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101 Stojanovska, L.; Law, C.; Lai, B.; Chung, T.; Nelson, K.; Day, S.; Apostolopoulos, V.; Haines, C.
Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Climacteric, 2015, 18(1), 69-78
High blood pressure, Depression, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
102 Kasper, S.; Gastpar, M.; Müller, W.E.; Volz, H.-P.; Möller, H.-J.; Schläfke, S.; Dienel, A.
Lavender oil preparation Silexan is effective in generalized anxiety disorder
A randomized, double-blind comparison to placebo and paroxetine
Int J Neuropsychopharmacol, 2014, epub ahead of print,
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Lavendula angustifolia, Oil, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
103 Liu, L.-Y.; Feng, B.; Chen, J.; Tan, Q.-R.; Chen, Z.-X.; Chen, W.-S.; Wang, P.-R.; Zhang, Z.-J.
Herbal medicine for hospitalized patients with severe depressive episode
A retrospective controlled study
J Affect Disord, 2015, 170, 71-77
Depression, Clinical research, Complementary and alternative medicine, Hospital, Non-randomized trial, Phytomedicine, Practice, Mental diseases, Retrospective design
104 Shahmansouri, N.; Farokhnia, M.; Abbasi, S.H.; Kassaian, S.E.; Noorbala Tafti, A.A.; Gougol, A.; Yekehtaz, H.; Forghani, S.; Mahmoodian, M.; Saroukhani, S.; Arjmandi-Beglar, A.; Akhondzadeh, S.
A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients
J Affect Disord, 2014, 155, 216-222
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
105 Firoozabadi, A.; Salehi, A.; Jahanbin, S.; Mohagheghzadeh, A.
Effectiveness of Cuscuta planiflora Ten. and Nepeta menthoides Boiss. & Buhse in major depression
A triple-blind randomized controlled trial study
J Evid Based Compl Altern Med, 2015, 20(2), 94-97
Cuscuta, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Cuscuta planiflora, Nepeta menthoides
106 Mao, J.J.; Li, Q.S.; Soeller, I.; Xie, S.X.; Amsterdam, J.D.
Rhodiola rosea therapy for major depressive disorder
A study protocol for a randomized, double-blind, placebo-controlled trial
J Clin Trials, 2014, 4(3), 170; (1-7) (Studienprotokoll)
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
107 Dording, C.M.; Schettler, P.J.; Dalton, E.D.; Parkin, S.R.; Walker, R.S.W.; Fehling, K.B.; Fava, M.; Mischoulon, D.
A double-blind placebo-controlled trial of Maca root as treatment for antidepressant-induced sexual dysfunction in women
eCAM, 2015, Article ID 949036, (1-9)
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lepidium, Lepidium meyenii, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sexual dysfunktion (female)
108 Mao, J.J.; Xie, S.X.; Zee, J.; Soeller, I.; Li, Q.S.; Rockwell, K.; Amsterdam, J.D.
Rhodiola rosea versus sertraline for major depressive disorder
A randomized placebo-controlled trial
Phytomed, 2015, 22(3), 394-399
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea
109 Tang, S.K.; Tse, M.Y.M.
Aromatherapy: Does it help to relieve pain, depression, anxiety, and stress in community-dwelling older persons?
Biomed Res Int, 2014, Article ID 430195, (1-12)
Anxiety, Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Non-randomized trial, Phytomedicine, Mental diseases, Pain, Stress, Inhalation
110 Talaei, A.; Hassanpour Moghadam, M.; Sajadi Tabassi, S.A.; Mohajeri, S.A.
Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder
A randomized, double-blind, placebo-controlled, pilot clinical trial
J Affect Disord, 2015, 174, 51-56
Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
111 Panahi, Y.; Badeli, R.; Karami, G.R.; Badeli, Z.; Sahebkar, A.
A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder
Complement Ther Med, 2015, 23(4), 598-602
Antioxidants, Chlorella, Chlorella vulgaris, Depression, Nutrition/diet, Clinical research, Complementary and alternative medicine, Dietary supplementation, Phytomedicine, Mental diseases, Randomized trial
