis, Geriatrics, Healthy probands, Chinese medicinal herbs, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Traditional Chinese medicine
1768 Black, C.D.; Herring, M.P.; Hurley, D.J.; O'Connor, P.J.
Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise
J Pain, 2010, 11(9), 894-903
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Muscle soreness, Phytomedicine, Placebo-controlled, Randomized trial, ginger
1769 Patel, M.; Schimpf, M.O.; O'Sullivan, D.M.; LaSala, C.A.
The use of senna with docusate for postoperative constipation after pelvic reconstructive surgery
A randomized, double-blind, placebo-controlled trial
Am J Obstet Gynecol, 2010, 202(5), 479.e1-e5
Surgery, Gynaecology, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Senna, Constipation
1770 Fa-lin, Z.; Zhen-yu, W.; Yan, H.; Tao, Z.; Kang, L.
Efficacy of blackcurrant oil soft capsule, a Chinese herbal drug, in hyperlipidemia treatment
Phytother Res, 2010, 24(S2), S209-S213
Observational trial, Chinese medicinal herbs, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Ribes, black currant, Metabolic diseases, Traditional Chinese medicine
1771 Huber, R.; Ditfurth, A.V.; Amann, F.; Güthlin, C.; Rostock, M.; Trittler, R.; Kümmerer, K.; Merfort, I.
Tormentil for active ulcerative colitis
An open-label, dose-escalating study
J Clin Gastroenterol, 2007, 41(9), 834-838
Observational trial, Ulcerative colitis, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, posology, Potentilla, Potentilla tormentilla
1772 Kuriyan, R.; Kumar, D.R.; Rajendran, R.; Kurpad, A.V.
An evaluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians
A double blind, placebo controlled trial
BMC Complement Altern Med, 2010, 10, 27; (1-8)
Hibiscus, Hibiscus sabdariffa, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
1773 Vakilian, K.; Atarha, M.; Bekhradi, R.; Chaman, R.
Healing advantages of lavender essential oil during episiotomy recovery
A clinical trial
Complement Ther Clin Pract, 2011, 17(1), 50-53
Aromatherapy, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula stoechas, Phytomedicine, Randomized trial, Obstetrics, Wound healing, episiotomy
1774 Lai, T.K.T.; Cheung, M.C.; Lo, C.K.; Ng, K.L.; Fung, Y.H.; Tong, M.; Yau, C.C.
Effectiveness of aroma massage on advanced cancer patients with constipation
A pilot study
Complement Ther Clin Pract, 2011, 17(1), 37-43
Aromatherapy, Clinical research, Complementary and alternative medicine, Cancer, Gastrointestinal tract, Manual therapy, Massage, Phytomedicine, Randomized trial, Constipation
1775 Lee, J.H.; Kwon, K.R.; Cho, C.K.; Han, S.S.R.; Yoo, H.S.
Advanced cancer cases treated with cultivated wild ginseng pharmacopunture
J Acupunct Meridian Stud, 2010, 3(2), 119-124
Acupuncture, Observational trial, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Traditional Chinese medicine, Pharmacopuncture, Panax, Panax ginseng
1776 Cornu, C.; Remontet, L.; Noel-Baron, F.; Nicolas, A.; Feugier-Favier, N.; Roy, P.; Claustrat, B.; Saadatian-Elahi, M.; Kassai, B.
A dietary supplement to improve the quality of sleep
A randomized placebo controlled trial
BMC Complement Altern Med, 2010, 10, 29; (1-9)
Nutrition/diet, hop, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
1777 Eshghi, F.; Hosseinimehr, S.J.; Rahmani, N.; Khademloo, M.; Norozi, M.S.; Hojati, O.
Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing
Results of a randomized, blind, placebo-control study
J Altern Complement Med, 2010, 16(6), 647-650
Aloe, Aloe vera, Surgery, Hemorrhoids, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Phytomedicine, Placebo-controlled, Randomized trial, Wound healing
1778 Klupp, N.; Chang, D.; Bensoussan, A.; Kiat, H.
A randomised controlled trial of Ganoderma lucidum for treatment of hyperglycaemia in persons with type II diabetes and metabolic syndrome
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 13 (Symposiumsbeitrag; Abstract)
Cordyceps, Cordyceps sinensis, Diabetes mellitus, Ganoderma, Ganoderma lucidum, Clinical research, Complementary and alternative medicine, Metabolic syndrome, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases
1779 Gasbarrini, G; Zaccone, V.; Covino, M.; Gallo, A.
Effectiveness of a "cold dessert", with or without the addition of a mixture of digestive herbs, in subjects with "functional dyspepsia"
J Biol Regul Homeost Agents, 2010, 24(1), 93-98
Observational trial, Cynara cardunculus subsp. flavescens, Dyspepsia, Nutrition/diet, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Melissa, lemon balm, Phytomedicine
1780 Isik, H.; Cevikbas, A.; Gürer, Ü.S.; Kiran, B.; Uresin, Y.; Rayaman, P.; Rayaman, E.; Gürbüz, B.; Büyüköztürk, S.
Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients
Med Princ Pract, 2010, 19(3), 206-211
Allergies, House-dust allergy, Hay fever, Immune system, Immunotherapy, Clinical research, Complementary and alternative medicine, Nigella sativa, Phytomedicine, Randomized trial
1781 Ji, W.; Li, J.; Lin, Y.; Song, Y.N.; Zhang, M.; Ke, Y.; Ren, Y.; Deng, X.; Zhang, J.; Huang, F.; Yu, D.
Report of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii
Clin Rheumatol, 2010, 29(9), 1067-1072
Observational trial, Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Bechterew's disease, Phytomedicine, Rheumatic diseases, Tripterygium, Tripterygium wilfordii
1782 Zick, S.; Sen, A.; Arnedt, T.
Chamomile high grade extract for chronic primary insomnia
A randomized controlled trial
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 17-18 (Symposiumsbeitrag; Abstract)
Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders
1783 Szczurko, O.; Boon, H.; Dan, L.; Shear, N.; Taddio, A.
Ginkgo biloba for the treatment of vitilgo vulgaris
An open label pilot clinical tial
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 23 (Symposiumsbeitrag; Abstract)
Observational trial, Ginkgo, Skin diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Vitiligo
1784 Wang, C.; Jacobson, E.; Yangga, T.; McAlindon, T.; Wang, K.-L.
Effect of Tibetan five nectar formula medicated bath therapy on Rheumatoid Arthritis
A systematic review
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 25 (Symposiumsbeitrag; Abstract)
Arthritis, Muscoskeletal -/Connective tissue system, Hydrotherapy, Clinical research, Complementary and alternative medicine, Physical therapy, Phytomedicine, Rheumatic diseases, Systematic review, Traditional Tibetan medicine
1785 Koula-Jenik, H.; Holzhauer, P.
Anwendungsbeobachtung zum präventiven Potenzial von Hanföl beim Capecitabin-induzierten Hand-Fuß-Syndrom
Dt Z Onkol, 2010, 42(2), 80-84
Observational trial, Cannabis, Cannabis sativa, Hand-foot syndrome, Skin diseases, Clinical research, Complementary and alternative medicine, Cancer, Oil, Phytomedicine
1786 Lipovac, M.; Chedraui, P.; Gruenhut, C.; Gocan, A.; Stammler, M.; Imhof, M.
Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extract
Maturitas, 2010, 65(3), 258-261
Anxiety, Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Mental diseases, Randomized trial, Trifolium, Trifolium pratense
1787 Lee, Y.H.; Lee, B.K.; Choi, Y.J.; Yoon, I.K.; Chang, B.C.; Gwak, H.S.
Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement
Int J Cardiol, 2010, 145(2), 275-276
Heart valve defect, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Panax, Panax ginseng
1788 McKay, D.L.; Chen, C.Y.; Saltzman, E.; Blumberg, J.B.
Hibius sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults
J Nutr, 2010, 140(2), 298-303
High blood pressure, Cardiovascular diseases, Hibiscus, Hibiscus sabdariffa, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Tea
1789 Deandrea, S.; Foschi, R.; Galeone, C.; La Vecchia, C.; Negri, E.; Hu, J.
Is temperature an effect modifier of the association between green tea intake and gastric cancer risk?