112 Chen, S.-L.; Chen, C.-H.
Effects of lavender tea on fatigue, depression, and maternal-infant attachement in sleep-disturbed postnatal women
Worldviews Evid Based Nurs, 2015, 12(6), 370-379
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Lavendula, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
113 Cropley, M.; Banks, A.P.; Boyle, J.
The effects of Rhodolia rosea L. extract on anxiety, stress, cognition and other mood symptoms
Phytother Res, 2015, 29(12), 1934-1939
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Mental diseases, Randomized trial, Rhodiola, Rhodiola rosea, Stress
114 Lopresti, A.L.; Maes, M.; Maker, G.L.; Hood, S.D.; Drummond, P.D.
Curcumin for the treatment of major depression
A randomised, double-blind, placebo controlled study
J Affect Disord, 2014, 167, 368-375
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
115 Lopresti, A.L.; Maes, M.; Meddens, M.J.M.; Maker, G.L.; Arnoldussen, E.; Drummond, P.D.
Curcumin and major depression
A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change
Eur Neuropsychopharmacol, 2015, 25, 38-50
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Mechanism of action
116 Al-Karawi, D.; Al Mamoori, D.A.; Tayyar, Y.
The role of curcumin administration in patients with major depressive disorder
Mini meta-analysis of clinical trials
Phytother Res, 2016, 30(2), 175-183
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
117 Mosaffa-Jahromi, M.; Tamaddon, A.-M.; Afsharypuor, S.; Salehi, S.H.; Pasalar, M.; Jafari, P.; Lankarani, K.B.
Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome
A randomized active and placebo-controlled clinical trial
J Evid Based Compl Altern Med, 2017, 22(1), 41-46
Aromatherapy, Depression, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Mentha, peppermint, Phytomedicine, Pimpinella, Pimpinella anisum, Placebo-controlled, Mental diseases, Randomized trial, Irritable bowel syndrome
118 Mazidi, M.; Shemshian, M.; Mousavi, S.H.; Norouzy, A.; Kermani, T.; Moghiman, T.; Sadeghi, A.; Mokhber, N.; Ghayour-Mobarhan, M.; Ferns, G.A.A.
A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression
J Complement Integr Med, 2016, 13(2), 195-199
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
119 Prichard, C.; Newcomb, P.
Benefit to family members of delivering hand massage with essential oils to critically ill patients
Am J Crit Care, 2015, 24(5), 446-449
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Non-randomized trial, Phytomedicine, Mental diseases, Intensivmedizin
120 Kim, H.S.; Kim, S.H.; Park, Y.S.; Kim, M.Y.
The effects of aroma massage and regular oil hand massage on the blood cortisol and serotonin level of elderly
Int J Bio Sci Bio Technol, 2016, 8(3), 119-126
Anxiety, Aromatherapy, Depression, Endocrinology, Geriatrics, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Serotonin, Cortisol
121 Lopresti, A.L.; Drummond, P.D.
Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression
A randomised, double-blind, placebo-controlled study
J Affect Disord, 2017, 207, 188-196
Crocus, Curcuma, Curcuma longa, Depression, Spices, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
122 Chang, S.M.; Chen, C.H.
Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women
A randomized controlled trial
J Adv Nurs, 2016, 72(2), 306-315
Depression, Gynaecology, Clinical research, Complementary and alternative medicine, Matricaria, Matricaria recutita, Phytomedicine, Mental diseases, Randomized trial, Sleep disorders, Obstetrics, Tea, Postpartum depression
123 Apaydin, E.A.; Maher, A.r.; Shanman, R.; Booth, M.S.; Miles, J.N.V.; Sorbero, M.E.; Hempel, S.
A systematic review of St. John’s wort for major depressive disorder
Syst Rev, 2016, 5, 148; (1-25)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
124 Ng, Q.X.; Venkatanarayanan, N.; Ho, C.Y.
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
125 Sayeed, M.S.B.; Shams, T.; Hossain, S.F.; Rahman, R.; Mostofa, A.G.M.; Kadir, M.F.; Mahmood, S.; Asaduzzaman, -
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
J Ethnopharmacol, 2014, 152, 156-162
Anxiety, Depression, Brain, Healthy probands, Clinical research, Complementary and alternative medicine, Nervous system, Nigella sativa, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
126 Kell, G.; Rao, A.; Beccaria, G.; Clayton, P.; Inarejos-García, A.M.; Prodanov, M.
affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.
Complement Ther Med, 2017, 33, 58-64
Crocus, Depression, Healthy probands, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
127 Firoozabadi, A.; Kolouri, S.; Zarshenas, M.M.; Salehi, A.; Mosavat, S.H.; Dastgheib, S.A.
Efficacy of a freeze-dried aqueous extract of Nepeta menthoides Boiss. and Buhse in the treatment of anxiety in patients with depression
A double-blind, randomized, controlled trial
J Herbal Med, 2017, 10, 17-23
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial, Nepeta menthoides
128 Yang, Y.P.; Lee, F.P.; Chao, H.C.; Hsu, F.Y.; Wang, J.J.
Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia
J Am Med Dir Assoc, 2016, 17(8), 719-724
Aromatherapy, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases
129 Yang, Y.-P.; Wang, C.-J.; Wang, J.-J.
Effect of aromatherapy massage on agitation and depressive mood in individuals with dementia
J Gerontol Nurs, 2016, 42(9), 38-46
Aromatherapy, Chamomilla, Citrus, Citrus sinensis, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Manual therapy, Massage, Nervous system, Phytomedicine, Mental diseases, Randomized trial
130 Nematolahi, P.; Mehrabani, M.; Karami-Mohajeri, S.; Dabaghzadeh, F.
Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students
A randomized clinical trial
Complement Ther Clin Pract, 2018, 30, 24-28
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Nervous system, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, rosemary, Sleep disorders
131 Yeung, K.S.; Hernandez, M.; Mao, J.J.; Haviland, I.; Gubili, J.
Herbal medicine for depression and anxiety
A systematic review with assessment of potential psycho-oncologic relevance
Phytother Res, 2018, 32(5), 865-891
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Mental diseases, Systematic review
132 Ghajar, A.; Neishabouri, S.M.; Velayati, N.; Jahangard, L.; Matinnia, N.; Haghighi, M.; Ghaleiha, A.; Afarideh, M.; Salimi, S.; Meysamie, A.; Akhondzadeh, S.
Crocus sativus L. versus Citalopram in the treatment of major depressive disorder with anxious distress
A double-blind, controlled clinical trial
Pharmacopsychiatry, 2017, 50(4), 152-160
Anxiety, Crocus, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Randomized trial
133 Ng, Q.X.; Koh, S.S.H.; Chan, H.W.; Ho, C.Y.X.
Clinical use of curcumin in depression
A meta-analysis
J Am Med Dir Assoc, 2017, 18(6), 503-508
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
134 Moazen-Zadeh, E.; Abbasi, S.H.; Safi-Aghdam, H.; Shahmansouri, N.; Arjmandi-Beglar, A.; Hajhosseinn Talasaz, A.; Salehiomran, A.; Forghani, S.; Akhondzadeh, S.
Effects of saffron on cognition, anxiety, and depression in patients undergoing coronary artery bypass grafting
A randomized double-blind placebo-controlled trial
J Altern Complement Med, 2018, 24(4), 361-368
Anxiety, Surgery, Crocus, Depression, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