Eur J Cancer Prev, 2010, 19(1), 18-22
Observational trial, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Stomach cancer, Phytomedicine, Tea
1790 Royer, D.J.; George, J.N.; Terrell, D.R.
Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nuritional supplements, foods and beverages
Eur J Haematol, 2010, 84(5), 421-429
Blood/Lymphatic system, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Systematic review, Thrombocytopaenia, Adverse effect
1791 Abdel-Ghaffar, F.; Semmler, M.; Al-Rasheid, K.; Klimpel, S.; Mehlhorn, H.
Efficacy of grapefruit extract on head lice
A clinical trial
Parasitol Res, 2009, 106(2), 445-449
Citrus, Citrus paradisi, Skin diseases, Clinical research, Complementary and alternative medicine, Lice, Pediatrics, Phytomedicine, Randomized trial
1792 Ogunleye, A.A.; Xue, F.; Michels, K.B.
Green tea consumption and breast cancer risk or recurrence
A meta-analysis
Breast Cancer Res Treat, 2010, 119(2), 477-484
Breast cancer, Camellia, Camellia sinensis, Clinical research, Complementary and alternative medicine, Cancer, Meta-analysis, Phytomedicine
1793 Wang, Q.M.; Gong, Q.Y.; Yan, J.J.; Jun-Zhu; Tang, J.J.; Wang, M.W.; Yang, Z.J.; Wang, L.S.
Association between green tea intake and coronary artery disease in a Chinese population
Circ J, 2010, 74(2), 294-300
Arteriosclerosis, Observational trial, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Phytomedicine, Tea
1794 Schlaeppi, M.; Bock, P.R.; Hanisch, J.; Karasmann, M.
Supportive treatment concepts with fermented mistletoe (Viscum album L.) extracts in cancer patients
Summary results from four controlled pharmacoepidemiological cohort studies with a total of 3,376 patients
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 48 (Symposiumsbeitrag; Abstract)
Anthroposophic medicine, Pancreatic cancer, Breast cancer, Bowel cancer, Clinical research, Complementary and alternative medicine, Cancer, Malignant melanoma, Mistletoe therapy, Non-randomized trial, Palliative care, Phytomedicine, Retrospective design, Viscum, Viscum album, Iscador
1795 Vosough-Ghanbari, S.; Rahimi, R.; Kharabaf, S.; Zeinali, S.; Mohammadirad, A.; Amini, S.; Yasa, N.; Salehnia, A.; Toliat, T.; Nikfar, S.; Larijani, B.; Abdollahi, M.
Effects of Satureja khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with type 2 diabetes mellitus
A double-blind randomized controlled trial
eCAM, 2010, 7(4), 465-470
Diabetes mellitus, Hypercholesterolemia, Clinical research, Complementary and alternative medicine, Phytomedicine, Randomized trial, Satureja, Satureja khuzestanica, Metabolic diseases
1796 Park, J.
Korean Red Ginseng alleviates dry mouth in women but not in men
A randomized, double-blind, placebo-controlled trial
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 54 (Symposiumsbeitrag; Abstract)
Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Dry mouth, Phytomedicine, Placebo-controlled, Randomized trial, Panax, Panax ginseng
1797 Staiger, C.; Giannetti, B.M.; Tschaikin, M.
Comfrey root extract ointment in the treatment of acute upper or lower back pain
Results of a RCT
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 54-55 (Symposiumsbeitrag; Abstract)
Muscoskeletal -/Connective tissue system, Clinical research, Complementary and alternative medicine, Low back pain, Phytomedicine, Placebo-controlled, Randomized trial, Back pain (non-specific), Symphytum
1798 Patki, P.; Karamakar, D.
Evaluation of efficacy and safety of a herbal formulation Cystone in the management of urolithiasis
Meta-analysis of 50 clinical studies
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 60 (Symposiumsbeitrag; Abstract)
Cystone, Urinary calculus, Urinary tract, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Meta-analysis, Phytomedicine
1799 Kim, E; Brodsky, M.; Song, M.Y.
Effect of capsaicin injection on weight loss
International Society for Complementary Medicine Research (ICCMR): ICCMR 2010. 5th International Congress on Complementary Medicine Research., 2010, 69 (Symposiumsbeitrag; Abstract)
Capsicum, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Randomized trial, Metabolic diseases, Overweight
1800 Wilson, D.; Evans, M.; Guthrie, N.; Sharma, P.; Baisley, J.; Schonlau, F.; Burki, C.
A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of Pycnogenol ((R)) for improving allergic rhinitis symptoms
A systematic review
Phytother Res, 2010, 24(8), 1115-1119
Allergies, Hay fever, Immune system, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Pycnogenol, Randomized trial