135 Yang, X.; Chen, X.; Fu, Y.; Luo, Q.; Du, L.; Qiu, H.; Qiu, T.; Zhang, L.; Meng, H.
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults
A meta-analysis of randomized controlled trials
Neuropsychiatr Dis Treat, 2018, 14, 1297-1305
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
136 Bahrami, T.; Rejeh, N.; Heravi-Karimooi, M.; Vaismoradi, M.; Tadrisi, S.D.; Sieloff, C.
Effect of aromatherapy massage on anxiety, depression, and physiologic parameters in older patients with the acute coronary syndrome
A randomized clinical trial
Int J Nurs Pract, 2017, 23(6), e12601; (1-10)
Anxiety, Aromatherapy, Depression, Geriatrics, Gynaecology, Cardiovascular diseases, Clinical research, Complementary and alternative medicine, Coronary heart disease, Lavendula, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial
137 Tóth, B.; Hegyi, P.; Lantos, T.; Szakács, Z.; Kerémi, B.; Varga, G.; Tenk, J.; Pétervári, E.; Balaskó, M.; Rumbus, Z.; Rakonczay, Z.; Bálint, E.R.; Kiss, T.; Csupor, D.
The efficacy of saffron in the treatment of mild to moderate depression
A meta-analysis
Planta Med, 2019, 85(1), 24-31
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
138 Ranjbar, M.; Firoozabadi, A.; Salehi, A.; Ghorbanifar, Z.; Zarshenas, M.M.; Sadeghniiat-Haghighi, K.; Rezaeizadeh, H.
Effects of herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. and Buhse) on insomnia severity, anxiety and depression in insomniacs
Randomized placebo controlled trial
Integr Med Res, 2018, 7(4), 328-332
Anxiety, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, lemon balm, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Sleep disorders, Nepeta menthoides
139 Ghazanfarpour, M.; Mohammadzadeh, F.; Shokrollahi, P.; Khadivzadeh, T.; Najaf Najafi, M.; Hajirezaee, H.; Afiat, M.
Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women
A double-blind randomised controlled trial
J Obstet Gynaecol, 2018, 38(1), 121-126
Anxiety, Depression, Foeniculum vulgare, Gynaecology, Clinical research, Complementary and alternative medicine, Menopause, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial
140 Xiong, M.; Li, Y.; Tang, P.; Zhang, Y.; Cao, M.; Ni, J.; Xing, M.
Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults
J Altern Complement Med, 2018, 24(7), 717-724
Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Citrus sinensis, Depression, Clinical research, Kombinationsarzneimittel, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Phytomedicine, Mental diseases, Randomized trial, Inhalation
141 Su, B.Y.; Tung, T.H.; Chien, W.H.
Effects of phytoestrogens on depressive symptoms in climacteric women
A meta-analysis of randomized controlled trials
J Altern Complement Med, 2018, 24(8), 850-851 (Letter)
Depression, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Systematic review
142 Zwanzger, P.; Wacker, A.
Silexan bei somatischen Angstsymptomen
Z Phytother, 2017, 38 (Suppl.1), 44 (Abstract (Poster))
Anxiety, Depression, Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Meta-analysis, Ear noises, Phytomedicine, Mental diseases, Silexan
143 Milajerdi, A.; Jazayeri, S.; Shirzadi, E.; Hashemzadeh, N.; Azizgol, A.; Djazayery, A.; Esmaillzadeh, A.; Akhondzadeh, S.
The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus
A double-blind, randomized and placebo-controlled clinical trial
Complement Ther Med, 2018, 41, 196-202
Anxiety, Crocus, Depression, Diabetes mellitus, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial, Metabolic diseases
144 Palhano-Fontes, F.; Barreto, D.; Onias, H.; Andrade, K.C.; Novaes, M.M.; Pessoa, J.A.; Mota-Rolim, S.A.; Osório, F.L.; Sanches, R.; Santos, R.G. dos; Tófoli, L.F.; Silveira, G.O. de; Yonamine, M.; Riba, J.; Santos, F.R.; Silva-Junior, A.A.; Alchieri, J.C.; Galvão-Coelho, N.L.; Lobão-Soares, B.; Hallak, J.C.; Arcoverde, E.; Maia-de-Oliveira, J.P.; Araújo, D.B.
Rapid antidrepressant effects of the psychedelic ayahuasca in treatment-resistant depression
A randomized placebo-controlled trial
Psychol Med, 2018, epub ahead of print, (epub)
yage, Depression, Ethnomedicine, Clinical research, Complementary and alternative medicine, Phytomedicine, Placebo-controlled, Mental diseases, Randomized trial